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44 th Annual Meeting and ToxExpo Program Description MONDAY #115 CHARACTERIZATION OF FUNCTIONAL VARIATION IN HUMAN GSTM3 IN GLIOMA CELLS USING RNAI. X. Liu, M. R. Campbell, G. S. Pittman and D. A. Bell. Molecular genetics, NIEHS, Research Triangle Park, NC. #116 DIFFERENTIAL GENE EXPRESSION IN F344 RATS FOLLOWING EXPOSURE TO EITHER POLYBROMINATED DIPHENYL ETHERS (PBDES) OR PCBs. J. M. Sanders 1,2 , L. T. Burka 1 and M. L. Cunningham 1 . 1 Laboratory of Pharmacology and Chemistry, NIEHS, Research Triangle Park, NC and 2 Department of Toxicology, NC State University, Raleigh, NC. #117 EXTRACTION OF GENES WITH STABLE EXPRESSION IN RAT LIVER TREATED WITH VARIOUS COMPOUNDS–ANALYSIS OF THE DATA IN THE TOXICOGENOMICS PROJECT IN JAPAN -. H. UEDA, T. KASAHARA, H. TOTSUKA, T. MIYAGISHIMA, T. URUSHIDANI and T. NAGAO. Toxicogenomics Project, National Institute of Health Science, Setagayaku, Tokyo, Japan. Sponsor: T. INOUE. #118 CHARACTERIZATION OF AN ACUTE MOLECULAR MARKER OF NON-GENOTOXIC HEPATOCARCINOGENESIS IN RODENTS BY GENE EXPRESSION PROFILING IN A LONG- TERM CLOFIBRIC ACID STUDY. C. Michel 1 , C. Desdouets 2 , R. A. Roberts 1,3 , K. R. Isaacs 4 and E. Boitier 1 . 1 Drug Safety Evaluation, Sanofi Aventis, Vitry-sur-Seine, France, 2 INSERM U370, Paris, France, 3 Safety Assessment, AstraZeneca, Cheshire, United Kingdom and 4 CITP, Harrogate, United Kingdom. #119 PROFILES OF GLOBAL GENE EXPRESSION IN IONIZING RADIATION-DAMAGED HUMAN DIPLOID FIBROBLASTS REVEAL SYNCHRONIZATION BEHIND THE G1 CHECKPOINT. T. Zhou 1 , J. W. Chou 2 , D. A. Simpson 1 , Y. Zhou 1 , T. E. Mullen 1 , M. Medeiros 1 , P. R. Bushel 2 , R. S. Paules 2 , X. Yang 1 , P. Hurban 3 , E. K. Lobenhofer 3 and W. K. Kaufmann 1 . 1 Pathology & Lab. Medicine, University of North Carolina, Chapel Hill, NC, 2 National Institute of Environmental Health Science, Research Triangle Park, NC and 3 Paradigm Genetics, Research Triangle Park, NC. #120 EXPRESSION OF THE HELIX-LOOP-HELIX INHIBITOR OF DNA BINDING-1 (ID-1) GENE IS REGULATED BY RETINOIC ACID IN NORMAL HUMAN KERATINOCYTES. L. A. White and C. M. Villano. Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ. #121 APPLICATION OF A CROSS-PLATFORM RNA STANDARD FOR ASSESSING MICROARRAY DATA COMPARABILITY. P. S. Pine 1 , B. A. Rosenzweig 1 , J. C. Fuscoe 2 , C. A. Afshari 3 , H. K. Hamadeh 3 , J. D. Retief 4 , Y. Turpaz 4 , E. Blomme 5 , R. Ciurlionis 5 , J. F. Waring 5 , R. S. Paules 6 , C. J. Tucker 6 , T. L. Fare 7 , E. M. Coffey 7 , Y. He 7 , J. Collins 8 , K. Jarnagin 9 , S. Fujimoto 9 , G. L. Kiser 10 , T. Kaysser- Kranich 10 , F. D. Sistare 11 , J. Sina 11 and K. Thompson 1 . 1 2 CDER, U.S. FDA, Silver Spring, MD, NCTR, U.S. FDA, Jefferson, AR, 3 Amgen Inc., Thousand Oaks, CA, 4 5 Affymetrix Inc., Santa Clara, CA, Abbott Laboratories, Abbott Park, IL, 6 NIEHS, Research Triangle Park, NC, 7 Rosetta Inpharmatics, Seattle, WA, 8 9 Agilent Technologies, Santa Clara, CA, Iconix Pharmaceuticals, Mountain View, CA, 10 GE Healthcare, Chandler, AZ and 11 Merck & Co. Inc., West Point, PA. #122 GENE EXPRESSION MODIFICATIONS IN A MOUSE EMPHYSEMA MODEL INDUCED BY ELASTASE. Q. Meng 1 , K. M. Waters 2 , J. M. Malard 2 , K. Lee 1 and J. G. Pounds 2 . 1 Battelle Toxicology Northwest, Richland, WA and 2 Pacific Northwest National Laboratories, Richland, WA. #123 TUMOR SUBTYPE CHEMOTHERAPEUTIC RESPONSES IN THE BREAST. K. Hoadley 1 , M. A. Troester 2 and C. M. Perou 1,2,3 . 1 Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 2 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC and 3 Department of Genetics, University of North Carolina, Chapel Hill, NC. Sponsor: J. Swenberg. #124 USE OF GENE EXPRESSION CHANGES IN CIRCULATING BLOOD CELLS TO MONITOR XENOESTROGEN EXPOSURE IN NEONATAL MICE. F. Lim, K. Antrobus, D. J. Moore, H. Tinwell, I. Kimber, J. Ashby, G. Orphanides and J. Moggs. Syngenta CTL, Macclesfield, Cheshire, United Kingdom. #125 COMPARISON OF WHOLE BLOOD GENE EXPRESSION PROFILES FROM THREE NON- HUMAN PRIMATE SPECIES AND HUMANS. C. S. Phillips and J. F. Dillman. Applied Pharmacology, USAMRICD, Aberdeen Proving Ground, MD. Sponsor: A. Sciuto. #126 THE BIOLOGY OF DRUG SIGNATURES. C. Pearson, R. Brennan, M. Fielden, B. Ganter, W. Hu, S. Tugendreich, A. Vladimirova and K. Kolaja. Iconix Pharmaceuticals, Inc., Mountain View, CA. #127 GENE EXPRESSION ANALYSIS OFFERS UNIQUE ADVANTAGES TO HISTOPATHOLOGY IN PREDICTION OF OVERALL LIVER CONDITION. A. N. Heinloth 1 , G. A. Boorman 2 and R. S. Paules 1 . 1 NCT, NIEHS, Research Triangle Park, NC and 2 ETP, NIEHS, Research Triangle Park, NC. 58 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #128 CHANGES IN GENE EXPRESSION INDUCED BY TECHNICAL CHLORDANE, CIS-NONACHLOR, TRANS-NONACHLOR AND OXYCHLORDANE IN RAT LIVERS MONITORED BY OLIGONUCLEOTIDE MICRO-ARRAYS. CURRAN, I.H.A., HIERLIHY, A., AND BONDY, G., TOXICOLOGY RESEARCH DIVISION, FOOD DIRECTORATE, HPFB, HEALTH CANADA, OTTAWA, ONTARIO, CANADA. I. Curran, A. Hierlihy and G. Bondy. Toxicology Research Division, Food Directorate, Health Canada, Ottawa, ON, Canada. Sponsor: G. Bondy. #129 EFFECT OF REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN THE RAT TESTES. T. Fukushima 1,2 , T. Yamamoto 1 , R. Kikkawa 1 , Y. Hamada 1 , I. Horii 1 and C. Mori 2 . 1 Worldwide Safety Sciences, Pfizer Global and Research Nagoya Laboratories, Taketoyo, Aichi, Japan and 2 Bioenvironmental Medicine, Chiba University, Chiba, Japan. Sponsor: M. Kurata. #130 GENE EXPRESSION CHANGES IN FETAL THYMUS EXPOSED TO ORGANIC COMPOUNDS EXTRACTED FROM DIESEL EXHAUST PARTICLES. T. Ito 1 , H. Nagai 1,2 , T. Lin 3 , R. E. Peterson 3 , C. Tohyama 1 , T. Kobayashi 1 and K. Nohara 1 . 1 National Institute for Environmental Studies, Tsukuba, Japan, 2 Science University of Tokyo, Noda, Japan and 3 University of Wisconsin, Madison, WI. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: ARSENIC AND URANIUM TOXICOLOGY Chairperson(s): John P. Christopher, CAL-EPA, Sacramento, CA and David S. Barber, University of Florida, Gainesville, FL. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #131 MOLECULAR CLONING AND CHARACTERIZATION OF HUMAN CYT19, AN S-ADENOSYL-L-METHIONINE:AS- METHYLTRANSFERASE FROM HEPG2 CELLS. A. McNally and D. Barber. University of Florida, Gainesville, FL. #132 GLOBAL CHANGES IN POSTTRANSLATIONAL COVALENT HISTONE MODIFICATIONS MEDIATED BY LOW-DOSE ARSENIC. J. F. Reichard and A. Puga. Environmental Health, University of Cincinnati, Cincinnati, OH. #133 ARSENIC CAUSES DOSE-DEPENDENT ENHANCEMENT AND SUPPRESSION OF RETINOIC ACID RECEPTOR (RAR)-MEDIATED GENE ACTIVATION. J. C. Davey, L. Ingram, C. Batki, J. Lariviere and J. W. Hamilton. Pharmacology & Toxicology, Dartmouth Medical School, Hanover, NH. #134 ARSENITE INHIBITS CELL CYCLE PROGRESSION OF U937 MYELOID LEUKEMIA CELLS THROUGH INDUCTION OF CDC25A DEGRADATION. G. McCollum Lehmann and M. J. McCabe. University of Rochester, Rochester, NY. #135 MOLECULAR MECHANISMS UNDERLYING INHIBITION OF INSULIN-STIMULATED GLUCOSE UPTAKE IN ADIPOCYTES EXPOSED TO TRIVALENT ARSENICALS. D. S. Paul, A. W. Harmon and M. Styblo. Department of Nutrition, University of North Carolina, Chapel Hill, NC. #136 FURTHER STUDIES ON ABERRANT GENE EXPRESSION IN ARSENIC-INDUCED MALIGNANT TRANSFORMATION OF LIVER EPITHELIAL CELLS. J. Liu 1 , L. Benbrahim-Tallaa 1 , Y. Xie 1 , X. Qian 2 , W. Qu 1 , J. Otstot 3 and M. Waalkes 1 . 1 Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, 2 LST, NIEHS, Research Triangle Park, NC and 3 DNA Sequencing Core, NIEHS, Research Triangle Park, NC. #137 ARSENITE DECREASES CYP3A INDUCTION IN CULTURED RAT HEPATOCYTES BY DUAL MECHANISMS. T. L. Noreault 1 , J. M. Jacobs 3,4 , R. C. Nichols 2,3 , H. W. Trask 4 , S. A. Wrighton 5 , P. R. Sinclair 1,2,4 , R. M. Evans 6 and J. F. Sinclair 1,2,4 . 1 Pharmacology & Toxicology, Dartmouth Medical School, Hanover, NH, 2 VA Medical Center, White River Junction, VT, 3 Microbiology/Immunology, Dartmouth Medical School, Hanover, NH, 4 Biochemistry, Dartmouth Medical School, Hanover, NH, 5 Lilly Research Laboratories, Indianapolis, IN and 6 Howard Hughes Medical Institute, Salk Institute for Biological Studies, San Diego, CA. #138 ANALYSIS OF GLOBAL AND GENE SPECIFIC DNA METHYLATION IN LIVERS OF NEWBORN MICE TRANSPLACENTALLY EXPOSED TO A CARCINOGENIC DOSE OF ARSENIC. Y. Xie 1 , J. Liu 1 , L. Benbrahim-Tallaa 1 , B. Diwan 2 and M. Waalkes 1 . 1 Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC and 2 BRP, SAIC-Frederick, NCI at Frederick, Frederick, MD. #139 ARSENITE INDUCES CYTOKERATIN EXPRESSION IN MICE LIVER. P. Ramirez 1 , M. Cerbon 2 and M. E. Gonsebatt 3 . 1 Laboratorio de Toxicologia Celular, FES Cuautitlan, Cuatitlan, Mexico, 2 Biologia, Facultad de Quimica, UNAM, Mexico, DF, Mexico and 3 Medical Genomics and Environmental Toxicology, Instituto de Investigaciones Biomedicas, UNAM, Mexico, DF, Mexico. #140 REDUCTION OF ARSENATE BY HUMAN ERYTHROCYTE (RBC) LYSATE AND RAT LIVER CYTOSOL (CS) IS LINKED TO GLYCOLYSIS. B. Nemeti and Z. Gregus. Department Pharmacology, University Pecs, Med. School, Pecs, Hungary. #141 THE ROLE OF THE RAS SIGNALING PATHWAY IN ANDROGEN-INDEPENDENCE ACQUIRED DURING ARSENIC-INDUCED MALIGNANT TRANSFORMATION OF HUMAN PROSTATE EPITHELIAL CELLS. L. Benbrahim-Tallaa 1 , M. Webber 2 and M. Waalkes 1 . 1 Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC and 2 Michigan State University, East Lansing, MI. #142 ARSENITE BINDING TO SUBSETS OF THE HUMAN ESTROGEN RECEPTOR-α. K. T. Kitchin and K. A. Wallace. Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC. MONDAY up-to-date information at www.toxicology.org 59
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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