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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1903 GENE EXPRESSION IN PORPHYRIA INDUCED BY 2, 3, 7, 8-TETRACHLORO-DIBENZO-P- DIOXIN IN SUSCEPTIBLE MICE. A. G. Smith, B. Clothier and R. Davies. MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom. #1904 STRESS- AND INFLAMMATORY-RELATED MNRA INDUCTION IN HEPATOCYTES AND NON-PARENCHYMAL CELLS RESPONSE TO OXIDATIVE STIMULI. T. Yamamoto, H. Utsumi, N. Shimada and N. Tsutsui. Mitsubishi Pharmacology Corporation, Kisarazu, Chiba, Japan. Sponsor: J. Sugimoto. #1905 DEVELOPMENT OF PROTEIN MICROARRAY TECHNOLOGY TO FACILITATE IDENTIFICATION OF PROTEINS ISOLATED BY GEL FILTRATION AND ION-EXCHANGE CHROMATOGRAPHIES. H. Kim 1,2 , Y. Yuan 1 , D. J. Kaplan 1 , D. A. Putt 1 , Z. Li 1 and K. Fleischmann 1 . 1 2 Detroit R&D, Inc., Detroit, MI and Institute of Environmental Health Sciences, Wayne State University, Detroit, MI. #1906 HEPATIC GENE EXPRESSION PROFILES OF RATS EXPOSED TO PERFLUOROOCTANESULFONATE (PFOS) IN UTERO. J. A. Bjork 1 , J. M. Berthiaume 1 , C. Lau 2 , J. L. Butenhoff 3 and K. B. Wallace 1 . 1 Biochem. & Mol. Biology, Medical School, University of Minnesota, Duluth, MN, 2 Reproductive Toxicology Division, NHEERL, U.S. EPA, Research Triangle Park, NC and 3 3M Company, St. Paul, MN. #1907 LIVER SLICE MODEL SYSTEM FOR BILIARY CELL EFFECTS: CHANGES IN CLINICAL CHEMISTRY PARAMETERS. H. P. Behrsing, C. Ip, L. Jimenez and C. A. Tyson. Toxicology Laboratory, SRI International, Menlo Park, CA. #1908 LIVER SLICE MODEL SYSTEM FOR BILIARY CELL EFFECTS: HISTOLOGICAL CHANGES. K. Amin, C. Ip, H. P. Behrsing and C. A. Tyson. Toxicology Laboratory, SRI International, Menlo Park, CA. #1909 IMPAIRED G1 TO S-PHASE SIGNALING EXPLAINS INHIBITED TISSUE REPAIR IN THIOACETAMIDE-TREATED TYPE 1 DIABETIC RATS. S. S. Devi and H. M. Mehendale. Toxicology, The University of Louisiana at Monroe, Monroe, LA. #1910 MOLECULAR MECHANISMS OF INHIBITED COMPENSATORY LIVER REPAIR UPON HEPATOTOXIC CHALLENGE IN TYPE 2 DIABETIC RATS. S. P. Sawant 1 , A. V. Dnyanmote 1 , J. R. Latendresse 2 , A. Warbritton 2 and H. M. Mehendale 1 . 1 The University of Louisiana at Monroe, Monroe, LA and 2 NCTR, Jefferson, AR. #1911 PPARβ-MEDIATED HEPATOTOXICITY IN A DIETARY MODEL OF NONALCOHOLIC STEATOHEPATITIS (NASH). M. A. Peraza, W. Shan, M. J. Kennett and J. M. Peters. Veterinary Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA. #1912 INDUCTION OF CYTOTOXICITY IN PRIMARY RAT HEPATOCYTES AND HUMAN HEPG2 CELLS BY SELECTED PPARγ AGONISTS. L. Guo 1 , L. Muskhelishvili 2 , E. Blann 1 , S. Dial 1 , E. Hermann 3 and Y. Dragan 1 . 1 Systems Toxicology, National Center for Toxicolological Research, Jefferson, AR, 2 Molecular Pathology Branch, Charles River Laboratories at NCTR, Jefferson, AR and 3 Center for Drug Evaluation and Research, Jefferson, AR. #1913 INDUCTION OF EARLY FIBROGENESIS IN PRECISION-CUT HUMAN AND RAT LIVER SLICES AFTER CARBON TETRACHLORIDE TOXICITY. M. van de Bovenkamp 1 , G. M. Groothuis 1 , A. L. Draaisma 1 , M. T. Merema 1 , D. K. Meijer 1 , S. L. Friedman 2 and P. Olinga 1 . 1 Pharmacokinetics and Drug Delivery, University of Groningen, Groningen, Netherlands and 2 Division of Liver Diseases, Mount Sinai School of Medicine, New York. Sponsor: A. Vickers. #1914 HUMAN LIVER AND KIDNEY SLICE VIABILITY IS EXTENDED AND PATHWAYS OF FIBROSIS ARE CHARACTERIZED. A. E. Vickers 1 , R. L. Fisher 2 and P. Olinga 3 . 1 Safety Evaluation, Allergan, Inc., Irvine, CA, 2 Vitron Inc., Tucson, AZ and 3 Department Pharmacokinetics & Drug Delivery, University Groningen, Groningen, Netherlands. #1915 THE EFFECT OF THE PPARα AGONIST WY-14, 643 ON MITOCHONDRIAL MEMBRANE POTENTIAL IN HUMAN AND RODENT LIVER CELL LINES. S. Barnes 1 , S. E. Boldt 2 , A. K. Hubbard 1 , J. Singh 2 and D. E. Amacher 2 . 1 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT and 2 Drug Safety Evaluation, Pfizer Inc., Groton, CT. #1916 IN SITU QUANTITATIVE EVALUATION OF PEROXISOMAL PROLIFERATION IN THE NON- HUMAN PRIMATE LIVER VIA LASER SCANNING CYTOMETRY (LSC). L. A. Obert 1 , V. Kostrubsky 1 , C. Okerberg 1 , J. Wijsman 1 , E. Urda 1 , J. Hanson 1 , K. Toy 1 , W. Collard 1 , W. Maier 1 , R. Bell 1 , L. Zwick 2 , S. Frantz 2 , R. Dunstan 1 and R. Adler 1 . 1 2 WWSS, Pfizer Inc., Ann Arbor, MI and MPI Research, Mattawan, MI. #1917 COMPARISON OF ALDEHYDE DEHYDROGENASE (ALDH) ACTIVITY IN THE LIVER AND LUNG. M. Yoon 1,2 , M. C. Madden 2 and H. A. Barton 2 . 1 NRC, The National Academies, Washington, DC and 2 NHEERL, U.S. EPA, Research Triangle Park, NC. #1918 ETHANOL HAS BIPHASIC EFFECTS ON EXPRESSION OF STEROL REGULATORY ELEMENT BINDING PROTEIN-1 (SREBP-1) IN RAT FGC-4 HEPATOMA CELLS WITH INHIBITION AT HIGH DOSES RESULTING IN INDUCTION OF ADH CLASS I. L. He 1,3 , M. J. Ronis 2,3 , F. A. Simmen 1,3 and T. M. Badger 1,3 . 1 Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, 2 Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR and 3 Arkansas Children’s Nutrition Center, Little Rock, AR. 194 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1919 ETHANOL INDUCES RAT HEPATIC ALCOHOL DEHYDROGENASE (ADH) CLASS I BY INTERFERING WITH POST-TRANSLATIONAL REGULATION OF STEROL REGULATORY ELEMENT BINDING PROTEIN-1 (SREBP-1). T. M. Badger 1,3 , L. He 1,3 , F. A. Simmen 1,3 and M. J. Ronis 2,3 . 1 Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, 2 Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR and 3 Arkansas Children’s Nutrition Center, Little Rock, AR. #1920 MICE WITH HEPATOCYTE-SPECIFIC RXRα DEFICIENCY HAVE ALTERED ALCOHOL METABOLISM. M. G. Kocsis, A. J. Mendy, G. Dai and Y. Y. Wan. Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS. #1921 TEMPORAL AND ZONAL EXPRESSION PATTERNS OF LIVER MRP4 AND NTCP FOLLOWING HEPATOTOXICANT EXPOSURE. L. Aleksunes 1 , G. Scheffer 2 and J. Manautou 1 . 1 Pharmaceutical Sciences, University of Connecticut, Storrs, CT and 2 Pathology, University Hospital Free University, Amsterdam, Netherlands. #1922 METHYLENEDIANILINE INJURY TO LIVERS OF TR - [LIVER CANALICULAR MRP2 TRANSPORTER-DEFICIENT] RATS IS NOT LINKED TO OXIDATIVE STRESS. M. F. Kanz, B. Ramasubramanian, Y. Chen, F. Nayeem and M. Treinen- Moslen. Pathology, University of Texas Medical Branch, Galveston, TX. #1923 PLASMA ESTERASE ACTIVITY PROTECTS AGAINST COCAINE HEPATOTOXICITY IN FEMALE MICE. M. S. Abdel-Rahman 1 , R. M. Turkall 1,2 and T. Visalli 1 . 1 Pharmacology/Physiology, UMDNJ, Newark, NJ and 2 Clinical Laboratory Sciences, School of Health Related Professions UMDNJ, Newark, NJ. #1924 IDENTIFICATION OF NOVEL SUBSTRATES AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE N-TERMINAL PHOSPHATASE ACTIVITY BASED ON ITS SUBCELLULAR LOCALIZATION. A. Enayetallah 1 , P. Srivastava 1 , M. Barber 2 , P. Mungalachetty 1 , B. Luo 1 and D. Grant 1 . 1 Pharmaceutical sciences, University of Connecticut, Storrs, CT and 2 Biotechnology/Bioservices Center, University of Connecticut, Storrs, CT. #1925 EFFECTS OF BETAINE SUPPLEMENTATION ON HEPATIC METABOLISM OF SULFUR- CONTAINING AMINO ACIDS IN MICE. Y. C. Kim 1 and S. K. Kim 2 . 1 College of Pharmacy, Seoul National University, Seoul, South Korea and 2 College of Pharmacy, Chungnam National University, Daijeon, South Korea. Sponsor: G. Carlson. #1926 APPLICATION OF QSARS TO EVALUATE MOLECULAR MECHANISMS OF HALOBENZENE INDUCED CYTOTOXICITY IN RAT HEPATOCYTES. K. Chan and P. J. O’Brien. Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada. Sponsor: G. Cherian. #1927 ACTIVATION OF PROMUTAGENS WITH HUMAN LIVER S9 AND HUMAN HEPATOCYTES USING CHINESE HAMSTER OVARY MICRONUCLEUS ASSAY. S. K. Roy 1 , A. P. Li 2,3 , B. Chris 4 , K. Paul 1 and A. Thilagar 1,2 . 1 SITEK Research Laboratories, Rockville, MD, 2 The ADMET Group, LLC, Rockville, MD, 3 In Vitro ADMET Laboratories, LLC, Rockville, MD and 4 Tissue Transformation Technologies Inc., Edison, NJ. #1928 RUBRATOXIN B INDUCED TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP)-1 SECRETION IN HEPG2 CELLS. H. Nagashima 1 , K. Maeda-Nakamura 1 , K. Iwashita 1 and T. Goto 2 . 1 National Food Research Institute, Tsukuba, Ibaraki, Japan and 2 Faculty of Agriculture, Shinshu University, Minamiminowa, Nagano, Japan. Sponsor: M. Fukayama. #1929 FUMONISIN B 1 AND TNFα INDUCED INCREASES IN SPHINGANINE AND SPHINGOSINE IN HEPG2 HEPATOCYTES ARE ATTENUATED BY SP600125, A JNK INHIBITOR. S. Hsiao 1 , P. D. Constable 2 , M. E. Tumbleson 3 and W. M. Haschek 1 . 1 Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, 2 Veterinary Clinical Medicine, University of Illinois at Urbanachampaign, Urbana, IL and 3 Agricultural and Biological Engineering, University of Illinois at Urbana- Champaign, Urbana, IL. #1930 AUGMENTATION OF LIPOPOLYSACCHARIDE- INDUCED GENE EXPRESSION AND LIVER INJURY BY RANITIDINE BUT NOT FAMOTIDINE. J. P. Luyendyk 1 , L. D. Lehman- McKeeman 2 , D. M. Nelson 2 , V. Bhaskaran 2 , B. D. Car 2 , G. H. Cantor 2 , C. M. North 1 , S. W. Newport 1 , J. F. Maddox 1 , P. E. Ganey 1 and R. A. Roth 1 . 1 Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI and 2 Discovery Toxicology, Bristol-Myers Squibb, Princeton, NJ. #1931 1H-NMR BASED METABONOMICS STUDY OF GALACTOSAMINE, METHYLENE DIANILINE, AND CLOFIBRATE IN RATS. N. Katsutani and T. Aoki. Eisai Co., Ltd.,, Drug Safety Research Laboratories, Hashima, Gifu-ken, Japan. #1932 EVALUATION OF A NOVEL ANTI-TUMOR DRUG USING IN VITRO TOXICITY SCREENING IN RAT HEPATOMA (H4IIE) CELLS, NORMAL RAT KIDNEY (NRK) CELLS, AND RAT PRIMARY HEPATOCYTES. P. C. Wilga, J. M. McKim, Jr., J. F. Pregenzer and D. K. Petrella. CeeTox, Kalamazoo, MI. #1933 UPREGULATION OF STEM CELL-DERIVED TYROSINE KINASE (STK) EXPRESSION IN LIVER MACROPHAGES AND ENDOTHELIAL CELLS DURING ACUTE ENDOTOXEMIA IS INDEPENDENT OF TUMOR NECROSIS FACTOR RECEPTOR-1. L. C. Chen, J. Laskin and D. Laskin. Joint Graduate Program in Toxicology, Rutgers University and UMDNJ-RWJMS, Piscataway, NJ. WEDNESDAY up-to-date information at www.toxicology.org 195
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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