Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #549 IN VIVO EXPOSURE OF PREPUBERTAL RATS TO METHOXYCHLOR (M) INHIBITS EX VIVO LEYDIG CELL (LC) BASAL AND HUMAN CHORIONIC GONADOTROPIN (HCG)- STIMULATED TESTOSTERONE (T) FORMATION. E. P. Murono and R. C. Derk. Pathology and Physiology Research Branch, CDC/NIOSH, Morgantown, WV. Sponsor: V. Castranova. #550 IN UTERO EXPOSURE TO 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN ALTERS SONIC HEDGEHOG AND BONE MORPHOGENIC PROTEIN 4 EXPRESSION IN THE DEVELOPING MOUSE UROGENITAL SINUS. W. A. Fritz, W. A. Bushman and R. E. Peterson. University of Wisconsin, Madison, WI. #551 CRITICAL WINDOW OF MALE REPRODUCTIVE TRACT DEVELOPMENT IN RATS FOLLOWING GESTATIONAL EXPOSURE TO DI-N-BUTYL PHTHALATE. C. M. Carruthers 1 and P. Foster 2 . 1 NIEHS, Research Triangle Park, NC and 2 NIEHS, Research Triangle Park, NC. #552 EFFECT OF DI(N-BUTYL) PHTHALATE ON MALE REPRODUCTIVE ORGAN DEVELOPMENT IN HYPOTHYROID RATS. H. Kim, E. Lee, M. Ahn and H. Kim. College of Pharmacy, Pusan National University, PUSAN, South Korea. Sponsor: I. Yu. #553 EFFECTS OF TCDD ON STEROIDOGENESIS OF RAT LEYDIG CELLS. K. P. Lai, H. Y. Yeung, M. H. Wong and C. K. Wong. Biology, Hong Kong Baptist University, Hong Kong, China. #554 ESTROGEN RECEPTOR ALPHA IS NOT REQUIRED FOR NORMAL PROSTATIC BUD FORMATION OR FOR INHIBITION OF PROSTATIC BUD FORMATION BY 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN (TCDD) IN MICE. S. M. Hicks 2 , T. Lin 1 , M. Mukai 3 , P. S. Cooke 3 and R. E. Peterson 1,2 . 1 School of Pharmacy, University of Wisconsin, Madison, WI, 2 Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI and 3 Department of Veterinary Biosciences, University of Illinois, Urbana, IL. #555 CHARACTERIZATION OF 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN (TCDD) RESPONSIVENESS IN MOUSE UROGENITAL SINUS (UGS) USING ARYL HYDROCARBON RECEPTOR (AHR)-DEPENDENT LACZ MICE. D. R. Kelman 1 , J. C. Bemis 3 , T. Lin 2 , T. A. Gasiewicz 3 and R. E. Peterson 1,2 . 1 Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, 2 Pharmacy, University of Wisconsin, Madison, WI and 3 Environmental Medicine, University of Rochester, Rochester, NY. #556 ANALYSIS OF CORTACTIN EXPRESSION IN THE ECTOPLASMIC SPECIALIZATION OF TESTES IN FLUTAMIDE TREATMENT MOUSE. R. Anahara 1 , Y. Toyama 2 , M. Maekawa 2 , M. Kai 3,4 , F. Ishino 5 , K. Toshimori 2 and C. Mori 1,6 . 1 Bioenvironmental Medicine, Chiba University, Chiba, Japan, 2 Anatomy and Developmental Biology, Chiba University, Chiba, Japan, 3 Pharmaceutical Research Laboratories, Kirin Brewery Co. Ltd., Gunma, Japan, 4 Division for Gene Research, Center for Biological Resources and Informatics, Tokyo, Japan, 5 Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan and 6 CREST, Japan Science and Technology Agency, Kawaguchi, Japan. #557 CHARACTERIZATION OF THE GENE EXPRESSION PROFILE INDUCED BY ETHYLENE GLYCOL MONOMETHYL ETHER IN THE RAT TESTIS WITH DNA MICROARRAYS. E. Blomme 1 , R. Ciurlionis 1 , K. Whitney 1 , I. Milicic 1 , M. Strakhova 1 and J. Waring 1 . 1 2 Abbott Labs, Abbott Park, IL and Abbott Labs, Abbott Park, IL. #558 THE USE OF CD-1 MICE FOR FERTILITY AND EARLY-EMBRYONIC DEVELOPMENT (ICH-1 STUDIES. L. Pinsonneault, A. St-Pierre, C. Tremblay, M. Adamo, L. Pouliot and K. Robinson. Reproductive Toxicology, CTBR Bio-Research Inc., Senneville, QC, Canada. Sponsor: M. Vezina. Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: GENE EXPRESSION II Chairperson(s): Curtis Klaassen, Kansas University Medical Center, Kansas City, KS. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #559 UNDERSTANDING HEPATIC VACUOLATION: GENE EXPRESSION ANALYSIS OF PHOSPHOLIPIDOSIS AND STEATOSIS IN RAT LIVER. D. Pelletier, B. Lu and M. Lawton. Molecular and Investigative Toxicology, Pfizer Inc., Groton, CT. #560 TOXICOGENOMIC STUDY OF HYCANTHONE, AN ANTITUMOR AGENT: MOLECULAR MECHANISMS OF HEPATOTOXICITY. A. E. Roberts, Y. Wang, X. Luo, R. Khan-Malek, V. Shultz, J. Morsman, N. Bowen, N. Bichet, O. Gillardeaux and V. Baker. Toxicology, Sanofi-aventis, Malvern, PA. #561 GENE EXPRESSION PROFILING IN RAT LIVER AND HEPATOCYTES TREATED WITH FIBRIC ACIDS: ANALYSIS OF THE DATA IN THE TOXICOGENONMICS PROJECT IN JAPAN. K. Tamura, T. Miyagishima, T. Urushidani and T. Nagao. Toxicogenomics Project, National Institute of Health Sciences, Tokyo, Japan. Sponsor: T. Inoue. 88 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #562 GENE EXPRESSION PROFILING IN RAT LIVER AND HEPATOCYTES TREATED WITH ETHIONINE–ANALYSIS OF THE DATA IN THE TOXICOGENOMICS PROJECT IN JAPAN -. T. Matsushita, T. Miyagishima, T. Urushidani and T. Nagao. Toxicogenomics Progect, National Institute of Health Sciences, Tokyo, Japan. Sponsor: T. Inoue. #563 GENE EXPRESSION ARRAY ANALYSIS OF MALE C3H AND C57BL/6 LIVER. J. C. Fuscoe 2,1 , A. Naito 1 , T. Han 2,1 and Y. Dragan 1 . 1 Systems Toxicology, National Center for Toxicolological Research, Jefferson, AR and 2 Center for Functional Genomics, NCTR, Jefferson, AR. #564 REGULATION OF MOUSE HEPATIC TRANSPORTERS BY PERFLUORODECANOIC ACID (PFDA). X. Cheng, J. M. Maher, M. Z. Dieter and C. D. Klaassen. Pharmacology & Toxicology, KUMC, Kansas City, KS. #565 ANALYSIS OF BENZO(A)PYRENE-INDUCED GENE EXPRESSION CHANGES IN FISHER 344 RAT LIVER BY QUANTITATIVE REAL-TIME PCR. A. U. N and J. C. Means. Chemistry/Environmental Institute, Western Michigan University, Kalamazoo, MI. #566 ALTERATIONS OF GENE EXPRESSION IN FEMALE LUNG ADENOCARCINOMA CL5 CELLS BY MOTORCYCLE EXHAUST PARTICULATES AND BENZO(A)PYRENE. T. Ueng and C. Hung. Institute of Toxicology, National Taiwan University, Taipei, Taiwan. #567 EXPRESSION OF GENES INVOLVED IN POLYCYCLIC AROMATIC HYDROCARBONS (PAH) TOXICITY IN HEPG2 CULTURE CELLS. F. Castorena-Torres 1 , M. Bermudez de Leon 2 , B. Cisneros 2 , J. E. Salinas-Moreno 3 and A. Albores 1 . 1 Toxicology Section., Cinvestav-IPN, Mexico City, Mexico, 2 Genetics and Biology Molecular Department, Cinvestav-IPN, Mexico City, Mexico and 3 Hospital General de Zona 24, IMSS, Nueva Rosita, Coah., Mexico. #568 EFFECTS OF DIETS CONTAINING HIGH SOY PROTEIN AND ISOFLAVONES ON GENE EXPRESSION IN FEMALE RAT LIVERS. A. Hierlihy, G. Cooke and I. Curran. Toxicology Research Division, Health Canada, Ottawa, ON, Canada. #569 A GENE SIGNATURE FOR BILE DUCT TOXINS. M. K. McMillian 1 , J. B. Parker 1 , A. M. Leone 1 , M. Kemmerer 1 , A. Y. Nie 1 , S. Bryant 1 , J. Herlich 1 , L. Yieh 2 , A. Bittner 2 , X. Liu 2 , J. Wan 2 , M. D. Johnson 1 and P. G. Lord 1 . 1 Mechanistic Toxicology, Johnson & Johnson PRD, LLC, Raritan, NJ and 2 Bioinformatics & Microarrays, Johnson & Johnson PRD, LLC, La Jolla, CA. #570 CENTRAL ROLE OF LIVER RECEPTOR HOMOLOG-1 IN INDUCING LIVER-SPECIFIC GENES AND REGULATING LIPID METABOLISM IN KIDNEY OF 5/6 NEPHRECTOMIZED RATS. H. Lu and C. D. Klaassen. Pharmacology and Toxicology, KU Medical Center, Kansas City, KS. #571 GENE EXPRESSION PROCESS IS A MAJOR INTRACELLULAR TARGET ASSOCIATED WITH A-NAPHTHYLISOTHIOCYANATE HEPATOTOXICITY. V. Chan 1 , A. R. Stapleton 1 and N. DelRaso 2 . 1 ManTech Environmental Technology, Inc., Wright-Patterson AFB, Dayton, OH and 2 Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory, Wright- Patterson AFB, Dayton, OH. Sponsor: J. Gearhart. #572 GESTATIONAL EXPOSURE TO THE PHYTOESTROGEN GENISTEIN INFLUENCES EPIGENETIC GENE REGULATION IN MICE. D. C. Dolinoy 1 , R. L. Jirtle 1 and R. A. Waterland 2 . 1 Department of Radiation Oncology, Duke University Medical Center, Durham, NC and 2 Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX. #573 USING RNA INTERFERENCE TO VALIDATE MECHANISMS OF TOXICITY. J. Milano and D. Tran. Safety Assessment, AstraZeneca, Wilmington, DE. Sponsor: P. Ciaccio. #574 CIGARETTE SMOKE CONDENSATE INHIBITS PROMOTER ACTIVITY OF LYSYL OXIDASE IN CULTURED LUNG FIBROBLASTS. S. Gao 1 , Y. Zhao 1 , L. Chen 1 , D. K. Chou 1 , P. Toselli 1 , I. Chou 2 , P. Stone 1 and W. Li 1 . 1 Biochemistry, Boston University School of Medicine, Boston, MA and 2 Microbiology, Boston University School of Medicine, Boston, MA. #575 REGULATION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR) BY TRANSFORMING GROWTH FACTOR BETA (TGF-BETA). J. Kocerha 1 , N. Denslow 1 and M. Prucha 2 . 1 Department of Physiological Sciences, University of Florida, Gainesville, FL and 2 Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL. #576 COMPENSATORY CHANGES IN PHASE I, II, AND III ENZYMES IN MICE LACKING THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP1/ABCC1). J. Sivils, L. Bain, R. A. Feldman, A. J. Zimmerman and I. Gonzalez. Biology, University of Texas El Paso, El Paso, TX. #577 TIME COURSE OF HEPG2 GENE EXPRESSION FOLLOWING TREATMENT WITH THIOXANTHONE ANTITUMOR COMPOUNDS. A. E. Roberts, X. Luo, Y. Wang, R. Khan-Malek, V. Shultz, J. Morsman, N. Bowen, N. Bichet, O. Gillardeaux and V. Baker. Sanofi-aventis, Malvern, PA. #578 ISOLATING (NEURO)TOXIC GENE EXPRESSION SIGNATURES. P. S. Spencer and N. and. Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, OR. MONDAY up-to-date information at www.toxicology.org 89
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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Program - Society of Toxicology

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