Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description #2148 REPRODUCTIVE EFFECTS OF EXPOSURE TO CONAZOLE FUNGICIDES IN THE MALE RAT. A. K. Goetz 1 , C. Blystone 1 , H. Ren 2 , J. E. Schmid 2 , H. P. Nichols 2 , W. Bao 2 , D. S. Best 2 , M. G. Narotsky 2 , D. C. Wolf 2 , J. C. Rockett 2 and D. J. Dix 2 . 1 Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC and 2 NHEERL, Office of Research and Development, U.S. EPA, Research Triangle Park, NC. #2149 COMPARISON OF GENE EXPRESSION PROFILES FROM RATS FED THREE TOXICOLOGICALLY DIFFERENT CONAZOLES. S. Hester, S. Thai, D. C. Wolf, W. Ward and S. C. Nesnow. Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC. #2150 PROFILING GENE EXPRESSION IN HUMAN H295R ADRENOCORTICAL CARCINOMA CELLS AND RAT TESTES TO IDENTIFY PATHWAYS OF TOXICITY FOR CONAZOLE FUNGICIDES. H. Ren 1 , J. E. Schmid 1 , J. Retief 2 , Y. Turpaz 2 , X. Zhang 3 , P. D. Jones 3 , J. L. Newsted 4 , J. P. Giesy 3 , D. C. Wolf 1 , C. R. Wood 1 , W. Bao 1 and D. J. Dix 1 . 1 NHEERL/ORD, U.S. EPA, Research Triangle Park, NC, 2 Affymetrix Inc., Santa Clara, CA, 3 Department of Zoology, Michigan State University, East Lansing, MI and 4 ENTRIX Inc., East Lansing, MI. #2151 REPRODUCTIVE TOXICITY OF EXPOSURE TO CONAZOLE FUNGICIDES IN THE FEMALE RAT. J. C. Rockett 1 , M. G. Narotsky 1 , I. Thillainadarajah 1 , C. R. Blystone 2,1 , A. K. Goetz 2,1 , H. Ren 1 , D. S. Best 1 , R. N. Murrell 2,1 , H. P. Nichols 1 , J. E. Schmid 1 , K. E. Thompson 3 and D. J. Dix 1 . 1 RTD/NHEERL/ORD, U.S. EPA, Research Triangle Park, NC, 2 Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC and 3 Reproductive Toxicology, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, New Brunswick, NJ. #2152 A RISK ASSESSMENT OF THE TRIAZINE HERBICIDE ATRAZINE. D. W. Gammon, C. N. Aldous, W. C. Carr, J. R. Sanborn and K. F. Pfeifer. Department of Pesticide Regulation, California EPA, Sacramento, CA. #2153 METHOXYCHLOR INHIBITS EXPRESSION OF ANTIOXIDANT ENZYMES IN THE MOUSE OVARY. R. K. Gupta, K. P. Miller, D. Tomic and J. A. Flaws. Toxicology, University of Maryland at Baltimore, Baltimore, MD. #2154 TRANSIENT ACTIVATION OF ACETYLCHOLINESTERASE BY PARAOXON. C. A. Rosenfeld 1 and L. G. Sultatos 2 . 1 Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Lafayette, NJ and 2 Pharmacology & Physiology, UMD New Jersey Medical School, Newark, NJ. #2155 EVALUATION FOR THE ADDITIVE TOXIC INFLUENCE OF ORGANOPHOSPHORUS PESTICIDES. M. Tahara 1,2 , R. Kubota 1 , H. Nakazawa 2 , A. Hirose 3 , M. Ema 3 , H. Tokunaga 1 and T. Nishimura 1 . 1 Division of Environmental Chemistry, National Institute of Health Sciences, Tokyo, Japan, 2 Department of Analytical Chemistry, Hoshi University, Tokyo, Japan and 3 Division of Risk Assessment, Biological, Safety Research Center, National Institute of Health Sciences, Tokyo, Japan. #2156 BIOLOGICAL MONITORING OF EXPOSURE TO ORGANOPHOSPHORUS INSECTICIDES IN GREENHOUSE WORKERS. M. Bouchard 1,3 , G. Carrier 1 , R. C. Brunet 2 , N. Noisel 1 , G. Labarre 1 , P. Dumas 3 and J. Weber 3 . 1 Environmental and Occupational Health, University of Montreal, Montreal, QC, Canada, 2 Mathematics and statistics, University of Montreal, Montreal, QC, Canada and 3 Risques biologiques, environnementaux et occupationnels, Institut national de sante publique du Quebec, Montreal, QC, Canada. #2157 KINETIC DATA ON PESTICIDE METABOLISM IN HUMANS TO ALLOW PBPK/PD MODELS FOR PARATHION AND CHLORPYRIFOS TO PREDICT SUSCEPTIBILITY. J. R. Olson, J. B. Knaak, B. P. McGarrigle, K. M. Kransler, R. J. Foxenberg and P. J. Kostyniak. Pharmacology and Toxicology, SUNY at Buffalo, Buffalo, NY. #2158 ORGANOPHOSPHORUS PESTICIDES INHIBIT PRENYLATED METHYLATED PROTEIN METHYL ESTERASE. N. S. Lamango. College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL. Sponsor: A. Ndifor. #2159 ASSESSING EXPOSURES TO FLEA CONTROL INSECTICIDES FROM THE FUR OF DOGS TREATED WITH FLEA COLLARS. K. Davis 1 , J. Chambers 1 , J. Moran 1 , N. Holifield 1 and S. Boone 2 . 1 Basic Science, Mississippi State University, Mississippi State, MS and 2 U.S. EPA, Stennis Space Center, MS. #2160 EFFECT OF PYRETHRINS ON CYTOCHROME P450 FORMS IN CULTURED RAT AND HUMAN HEPATOCYTES. B. G. Lake 1 , R. J. Price 1 , A. M. Giddings 1 , C. Meredith 1 and T. G. Osimitz 2 . 1 Molecular Sciences, BIBRA International Ltd.,, Carshalton, Surrey, United Kingdom and 2 Science Strategies LLC, Charlottesville, VA. #2161 RELATIVE POTENCIES FOR ACUTE EFFECTS OF PYRETHROIDS ON MOTOR FUNCTION IN RATS. M. J. Wolansky 1 , M. J. DeVito 2 , C. Gennings 3 , W. Carter 3 , R. A. Carchman 3 and K. M. Crofton 2 . 1 National Research Council, Research Triangle Park, NC, 2 NTD and ETD, U.S. EPA, Research Triangle Park, NC and 3 Solveritas, LLC, Richmond, VA. THURSDAY 214 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #2162 USING ARRAY TECHNOLOGY TO IDENTIFY POTENTIAL BIOMARKERS FOR PYRETHROID INSECTICIDES. J. Harrill 1 , M. J. Wolansky 2 , S. Hester 3 , J. M. Hedge 4 and K. M. Crofton 4,1 . 1 Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC, 2 National Research Council, Research Triangle Park, NC, 3 ETD, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC and 4 NTD, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #2163 ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASE AND TRANSCRIPTIONAL FACTORS PRECEDES CYCLOOXYGENASE-2 GENE EXPRESSION IN MACROPHAGES EXPOSED TO THE O, P- DDT. J. Kim 1,2 , E. Han 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea. #2164 SUCCESSFUL ELIMINATION OF PARAQUAT BY HEMOPERFUSION USING PULSATILE EXTRACORPOREAL CIRCULATION. E. Hwang 1 , S. Lee 2 , J. Hwang 2 , J. Lee 3 , C. Lee 4 and Y. Kim 1 . 1 Department of Thoracic and Cardiovascular Surgery, Konkuk University Chungju Hospital, Chungju, South Korea, 2 Department of Thoracic and Cardiovascular Surgery, Konkuk University Hospital, Seoul, South Korea, 3 Department of Emergency Medicine, Konkuk University Chungju Hospital, Chungju, South Korea and 4 Department of Diagnostic and Experimental Medicine, Konkuk University Chungju Hospital, Chungju, South Korea. #2165 DDT-INDUCED AROMATASE AND CYCLOOXYGENASE-2 GENE EXPRESSION IN TESTICULAR LEYDIG R2C CELLS. D. Oh 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea. #2166 INDUCTION OF CYP3A4 BY O, P’-DDT IN HEPG2 CELLS. I. M. Medina and G. Elizondo- Azuela. Toxicology, CINVESTAV-IPN, Mexico City, D.F., Mexico. Sponsor: B. Quintanilla-Vega. #2167 N-DEALKYLATION IS A KEY DETERMINANT IN THE HEPATOTOXICITY OF CHLOROACETANILIDE HERBICIDE ALACHLOR. V. M. Kale and S. A. Meyer. Toxicology, University of Louisiana at Monroe, Monroe, LA. #2168 TRIBUTYLTIN REGULATED STEROIDOGENIC ENZYME GENES EXPRESSION AND CHANGES SEXUAL HORMONE IN MOUSE TESTICULAR LEYDIG CELLS. H. Kim 1,2 , K. Lee 1 , K. Jung 1,2 , D. Oh 1,2 , K. Oh 1,2 , J. Choi 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea. #2169 TRIBUTYLTIN INDUCE CELL CYCLE ARREST IN RAT TESTICULAR LEYDIG CELLS. D. Kim 3 , K. Lee 1,2 , D. Oh 1,2 , J. Kim 1,2 , H. Kim 1,2 , D. Shin 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea, 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea and 3 Pathology, College of Oriental Medicine, Daejeon University, Daejeon, South Korea. #2170 THE BIPYRIDYL HERBICIDE PARAQUAT CAUSES OXIDATIVE STRESS-MEDIATED TOXICITY IN HUMAN NEUROBLASTOMA SH- SY5Y CELLS: RELEVANCE TO PARKINSON`S DISEASE. W. Yang and E. Tiffany-Castiglioni. Veterinary Integrative Biosciences, Texas A&M University, College Station, TX. Thursday Morning, March 10 8:30 AM to 11:30 AM La Louisiane Ballroom B POSTER SESSION: DERMAL TOXICOLOGY Chairperson(s): James McDougal, Wright State University, Pharmacology and Toxicology, Dayton, OH and Paul Howard, U.S. FDA, NCTR Biochemical Toxicology, Jefferson, AR. Displayed: 8:30 AM–11:30 AM Attended: 8:30 AM–10:00 AM #2171 DIFFERENTIAL INDUCTION OF CYCLOOXYGENASE-2 (COX-2) AND HEME OXYGENASE-1 (HO-1) BY UVB LIGHT IN GROWING AND CALCIUM-DIFFERENTIATED PRIMARY CULTURES OF MOUSE KERATINOCYTES. A. T. Black 1 , M. P. Shakarjian 2 , D. R. Gerecke 1,3 , A. M. Vetrano 3 , D. E. Heck 1,3 and J. D. Laskin 1,4 . 1 Joint Graduate Program in Toxicology, Rutgers University, Piscataway, NJ, 2 Department of Medicine, UMDNJ-Robert W Johnson Med. Sch, Piscataway, NJ, 3 Pharmacology and Toxicology, Rutgers University, Piscataway, NJ and 4 Environmental and Occupational Medicine, UMDNJ-Robert W Johnson Med. Sch, Piscataway, NJ. #2172 DECREASING MALATHION APPLICATION TIME FOR LICE TREATMENT REDUCES TRANSDERMAL ABSORPTION. R. Brand 1,2 , A. Charron 1 and R. Brand 1,2 . 1 Internal Medicine, Evanston Northwestern Healthcare, Evanston, IL and 2 Internal Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL. Sponsor: P. Iversen. #2173 DERMAL PENETRATION OF SODIUM LAURYL SULPHATE AND ITS EFFECT UPON THE ABSORPTION OF OTHER CHEMICALS IN VITRO. J. Wakefield 1 , D. Lockley 2 , R. Pendlington 2 and F. Williams 1 . 1 Environmental Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom and 2 SEAC, Unilever Colworth, Sharnbrook, Bedfordshire, United Kingdom. THURSDAY up-to-date information at www.toxicology.org 215
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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