44 th Annual Meeting and ToxExpo <strong>Program</strong> Description THURSDAY #2294 CARDIOLIPIN IS A PREFERRED SUBSTRATE FOR CYTOCHROME C INDUCED OXIDATION DURING INTRINSIC APOTOSIS. V. A. Tyurin 1 , Y. Y. Tyurina 1 , A. Lysytsya 1 , A. A. Amoscato 2 , J. Jiang 1 , Q. Zhao 1 , M. Zou 1 , V. B. Ritov 3 and V. E. Kagan 1 . 1 Department <strong>of</strong> Environmental and Occupational Health, Center for Free Radical and Antioxidant Health University <strong>of</strong> Pittsburgh, Pittsburgh, PA, 2 Mass Spectrometry Facility, University <strong>of</strong> Pittsburgh, Pittsburgh, PA and 3 Department <strong>of</strong> Medicine, University <strong>of</strong> Pittsburgh, Pittsburgh, PA. #2295 CYTOCHROME C CATALYZED CARDIOLIPIN OXIDATION IS ESSENTIAL FOR THE RELEASE OF PROAPOPTOTIC FACTORS FROM MITOCHONDRIA. J. Jiang 1 , V. A. Tyurin 1 , Y. Y. Tyurina 1 , V. Kini 1 , P. Cai 1 , V. B. Ritov 2 and V. E. Kagan 1 . 1 Center for Free Radical and Antioxidant Health, Department <strong>of</strong> Environmental and Occupational Health, University <strong>of</strong> Pittsburgh, Pittsburgh, PA and 2 Department <strong>of</strong> Medicine, University <strong>of</strong> Pittsburgh, Pittsburgh, PA. #2296 TWO FACETS OF ETOPOSIDE:PRO- APOPTOTIC AGENT AND ANTIOXIDANT. V. A. Kini 1 , Y. Y. Tyurina 1 , V. A. Tyurin 1 , A. Lysytsya 1 , J. Yalowich 2,1 and V. E. Kagan 1,2 . 1 Department <strong>of</strong> EOH, Center for Free Radical and Antioxidant Health, University <strong>of</strong> Pittsburgh, Pittsburgh, PA and 2 Department <strong>of</strong> Pharmacology, University <strong>of</strong> Pittsburgh, Pittsburgh, PA. #2297 HL-60 CELLS WITH METABOLICALLY BIOENGINEERED POLYUNSATURATED CARDIOLIPIN MOLECULAR SPECIES EXERT INCREASED SENSITIVITY TO APOPTOSIS. Y. Y. Tyurina, V. A. Tyurin, Y. Fujii and V. E. Kagan. Department <strong>of</strong> Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University <strong>of</strong> Pittsburgh, Pittsburgh, PA. #2298 IDENTIFICATION OF NUR77 AGONISTS THAT INDUCE APOPTOSIS AND INHIBIT CANCER CELL SURVIVAL THROUGH NUCLEAR PATHWAYS. S. Chintharlapalli 1 , S. Papineni 1 , R. Burghardt 2 and S. Safe 1,3,4 . 1 Biochemistry & Biophysics, Texas A&M University, College Station, TX, 2 Veterinary Anatomy & Public Health, Texas A&M University, College Station, TX, 3 Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX and 4 Institute <strong>of</strong> Biosciences & Technology, Texas A&M University Health Science Center, Houston, TX. #2299 THE IBM OF SMAC IS DISPENSABLE FOR APOPTOTIC FUNCTION. S. P. Burke and J. B. Smith. Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Alabama Birmingham, Birmingham, AL. Sponsor: C. Lamartiniere. #2300 INVOLVEMENT OF THE AP-1 COMPLEX IN THE NEUROPROTECTIVE EFFECT OF PACAP AGAINST CERAMIDE-INDUCED TOXICITY. N. Aubert 1,2 , A. Falluel-Morel 2 , C. Fisch 1 , D. Vaudry 2 , S. de Jouffrey 1 , A. Fournier 3 , R. Forster 1 , H. Vaudry 2 and B. Gonzalez 2 . 1 CIT, Evreux, France, 2 INSERM-IFRMP 23, Rouen, France and 3 INRS-Institut Armand Frappier, Quebec, Canada. #2301 ACTIVATION OF ENDONUCLEASE, OR CASPASE-ACTIVATED DNASE (CAD), AS A MARKER OF APOPTOSIS RATHER THAN NECROSIS IN DRUG- OR CHEMICAL-INDUCED ONCOSIS IN VIVO. S. D. Ray 1 , S. Stohs 2 and G. B. Corcoran 3 . 1 Mol. <strong>Toxicology</strong>. Prog./Pharmacology Scs., AMS College <strong>of</strong> Pharmacology/LIU, Brooklyn, NY, 2 AdvoCare International, Carrollton, TX and 3 Pharmaceutical Sciences, Wayne State University, Detroit, MI. #2302 APOPTOSE TRIGGERED MICRONUCLEI: THE ROLE OF APOPTOSIS ON THE OUTCOME OF MICRONUCLEUS ASSAY. M. Kabiri. San<strong>of</strong>i- Aventis, Hattersheim, Germany. Sponsor: M. Bonnefoi. #2303 ISOLATION OF THE APOPTOSIS INDUCING CONSTITUENTS OF GUAIACUM SANCTUM L. AND GUAIACUM OFFICINALE L. (ZYGOPHYLLACCEAE) ON HUMAN BREAST CELLS IN VITRO. K. J. Chavez 1 , S. Schwaiger 2 , K. Renner 3 , J. A. Flanders 4 , H. Stuppner 2 and E. Rodriguez 5 . 1 Department <strong>of</strong> Comparative Environmental <strong>Toxicology</strong>, Cornell University, Ithaca, NY, 2 Institute fur Pharmazie, Abt Pharmakognosie, Universitae Innsbruck, Innsbruck, Austria, 3 Biozentrum, Division Molekulare Pathophysiologie, Medizinische Universitae Innsbruck, Innsbruck, Austria, 4 Department <strong>of</strong> Clinical Sciences and Molecular Medicine, Cornell University, Ithaca, NY and 5 Department <strong>of</strong> Plant Biology, Cornell University, Ithaca, NY. 224 SOT’s 44 th Annual Meeting
Author Index 44 th Annual Meeting and ToxExpo AUTHOR INDEX The numerals following the author’s names refer to the abstract numbers. The asterisk after the abstract number indicates the author is the first presenter. A Aalbers, M ............................................... 903 Aardema, M J ........................................ 2209 Aase, A ..................................................... 450 Abadin, H .............................................2086* Abbey, A ................................................. 1951 Abbott, B ................................................ 1224 Abbott, B D .............................................680* Abbott, L C ...................................... 618, 619 Abdalla, E ...............................................1108 Abdel-Rahman, A A ..............................962* Abdel-Rahman, M S ............................1923* Abdel-Rahman, S Z .................... 1274, 2236 Abdelrahim, M ....................................1807* Abdullah, I ............................................ 1378 Abdullah, S ............................................ 1780 Abe, J ................................................ 831, 837 Abe, K .................................................... 1424 Abel, M D .............................................. 1255 Abel, S J .................................................... 647 Abel, S ..................................................... 113* Abou-Donia, M ..................................... 1952 Abou-Donia, M B ................. 961, 962, 1620 Abou-Hadeed, A H .................................. 79 Abouzakhar, F S ....................................946* Abraham, V ..........................................1851* Abraham, W ............................................ 474 Abromovitz, M W .................................. 372 Acevedo, S ............................................... 414 Acevedo, S P ......................................... 1279 Achanzar, W .......................................... 1619 Ackerman, J I .............................2205*, 2230 Acosta-Saavedra, L C ..........627, 1146, 1875 Adair, B .................................................. 1817 Adair, B M ....................................692*, 1231 Adami, H ................................................. 295 Adamo, M ............................. 262, 558, 1462 Adams, A ............................................... 1383 Adams, D F ............................................536* Adams, J .................................................899* Adams, R J ............................................... 678 Addai, A ................................................. 1498 Adibzadeh, M ....................................... 1878 Adkins, J N .............................................918* Adler, R .................................................. 1916 Adlercreutz, H ...................................... 1490 Adriaens, E ..................................... 481, 482, .............................................2006, 2009, 2015* Afan, R ..................................................... 473 Affatato, A A ................................ 1274, 2236 Afriyie-Gyawu, E ...................... 1283, 1309, .......................................................1400, 1402* Afshari, A ............................................... 1468 Afshari, C .............................................. 1784 Afshari, C A ............................................. 121 Agca, Y ..................................................... 546 Ahaghatu, E .......................................... 2190 Ahlgren, S .............................................. 2260 Ahmad, S .................................... 1138*, 1604 Ahmed, A E ..................................214*, 1076 Ahmed, R ................................................ 154 Ahmed, S ................................................. 887 Ahn, K .....................................................1148 Ahn, M ..................................................... 552 Ahr, H .....................................................2114 Ahr, H J .................................................1735* Aiyar, R .................................................1383* Aizawa, Y ................................ 459, 607, 944 Akahori, F ................................................ 954 Aksinenko, A Y ................. 1936, 1937, 1938 Akunyili, D N ....................................... 1439 Al-Hamdani, S ...................................... 1589 Al-Zoughool, M H ..............................1797* Alatorre Rico, J ........................................ 252 Alavanja, M R ....................................... 1333 Albano, E ................................................. 906 Albershardt, D J .................................... 1499 Alberston, T E ........................................... 46 Albert, R ................................................. 1512 Albertini, R J .........................................1030* Albores, A ................................................ 567 Alcaraz-Contreras, Y ............................ 1412 Alcocer, M .............................................. 1710 Alden, C L ............................................. 2027 Aldous, C N .......................................... 2152 Aldous, K M .......................................... 1288 Aldridge, J E ...........................................965* Aleksunes, L .........................................1921* Aleksunes, L M ................................. 67, 815 Aleman, F ................................................ 684 Alenius, H ............................................. 1885 Aleo, M D ................................................ 520 Alepee, N ................................................. 481 Alex, L ...................................................... 466 Alexander, B .......................................... 1798 Alexander, M .......................................... 678 Alexeeff, G ............................................. 2105 Alexeeff, G V .............................. 1476*, 2111 Alexiadis, V ............................................. 109 Aley, P ...................................................... 608 Algaier, J ................................................ 2069 Ali, K .......................................................1139 Ali, K A ................................................. 1140* Ali, M A .................................................. 2275 Ali, M Y ...................................................516* Ali, S ....................................................... 1098 Ali, S F ............................. 1099*, 1702, 1989* Alink, G ................................................1319* Allaben, W T ......................................... 1813 Allan, L L ..................992, 1359, 1870, 1871* Allayee, H .............................................. 1373 Allen, B ...................................................398* Allen, D ...................1997, 2005, 2007*, 2008 Allen, D A ................................................ 663 Allen, J ..............................2144, 2146*, 2147 Allen, J W ............................................. 1103* Allen, R ...................................................1177 Allen-H<strong>of</strong>fmann, B ....................... 105, 1364 Allgood, J C ............................................. 735 Allison, H M ............................................ 159 Alnafisi, A ................................................ 503 Alnouti, Y .............................................. 1244 Alnouti, Y M .........................................2140* Alt, B ...................................................... 1790 Alvarez, M M .......................................1609* Alvey, J D ................................................. 180 Amacher, D ............................................. 490 Amacher, D E ........................ 533, 716, 1915 Amantana, A ........................................1246* Amaratunga, D ....................................... 755 Amato, C A .............................................. 344 Amato, C M ..........................................2179* Amberg, A ............................ 114, 510*, 1038 Ambroso, J L ........................................... 905 Ambrosone, C ........................................298* Amin, K ...................................... 1170, 1908* Ammenheuser, M ................................. 1042 Amoruso, M A .....................................1514* Amoscato, A A ...................................... 2294 An, J Y ...................................................... 720 Anahara, R .............................................556* Anand, S .................................................. 956 Anand, S S ......................................73, 2095* Anantharam, V ............................. 633, 1526 And, N ..................................................... 578 Anders, F ..............................................1073* Anders, N J .............................................. 985 Andersen, M ........................................1982* Andersen, M E ........... 276, 848, 855*, 1676* Anderson, D ............................................ 437 Anderson, G R .......................................713* Anderson, K E ......................................... 727 Anderson, L M .....................................1013* Anderson, S A ......................................... 465 Anderson, S P ....................57, 58*, 59, 2286 Andreas, C ............................................1038* Andreasen, E A ..........................2241, 2242* Andrew, A S ............................................ 154 Andrew, M M ........................................ 1005 Andrews, D L ........................................ 1214 Andrews, L .............................................. 805 Andrus, A K ............................................ 269 Anestis, D K .......................................... 2121 Angerer, J ............................................... 1282 Ankarberg, E ..........................................974* Ankley, G ............................................... 1583 Ankley, G T ........................................... 1746 Annaert, P ................................................ 268 Annalora, A ............................................. 715 Annalora, A J ..........................................724* Annis, M L ............................................. 1289 Anraku, R .............................................. 1094 Ansari, G ...........................................82, 912* Ansari, G A .................................. 1558, 1629 Ansari, G S .............................................. 913 up-to-date information at www.toxicology.org 225 Ansari, R .................................................. 706 Anthony, J ........................................ 776, 787 Anthony, J S ............................................773* Antkiewicz, D S ...................................1825* Antonini, J M .....................939, 1449, 1468* Antony, V ............................................... 2108 Antoun, M ............................................. 2219 Antrobus, K ............................................. 124 Ao, K ...................................................... 2043 Aoki, T ................................................... 1931 Aoki, Y ............................................. 393, 816 Aouabdi, S ..............................................580* Api, A ........................1182, 1183, 1202, 1578 Aposhian, H V .............................153, 1329* Aposhian, M M ..................................... 1329 Apte, U ....................................................... 59 Apte, U M ...................................1047, 1052* Aquino, E E ........................................... 1539 Arakawa, S .............................................. 708 Aravantinou, M .....................................609* Arcaro, K F ...........................................1281* Arcelin, G ...............................................1199 Archer, D ............................................... 1710 Arepalli, S ........................................ 701, 702 Arfsten, D P ....................545*, 783, 792, 888 Argonza, D .............................................. 473 Ariazi, E ................................................. 1807 Arimoto, R ............................................... 199 Arjah, K .................................................. 1780 Arjun, B .................................................. 2263 Armagost, J ...........................................2231* Armour, C ................................................ 287 Arnold, L L .................................. 1502, 1505 Arocena, M ............................................ 2193 Aronson, J .............................................. 1036 Aronson, J F ..................................... 469, 498 Arreola-Mendoza, L ............................ 1132* Arrieta, D E ..........................................1278* Arrington, D .........................................2128* Arthurton, J A ....................................... 1812 Arts, J H ......................................1208*, 1518 Arunajadai, S ........................................ 2056 Arvidson, K ........................................... 2204 Arzuaga, X ..............................................957* Asamoto, M ................................... 765, 1424 Asare, N ................................................2287* Aschner, J ................................................. 620 Aschner, M .....................486, 595, 599, 620* Asgharian, B ................................. 699, 2110* Ashby, J ................................ 124, 1736, 1739 Ashikaga, T ................................ 1192*, 1193 Ashley, J A ............................................. 1009 Ask, K ..................................................... 2287 Aspeslet, L J ........................................... 1255 Aspinall, L J ........................................... 1293 Asuzu, I U ............................................ 1411* Atchison, D K .........................................623* Atchison, W D ............... 623, 624, 625, 1059 Atkins, J ................................................... 767 Atkinson, A ..................................1139, 1140 Atsumi, F ............................................... 1433 Attenborough, S ................................... 1206 Attia, M .................................................... 470 Au, C .......................................................486* Aubert, N ..............................................2300* Aubrecht, J .............................333, 334*, 335, .............................................. 2205, 2230, 2233 Auerbach, S ............................................. 290 Augustine, M S ..................................... 1726 Auletta, C .............................................1641* Auman, J T .............................................757* Ausman, K D ........................................ 1862 Aust, A E .................................................638* Autenrieth, R ........................................ 1290 Autenrieth, R L ..................................... 1593 Authier, S ............................................... 1935 Auttachoat, W ....................891, 1212*, 1716 Avadhani, N G ........................................ 205 Avakian, A P ...........................................1117 Avila-Casado, M ....................................1153 Avila-Costa, M ............................. 608*, 1153 Avlasevich, S ......................................... 2212 Avram, M D ................................... 153, 1329 Awasthi, Y C ......................................... 1832 Awooda, I .............................................. 1368 Ayala-Fierro, F ..................................... 1190* Ayres, P H .................1185, 1187, 1515, 1516 Azadi, S ...................................................1211 Aziz, R M ..............................................1486* Azua, A .................................................. 1588 B B’Hymer, C .....................................190*, 191 Baba, Y ................................................... 2277 Babb, A ..................................................1637* Babin, M C ................................... 2201, 2202 Babu, R ................................................... 2004 Babus, J .................................................... 422 Babus, J B ............................................... 1260 Babus, J K ............................1109, 1811, 1823 Backes, W L ..................................... 725, 740 Backlund, M .......................................... 1358 Backstrom, M .......................................... 679 Backus, G ..............................................1857* Bacon, C W .................................. 1395, 1396 Badeaux, J V .............................................. 74 Baden, D .................................................474* Baden, D G ...........................527, 1101, 2227 Badger, T ................................................ 1036 Badger, T M ........74, 274, 1737, 1918, 1919* Badham, H J .........................................1806* Bae, O ......................................................150* Bagchi, D ............................. 809, 1393, 1414 Bagchi, M ............................809, 1393*, 1414 Bagi, C ...................................................... 540 Bagley, D M ........................................... 2001 Bahnemann, R ................................. 58, 2286 Bai, Y ........................................................ 817 Bailey, A ................................................... 715 Bailey, G P ................................................ 268 Bailey, G S ................................................ 758 Bailey, K ................................................1816* Bailey, M M ..........................................1067* Bailey, R E ...............................................1197 Bailey, W J .................................................. 56 Bain, L ...................................................... 576 Baird, W M ................................. 1499, 1814, .............................................. 2019, 2271, 2272 Bajt, M ...................................................1053* Baker, D .................................................... 530 Baker, G .................................................... 210 Baker, G L ...............................................917* Baker, S ............................................362, 625* Baker, V ............................................ 560, 577 Bakheet, S A ..........................................1063* Balagopal, G .......................................... 1258 Balagopal, g ..........................................1622* Balduchelly, Y ......................................... 219 Bale, A S ..........................................49*, 1547 Ball, G ........................................... 2098, 2103 Ball, J G .................................................. 2122 Ball, L M ........................................500, 1847* Balletta, L D ............................................... 60 Ballinger, S W .......................................1010* Balu, N ................................................... 2268 Bammler, T .............................................. 579 Bammler, T K ........................................ 1495 Bandiera, S M .............................1491*, 1562 Bando, K ................................................ 1730 Banerjee, A ............................................1047* Banker, G A ............................................ 1550 Banks, C ............................1460*, 1462, 1464 Bannon, D ...............................................1151 Bannon, G .............................................. 1307 Bansal, R .......................................986*, 1086 Banyard, A ............................................. 1200 Bao, A ......................................................... 47 Bao, W ...............................1709*, 2148, 2150 Barati, M ................................................ 1226 Baravik, J G ........................................... 1299 Barbee, G C ...........................................1593* Barbee, R ................................................ 1369 Barbee, S J .............................................. 1482 Barber, D .................................131, 161, 600* Barber, D S ............................................. 1546 Barber, M ............................................... 1924 Barber, R S ............................................. 1255 Barchowsky, A .............................1133, 1162 Barger, M ....................................... 360, 1443 Barger, M W ............................................ 212 Bargren, G L ................................ 1312, 1313 Barhoumi, R .........................................1368* Barich, J .................................................. 1593 Baril, M .................................................... 244
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