Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #519 USE OF IN VITRO TECHNOLOGIES AND METABONOMICS IN THE STUDY OF PHOSPHOLIPIDOSIS. C. E. Thomas 1 , J. M. Colet 2 , A. Meissner 2 , B. Halstead 1 , R. Morgan 1 , K. Kramer 2 , W. Dewe 3 and D. Monteith 1 . 1 Inv. Toxicology., Lilly Research Labs, Greenfield, IN, 2 Inv. Toxicology., Lilly Development Centre, Mont-Saint-Guibert, Belgium and 3 Statistics, Lilly Development Centre, Mont-Saint- Guibert, Belgium. #520 EVALUATION OF VITAMIN K AND VITAMIN K EPOXIDE AS BIOMARKERS OF COAGULOPATHY IN RAT SERUM UTILIZING HPLC. K. A. Navetta, P. E. Quintas, M. D. Aleo and J. L. Colangelo. Safety Sciences, Pfizer, Groton, CT. #521 A MOLECULAR BASIS FOR THE PREDICTION OF RENAL TUBULAR INJURY BY DRUG SIGNATURES FOLLOWING SHORT-TERM COMPOUND TREATMENT. M. Fielden, G. Natsoulis and K. Kolaja. Chemogenomics and Toxicology, Iconix Pharmaceuticals Inc., Mountain View, CA. #522 BIOMARKERS THAT CHARACTERIZE FIBROSIS AND BILE DUCT HYPERPLASIA. A. Vladimirova, R. Brennan, M. Fielden, K. Kolaja and C. Pearson. Iconix Pharmaceuticals, Inc., Mountain View, CA. #523 MULTI-ADDUCT ANALYSIS OF GLOBIN FROM MICE AND RATS AFTER INHALATION EXPOSURE TO 1, 3-BUTADIENE. N. I. Georgieva 1 , G. Boysen 1 , P. B. Upton 1 , Y. Li 1 , V. Walker 2 and J. A. Swenberg 1 . 1 ESE, UNC, Chapel Hill, NC and 2 Lovelace Respiratory Research Institute, Albuquerque, NM. #524 INTERACTIONS OF COMPLEX CHEMICAL MIXTURES FROM CONTAMINATED SEDIMENTS AT A SUPERFUND SITE. A. Gillespie 1 , T. D. Phillips 1 , T. J. McDonald 2 , L. He 1 , G. Zhou 2,1 and K. Donnelly 2,1 . 1 VIBS, Texas A&M University, College Station, TX and 2 EOH, Texas A&M University H.S.C., S.R.P.H., College Station, TX. #525 CORRELATION OF HEXENAL-DERIVED DNA BINDING WITH DETOXIFICATION AND DNA REPAIR STATUS IN CULTURED CELLS. M. D. Stout 1 , J. Nakamura 2 , G. Boysen 2 , M. W. Powley 2 and J. A. Swenberg 1,2 . 1 Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC and 2 Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC. #526 COMPARISON OF PLASMA AND URINE SAMPLES FROM ANIT-EXPOSED F344 RATS USING NMR SPECTROSCOPY. D. Mahle 1 , N. J. DelRaso 1 , S. C. Gustafson 2 , C. L. Leakeas 2 , M. P. Westrick 1 , A. E. Neuforth 3 and N. V. Reo 3 . 1 AFRL/HEPB, US Air Force, Wright-Patterson AFB, OH, 2 AFIT/ENG, US Air Force, Wright-Patterson AFB, OH and 3 Wright State University, Fairborn, OH. #527 USE OF METABOLOMICS TO IDENTIFY BIOMARKERS OF BREVETOXIN EXPOSURE. A. J. bourdelais 1 , J. Benson 2 , A. Higgins 3 , H. Mei 3 , K. Powell 3 , K. Wang 3 , B. Tibbetts 2 and D. G. Baden 1 . 1 2 CMS, UNCW, Wilmington, NC, Lovelace Respiratory Research Institute, Albuquerque, NM and 3 Icoria, Research Triangle Park, NC. #528 CAN LEVELS OF PLASMA TESTOSTERONE BE USED TO PREDICT MALE SEXUAL MATURITY IN RHESUS MONKEYS (MACACA MULATTA)? M. D. Saunders, R. Davis, S. Fox and L. Earl. Toxicology Operations, Huntingdon Life Sciences, Huntingdon, United Kingdom. Sponsor: C. Hardy. #529 ADMINISTRATION OF A MEK INHIBITOR RESULTS IN TISSUE MINERALIZATION IN THE RAT DUE TO DYSREGULATION OF PHOSPHORUS AND CALCIUM HOMEOSTASIS. A. P. Brown, C. Courtney, T. Carlson and M. Graziano. Safety Sciences, Pfizer Global Research and Development, Ann Arbor, MI. #530 USE OF METABONOMIC ANALYSIS FOR BIOMARKERS OF MUSCULOSKELETAL SYNDROME IN RATS. F. Grzemski 1 , L. C. Robosky 2 , M. D. Reily 2 , D. Baker 2 , C. A. Lesch 3 , M. G. Evans 1 , D. F. Wells 1 and D. G. Robertson 3 . 1 Safety Sciences, Pfizer, Ann Arbor, MI, 2 Discovery Technology, Pfizer, Ann Arbor, MI and 3 Inflammation Pharmacology, Pfizer, Ann Arbor, MI. #531 INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURE. R. Kikkawa, T. Yamamoto, T. Fukushima, Y. Hamada, H. Yamada and I. Horii. PGRD Nagoya Lab., Pfizer Japan Inc., Taketoyo, Aichi, Japan. Sponsor: K. Masaaki. #532 THE IDENTIFICATION OF POTENTIAL VASCULITIS BIOMARKERS TARGETED THROUGH SELDI SCREENING. C. Drupa 1 , J. L. Colangelo 1 , R. A. Goldstein 1 , M. L. Mirsky 1 , R. M. Leimgruber 2 , M. Cabonce 2 , P. W. Brown 2 and E. Dalmasso 3 . 1 World Wide Safety Sciences, Pfizer, Groton, CT, 2 World Wide Safety Sciences, Pfizer, St. Louis, MO and 3 Ciphergen Biosystems, Inc., Fremont, CA. Sponsor: M. Lawton. #533 ALANINE AMINOTRANSFERASE ACTIVITY IN THE FA2N-4 HEPATOCYTE CLONE. E. R. Jackson and D. E. Amacher. Safety Sciences, Pfizer, Inc., Groton, CT. #534 TOXICOLOGIC AND PATHOLOGIC SURVEILLANCE OF SEARCH & RESCUE DOGS DEPLOYED TO THE WORLD TRADE CENTER, THE PENTAGON, AND THE STATEN ISLAND FRESH KILLS LANDFILL SITES. W. K. Rumbeiha 1 , S. D. Fitzgerald 1 , E. W. Braselton 1 , C. M. Otto 2 and A. B. Downend 2 . 1 Pathobiology and Diagnostic Investigagtion, Michigan State University, Lansing, MI and 2 Clinical Sciences, School of Veterinary Medicine, University of Pennsyllvania, Philadelphia, PA. #535 SEQUENCE AND EXPRESSION ANALYSIS OF CANINE ALT1 AND ALT2. L. Nelms, B. Lu and M. Lawton. Pfizer, Groton, CT. 86 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #536 AUTOMATED BIOCHEMICAL MEASUREMENTS OF ACYL-COA OXIDASE AND CARNITINE PALMITOYLTRANSFERASE FOR ASSESSMENT OF PPAR-INDUCED PEROXISOME PROLIFERATION IN CYNOMOLGUS MONKEYS. D. F. Adams, M. A. Tirmenstein, K. M. Lynch, C. X. Hu, B. E. Maleeff, T. L. Gales, T. S. Sellers, D. Ennulat and L. W. Schwartz. Safety Asssessment, GlaxoSmithKline, King of Prussia, PA. #537 EVALUATING TOXICOLOGY AT A SYSTEMS LEVEL USING COHERENT ANALYSIS OF LARGE-SCALE DATA STREAMS. I. Shah, Z. Cai, B. Bullard, T. Colatsky, A. Berger, M. Fedor, P. Hurban, G. Yuan and A. Higgins. Icoria, INC, Research Triangle Park, NC. Sponsor: N. Sponsor. #538 A COMPARISON OF THE SPECIFICITY AND SENSITIVITY OF TRADITIONAL BIOMARKERS OF NEPHROTOXICITY IN THE RAT WITH METABONOMIC AND PROTEOMIC METHODOLOGIES. A. C. Gibbs. Scientific and Regulatory Consulting, Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: D. Everett. #539 THE RELATIONSHIP OF TREATMENT- RELATED DECREASES IN SERUM ALKALINE PHOSPHATASE ACTIVITY WITH ALTERATIONS IN BODY WEIGHT FOR RATS IN 13-WEEK TOXICITY STUDIES. L. Betz 2 , E. Harvey 2 and G. Travlos 1 . 1 NIEHS, Durham, NC and 2 Constella Health Sciences, Durham, NC. Sponsor: C. Portier. #540 IDENTIFYING CANDIDATE BIOMARKERS OF VITAMIN D ANALOG–INDUCED RENAL MINERALIZATION USING A SYSTEMS BIOLOGY APPROACH. C. I. Nduaka 1 , L. Jones 2 , M. Boren 1 , N. hanson 1 , T. Osborne 3 , K. Herbert 1 , L. Nelms 1 , M. Nowakowski 1 , K. Steever 1 , C. Edmond 1 , D. Blackwell 1 , M. Delnomdedieu 1 , C. Bagi 1 , F. Geoly 1 and M. Lawton 1 . 1 World Wide Safety Sciences, Pfizer Inc., Groton, CT, 2 University of Maryland, Baltimore, MD and 3 University of Illinois, Chicago, IL. Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: MALE REPRODUCTIVE Chairperson(s): Sandra Morseth, Morseth Consulting LLC, Jefferson, MD and Darryl Arfsten, US Navy, Wright-Patterson AFB, OH. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #541 EFFECT OF TESTICULAR EDEMA ON SPERMATOGENESIS IN TOXICANT-TREATED RAT TESTES. K. Porter, C. C. Weng and M. L. Meistrich. Experimental Radiation Oncology, U.T. M.D. Anderson Cancer Center, Houston, TX. #542 EFFECT OF ETHYLENE GLYCOL MONOETHYL ETHER ON SPERM MOTION IN RAT. R. WANG 1 , K. OHTANI 1 , N. JIA 2 , M. SUDA 1 , X. GAO 2 and T. HONMA 1 . 1 National Institute Ind. Health, Kawasaki, Kanagawa, Japan and 2 Beijing Diseases Control and Prevention Center, Beijing, China. Sponsor: X. YU. #543 CHANGES OF GENE EXPRESSION IN THE EPIDIDYMIDES AND SPERM ACROSOME REACTION IN RATS TREATED WITH SULFASALAZINE FOR SEVERAL DAYS. Y. Hamada 1 , T. Fukushima 1,2 , M. Komiyama 2 , C. Mori 2 and I. Horii 1 . 1 Worldwide Safety Sciences, Pfizer Global and Research Nagoya Laboratories, Taketoyo, Aichi, Japan and 2 Bioenvironmental Medicine, Chiba University, Chiba, Japan. Sponsor: M. Kurata. #544 DEVELOPMENTAL TOXICOLOGY OF CJC-1131, A LONG-ACTING GLP-1 ANALOGUE. B. Lawrence 1 , S. Wen 1 , Y. Fukushima 1 , E. M. Lewis 2 , S. Morseth 3 and J. Castaigne 1 . 1 ConjuChem, Inc., Montreal, QC, Canada, 2 Argus Research, Horsham, PA and 3 Morseth Consulting LLC., Jefferson, MD. #545 EFFECT OF IMPLANTED DEPLETED URANIUM (DU) ON MALE RAT REPRODUCTIVE SUCCESS, SPERM CONCENTRATION AND MOTION. D. P. Arfsten 1 , E. R. Wilfong 1 , E. W. Johnson 1 , D. J. Schaeffer 2 and K. R. Still 1 . 1 NHRC EHE Lab., Wright-Patterson AFB, OH and 2 Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL. #546 THE EFFECTS OF SUBACUTE ORAL EXPOSURE TO VINCLOZOLIN ON REPRODUCTIVE PARAMETERS IN PERIPUBERTAL AND POST-PUBERTAL BOARS. T. J. Evans 1 , E. M. Walters 1 , Y. Agca 1 , T. J. Fangman 2 , F. Williams III 1 , J. K. Critser 1 and R. A. Hess 3 . 1 Veterinary Pathobiology, University of Missouri, Columbia, MO, 2 Veterinary Extension and Continuing Education, University of Missouri, Columbia, MO and 3 Veterinary Biosciences, University of Illinois, Urbana, IL. #547 DELAYED PREPUTIAL SEPARATION (PPS) AND SP22 MEASUREMENT IN RATS ADMINISTERED BROMOCHLOROACETIC ACID (BCA) IN DRINKING WATER. C. S. Sloan 1 , G. R. Klinefelter 2 , J. M. Goldman 2 , K. D. Vick 1 , P. A. Fail 1 and R. W. Tyl 1 . 1 Life Sciences and Toxicology, RTI International, Research Triangle Park, NC and 2 Reproductive Toxicology Division, NHEERL, U.S. EPA, Research Triangle Park, NC. #548 USE OF 5α-DIHYDROTESTOSTERONE (DHT)- EXPOSED UROGENITAL SINUSES (UGS) FROM FEMALE MICE TO INVESTIGATE INHIBITION OF PROSTATIC BUDDING CAUSED BY 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN (TCDD). T. Lin and R. E. Peterson. School of Pharmacy, University of Wisconsin, Madison, WI. MONDAY up-to-date information at www.toxicology.org 87
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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2005 Award Winners The Society of T
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Program - Society of Toxicology

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