Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #604 EFFECT OF INORGANIC ARSENIC EXPOSURE INITIATING FROM IN UTERO THROUGH AFTER BIRTH ON THE NEUROBEHAVIOR AND NEUROTRANSMITTERS IN THE BRAIN OF MOUSE OFFSPRING. T. Itoh 1 , Y. Nakagi 1 , K. Nakai 2 , H. Sato 2 , C. Watanabe 3 , H. Yamauchi 4 and T. Yoshida 1 . 1 Asahikawa Medical College, Asahikawa, Japan, 2 Tohoku University, Sendai, Japan, 3 Tokyo University, Tokyo, Japan and 4 St. Marianna Medical College, Kawasaki, Japan. #605 NEUROBEHAVIORAL CHANGES IN METALLOTHIONEIN-NULL MICE PRENATALLY EXPOSED TO MERCURY VAPOR. M. Yoshida 1 , C. Watanabe 2 , K. Horie 1 , M. Satoh 3 , M. Sawada 4 and A. Shimada 4 . 1 Department of Biochemistry, St. Marianna University School of Medicine, Kawasaki, Japan, 2 Department of Human Ecology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, 3 Department of Hygienics, Gifu Pharmaceutical University, Gifu, Japan and 4 Department of Veterinary Pathology, Tottori University, Tottori, Japan. #606 MERCURY EXPOSURE OF MOTHERS AND NEWBORNS IN SURINAM: A PILOT STUDY. S. Mohan 1 , M. Tiller 2 , G. B. Vandervoet 2 , H. Kanhai 2 and F. A. de Wolff 2 . 1 Department of Obstetrics and Gynecology, ‘s Lands Hospital, Gravenstratt, Netherlands and 2 Toxicology Laboratory, Leiden University Medical Center, Leiden, Netherlands. #607 THE EFFECTS OF TRIBUTYLTIN (TBT) CHLORIDE ON DOPAMINE METABOLISM IN BRAIN TISSUES OF FEMALE MICE AFTER SUBACUTE ORAL EXPOSURE. M. Tsunoda 1 , Y. Kudo 1 , K. Nakano 2 , N. Konno 3 , Y. Sugita-Konishi 4 and Y. Aizawa 1 . 1 Preventive Medicine and Public Health, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan, 2 Fukushima Prefecture Ken-poku Public Health and Welfare Office, Fukushima, Japan, 3 Home Economics, Koriyama Women’s University, Koriyama, Fukushima, Japan and 4 Division of Microbiology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan. #608 BLOOD BRAIN BARRIER (BBB) DISRUPTION AFTER VANADIUM INHALATION. M. AVILA- COSTA 1,2 , A. Zepeda-Rodriguez 2 , L. Colin-Barenque 1 , F. Pasos 2 , P. Aley 1 , A. Gonzalez-Villalva 2 , P. Mussali- Galante 2 , J. Ordonez-Librado 1 , A. Gutierrez-Valdez 1 , V. Rodriguez-Lara 2 , A. Reyes-Olivera 1 , G. Pinon-Zarate 2 , M. Rojas-Lemus 2 , V. Delgado 2 , B. Chavez 2 and T. I. Fortoul 2 . 1 Neurosciencias, UNAM, Mexico, D.F., Mexico and 2 Biologia Celular Y Tisular, UNAM, Mexico, D.F., Mexico. #609 CYTOTOXIC EFFECTS OF TELLURIUM TETRACHLORIDE AND (4-METHOXYPHENYL) TRICHLOROTELLURIUM ON RAT HIPPOCAMPAL ASTROCYTES. M. Aravantinou 2 and D. Hardej 1 . 1 Pharmaceutical Sciences, St. John’s University, Jamaica, NY and 2 Biological Sciences, St. John’s University, Jamaica, NY. Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: NEUROTOXICITY OF METALS: MECHANISMS Chairperson(s): Richard Seegal, New York State Department of Health, Albany, NY and Damani Parran, National Institute of Environmental Health Science, Raleigh, NC. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #610 TMT-INDUCED NEUROGENESIS IN THE ADULT MOUSE HIPPOCAMPUS. B. C. Weig, K. R. Reuhl and H. E. Lowndes. Department of Pharmacology and Toxicology, Joint Graduate Program in Toxicology, Rutgers University, Piscataway, NJ. #611 NEURONAL MICROTUBULE DAMAGE CAUSED BY IN VITRO EXPOSURE TO LEAD AND METHYLMERCURY. J. L. Bisson 1 and K. R. Reuhl 1,2 . 1 Joint Graduate Program in Toxicology, Rutgers/UMDNJ, Piscataway, NJ and 2 Neurotoxicology Labs, Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ. #612 THE EFFECTS OF MANCOZEB ON THE MICROTUBULAR ARCHITECTURE OF RAT HIPPOCAMPAL ASTROCYTES. M. M. Tsang and L. D. Trombetta. Pharmaceutical Sciences, St. Johns Universtty, Jamaica, NY. #613 NEUROPROTECTIVE EFFECTS OF MELATONIN ON NEUROBLASTOMA CELLS EXPOSED TO LEAD. C. S. Chetty 1 , A. O. Dennis 1 , J. Heinz 1 , M. C. Vemuri 2 and C. Suresh 1 . 1 Natural Sciences and Mathematics, Savannah State University, Savannah, GA and 2 Surgery, Children’s Hospital of Philadelphia, Philadelphia, PA. #614 BLOCKAGE OF INTERLEUKIN-6 SECRETION FROM ASTROGLIA BY LEAD: INVOLVEMENT OF GRP78. Y. Qian 1 , F. Valencia 1 , Y. Zheng 1 , K. S. Ramos 2 and E. Tiffany-Castiglioni 1 . 1 Texas A&M University, College Station, TX and 2 University of Louisville Health Sciences Center, Louisville, KY. #615 MANGANESE INDUCED APOPTOSIS IN SH- SY5Y HUMAN NEUROBLASTOMA CELLS. A. P. Stephenson and R. Reams. College of Pharmacy, Florida A&M University, Tallahassee, FL. #616 THE MODULATION OF METALLOTHIONEIN-3 (MT-3) EXPRESSION IN MOUSE ASTROCYTES IN RESPONSE TO PROINFLAMMATORY MEDIATORS, SECOND MESSENGER ACTIVATORS, AND CELL STRESS. S. H. Garrett. Pathology, University of North Dakota, Grand Forks, ND. #617 MANGANESE-INDUCED ALTERATIONS IN NFκB-RELATED GENE EXPRESSION BY ACTIVATED MICROGLIA. P. L. Crittenden and N. M. Filipov. Center for Environmental Health Sciences, Basic Sciences, Coll. Vet. Med., Mississippi State University, Mississippi State, MS. 92 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #618 DIFFERENTIAL GENE EXPRESSION AT TWO DOSES OF METHYLMERCURY IN MOUSE CEREBELLA AS ANALYZED BY APOPTOSIS- SPECIFIC MICROARRAY. K. A. Thuett, S. Bellum and L. C. Abbott. Veterinary Integrative Biosciences, Texas A&M University / College of Veterinary Medicine & Biomedical Sciences, College Station, TX. #619 FORMATION OF REACTIVE OXYGEN SPECIES IN CEREBELLAR GRANULE CELLS OF MICE EXPOSED TO METHYLMERCURY. S. Bellum, K. A. Thuett and L. C. Abbott. Veterinary Integrative Biosciences, Texas A&M University, College Station, TX. #620 METHYLMERCURY (MEHG)-INDUCED REACTIVE OXYGEN SPECIES (ROS) LEVELS ARE MODULATED BY INTRACELLULAR REDOX. M. Aschner 2 , G. Shanker 1 , T. Syversen 3 , J. Aschner 2 and U. Sonnewald 3 . 1 Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, 2 Pediatrics, Vanderbilt University Medical Center, Nashville, TN and 3 Neuroscience, University of Trondheim, Trondheim, Norway. #621 EFFECTS OF METHYLMERCURY ON MITOCHONDRIAL FUNCTION AND REACTIVE OXYGEN SPECIES FORMATION IN STRIATAL SYNAPTOSOMES FROM RAT. A. Dreiem 1 and R. F. Seegal 1,2 . 1 New York State Department of Health, Wadsworth Center, Albany, NY and 2 School of Public Health, University at Albany, Albany, NY. #622 POTENTIATION OF MITOCHONDRIAL SUSCEPTIBILITY, OXIDATIVE STRESS AND NF-KB SIGNALING FOLLOWING CHEMICAL MIXTURE (LEAD AND ARSENIC)-INDUCED NEUROTOXICITY. R. Yasmeen, G. Hashim, O. Ogunmosin, D. Ghosh and P. G. Gunasekar. Biology, Texas Southern University, Houston, TX. #623 EFFECTS OF GABA- B RECEPTOR ACTIVATION & INHIBITON ON METHYLMERCURY- INDUCED ALTERATIONS OF INTRACELLULAR CA IN RAT CEREBELLAR GRANULE NEURONS. D. K. Atchison and W. D. Atchison. Department Pharmacology/Toxicology, Mich State University, East Lansing, MI. #624 COMPARATIVE EFFECTS OF METHYLMERCURY (MEHG) ON INTRACELLULAR CA IN RAT CEREBELLAR GRANULE & CORTICAL NEURONS IN CULTURE. A. Segarra and W. D. Atchison. Department Pharmacology/Toxicology, Mich State University, East Lansing, MI. #625 EFFECTS OF SEMI-CHRONIC METHYLMERCURY EXPOSURE ON INTRACELLULAR CALCIUM LEVELS IN RAT UNDIFFERENTIATED PC12 CELLS. S. Baker 2,1 and W. D. Atchison 1,2 . 1 Department Pharmacology/Toxicology, Mich State University, East Lansing, MI and 2 Coll Vet. Med., Mich State University, East Lansing, MI. #626 EFFECTS OF THIMEROSAL ON NGF SIGNAL TRANSDUCTION AND CELL DEATH IN NEUROBLASTOMA CELLS. D. K. Parran, A. M. Barker and M. F. Ehrich. Biomedical Sciences, Virginia Tech, Blacksburg, VA. #627 METHYL MERCURY (MEHG) ALTERS IL-6 SIGNAL TRANSDUCTION IN MOUSE CEREBELLAR CELLS IN CULTURE. E. S. Calderon-Aranda 1,2 , L. C. Acosta-Saavedra 2 and E. K. Silbergeld 1 . 1 EHS, BSPH, Johns Hopkins University, Baltimore, MD and 2 Toxicologia, Cinvestav, Mexico, DF, Mexico. #628 ACUTE EXPOSURE TO URANYL ION (UO2) IN VITRO DIMINISHES K+-STIMULATED GLUTAMATE/GABA RELEASE INDEPENDENT OF EXTRACELLULAR CALCIUM. S. M. Lasley and K. R. Vietti. Biomedical & Therapeutic Sciences, University of Illinois College of Medicine, Peoria, IL. #629 EFFECTS OF LOW-LEVEL MN EXPOSURE ON THE METABOLISM OF AMINO ACIDS, GABA, AND CELLULAR RESPIRATION IN GABAERGIC AF5 NEURAL CELLS. D. R. Crooks 1 , N. Welch 1 , A. F. Rosenthal 1 , J. Sanchez 2 , W. J. Freed 2 and D. R. Smith 1 . 1 Environmental Toxicology, University of Calif. Santa Cruz, Santa Cruz, CA and 2 Cellular Neurobiology Branch, National Institute on Drug Abuse, Baltimore, MD. #630 MN ALTERS CELLULAR COMT-1, SECRETOGRANIN II, AND UCH-LI LEVELS IN PC12 CELLS: IMPLICATIONS FOR MN NEUROTOXICITY. D. R. Smith, S. Reaney, S. Whitman, R. Gwiazda and T. Holman. Environmental Toxicology, University of California, Santa Cruz, CA. #631 MANGANESE INHIBITS THE BINDING OF THE COCAINE ANALOG [ 3 H]-WIN 35, 428 TO THE DOPAMINE TRANSPORTER (DAT) FROM RAT STRIATUM. M. Chen, E. Furukawa and T. R. Guilarte. Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. #632 DIFFERENTIAL EFFECTS OF MANGANESE (MN) AND MPP + IN DIFFERENTIATED AND NON-DIFFERENTIATED PC12 CELLS. L. T. Russel, K. S. Squibb and A. M. Elnabawi. Program in Toxicology, University of Maryland School of Medicine, Baltimore, MD. #633 NEUROTOXIC EFFECT OF MANGANESE AND NEUROPROTECTIVE EFFECT OF COPPER IN A CELL CULTURE MODEL OF PRION DISEASES. C. J. Choi, V. Anantharam, A. Kanthasamy and A. Kanthasamy. Biomedical Sciences, Iowa State University, Ames, IA. #634 MECHANISM OF ARSENIC PERIPHERAL NEUROTOXICITY. A. Vahidnia, G. B. Vandervoet and F. A. de Wolff. Toxicology Laboratory, Leiden University Medical Center, Leiden, Netherlands. Abstract 635 is located on page 97. MONDAY up-to-date information at www.toxicology.org 93
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Program - Society of Toxicology

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