Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description Tuesday Afternoon, March 8 4:30 PM to 6:00 PM Room 208 Tuesday Afternoon, March 8 4:30 PM to 6:00 PM Room 220 TUESDAY SUNSET SESSION: IN VITRO TOXICITY TESTING OF AIR POLLUTANTS: PROS AND CONS Chairperson(s): Ian Gilmour, U.S. EPA, Research Triangle Park, NC and JeanClare Seagrave, Lovelace Respiratory Research Institute, Albuquerque, NM. Endorsed by: In Vitro SS Inhalation SS* Risk Assessment SS Student Advisory Committee The increasing evidence for adverse health effects resulting from acute and chronic exposure to air pollution has driven efforts to identify which components cause these effects and by what mechanisms. This, in turn, has created a need for rapid, cost-effective methods for in vitro screening and mechanistic studies. The respiratory tract is the first target of aerosols, but in vitro studies of this system are complicated by species differences, varied regional anatomy and physiology, as well as the fact that aerosols interact at the gas/air inter-phase of the lung surface. In addition to containing over forty different cell types that may respond quite differently to a given stimulus, host susceptibility factors that may be driven by genetics, and previous exposures may impact on observed effects. The purpose of this session is to review issues regarding the selection of models, exposure methods, doses, and endpoints and to determine how these systems may reflect inhalation exposures in the exposed population. #1015 4:30 IN VITRO TOXICITY TESTING OF AIR POLLUTANTS: PROS AND CONS. M. Gilmour 1 and J. Seagrave 2 . 1 NHEERL, U.S. EPA, Research Triangle Park, NC and 2 LRRI, Albuquerque, NM. #1016 4:35 CELL POPULATIONS WITHIN THE RESPIRATORY TRACT. C. G. Plopper. Anatomy, Physiology and Cell Biology, Universtiy of California, Davis, CA. #1017 4:45 SYSTEMS FOR EXPOSING LUNG CELLS TO AEROSOLS. J. Seagrave and J. D. McDonald. Lovelace Respiratory Research Institute, Albuquerque, NM. #1018 5:00 ANALYTICAL TOOLS FOR ASSESSING AIR POLLUTION TOXICITY USING DIFFERENT IN VITRO CELL CULTURE MODELS. I. Jaspers. CEMALB, University of North Carolina, Chapel Hill, NC. #1019 5:15 IN VITRO CORRELATION WITH IN VIVO EXPOSURES. R. Devlin and L. Dailey. U.S. EPA, Research Triangle Park, NC. SUNSET SESSION: TOXICOLOGY INFORMATION AND DATA UPDATE Chairperson(s): Philip Wexler, National Library of Medicine, Bethesda, MD. Endorsed by: National Capital Area Chapter As the Web and its online resources continue to expand and change rapidly, there is an increasing plethora of databases, documents, and other digital tools available to the toxicology community. Toxicologists with even formidable research skills are often knowledgeable about only a small fraction of what is available, and they are often not kept apprised of the newest developments. This symposium highlights major Web-based resources from all sectors–government, academia, industry, non-profits–which can benefit toxicologists in their daily research and other work. This program takes a look at a few of these resources. The National Library of Medicine’s Toxicology and Environmental Health Information Program is a major purveyor of toxicological information and data through its TOXNET system and other databases, geared to both the professional and the public. The Center for Research on Environmental and Occupational Toxicology (CROET) focuses on health and safety in the workforce and supports a number of information activities, including its Toxicology Information Center. The National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program offer a number of unique online databases and make available online numerous test reports and the Report on Carcinogens. EPA has recently unveiled its Distributed Structure Searchable Toxicity (DSS-TOX) database, another powerful tool of potential interest. #1020 4:30 TOXICOLOGY INFORMATION AND DATA UPDATE. P. Wexler. Toxicology and Environmental Health Information Program, National Library of Medicine, Bethesda, MD. #1021 4:32 THE NATIONAL LIBRARY OF MEDICINE’S (NLM) WORLD LIBRARY OF TOXICOLOGY, CHEMICAL SAFETY AND ENVIRONMENTAL HEALTH. P. Wexler. Toxicology and Environmental Health Information Program, National Library of Medicine, Bethesda, MD. #1022 4:47 WEB-BASED RESOURCES SPONSORED BY THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS) AND THE NATIONAL TOXICOLOGY PROGRAM (NTP). L. L. Wright. US Department of Health and Human Services, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Sponsor: P. Wexler. #1023 5:02 THE CENTER FOR RESEARCH ON OCCUPATIONAL AND ENVIRONMENTAL TOXICOLOGY (CROET). F. Berman. Oregon Health and Science University, Portland, OR. Sponsor: P. Wexler. #1024 5:22 DSSTOX STRUCTURE-SEARCHABLE PUBLIC TOXICITY DATABASE NETWORK: CURRENT PROGRESS AND NEW INITIATIVES TO IMPROVE CHEMO-BIOINFORMATICS CAPABILITIES. A. M. Richard 1 and B. A. Rogers 1 . 1 2 U.S. EPA, Research Triangle Park, NC and NCCU Student COOP, U.S. EPA, Research Triangle Park, NC. Sponsor: L. King. Abstract 1025 is located on page 129. 150 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Tuesday Afternoon, March 8 5:30 PM to 6:30 PM Room 216 Wednesday Morning, March 9 8:30 AM to 11:30 AM Room RO4 REGIONAL CHAPTER CONTACTS FOR K–12 EDUCATION MEETING Chairperson(s): Marion Miller, University of California, Davis, Davis, CA. Sponsored by: Education Committee Education Subcommittee for K–12 Education SOT Regional Chapter Contacts for K–12 Education and others interested in outreach to schools and teachers are invited to attend an informal meeting to discuss K–12 education activities at the regional level. Light refreshments will be available. Tuesday Evening Tuesday Evening, March 8 6:00 PM to 7:30 PM See Events Calendar on Pages 2–6 for Room Listings SPECIALTY SECTION MEETINGS: BIOLOGICAL MODELING, CARCINOGENESIS, IN VITRO, INHALATION, METALS, NEUROTOXICOLOGY, REGULATORY AND SAFETY EVALUATION Tuesday Evening, March 8 6:00 PM to 11:00 PM See Events Calendar on Pages 2–6 for Room Listings REGIONAL CHAPTER MEETINGS/RECEPTIONS Many of the Regional Chapters meet during the SOT Annual Meeting. Details for these Regional Chapter receptions and meetings are listed in Program’s Events Calendar. Wednesday Morning, March 9 8:30 AM to 9:30 AM Room 215 Wednesday Morning INFORMATIONAL SESSION: DEFINING MOLECULAR MECHANISMS OF TOXICITY USING AFFYMETRIX GENECHIP® ARRAYS — PRESENTED BY AFFYMETRIX Though leaders in the use of Affymetrix microarray technologies will share the techniques and strategies they have used successfully to apply GeneChip products to their research. SYMPOSIUM SESSION: BIOMARKERS OF OXIDATIVE STRESS: NEW PROSPECTS AND APPROACHES Chairperson(s): Daniel C. Liebler, Vanderbilt University, Nashville, TN and Maria Kadiiska, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Endorsed by: Mechanisms SS* Risk Assessment SS Student Advisory Committee Oxidative stress plays a key role in the development of cardiovascular disease, neurodegenerative diseases, and cancer. Many toxic chemicals associated with increased risk of these diseases also induce oxidative stress. Assessment of oxidative stress in clinical studies has been hampered by a dearth of robust, sensitive, and well-validated biomarkers. This symposium will address new opportunities to develop oxidative stress biomarkers for application to human clinical studies. Dr. Maria Kadiiska (NIEHS) will discuss the Biomarkers of Oxidative Stress Study (BOSS), which evaluated several different noninvasive or minimally invasive chemical markers of carbon tetrachloride- or ozoneinduced oxidative stress in rats. Dr. Stanley Hazen (Cleveland Clinic Foundation) will describe the development and validation of multiplexed LC- MS-MS assays for specific lipid and protein oxidation products in human serum and the application of these markers to assess oxidative stress endpoints as risk factors for cardiovascular disease. Dr. Ian Blair (University of Pennsylvania) will present recent developments in the identification and LC-MS-MS-based analysis of products of oxidative DNA damage and DNA adducts derived from electrophilic lipid oxidation products. Dr. Lawrence Marnett (Vanderbilt University) will discuss recent findings that DNA adducts derived from electrophilic products of lipid oxidation undergo metabolism to a series of products that can be analyzed as potential urinary biomarkers of oxidative stress. Dr. Daniel Liebler (Vanderbilt University) will discuss the identification of albumin adducts formed by reactive products of lipid oxidation and the potential application of these adducts as serum biomarkers of oxidative stress in vivo. #1320 8:30 BIOMARKERS OF OXIDATIVE STRESS: NEW PROSPECTS AND APPROACHES. D. C. Liebler. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN. #1321 8:35 PRODUCTS OF OXIDATION AS MEASURABLE INDICATORS OF OXIDATIVE STRESS: VALIDATION OF BIOMARKERS FROM RODENT CCL4 AND OZONE EXPOSURE. M. Kadiiska. Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Sponsor: D. Liebler. #1322 9:10 MOLECULAR MECHANISMS OF OXIDANT STRESS IN AT-RISK SUBJECTS UNDERGOING REVASCULARIZATION. S. Hazen. Department of Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH. Sponsor: D. Liebler. #1323 9:45 NOVEL BIOMARKERS OF OXIDATIVE STRESS- INDUCED DNA DAMAGE. I. Blair. Department of Pharmacology, University of Pennsylvania, Philadelphia, PA. Sponsor: D. Liebler. #1324 10:20 URINARY DNA ADDUCTS AND THEIR METABOLITES AS BIOMARKERS OF OXIDATIVE STRESS. L. Marnett. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN. WEDNESDAY up-to-date information at www.toxicology.org 151
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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