Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
MONDAY
#143 ALTERED PROTEIN EXPRESSION
FOLLOWING IN UTERO EXPOSURE TO
ARSENIC. C. Lantz, J. S. Petrick and A. M. Hays. Cell
Biology and Anatomy, University of Arizona, Tucson,
AZ.
#144 ABERRANT GENE EXPRESSION IN THE
NEONATAL MOUSE LUNG FOLLOWING IN
UTERO EXPOSURE TO INORGANIC ARSENIC.
J. Shen 1 , Y. Xie 1 , J. Liu 1 , B. Diwan 2 and M. Waalkes 1 .
1 Laboratory of Comparative Carcinogenesis, NCI at
NIEHS, Research Triangle Park, NC and 2 BRP, SAIC-
Frederick, NCI at Frederick, Frederick, MD.
#145 ARSENIC INDUCES CHROMOSOMAL AND
CENTROMERIC ABNORMALITIES, IN HUMAN
LUNG CELLS. J. P. Lynch 1,2 , S. S. Wise 1,2 and J. P.
Wise 1,2 . 1 Wise Laboratory of Environmental and
Genetic Toxicology, University of Southern Maine,
Portland, ME and 2 Maine Center for Toxicology and
Environmental Health, University of Southern Maine,
Portland, ME.
#146 CHARACTERIZATION OF HUMAN BLADDER
UROTHELIAL CELLS MALIGNANTLY
TRANSFORMED BY ARSENITE. K. E. Billings 1 , T.
G. Bredfeldt 1 , X. H. Zheng 1 , M. J. Kopplin 1 , G. S.
Watts 2 , D. A. Sens 4 , E. A. Mash 3 and A. J. Gandolfi 1 .
1 Depts of Pharmacology and Toxicology, University of
AZ, Tucson, AZ, 2 AZ Cancer Center, University of AZ,
Tucson, AZ, 3 Department of Chemistry, University of
AZ, Tucson, AZ and 4 Depts of Pathology and Surgery,
School of Medicine and Health Sciences, University of
ND, Grand Forks, ND.
#147 ARSENITE AND MONOMETHYL ARSONOUS
ACID-INDUCED TOXICITY IN HUMAN
UROTHELIAL CELLS. T. G. Bredfeldt 1 , K. E.
Billings 1 , X. H. Zheng 1 , E. A. Mash 2 , F. E. Domann 3 , S.
S. Lau 1 , D. A. Sens 4 and A. J. Gandolfi 1 . 1 Pharmacology
and Toxicology, University of AZ, Tucson, AZ,
2 3 Chemistry, University of AZ, Tucson, AZ, Radiation
Oncology, University of IA, Iowa City, IA and
4 Pathology and Surgery, University of ND, Grand
Forks, ND.
#148 METABOLISM AND TOXICITY OF ARSENIC IN
HUMAN URINARY BLADDER EPITHELIAL
CELLS EXPRESSING RAT ARSENIC (+3)-
METHYLTRANSFERASE. Z. Drobna 1 , S. B.
Waters 2 , V. Devesa 3 , A. W. Harmon 1 , D. J. Thomas 4 and
M. Styblo 1,3 . 1 Pediatrics, UNC Chapel Hill, NC, Chapel
Hill, NC, 2 Curriculum in Toxicology, UNC, Chapel
Hill, NC, 3 CEMALB, UNC, Chapel Hill, NC and
4 NHEERL, U.S. EPA, Triangle Research Park, NC.
#149 GLYCERALDEHYDE 3-PHOSPHATE
DEHYDROGENASE (GAPDH) AS AN ARSENATE
REDUCTASE IN HUMAN RED BLOOD CELLS
(HRBC) AND RAT LIVER CYTOSOL (RLC). Z.
Gregus and B. Nemeti. Department Pharmacology,
University Pecs, Med. School, Pecs, Hungary.
#150 ARSENITE INDUCES PROCOAGULANT
ACTIVITY IN HUMAN PLATELETS BY
PHOSPHATIDYLSERINE EXPOSURE AND
MICROPARTICLE GENERATION. O. Bae, K. Lim
and J. Chung. College of Pharmacy, Seoul National
University, Seoul, South Korea.
#151 ARSENIC METHYLTRANSFERASE CYT19
EXPRESSION AND ACTIVITY IN RAT TISSUES.
Y. Kobayashi 1,2 , T. Hayakawa 1 and S. Hirano 1 .
1 Environmental Health Sciences Division, National
Institute for Environmental Studies, Tsukuba, Ibaraki,
Japan and 2 Japan Foundation for Aging and Health,
Chita, Aichi, Japan.
#152 THE ROLE OF VALENCE AND METHYLATION
STATE ON THE ACTIVITY OF ARSENIC
DURING MITOSIS. A. D. Kligerman, C. L. Doerr and
A. H. Tennant. Environmental Carcinogenesis Division,
U.S. EPA, Research Triangle Park, NC. Sponsor: D.
Wolf.
#153 INORGANIC ARSENIC BIOTRANSFORMATION
AND MMA(V) REDUCTASE/GSTO1-1
KNOCKOUT MICE. U. K. Chowdhury, R. A.
Zakharyan, M. D. Avram, M. Wollenberg, A.
Hernandez, M. Kopplin and H. V. Aposhian. Molecular
and Cellular Biology, University of Arizona, Tucson,
AZ.
#154 DETERMINATION OF TRANSCRIPTION
FACTORS IMPORTANT IN ARSENIC-INDUCED
ALTERATIONS IN GENE EXPRESSION. A. Hays 1 ,
R. Pandey 2 , R. Ahmed 1 , A. S. Andrew 3 , J. W. Hamilton 3
and C. Lantz 1 . 1 Cell Biology and Anatomy, University
of Arizona, Tucson, AZ, 2 Arizona Cancer Center,
University of Arizona, Tucson, AZ and 3 Pharmacology
& Toxicology, Dartmouth Medical School, Hanover,
NH.
#155 ARSENIC IN SEAFOOD: WHAT PERCENTAGE
OF THE TOTAL IS INORGANIC ARSENIC? L. L.
Chappell 1 , J. Colman 1 , R. M. Lorenzana 3 , P. McGinnis 2 ,
R. Troast 4 and A. Yeow 4 . 1 Environ Sciences Ctr,
Syracuse Research Corp, Syracuse, NY, 2 Syracuse
Research Corp, Philadelphia, PA, 3 ORD Region 10,
U.S. EPA, Seattle, WA and 4 OSRTI, U.S. EPA,
Washington, DC.
#156 ASSESSMENT OF EXPOSURE TO ARSENIC AND
LIFE STYLE IN KOREAN. J. Park 1 , W. Lee 1 , M.
Choi 4 , E. Park 2 , K. Park 3 and S. Kim 3 . 1 Preventive
Medicine, Chung-Ang University, Seoul, South Korea,
2 Pathology, Chung-Ang University, Seoul, South Korea,
3 Advanced Analysis Center, Korea Institute of Science
and Technology, Seoul, South Korea and 4 Chung-Un
University, Chung-Un, South Korea.
#157 URANYL ACETATE INDUCED OXIDATIVE
STRESS IN CHINESE HAMSTER OVARY AA8
CELLS: EFFECT ON DNA OXIDATION. J.
Orozco 1 , A. M. Hays 1 , M. Yazzie 2 , D. M. Stearns 2 and
C. Lantz 1 . 1 Cell Biology and Anatomy, University of
Arizona, Tucson, AZ and 2 Department of Chemistry and
Biochemistry, Northern Arizona University, Flagstaff,
AZ.
#158 THE HPRT SPECTRA OF SPONTANEOUS,
URANYL-ACETATE- AND HYDROGEN-
PEROXIDE-INDUCED HPRT MUTANTS IN
CHINESE HAMSTER OVARY EM9 CELLS. V. H.
Coryell and D. M. Stearns. Chemistry and
Biochemistry, Northern Arizona University, Flagstaff,
AZ.
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SOT’s 44 th Annual Meeting