Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description THURSDAY #2265 DETECTION OF ELEVATED 8- HYDROXYDEOXYGUANOSINE IN FRESHLY ISOLATED MOUSE LUNG CELLS FOLLOWING IN VIVO TREATMENT WITH AFLATOXIN B 1 K. A. Guindon, S. L. Graham, L. L. Bedard and T. E. Massey. Pharmacology and Toxicology, Queen, Kingston, ON, Canada. #2266 LIPID HYDROPEROXIDE-DERIVED DNA ADDUCTS GENERATED THROUGH REDOX CYCLING OF BENZO(A)PYRENE QUINONE. J. Xu, S. Lee and I. A. Blair. Department of Pharmacology, University of Pennsylvania, Philadelphia, PA. Sponsor: S. Burchiel. #2267 METABOLISM OF 7H-DIBENZO[C, G]CARBAZOLE (DBC) OR BENZO[A]PYRENE (BAP) IN CYP1A2 OR AHR GENE KNOCKOUTS: IMPLICATIONS FOR CARCINOGENICITY. D. Ginsburg, G. Talaska, K. LaDow, B. Schumann, A. Puga and D. Warshawsky. Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH. #2268 CHARACTERIZATION OF STABLE BENZO[A]PYRENE-7, 8-QUINONE-DNA ADDUCTS IN CALF THYMUS DNA. J. A. Ross, G. Nelson, W. T. Padgett, N. Balu, G. R. Lambert and S. Nesnow. Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC. Sponsor: D. Wolf. #2269 INDUCTION AND PERSISTENCE OF BENZO(A)PYRENE- AND DIBENZO[A, L]PYRENE-DNA ADDUCTS IN DNA REPAIR- PROFICIENT AND DEFICENT CELLS. W. A. Spencer and D. K. Orren. Toxicology, University of Kentucky, Lexington, KY. Sponsor: M. Vore. #2270 COMPARISON OF DNA ADDUCT FORMATION BETWEEN TISSUES FROM MICE TREATED WITH COMPLEX PAH MIXTURES. T. D. Phillips, A. M. Gillespie, L. Cizmas, G. Zhou, T. J. McDonald, Y. Qian and K. C. Donnelly. Texas A&M University, College Station, TX. #2271 METABOLIC ACTIVATION AND PAH-DNA ADDUCT FORMATION FROM URBAN DUST PARTICULATE MATTER (SRM 1649A) IN HUMAN MAMMARY EPITHELIAL CELLS IN CULTURE. L. A. Courter and W. M. Baird. Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR. #2272 DIESEL EXHAUST PARTICLES CAUSE INCREASED LEVELS OF DNA DELETIONS AND DNA ADDUCT FORMATION AFTER TRANSPLACENTAL EXPOSURE IN MICE. R. Reliene 1 , A. Hlavacova 1 , B. Mahadevan 2 , W. M. Baird 2 and R. H. Schiestl 1 . 1 Pathology, Environmental Health and Radiation Oncology, UCLA, Los Angeles, CA and 2 Environmental Molecular Toxicology, Oregon State University, Corvallis, OR. #2273 MLH1-DEFICIENT MICE ARE HYPERSENSITIVE TO PHIP-INDUCED MUTATION AND ABERRANT CRYPT FOCI: EVIDENCE FOR DIFFERENTIAL PROCESSING OF PHIP ADDUCT MISPAIRS BY THE MISMATCH REPAIR PATHWAY. S. Smith-Roe, S. S. Crain and A. B. Buermeyer. Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR. Sponsor: L. Curtis. #2274 OXIDATIVE METABOLISM OF THE SERM, RALOXIFENE LEADS TO PROTEIN COVALENT MODIFICATION. J. Liu, Q. Li, C. Luckie, X. Yang, M. Chang, R. B. van Breemen, G. R. Thatcher and J. L. Bolton. Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL. #2275 IDENTIFICATION OF ELECTROPHILE BINDING MOTIFS ON QUINONE-THIOETHER ADDUCTED RENAL PROTEINS. M. E. Bowen 1 , M. T. Labenski 1 , C. Kernag 1 , G. Tsaprailis 1 , M. A. Ali 2 , E. A. Mash 2 , T. J. Monks 1 and S. S. Lau 1 . 1 Pharmacology and Toxicology, University of Arizona, Tucson, AZ and 2 Chemistry, University of Arizona, Tucson, AZ. Thursday Morning, March 10 8:30 AM to 11:30 AM La Louisiane Ballroom B POSTER SESSION: APOPTOSIS Chairperson(s): Jessica Berthiaume, University of Minnesota, Duluth, MN. Displayed: 8:30 AM–11:30 AM Attended: 8:30 AM-10:00 AM #2276 MOLECULAR MECHANISMS OF HYDROQUINONE INDUCED APOPTOSIS. S. H. inayat-hussain 1,2 , V. Gogvadze 3 , S. Orrenius 3 and D. Ross 1 . 1 Pharmacology Sciences, University of Colorado, denver, CO, 2 Biomedical Sciences, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, wp, Malaysia and 3 Toxicology Division, Karolinska Institutet, Stockholm, Sweden. #2277 BIOCHEMICAL AND MICROARRAY ANALYSES OF BUPIVACAINE-INDUCED APOPTOSIS. A. Unami 1,3 , Y. Shinohara 2 , K. Omura 1 , M. Matsumoto 1 , Y. Oishi 1 and Y. Baba 3 . 1 Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,, Osaka, Japan, 2 Institute for Genome Research, The University of Tokushima, Tokushima, Japan and 3 Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan. Sponsor: M. Takahashi. #2278 1, 1-DICHLOROETHYLENE-INDUCED MITOCHONDRIAL DAMAGE PRECEDES APOPTOTIC CELL DEATH OF BRONCHIOLAR EPITHELIAL CELLS IN MURINE LUNG. E. J. Martin and P. Forkert. Department of Anatomy and Cell Biology, Queen’s University, Kingston, ON, Canada. 222 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #2279 TMT TOXICITY IN HIPPOCAMPAL CELLS IS ASSOCIATED WITH INDUCTION OF BAX AND INOS EXPRESSION. L. zhang, L. li, K. Prabhakaran, J. L. Borowitz and G. E. Isom. Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN. #2280 GENDER -SPECIFIC DIFFERENCES IN APOPTOTIC INDICES IN RAT LIVER AFTER CHRONIC ETHANOL CONSUMPTION. T. V. Curry-McCoy 2 , R. L. White 1 , S. L. Todero 1 and T. M. Donohue 1 . 1 Research, VA Medical Center, Omaha, NE and 2 Pathology/Microbiology, University of Nebraska Medical Center, Omaha, NE. Sponsor: R. Pollenz. #2281 CALYCULIN A, A PP1/PP2A INHIBITOR, DELAYS APOPTOTIC SIGNALING IN TGHQ-TREATED HL-60 CELLS. M. Yang, S. S. Lau and T. J. Monks. Pharmacology and Toxicology, University of Arizona, Tucson, AZ. #2282 SINGLE-WALLED CARBON NANOTUBES ACTIVATE RAW 264.7 MACROPHAGES: ROLE IN OXIDATIVE STRESS AND INFLAMMATORY RESPONSE. A. I. Potapovich 1 , A. N. Osipov 1 , E. R. Kisin 2 , D. Schwegler-Berry 2 , A. A. Shvedova 2 and V. E. Kagan 1 . 1 Department of EOH, Center for Free Radical & Antioxidant Health, University of Pittsburgh, Pittsburgh, PA and 2 Pathology & Physiology Research Branch, NIOSH, Morgantown, WV. #2283 PHYSICAL AND CHEMICAL INTERACTION BETWEEN CARDIOLIPIN AND CYTOCHROME C. N. A. Belikova 1,2 , A. N. Osipov 1,2 , A. A. Kapralov 1,2 , M. V. Potapovich 1,2 and V. E. Kagan 1,2 . 1 Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA and 2 Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. #2284 CARDIOLIPIN DESTABILIZES CYTOCHROME C IN MITOCHONDRIA AND MAKES ITS CATALYTIC SITE ACCESSIBLE TO SMALL LIGANDS: ROLE IN APOPTOSIS. A. N. Osipov 1,2 , I. V. Kurnikov 2 , Y. A. Vladimirov 2 , N. A. Belikova 1,2 , D. A. Stoyanovsky 3 , M. V. Potapovich 1,2 , G. G. Borisenko 2 , A. A. Kapralov 1,2 , Y. Y. Tyurina 1,2 , V. A. Tyurin 1,2 , J. Jiang 1,2 , V. Kini 1,2 , A. Lysytsya 2 , V. B. Ritov 1 , A. M. Choi 3 , S. W. Ryter 3 and V. E. Kagan 1,2 . 1 Center for Free Radical & Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 2 Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA and 3 Department of Pulmonary Medicine and Surgery, University of Pittsburgh, Pittsburgh, PA. #2285 BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTORS BY KETAMINE PRODUCES LOSS OF MONKEY FRONTAL CORTICAL NEURONS IN CULTURE. C. Wang 1 , N. Sadovova 3 , X. Fu 2 , A. Scallet 1 , L. Schmued 1 , J. Hanig 4 and W. Slikker 1 . 1 Division of Neurotoxicology, NCTR/FDA, Jefferson, AR, 2 Charles River Laboratories, Jefferson, AR, 3 Division of Biochemical Toxicology, NCTR/FDA, Jefferson, AR and 4 CDER/FDA, Rockville, MD. #2286 ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA ENHANCES HEPATOCYTE APOPTOSIS. S. Xiao 1 , S. P. Anderson 2 , C. Swanson 1 , R. Bahnemann 3 , K. A. Voss 4 , A. J. Stauber 1 and J. C. Corton 5,1 . 1 CIIT, Research Triangle Park, NC, 2 GSK, Research Triangle Park, NC, 3 BASF, Ludwigshafen, Germany, 4 USDA, Athens, GA and 5 ToxicoGenomics, Chapel Hill, NC. #2287 METABOLISM OF NITRO-PAHS ELICITS APOPTOTIC AND NECROTIC RESPONSES IN HEPA 1C1C7 CELLS. N. Asare 1 , K. Ask 2 , N. Landvik 1 and J. A. Holme 1 . 1 National Public Health Institute, Oslo, Norway and 2 Macmaster University, Hamilton, ON, Canada. Sponsor: E. Dybing. #2288 THE ROLES OF MITOCHONDRIA AND CASPASE-6 IN 7-12-DIMETHYL- BENZ[α]ANTHRACENCE-INDUCED BONE MARROW B CELL APOPTOSIS. J. K. Emberley 1 , J. J. Schlezinger 2 , H. Ryu 2 and D. H. Sherr 2 . 1 Microbiology, Boston University School of Medicine, Boston, MA and 2 Environmental Health, Boston University School of Public Health, Boston, MA. #2289 AMELIORATION OF PARAQUAT AND CADMIUM CHLORIDE INDUCED APOPTOSIS BY κ-CARRAGEENAN IN RAT PLEURAL MESOTHELIAL CELL CULTURES. P. Kanade and J. M. Cerreta. Department of Pharmaceutical Sciences, Saint John’s University, Jamaica, NY. Sponsor: L. Trombetta. #2290 STUDY ON THE TOXICITY OF CADMIUM AND THE PROTECTIVE EFFECT OF FOOD COMPONENTS IN CELLS WITH HORMONE RECEPTORS. T. Kim, T. Kang, H. Moon, I. Kang, Y. Lee and S. Han. Endocrine Toxicology Division, National Institute of Toxicological Research, Seoul, South Korea. #2291 DIFFERENTIATION OF CISPLATIN-INDUCED DNA DAMAGE AND APOPTOSIS BY PHOSPHORYLATION OF HISTONE H2A.X. X. Feng 1 , A. Modi 2 , K. Stams 3 and P. Lord 1 . 1 Johnson & Johnson PRD, Raritan, NJ, 2 Columbia University, New York City, NY and 3 AstraZeneca Pharmaceuticals LP, Waltham, MA. Sponsor: C. Wang. #2292 CISPLATIN-INDUCED APOPTOSIS OF GC1 TESTICULAR GERM CELLS MAY OCCUR BY AN AUTOCRINE MECHANISM INVOLVING FASL/FAS- OR TRAIL/DR5-MEIDATED SIGNALING. Y. Ye and J. H. Richburg. College of Pharmacy, The University of Texas at Austin, Austin, TX. #2293 A DECREASE IN AKT LEVELS CORRELATES WITH SENSITIVITY TO ARSENIC-INDUCED GROWTH INHIBITION. M. Colombo, W. H. Miller and K. K. Mann. Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada. THURSDAY up-to-date information at www.toxicology.org 223
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Annual Meeting Events Calendar (Con
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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