Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#1747 EFFECTS OF VARIOUS LACTONE-
DERIVATIVES ON AROMATASE (CYP19)
ACTIVITY IN H295R HUMAN
ADRENOCORTICAL CARCINOMA CELLS AND
(ANTI)ANDROGENICITY IN TRANSFECTED
LNCAP HUMAN PROSTATE CANCER CELLS. T.
Sanderson 1 , S. Nijmeijer 1 , D. Scholten 1 , M. van den
Berg 1 , S. Cowell 2 , E. Guns 2 , C. Nelson 2 and S.
Ruchirawat 3 . 1 Institute for Risk Assessment Sciences,
Utrecht University, Utrecht, NL, Netherlands, 2 The
Prostate Centre, Vancouver General Hospital,
Vancouver, BC, Canada and 3 Laboratory of Medicinal
Chemistry, Chulabhorn Research Institute, Bangkok,
Thailand.
#1748 IN VITRO EFFECTS OF BROMINATED FLAME
RETARDANTS ON THE ADRENOCORTICAL
ENZYME CYP17. A NOVEL ENDOCRINE
MECHANISM OF ACTION? R. Fernandez Canton 1 ,
T. Sanderson 1 , S. Nijmeijer 1 , A. Bergman 2 and M. van
den Berg 1 . 1 Institute for Risk Assessment Sciences,
IRAS, Utrecht, Netherlands and 2 Department of
Environmental Chemistry and Analytical Chemistry.
Stockholm University, Stockholm, Sweden.
#1749 ESTROGENIC ACTIVITY OF THE
POLYBROMINATED DIPHENYL ETHERS
FLAME RETARDANTS. M. Mercado Feliciano 1 and
R. M. Bigsby 2 . 1 Pharmacology and Toxicology, Indiana
University School of Medicine, Indianapolis, IN and
2 Obstetrics and Gynecology, Indiana University School
of Medicine, Indianapolis, IN. Sponsor: L. Kamendulis.
#1750 SCREENING ASSAYS FOR ANDROGENIC
ACTIVITIES OF XENOBIOTICS. S. O. Mueller and
S. Simon. Toxicology, Merck KGaA, Darmstadt,
Germany.
#1751 EVALUATION OF POTENTIAL ESTROGENIC
AND ANDROGENIC ACTIVITY OF
OCTAMETHYLCYCLOTETRASILOXANE (D4)
AND DECAMETHYLCYCLOPENTASILOXANE
(D5). A. L. Quinn, S. D. Crofoot, J. M. Tobin, J. M.
Regan, J. M. McMahon and K. P. Plotzke. Dow Corning
Corporation, Midland, MI.
#1752 ESTROGENIC ENDOCRINE DISRUPTOR
POTENCY OF ORGANOCHLORINE
PESTICIDES DETECTED USING THE LUMI-
CELL TM ER BIOASSAY. J. D. Gordon 1 , A. C. Chu 1 ,
M. D. Chu 2 , M. S. Denison 3 and G. C. Clark 1 .
1 Xenobiotic Detection Systems, Inc., Durham, NC,
2 Alta Analytical PerspectivesInc., Wilmington, NC and
3 Department of Environmental Toxicology, University
of California, Davis, Davis, CA.
#1753 SENSITIVE METHOD FOR DETERMINING
PESTICIDE ESTROGENIETY AT PICOMOLAR
LEVELS USING A SERUM-FREE BG-1 OVARIAN
CELL MODEL. P. Wong and F. Matsumura. Ctr for
Health and the Environment, UC Davis, Davis, CA.
#1754 GENE EXPRESSION PATTERNS OF THE
AMPHIBIAN HPT-AXIS IN NORMAL
DEVELOPMENT AND AFTER EXPOSURE TO
THE MODULATORS METHIMAZOLE,
PERCHLORATE AND PROPYLTHIOURACIL. J.
J. Korte, H. M. Kerr, S. L. Batterman, G. W. Holcombe,
P. A. Kosian, J. E. Tietge and S. J. Degitz. MED,
NHEERL, ORD, U.S. EPA, Duluth, MN. Sponsor: J.
Nichols.
#1755 PROTEIN PROFILING OF XENOPUS LAEVIS
BRAIN CELLS FOLLOWING EXPOSURE TO T4
SYNTHESIS INHIBITORS: POTENTIAL
APPLICATION TO THE
ASSESSMENT/DIAGNOSIS OF XENOBIOTICS
THAT PERTURB THE THYROID PATHWAY. J.
Serrano 1 , B. Witthuhn 2 , L. Higgings 2 , J. Tietge 1 , J.
Korte 1 , P. Kosian 1 , G. Holcombe 1 and S. Degitz 1 .
1 ORD/NHEERL/MED, U.S. EPA, Duluth, MN and
2 Biochemistry and Molecular Biology, University of
Minnesota, St. Paul, MN. Sponsor: J. Nichols.
#1756 PHENOBARBITAL AFFECTS THYROID
HISTOLOGY AND LARVAL DEVELOPMENT IN
THE AFRICAN CLAWED FROG, XENOPUS
LAEVIS. M. J. Chowdhury, G. W. Holcombe, P. A.
Kosian, J. E. Tietge and S. J. Degitz. Mid-Continent
Ecology Division, U.S. EPA, Duluth, MN. Sponsor: J.
Nichols.
#1757 SUBLETHAL EFFECTS OF CADMIUM ON
DEVELOPMENT IN RANA PIPIENS AND
XENOPUS TROPICALIS. J. A. Gross 1,2 , T. Chen 2 and
W. H. Karasov 2 . 1 Animal Sciences, University of
Wisconsin–Madison, Madison, WI and 2 Wildlife
Ecology, University of Wisconsin–Madison, Madison,
WI.
#1758 MECHANISMS OF GERMINAL VESICLE
BREAKDOWN (GVBD) INHIBITION BY
PHENYL-SUBSTITUTED GLYCOL ETHERS IN
XENOPUS OOCYTES IN VITRO. D. J. Fort 1 , R. L.
Rogers 1 , J. H. Thomas 1 , P. D. Guiney 2 and J. A. Weeks 2 .
1 Fort Environmental Laboratories, Stillwater, OK and
2 Product Safety & Environmental Assessment, SC
Johnson & Son, Racine, WI.
#1759 NON-ADDITIVE DOSE DEPENDENT GENE
EXPRESSION PATTERNS EXHIBITED BY A
MIXTURE OF 17-ALPHA ETHYNYLESTRADIOL
AND GENISTEIN IN VIVO. R. Gupta 2,3,4 , L. D.
Burgoon 1,3,4 , A. Harney 2,3,4 , D. R. Boverhof 2,3,4 , J.
Kwekel 2,3,4 , C. Gennings 5 and T. R. Zacharewki 2,3,4 .
1 Pharmacology & Toxicology, Michigan State
University, East Lansing, MI, 2 Biochemistry &
Molecular Biology, Michigan State University, East
Lansing, MI, 3 Center for Integrative Toxicology,
Michigan State University, East Lansing, MI, 4 National
Food Safety & Toxicology Center, Michigan State
University, East Lansing, MI and 5 Biostatistics, Virginia
Commonwealth University, Richmond, VA.
WEDNESDAY
up-to-date information at www.toxicology.org 183