Program - Society of Toxicology
Program - Society of Toxicology
Program - Society of Toxicology
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#853 A HUMAN PBTK MODEL DESCRIBING<br />
ACETONE KINETICS IN BREATH AND BLOOD<br />
AT DIFFERENT WORKLOADS. A. Mork and G.<br />
Johanson. Work Environment <strong>Toxicology</strong>, Karolinska<br />
Institute, Stockholm, Sweden.<br />
#854 EVALUATION OF ORAL AND INTRAVENOUS<br />
ROUTE PHARMACOKINETICS, PLASMA<br />
PROTEIN BINDING AND UTERINE TISSUE<br />
DOSE METRICS OF BISPHENOL A: A<br />
PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC APPROACH. J. G.<br />
Teeguarden 1 , J. M. Waechter 3 , H. J. Clewell 2 , T. R.<br />
Covington 2 and H. A. Barton 4 . 1 Biological Monitoring<br />
and Modeling, Pacific Northwest National Laboratory,<br />
Richland, WA, 2 ENVIRON International, Ruston, LA,<br />
3 The Dow Chemical Company, Midland, MI and<br />
4 NHEERL, U.S. EPA, Research Triangle Park, NC.<br />
#855 LACK OF BIOACCUMULATION WITH<br />
REPEATED, PERIODIC EXPOSURES OF<br />
CYCLIC SILOXANES. M. E. Andersen 1 , M. B.<br />
Reddy 2 and K. P. Plotzke 3 . 1 CIIT, Research Triangle<br />
Park, NC, 2 Colorado State University, Fort Collins, CO<br />
and 3 Dow Corning Corporation, Midland, MI.<br />
#856 IMPACT OF MODEL MISSPECIFICATION ON A<br />
PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL FOR DMA. C. R.<br />
Eklund, M. V. Evans and E. M. Kenyon.<br />
ORD/NHEERL/ETD, U. S. EPA, Research Triangle<br />
Park, NC.<br />
#857 HUMAN PBPK MODELING OF CLINICAL CASE<br />
REPORTS OF ETHYLENE GLYCOL<br />
OVERDOSING: INCORPORATION OF<br />
THERAPEUTIC INTERVENTIONS. R. A. Corley 1<br />
and K. E. McMartin 2 . 1 Battelle Northwest, Richland,<br />
WA and 2 Louisiana State University Health Sciences<br />
Center, Shreveport, LA.<br />
#858 DEVELOPMENT OF A PHYSIOLOGICALLY<br />
BASED PHARMACOKINETIC (PBPK) MODEL<br />
TO COMPARE DIFFERENCES IN DISPOSITION<br />
OF TRICHLOROETHYLENE(TCE), AND<br />
METABOLITES IN ADULT VERSUS ELDERLY<br />
RATS. M. V. Evans 1 , R. Tornero-Velez 2 , M. J. DeVito 2 ,<br />
M. Okino 3 , A. Geller 2 , J. Blancato 2 and L. Birnbaum 2 .<br />
1 U.S. EPA/NHEERL, Research Triangle Park, NC,<br />
2 U.S. EPA/NERL, Research Triangle Park, NC and<br />
3 U.S. EPA/NERL, LV, NV.<br />
#859 A PBPK MODEL TO EVALUATE VARIABILITY<br />
IN RENAL CLEARANCE. R. S. DeWoskin 1 and C.<br />
M. Thompson 2 . 1 ORD/NCEA, U.S. EPA, Research<br />
Triangle Park, NC and 2 Risk Policy Fellow / NCEA,<br />
AAAS, Washington, DC.<br />
#860 DEVELOPMENT OF A PHYSIOLOGICALLY<br />
BASED PHARMACOKINETIC MODEL FOR<br />
SCH-D IN THE RAT. G. Pastino 1 , C. Rosenfeld 1,2 , C.<br />
Cox 1 , I. Knemeyer 1 , K. Fellows 1 and L. Sultatos 2 .<br />
1 Schering Plough research Institute, Lafayette, NJ and<br />
2 University <strong>of</strong> Medicine and Dentistry <strong>of</strong> New Jersey,<br />
Newark, NJ.<br />
#861 PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL FOR ALL-TRANS<br />
RETINOIC ACID IN PREGNANT CD-1 MICE. J.<br />
L. Campbell 1 , D. Warren 2 , M. Smith 1 and J. W. Fisher 1 .<br />
1 Environmental Health Science, University <strong>of</strong> Georgia,<br />
Athens, GA and 2 <strong>Program</strong> in Environmental Science,<br />
University <strong>of</strong> South Carolina-Beaufort, Beaufort, SC.<br />
#862 PREDICTION OF DI-N-BUTYLPHTHALATE<br />
(DBP) LEVELS IN PREGNANT RATS USING A<br />
PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC (PBPK) MODEL. J. J.<br />
Kremer, R. A. Clewell and S. J. Borgh<strong>of</strong>f. CIIT Centers<br />
for Health Research, Research Triangle Park, NC.<br />
#863 PULMONARY FUNCTION IN RATS DURING<br />
PREGNANCY. T. Leavens, C. Parkinson, A. James, D.<br />
House and D. Dorman. CIIT Centers for Health<br />
Research, Research Triangle Park, NC.<br />
#864 A PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC (PBPK) MODEL FOR THE<br />
PESTICIDE MONOMETHYLARSONIC ACID<br />
(MMA V ). E. M. Kenyon, M. F. Hughes, C. Eklund and<br />
M. V. Evans. U.S. EPA, Research Triangle Park, NC.<br />
#865 DEVELOPMENT OF A HYBRID REACTION<br />
NETWORK-PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC MODEL OF<br />
BENZO(A)PYRENE AND ITS METABOLITES. K.<br />
F. Reardon 1,2 , K. H. Liao 1,2 and R. S. Yang 1 .<br />
1 Quantitative and Computational <strong>Toxicology</strong> Group,<br />
Center for Environmental <strong>Toxicology</strong> and Technology,<br />
Colorado State University, Fort Collins, CO and<br />
2 Department <strong>of</strong> Chemical Engineering, Colorado State<br />
University, Fort Collins, CO.<br />
#866 VALIDATION OF A HUMAN<br />
PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL FOR VINYL<br />
ACETATE AGAINST HUMAN NASAL<br />
DOSIMETRY DATA. P. M. Hinderliter 1 , K. D.<br />
Thrall 2 , R. A. Corley 2 , L. J. Bloemen 3 and B. S.<br />
Matthew 1 . 1 Haskell Laboratory for Health and<br />
Environmental Sciences, Newark, DE, 2 Biological<br />
Sciences Division, Battelle Pacific Northwest<br />
Laboratories, Richland, WA and 3 Epidemiology, Health<br />
Services, Dow Benelux NV, Terneuzen, Netherlands.<br />
#867 DEVELOPMENT AND EVALUATION OF A PBPK<br />
MODEL FOR THE FATE OF 2-<br />
BUTOXYETHANOL IN HUMANS AFTER<br />
DERMAL AND INHALATION EXPOSURE. S.<br />
kezic, J. Kruse and I. Jakasa. Coronel Institute,<br />
Academic Medical Centre, Amsterdam, Netherlands.<br />
Sponsor: P. Boogaard.<br />
#868 PHYSIOLOGICAL MODELING OF THE<br />
TOXICOKINETICS OF METHYL TERT-BUTYL<br />
ETHER (MTBE) AND ITS METABOLITE TERT-<br />
BUTANOL (TBA) IN HUMANS. K. Krishnan 1,3 , A.<br />
Nihlen 2 , L. Ernstgard 3 and G. Johanson 3 . 1 Universite de<br />
Montreal, Montreal, QC, Canada, 2 Active Biotech<br />
Research AB, Lund, Sweden and 3 Work Environment<br />
<strong>Toxicology</strong>, Karolinska Institute, Stockholm, Sweden.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 115
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