Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#2279 TMT TOXICITY IN HIPPOCAMPAL CELLS IS
ASSOCIATED WITH INDUCTION OF BAX AND
INOS EXPRESSION. L. zhang, L. li, K. Prabhakaran,
J. L. Borowitz and G. E. Isom. Medicinal Chemistry and
Molecular Pharmacology, Purdue University, West
Lafayette, IN.
#2280 GENDER -SPECIFIC DIFFERENCES IN
APOPTOTIC INDICES IN RAT LIVER AFTER
CHRONIC ETHANOL CONSUMPTION. T. V.
Curry-McCoy 2 , R. L. White 1 , S. L. Todero 1 and T. M.
Donohue 1 . 1 Research, VA Medical Center, Omaha, NE
and 2 Pathology/Microbiology, University of Nebraska
Medical Center, Omaha, NE. Sponsor: R. Pollenz.
#2281 CALYCULIN A, A PP1/PP2A INHIBITOR, DELAYS
APOPTOTIC SIGNALING IN TGHQ-TREATED
HL-60 CELLS. M. Yang, S. S. Lau and T. J. Monks.
Pharmacology and Toxicology, University of Arizona,
Tucson, AZ.
#2282 SINGLE-WALLED CARBON NANOTUBES
ACTIVATE RAW 264.7 MACROPHAGES: ROLE
IN OXIDATIVE STRESS AND INFLAMMATORY
RESPONSE. A. I. Potapovich 1 , A. N. Osipov 1 , E. R.
Kisin 2 , D. Schwegler-Berry 2 , A. A. Shvedova 2 and V. E.
Kagan 1 . 1 Department of EOH, Center for Free Radical
& Antioxidant Health, University of Pittsburgh,
Pittsburgh, PA and 2 Pathology & Physiology Research
Branch, NIOSH, Morgantown, WV.
#2283 PHYSICAL AND CHEMICAL INTERACTION
BETWEEN CARDIOLIPIN AND CYTOCHROME
C. N. A. Belikova 1,2 , A. N. Osipov 1,2 , A. A. Kapralov 1,2 ,
M. V. Potapovich 1,2 and V. E. Kagan 1,2 . 1 Center for Free
Radical and Antioxidant Health, University of
Pittsburgh, Pittsburgh, PA and 2 Department of
Environmental and Occupational Health, University of
Pittsburgh, Pittsburgh, PA.
#2284 CARDIOLIPIN DESTABILIZES CYTOCHROME
C IN MITOCHONDRIA AND MAKES ITS
CATALYTIC SITE ACCESSIBLE TO SMALL
LIGANDS: ROLE IN APOPTOSIS. A. N. Osipov 1,2 ,
I. V. Kurnikov 2 , Y. A. Vladimirov 2 , N. A. Belikova 1,2 , D.
A. Stoyanovsky 3 , M. V. Potapovich 1,2 , G. G.
Borisenko 2 , A. A. Kapralov 1,2 , Y. Y. Tyurina 1,2 , V. A.
Tyurin 1,2 , J. Jiang 1,2 , V. Kini 1,2 , A. Lysytsya 2 , V. B.
Ritov 1 , A. M. Choi 3 , S. W. Ryter 3 and V. E. Kagan 1,2 .
1 Center for Free Radical & Antioxidant Health,
University of Pittsburgh, Pittsburgh, PA, 2 Department of
Environmental and Occupational Health, University of
Pittsburgh, Pittsburgh, PA and 3 Department of
Pulmonary Medicine and Surgery, University of
Pittsburgh, Pittsburgh, PA.
#2285 BLOCKADE OF N-METHYL-D-ASPARTATE
RECEPTORS BY KETAMINE PRODUCES LOSS
OF MONKEY FRONTAL CORTICAL NEURONS
IN CULTURE. C. Wang 1 , N. Sadovova 3 , X. Fu 2 , A.
Scallet 1 , L. Schmued 1 , J. Hanig 4 and W. Slikker 1 .
1 Division of Neurotoxicology, NCTR/FDA, Jefferson,
AR, 2 Charles River Laboratories, Jefferson, AR,
3 Division of Biochemical Toxicology, NCTR/FDA,
Jefferson, AR and 4 CDER/FDA, Rockville, MD.
#2286 ACTIVATION OF PEROXISOME
PROLIFERATOR-ACTIVATED RECEPTOR
ALPHA ENHANCES HEPATOCYTE APOPTOSIS.
S. Xiao 1 , S. P. Anderson 2 , C. Swanson 1 , R. Bahnemann 3 ,
K. A. Voss 4 , A. J. Stauber 1 and J. C. Corton 5,1 . 1 CIIT,
Research Triangle Park, NC, 2 GSK, Research Triangle
Park, NC, 3 BASF, Ludwigshafen, Germany, 4 USDA,
Athens, GA and 5 ToxicoGenomics, Chapel Hill, NC.
#2287 METABOLISM OF NITRO-PAHS ELICITS
APOPTOTIC AND NECROTIC RESPONSES IN
HEPA 1C1C7 CELLS. N. Asare 1 , K. Ask 2 , N.
Landvik 1 and J. A. Holme 1 . 1 National Public Health
Institute, Oslo, Norway and 2 Macmaster University,
Hamilton, ON, Canada. Sponsor: E. Dybing.
#2288 THE ROLES OF MITOCHONDRIA AND
CASPASE-6 IN 7-12-DIMETHYL-
BENZ[α]ANTHRACENCE-INDUCED BONE
MARROW B CELL APOPTOSIS. J. K. Emberley 1 , J.
J. Schlezinger 2 , H. Ryu 2 and D. H. Sherr 2 .
1 Microbiology, Boston University School of Medicine,
Boston, MA and 2 Environmental Health, Boston
University School of Public Health, Boston, MA.
#2289 AMELIORATION OF PARAQUAT AND
CADMIUM CHLORIDE INDUCED APOPTOSIS
BY κ-CARRAGEENAN IN RAT PLEURAL
MESOTHELIAL CELL CULTURES. P. Kanade and
J. M. Cerreta. Department of Pharmaceutical Sciences,
Saint John’s University, Jamaica, NY. Sponsor: L.
Trombetta.
#2290 STUDY ON THE TOXICITY OF CADMIUM AND
THE PROTECTIVE EFFECT OF FOOD
COMPONENTS IN CELLS WITH HORMONE
RECEPTORS. T. Kim, T. Kang, H. Moon, I. Kang, Y.
Lee and S. Han. Endocrine Toxicology Division,
National Institute of Toxicological Research, Seoul,
South Korea.
#2291 DIFFERENTIATION OF CISPLATIN-INDUCED
DNA DAMAGE AND APOPTOSIS BY
PHOSPHORYLATION OF HISTONE H2A.X. X.
Feng 1 , A. Modi 2 , K. Stams 3 and P. Lord 1 . 1 Johnson &
Johnson PRD, Raritan, NJ, 2 Columbia University, New
York City, NY and 3 AstraZeneca Pharmaceuticals LP,
Waltham, MA. Sponsor: C. Wang.
#2292 CISPLATIN-INDUCED APOPTOSIS OF GC1
TESTICULAR GERM CELLS MAY OCCUR BY
AN AUTOCRINE MECHANISM INVOLVING
FASL/FAS- OR TRAIL/DR5-MEIDATED
SIGNALING. Y. Ye and J. H. Richburg. College of
Pharmacy, The University of Texas at Austin, Austin,
TX.
#2293 A DECREASE IN AKT LEVELS CORRELATES
WITH SENSITIVITY TO ARSENIC-INDUCED
GROWTH INHIBITION. M. Colombo, W. H. Miller
and K. K. Mann. Lady Davis Institute for Medical
Research, McGill University, Montreal, QC, Canada.
THURSDAY
up-to-date information at www.toxicology.org 223