Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#1664 4:30 ADVANCES IN MATERIAL SAFETY DATA
SHEET COMMUNICATION. M. McDiarmid 1 and L.
Frazier 2 . 1 Occupational Health Project, University of
Maryland, Baltimore, MD and 2 Department of
Preventive Medicine, University of Kansas School of
Medicine, Wichita, KS.
#1665 4:40 ISSUES WITH MSDS COMMUNICATION OF
REPORDUCTIVE HAZARDS. L. Frazier 1,2 , M. J.
Rall 2 and D. B. Fromer 1 . 1 Preventive Medicine and
Public Health, University of Kansas School of
Medicine-Wichita, Wichita, KS and 2 Obstetrics and
Gynecology, University of Kansas School of Medicine-
Wichita, Wichita, KS. Sponsor: M. McDiarmid.
#1666 5:00 DEVELOPING GOOD MSDS
COMMUNICATIONS IN INDUSTRY. J. S. Bus. The
Dow Chemical Company, Midland, MI.
#1667 5:20 MSDSS IN CANADA AND THE
COMMUNICATION OF REPRODUCTIVE
TOXICITY. P. Demers. School of Occ/Env Hygiene,
University of British Columbia, Vancouver, BC,
Canada. Sponsor: M. McDiarmid.
#1668 5:40 STRENGTHS OF THE NJ HAZARDOUS
SUBSTANCE FACT SHEET PROGRAM: HOW
TO WRITE A BETTER MSDS. R. Willinger, JD
MPH and A. Sobieszczyk, MD PhD. Right to Know
Program, New Jersey Department of Health and Senior
Services, Trenton, NJ. Sponsor: B. Grajewski.
Wednesday Afternoon, March 9
4:30 PM to 6:00 PM
Room 208
#1670 4:32 IMPROVED NUTRITION THROUGH MODERN
BIOTECHNOLOGY. M. Newell–McGloughlin.
University of California Systemwide Biotechnology
Research and Education Program, U.C. Davis, Davis,
CA. Sponsor: B. Hammond.
#1671 4:47 CASE STUDY FOR THE SAFETY ASSESSMENT
OF A NUTRITIONALLY IMPROVED
FEED/FOOD CROP. B. G. Hammond, T. Reynolds, G.
Hartnell, E. Rice, R. McCoy and K. Glenn. Product
Safety Center, Monsanto Company, St. Louis, MO.
#1672 5:02 SAFETY ASSESSMENT OF NUTRITIONALLY
IMPROVED CROPS THROUGH MODERN
BIOTECHNOLOGY. H. A. Kuiper, G. A. Kleter and
E. J. Kok. RIKILT, Institute of Food Safety,
Wageningen University and Research Center,
Wageningen, Netherlands. Sponsor: B. Hammond.
#1673 5:22 SAFETY AND NUTRITIONAL ASSESSMENT OF
FOODS AND FEEDS NUTRITIONALLY
IMPROVED THROUGH BIOTECHNOLOGY. I. C.
Munro. CANTOX Health Sciences International,
Mississauga, ON, Canada.
Wednesday Afternoon, March 9
4:30 PM to 6:00 PM
Room 220
SUNSET SESSION: VINYL CHLORIDE: LEGACY AND LESSONS
LEARNED
Chairperson(s): Roger O. McClellan, Toxicology and Human Health Risk
Analysis, Albuquerque, NM and Melvin Andersen, CIIT Centers for Health
Research, Research Triangle Park, NC.
SUNSET SESSION: THE SAFETY ASSESSMENT OF
NUTRITIONALLY IMPROVED FOOD AND FEED CROPS
Chairperson(s): Bruce Hammond, Monsanto, St. Louis, MO and Philip M.
Bolger, U.S. FDA, College Park, MD.
Endorsed by:
Food Safety SS*
Regulatory and Safety Evaluation SS
Student Advisory Committee
The first generation of food and feed crops developed through modern agricultural
biotechnology were designed to improve agronomic characteristics such as
control of noxious weeds (herbicide tolerance) or protection against insect pests.
The next generation of products under development include crops that have
improved nutritional characteristics. Speakers for this workshop will discuss (1)
various biotechnology approaches that are being used to improve nutritional
characteristics of feed/food crops, (2) a case study for the safety and nutritional
assessment of a nutritionally improved food/feed crop (3) recommendations of
the EU ENTRANSFOOD working group on safety assessment of foods derived
from genetically modified crops (4) conclusions from a recent ILSI workshop
entitled Nutritional and Safety Assessments of Foods and Feeds Nutritionally
Improved through Biotechnology. At the end of the presentations, a panel
discussion will compare and contrast recommendations from the SOT,
ENTRANSFOOD and ILSI workgroups regarding the safety assessment of
nutritionally improved crops.
#1669 4:30 THE SAFETY ASSESSMENT OF
NUTRITIONALLY IMPROVED FOOD AND FEED
CROPS. B. G. Hammond. Product Safety Center,
Monsanto Company, St. Louis, MO.
Endorsed by:
Biological Modeling SS
Carcinogenesis SS
Comparative and Veterinary SS
Risk Assessment SS*
Vinyl chloride is a major commodity chemical that has been extensively studied
relative to its toxicological and carcinogenic properties. Early research
conducted by producers and users of vinyl chloride focused on its toxicological
properties. The research results were used in a standard safety factor framework
to derive threshold limit values for occupational exposure. Long-term rodent
inhalation studies were initiated to investigate the potential for chronic toxicity
and carcinogenicity. Almost concurrently, carcinogenic responses were
observed in the rodent studies and case reports were published on a finding of
a rare cancer, hepatic angiosarcomas in workers exposed to high levels of vinyl
chloride. More stringent occupational exposure limits were instituted and
further research on vinyl chloride initiated. This included epidemiological
studies of workers, animal carcinogenicity bioassays and mechanistic investigations.
The initial results, while confirming the carcinogenicity of vinyl chloride
in humans and rodents, appeared to yield marked differences in carcinogenic
potency in humans and rodents. Further research on the metabolic kinetics and
molecular dosimetry of vinyl chloride and its metabolites provided a basis for
reconciling the original apparent species differences in potency and provided a
mechanistic basis for the very specific carcinogenic response, hepatic angiosarcomas.
The more stringent exposure standards have been effective in protecting
workers. In retrospect, the research conducted on vinyl chloride may be viewed
as a success story for how mechanism-based findings can be used to establish
appropriate health protective standards. Moreover, the research approach used
with vinyl chloride has served as a template for evaluating the toxicity and
carcinogenicity of other chemicals.
WEDNESDAY
up-to-date information at www.toxicology.org 199