Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1606 NECROSIS AND NOT APOPTOSIS IS THE PREDOMINANT MODE OF CELL DEATH IN MORTAL HUMAN PROXIMAL TUBULE CELLS EXPOSED TO CADMIUM CHLORIDE. S. Somji 1 , S. H. Garrett 1 , M. Sens 1 and D. A. Sens 2 . 1 Pathology, University of North Dakota, Grand Forks, ND and 2 Surgery, University of North Dakota, Grand Forks, ND. #1607 CADMIUM-INDUCED CELL CYCLE ARREST IN RAT KIDNEY EPITHELIAL CELLS IS MEDIATED THROUGH P53 ACTIVATION. J. Xie and Z. A. Shaikh. Department of Biomedical and Pharmaceutical Science, University of Rhode Island, Kingston, RI. #1608 CADMIUM-INDUCED CARCINOGENIC TRANSFORMATION OF HUMAN PANCREATIC DUCTAL CELLS. W. Qu 1 , B. Diwan 2 , D. Broderick 1 , M. Tsao 3 and M. Waalkes 1 . 1 Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, 2 BRP, SAIC-Frederick, NCI at Frederick, Frederick, MD and 3 Ontario Cancer Institute, Toronto, ON, Canada. #1609 CADMIUM MAY AFFECT THE LIGAND INDUCED MIGRATORY ABILITY OF IMMORTALIZED EXTRAVILLOUS TROPHOBLAST CELLS. M. M. Alvarez and C. Chakraborty. Pathology, University of Western Ontario, London, ON, Canada. Sponsor: M. Cherian. #1610 CHRONIC EXPOSURE TO CADMIUM INDUCES ANEMIA WITH HIGH IRON STORAGE THROUGH DEFECTIVE IRON UTILIZATION AND ENHANCED IRON ABSORPTION IN RATS. H. Horiguchi, E. Oguma, H. Uno and F. Kayama. Jichi Medical School, Tochigi, Japan. Sponsor: T. Yoshida. #1611 BEHAVIORAL ALTERATIONS OF C57BL AND METALLOTHIONEIN KNOCK-OUT MICE PERINATALLY EXPOSED TO LOW LEVEL OF CADMIUM. C. Watanabe 1 , A. Watanabe 1 , M. Satoh 2 , K. Yoshida 3 , K. Mori 3 , H. Ishitobi 1 and A. Honda 2 . 1 Human Ecology, University of Tokyo, Tokyo, Japan, 2 Hygienics, Gifu Pharmaceutical University, Gifu, Japan and 3 Endocrinology, Tohoku University School of Medicine, Sendai, Japan. #1612 MODULATION OF ACUTE HEPATOTOXICITY OF CADMIUM BY SIMULTANEOUS ADMINISTRATION OF COBALT IN MICE. S. Himeno. Fac. of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. Sponsor: M. Sato. #1613 LIVER INJURY IN METALLOTHIONEIN-NULL MICE AFTER TREATMENT WITH THIOACETAMIDE. S. Jiang and G. M. CHERIAN. Pathology, University.of Western Ont, London, ON, Canada. #1614 THE NORMAL HUMAN PROSTATE EPITHELIAL CELL LINE, RWPE-1, AS AN IN VITRO MODEL SYSTEM OF METALLOTHIONEIN REGULATION IN THE PROSTATE. R. K. Singh 1 , S. Somji 1 , M. Sens 1 , D. A. Sens 2 and S. H. Garrett 1 . 1 Pathology, University of North Dakota, Grand Forks, ND and 2 Surgery, University of North Dakota, Grand Forks, ND. #1615 METALLOTHIONEIN SUSTAINS METALLOPROTEINASE2 GENE EXPRESSION IN IMMORTALIZED FIBROBLAST CELLS. M. Takiguchi 1,2 , M. Higashimoto 2 , S. Suzuki 2 , S. Yoshihara 1 and M. Sato 2 . 1 Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima, Japan and 2 Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. #1616 POST-TRANSLATIONAL STABILIZATION OF METALLOTHIONEIN ISOFORM 3 IN THE NORMAL BLADDER CELL LINE, UROTSA. D. A. Sens 1 , S. Somji 2 , R. Singh 2 , M. Sens 2 and S. H. Garrett 2 . 1 Surgery, University of North Dakota, Grand Forks, ND and 2 Pathology, University of North Dakota, Grand Forks, ND. #1617 ACTIVITY OF METAL-RESPONSIVE TRANSCRIPTION FACTOR 1 IS MODULATED BY METALLOTHIONEIN. T. Kimura 1 , N. Itoh 2 , T. Sone 1 , M. Isobe 1 and K. Tanaka 2 . 1 Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Japan and 2 Department of Toxicology, Graduate school of Pharmaceutical Sciences, Osaka University, Suita, Japan. #1618 THE EFFECT OF METALLOTHIONEIN ISOFORM-3 MUTANTS ON THE DIFFERENTIATION OF BREAST CANCER MCF- 7 CELLS. M. Sens 1 , S. H. Garrett 1 , S. Somji 1 and D. A. Sens 2 . 1 Pathology, University of North Dakota, Grand Forks, ND and 2 Surgery, University of North Dakota, Grand Forks, ND. #1619 PRODUCTION OF METALLOTHIONEIN POLYCLONAL ANTIBODIES USING CHICHENS AS MODEL. E. Brambila 1 , A. Ortiz/Bueno 1 , B. Leon- Chavez 1 , W. Achanzar 2 and M. P. Waalkes 2 . 1 Clinical Chemistry, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico and 2 NIH, Research Triangle Park, NC. Wednesday Morning, March 9 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: IN VITRO Chairperson(s): Mohamed Abou-Donia, Duke University, Durham, NC and Bhupendra Kaphalia, University Of Texas, Galveston, TX. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #1620 INTERACTION OF PB AND DEET, ALONE AND IN COMBINATION WITH P-GLYCOPROTEIN EXPRESSED IN E. COLI LEAKY MUTANT. E. M. El-Masry and M. B. Abou-Donia. Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC. #1621 HORMESIS EFFECT OF TRACE METALS ON CULTURED NORMAL AND IMMORTAL HUMAN MAMMARY CELLS. C. N. Cheng, A. Marino, C. M. Schmidt, R. Konsoula and F. A. Barile. Pharmaceutical Sciences, St. John’s University College of Pharmacy, Jamaica, NY. 172 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1629 ETHANOL-INDUCED TOXICITY AND #1622 INTERACTIVE TOXICITY OF MERCURY AND 9 BioReliance, Rockville, MD. POLYCHLORINATED BIPHENYL IN THE NEUROELECTROPHYSIOLOGY OF RAT EMBRYO. G. Balagopal 1 and H. Chan 2 . 1 Human Toxicology Section–Standards Development Branch, Ontario Ministry of Environment, Toronto, ON, Canada and 2 Center for Indegenous People’s Nutrition and APOPTOSIS IN HEPG2 CELLS AND VA-13 CELLS: ROLE OF FATTY ACID ETHYL ESTERS. H. Wu 1 , K. Bhopale 1 , G. A. Ansari 1 and B. S. Kaphalia 1 . 1 Pathology, University of Texas Medical Branch, Galveston, TX, 2 Pathology, University of Texas Medical Branch, Galveston, TX, 3 Pathology, University Environment, Macdonald Campus, McGill University, of Texas Medical Branch, Galveston, TX and 4 Montreal, QC, Canada. Pathology, University of Texas Medical Branch, #1623 COMPARATIVE EVALUATION OF Galveston, TX. SURFACTANTS ON IN VITRO RABBIT AND HUMAN CORNEAS. H. F. Edelhauser 1 , B. Boykin 1 , #1630 OPTIMIZATION OF AN IN VITRO LONG TERM CORNEAL CULTURE ASSAY. H. A. Raabe 1 , L. G. Holley 1 and M. E. Blazka 2 . 1 Emory Eye Center, Bruner 2 , T. Snyder 1 , N. Wilt 1 and J. W. Harbell 1 . Emory University, Atlanta, GA and 2 1 Colgate-Palmolive Institute for In Vitro Sciences, Gaithersburg, MD and 2 Co., Piscataway, NJ. The Gillette Co., Boston, MA. #1624 ESTABLISHMENT OF AN IN VITRO BRAIN BARRIER EPITHELIAL TRANSPORT SYSTEM FOR TOXICOLOGICAL STUDIES. L. Shi and W. Zheng. School of Health Sciences, Purdue University, West Lafayette, IN. #1631 AN EXPANDED REFERENCE DATA-BASE OF IN VITRO OCULAR IRRITATION SCORES FOR MARKETED COSMETIC AND PERSONAL CARE PRODUCTS USING A TISSUE EQUIVALENT MODEL. R. R. Binetti, M. D. Hines, R. Hamid, S. D. #1625 Gettings and B. C. Jones. Avon Products Inc., Suffern, A GERM-LINE STEM CELL LINE AS A MODEL NY. FOR EVALUATING THE CYTOTOXICITY OF NANOPARTICLES IN VITRO. L. Braydich-Stolle 1 , #1632 EFFECT OF THE PROTEASOME INHIBITOR S. Hussain 2 , J. Schlager 3 and M. Hofmann 1 . PS-341 ON NEURONAL CELLS IN VITRO. V. 1 Department of Biology, University of Dayton, Dayton, Csizmadia, A. Raczynski, J. Rottman, K. Ganley, P. OH, 2 ManTech Environmental Technology, Inc., Dayton, OH and 3 Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH. Bouchard and V. Sasseville. Drug Safety and Disposition, Millennium Pharmaceuticals, Inc., Cambridge, MA. Sponsor: A. Carl. #1626 VALIDATION OF AN IN VITRO CELL LINE FOR SCREENING MYELOTOXICITY. T. Huggett 1 , A. #1633 DEVELOPMENT OF IN VITRO CARDIOTOXICITY ASSAY USING RAT Saad 2 , T. Kelly 1 , F. Pognan 3 , M. Otieno 1 and D. Brott 1 . CARDIOMYOCYTES CULTURED ON 1 AstraZeneca Pharmaceuticals, Wilmington, DE, COLLAGEN GEL. T. Inoue, A. Shioda and K. 2 AstraZeneca Pharmaceuticals, Sodertalje, Sweden and Kobayashi. Pre-Clinical Research Department 2, Chugai 3 AstraZeneca Pharmaceuticals, Alderly Park, United Pharmaceutical Co., Ltd.,, Kamakura, Japan. Sponsor: Kingdom. R. Nagata. #1627 CORRELATION OF IN VITRO CYTOTOXICITY WITH PARACELLULAR PERMEABILITY IN CACO-2 CELLS. R. Konsoula and F. A. Barile. Pharmaceutical Sciences, St. John’s University College of Pharmacy, Jamaica, NY. #1634 EVALUATION OF CIGARETTE SMOKE CYTOTOXICITY UNDER IN VITRO CONDITIONS. H. E. Hartman, F. Sheabar, G. Holloway, J. Ye and S. Millett. Toxicology, Arista Laboratories, Inc., Richmond, VA. #1628 PROTOCOL OPTIMIZATION FOR THE EVALUATION OF IN VITRO CYTOTOXICITY ASSAYS FOR ESTIMATING RODENT AND HUMAN ACUTE SYSTEMIC TOXICITY. M. Paris 1,2 , J. Strickland 1,2 , W. Stokes 1 , S. Casati 3 , R. Tice 1,2 , H. Raabe 4 , C. Cao 5 , R. Clothier 6 , J. Haseman 7 , P. Crockett 8 , M. Wenk 9 , M. Vallant 7 , G. Mun 4 , G. Moyer 4 , J. Madren-Whalley 5 , C. Krishna 5 , M. Owen 6 and N. Bourne 6 . 1 NICEATM, NIEHS, Research Triangle Park, NC, 2 ILS, Inc., Research Triangle Park, NC, 3 JRC, ECVAM, Ispra, Italy, 4 IIVS, Gaithersburg, MD, 5 ECBC, USArmy, Aberdeen Proving Ground, MD, 6 University of Nottingham, Nottingham, United Kingdom, 7 NIEHS, Research Triangle Park, NC, 8 Constella Group, Research Triangle Park, NC and #1635 IN VITRO MODEL FOR VASCULAR DEVELOPMENT IN MOUSE EMBRYONIC STEM CELLS. G. RHEE 1 , G. Kim 1 , J. Seok 1 , S. Kim 1 , S. Kwack 1 , R. Lee 1 , S. Lee 1 , H. Chung 2 and D. Cho 1 . 1 Department of Toxicology, National Institute of Toxicological Research, Seoul, South Korea and 2 Cell and Gene Therapy Research Institute, Pochon CHA University, Seoul, South Korea. WEDNESDAY up-to-date information at www.toxicology.org 173
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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