Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
Tuesday Afternoon, March 8
4:30 PM to 6:00 PM
Room 208
Tuesday Afternoon, March 8
4:30 PM to 6:00 PM
Room 220
TUESDAY
SUNSET SESSION: IN VITRO TOXICITY TESTING OF AIR
POLLUTANTS: PROS AND CONS
Chairperson(s): Ian Gilmour, U.S. EPA, Research Triangle Park, NC and
JeanClare Seagrave, Lovelace Respiratory Research Institute, Albuquerque,
NM.
Endorsed by:
In Vitro SS
Inhalation SS*
Risk Assessment SS
Student Advisory Committee
The increasing evidence for adverse health effects resulting from acute and
chronic exposure to air pollution has driven efforts to identify which components
cause these effects and by what mechanisms. This, in turn, has created a
need for rapid, cost-effective methods for in vitro screening and mechanistic
studies. The respiratory tract is the first target of aerosols, but in vitro studies of
this system are complicated by species differences, varied regional anatomy and
physiology, as well as the fact that aerosols interact at the gas/air inter-phase of
the lung surface. In addition to containing over forty different cell types that
may respond quite differently to a given stimulus, host susceptibility factors that
may be driven by genetics, and previous exposures may impact on observed
effects. The purpose of this session is to review issues regarding the selection of
models, exposure methods, doses, and endpoints and to determine how these
systems may reflect inhalation exposures in the exposed population.
#1015 4:30 IN VITRO TOXICITY TESTING OF AIR
POLLUTANTS: PROS AND CONS. M. Gilmour 1
and J. Seagrave 2 . 1 NHEERL, U.S. EPA, Research
Triangle Park, NC and 2 LRRI, Albuquerque, NM.
#1016 4:35 CELL POPULATIONS WITHIN THE
RESPIRATORY TRACT. C. G. Plopper. Anatomy,
Physiology and Cell Biology, Universtiy of California,
Davis, CA.
#1017 4:45 SYSTEMS FOR EXPOSING LUNG CELLS TO
AEROSOLS. J. Seagrave and J. D. McDonald.
Lovelace Respiratory Research Institute, Albuquerque,
NM.
#1018 5:00 ANALYTICAL TOOLS FOR ASSESSING AIR
POLLUTION TOXICITY USING DIFFERENT IN
VITRO CELL CULTURE MODELS. I. Jaspers.
CEMALB, University of North Carolina, Chapel Hill,
NC.
#1019 5:15 IN VITRO CORRELATION WITH IN VIVO
EXPOSURES. R. Devlin and L. Dailey. U.S. EPA,
Research Triangle Park, NC.
SUNSET SESSION: TOXICOLOGY INFORMATION AND DATA
UPDATE
Chairperson(s): Philip Wexler, National Library of Medicine, Bethesda, MD.
Endorsed by:
National Capital Area Chapter
As the Web and its online resources continue to expand and change rapidly,
there is an increasing plethora of databases, documents, and other digital tools
available to the toxicology community. Toxicologists with even formidable
research skills are often knowledgeable about only a small fraction of what is
available, and they are often not kept apprised of the newest developments. This
symposium highlights major Web-based resources from all sectors–government,
academia, industry, non-profits–which can benefit toxicologists in their daily
research and other work. This program takes a look at a few of these resources.
The National Library of Medicine’s Toxicology and Environmental Health
Information Program is a major purveyor of toxicological information and data
through its TOXNET system and other databases, geared to both the professional
and the public. The Center for Research on Environmental and
Occupational Toxicology (CROET) focuses on health and safety in the workforce
and supports a number of information activities, including its Toxicology
Information Center. The National Institute of Environmental Health Sciences
(NIEHS) and the National Toxicology Program offer a number of unique online
databases and make available online numerous test reports and the Report on
Carcinogens. EPA has recently unveiled its Distributed Structure Searchable
Toxicity (DSS-TOX) database, another powerful tool of potential interest.
#1020 4:30 TOXICOLOGY INFORMATION AND DATA
UPDATE. P. Wexler. Toxicology and Environmental
Health Information Program, National Library of
Medicine, Bethesda, MD.
#1021 4:32 THE NATIONAL LIBRARY OF MEDICINE’S
(NLM) WORLD LIBRARY OF TOXICOLOGY,
CHEMICAL SAFETY AND ENVIRONMENTAL
HEALTH. P. Wexler. Toxicology and Environmental
Health Information Program, National Library of
Medicine, Bethesda, MD.
#1022 4:47 WEB-BASED RESOURCES SPONSORED BY THE
NATIONAL INSTITUTE OF ENVIRONMENTAL
HEALTH SCIENCES (NIEHS) AND THE
NATIONAL TOXICOLOGY PROGRAM (NTP). L.
L. Wright. US Department of Health and Human
Services, National Institute of Environmental Health
Sciences, Research Triangle Park, NC. Sponsor: P.
Wexler.
#1023 5:02 THE CENTER FOR RESEARCH ON
OCCUPATIONAL AND ENVIRONMENTAL
TOXICOLOGY (CROET). F. Berman. Oregon Health
and Science University, Portland, OR. Sponsor: P.
Wexler.
#1024 5:22 DSSTOX STRUCTURE-SEARCHABLE PUBLIC
TOXICITY DATABASE NETWORK: CURRENT
PROGRESS AND NEW INITIATIVES TO
IMPROVE CHEMO-BIOINFORMATICS
CAPABILITIES. A. M. Richard 1 and B. A. Rogers 1 .
1 2 U.S. EPA, Research Triangle Park, NC and NCCU
Student COOP, U.S. EPA, Research Triangle Park, NC.
Sponsor: L. King.
Abstract 1025 is located on page 129.
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SOT’s 44 th Annual Meeting