Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
TUESDAY
#757 GENE EXPRESSION PROFILING IDENTIFIES
GENE CHANGES INDICATIVE OF POTENTIAL
EARLY NEOPLASTIC LIVER LESIONS CAUSED
BY THE RODENT HEPATOCARCINOGEN
METHYLEUGENOL. J. T. Auman, J. Foley and R. S.
Paules. National Center for Toxicogenomics, NIEHS,
Research Triangle Park, NC.
#758 GENE REGULATION PATTERNS IN RAINBOW
TROUT AFLATOXIN B 1 -INDUCED
HEPATOCELLULAR CARCINOMA COMPARED
TO NORMAL ADJACENT LIVER. S. C. Tilton 1,2 , J.
D. Hendricks 1 , G. S. Bailey 1,2 and D. E. Williams 1,2 .
1 Environmental & Molecular Toxicology Department
and Marine & Freshwater Biomedical Sciences Center,
Oregon State University, Corvallis, OR and 2 Linus
Pauling Institute, Oregon State University, Corvallis,
OR.
#759 TOXICOGENOMIC ANALYSIS OF NUCLEAR
RECEPTOR-MEDIATED AND -INDEPENDENT
RESPONSES TO PEROXISOME
PROLIFERATORS. C. G. Woods 1 , B. U. Bradford 1 ,
M. L. Cunningham 2 , M. Kadiiska 3 , R. P. Mason 3 , A. M.
Burns 4 , J. M. Peters 4 and I. Rusyn 1 . 1 Environmental
Science and Engineering, UNC, Chapel Hill, NC, 2 NCT
and NTP, NIEHS, Research Triangle Park, NC,
3 Laboratory of Pharmacology and Chemistry, NIEHS,
Research Triangle Park, NC and 4 Veterinary Science,
PSU, University Park, PA. Sponsor: I. Rusyn.
#760 COMPARATIVE EEFFECTS OF
TRICHLORACETIC ACID ON RODENT AND
HUMAN HEPATOCYTES: ROLE OF
PEROXISOME PROLIFERATOR ACTIVATED
RECEPTOR α (PPARα). D. J. Smith, X. Pu, L. M.
Kamendulis and J. E. Klaunig. Division of Toxicology,
Indiana University School of Medicine, Indianapolis,
IN.
#761 THE EFFECTS OF AMMONIUM
PERFLUOROOCTANOATE (APFO) ON THE
TRANSCRIPTIONAL PROFILE OF PANCREAS
AND LIVER OF MALE RATS. S. Plummer, O.
Vassieva and C. Elcombe. CXR Biosciences Ltd.,
Dundee, United Kingdom.
#762 EFFECT OF 6MONTS ADMINISTRATION OF
HEPATIC TUMOR PROMOTERS ON IGF
SIGNALING PATHWAY EXPRESSION IN THE
RAT LIVER. A. Naito, S. Dial and Y. Dragan. Division
of System Toxicology, NCTR, Jefferson, AR.
#763 DIFFERENTIAL CHANGES OF GENE
EXPRESSION PROFILES IN MALE LONG-
EVANS CINNAMON AND F344 RATS BY THE
ADMINISTRATION OF N-
NITROSOMORPHOLINE. Y. Kawano 1 , K.
Nakayama 1 , D. Nakae 2 , A. Maekawa 2 , M. Tsuchitani 1
and M. Sekijima 1 . 1 Mitsubishi Chemical Safety Institute
Ltd.,, Ibaraki, Japan and 2 Sasaki Institute, Sasaki
Foundation, Tokyo, Japan.
#764 DOWN-REGULATION OF E-CADHERIN BY THE
INTEGRIN-LINKED KINASE PATHWAY (ILK) IN
HEPATOCYTES; A POSSIBLE MECHANISM
FOR HEXACHLOROBENZENE-INDUCED
TUMOR PROMOTION. I. Plante, D. G. Cyr and M.
Charbonneau. INRS-Institut Armand-Frappier,
Universite du Quebec, Montreal, QC, Canada.
#765 TOXICOGENOMIC APPROACH FOR
PREDICTION OF HEPATOCARCINOGENS
USING RAT HEPATOMA CELLS AND
COMPARISON OF GENE EXPRESSION
PATTERNS WITH CHEMICAL-TREATED RAT
AND HUMAN HEPATOMA CELLS. K.
TSUJIMURA 1,2 , M. Asamoto 1 , S. Suzuki 1 , K. Ogawa 1
and T. Shirai 1 . 1 Department of Experimental Pathology
and Tumor Biology, Nagoya City University Graduate
School of Medical Sciences, Nagoya, Aichi, Japan and
2 Chemicals Assessment Center, Hita laboratory,
Chemicals Evaluation and Research Institute, Hita, Oita,
Japan.
Tuesday Morning, March 8
9:30 AM to 12:30 PM
Exhibit Hall
POSTER SESSION: CHEMICAL & BIOLOGICAL WEAPONS
Chairperson(s): Alan Brimfield, USAMRICD, Aberdeen Proving Groud, MD
and Gary Rosenthal, RxKinetix, Louisville, CO.
Displayed: 9:30 AM–12:30 PM
Attended: 9:30 AM–11:00 AM
#766 EVALUATION OF A VACCINE DELIVERY
SYSTEM FOR RECOMBINANT ANTHRAX
PROTECTIVE ANTIGEN IN RABBITS. J. M.
Blonder 1 , C. Coeshott 1 , E. Verderber 1 , A. Samaniego 1 ,
S. Smithson 2 , M. Westerink 2 and G. Rosenthal 1 .
1 2 RxKinetix, Louisville, CO and Department Medicine,
Medical College of Ohio, Toledo, OH.
#767 HISTOLOGICAL RESPONSE OF RAT ORGANS
TO REPEATED BLAST OVERPRESSURE
EXPOSURE. EFFECTS OF NUMBER OF
EXPOSURES AND TIME AFTER EXPOSURE. N.
Elsayed 1,2 , N. Gorbunov 3 , A. Januszkiewicz 3 and J.
Atkins 3 . 1 Hurley Consulting Associates, Chatham, NJ,
2 SUNY Downstate Medical Center, Brooklyn, NY and
3 Walter Reed Army Institute of Research, Silver Spring,
MD.
#768 DEVELOPMENT OF A MICROBIAL RISK
ASSESSMENT METHODS COMPENDIUM AND
ASSESSMENT OF SECONDARY DATA U. M.
Coleman 1 , P. McClure 1 , P. McGinnis 2 , R. Starmer 1 , P.
Rodgers 3 , I. Baumel 4,6 , J. Choich 4,7 and E. Brady-
Roberts 4,5 . 1 Environ Sciences Ctr, Syracuse Research
Corp, Syracuse, NY, 2 Syr Res Corp, Philadelphia, PA,
3 Battelle Mem Inst, Columbus, OH,
4 NHomeland Sec
Res, U.S. EPA, Washington, DC, 5 NHomeland Sec Res,
U.S. EPA, Cincinnati, OH, 6 U.S. EPA, Washington, DC
and 7 Amer Assn Adv Sciences, Washington, DC.
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SOT’s 44 th Annual Meeting