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44 th Annual Meeting and ToxExpo Program Description TUESDAY Tuesday Morning, March 8 8:30 AM to 11:30 AM Room 220 PLATFORM SESSION: EVALUATING DNA DAMAGE AND REPAIR Chairperson(s): Toby G. Rossman, New York University School of Medicine, Tuxedo, NY and John E. French, NIEHS, Research Triangle Park, NC. #697 8:30 GENETIC TOXICOLOGY TESTING IN HTS. R. M. Walmsley 1,2 , P. Cahill 2 , A. Knight 2 and N. Billinton 2 . 1 Biomolecular Sciences, UMIST, Manchester, England, United Kingdom and 2 Product Development, Gentronix Ltd., Manchester, United Kingdom. Sponsor: S. Dean. #698 8:50 AMES II AND DEREK VERSUS THE STANDARD AMES PROTOCOL: A COMPARATIVE STUDY. C. Andreas, K. Braun, I. Stammberger, H. Spirkl and A. Amberg. Sanofi-Aventis, Hattersheim, Germany. Sponsor: M. Bonnefoi. #699 9:10 STUDY IN VITRO OF THE TUMORIGENIC ACTION OF ACRYLAMIDE ON THYROID CELLS. J. DUMONT 1 , J. Van Sande 1 , C. Massart 1 , M. Friedman 2 and V. CHICO-GALDEZ 1 . 1 I.R.I.B.H.M., ULB, Brussels, Belgium and 2 Free Consultant, Orlando, FL. #700 9:30 UNEXPECTED CLASTOGENICITY OF SOME PHARMACEUTICALS IS DUE TO DNA INTERCALATION. R. D. Snyder 1 , G. B. Zairov 1 and L. B. Hendry 2 . 1 Investigative and Molecular Toxicology, Schering-Plough, Lafayette, NJ, 2 Schering- Plough, Lafayette, NJ and 3 Accelerated Pharmaceuticals, Augusta, GA. #701 9:50 PHOSPHOTRIESTER ALKYLATION OF DNA BY MNU AND MMS. L. H. Pottenger, F. Zhang, M. J. Bartels, M. R. Schisler and B. B. Gollapudi. Toxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, MI. #702 10:10 RECOGNITION AND REPAIR OF BUTADIENE EPOXIDE DNA ADDUCTS: INVOLVEMENT OF NUCLEOTIDE EXCISION REPAIR. J. Wickliffe 1 , O. Masters 2 , S. Herring 1 , M. Ammenheuser 1 , L. Galbert 1 , J. Xie 1 , R. S. Lloyd 3 and J. Ward 1 . 1 University of Texas Medical Branch, Galveston, TX, 2 University of Oklahoma, Norman, OK and 3 Oregon Health and Science University, Portland, OR. #703 10:30 BENZO[A]PYRENE-DNA ADDUCTS DERIVED FROM DIOL-EPOXIDE AND QUINONE PATHWAYS. Q. Ruan 1 , Q. Dai 2 , H. Kim 1 , R. G. Harvey 2 , T. M. Penning 1 and I. A. Blair 1 . 1 Department of Pharmacology, University of Pennsylvania, Philadelphia, PA and 2 Ben May Institute for Cancer Research, University of Chicago, Chicago, IL. Sponsor: S. Burchiel. #704 10:50 SIGNALING PATHWAYS FOR DNA DAMAGE AND REPAIR, APOPTOSIS AND LYMPHOID PROGENITOR CELL SURVIVAL ARE DYSREGULATED BY N-ACETYL-L-CYSTEINE. J. E. French 1 , K. R. Martin 2 , F. W. Kari 1 and J. C. Barrett 3 . 1 Laboratory of Molecular Toxicology, NIEHS, NIH, Research Triangle Park, NC, 2 Nutrition and Cancer Laboratory, Pennsylvania State University, University Park, PA and 3 Laboratory of Biosystems and Cancer, NCI, Bethesda, MD. #705 11:10 PREVENTION OF ARSENIC CO- CARCINOGENESIS BY SELENIUM COMPOUNDS. T. G. Rossman, A. N. Uddin and F. J. Burns. Environment Med., New York University School of Medicine, Tuxedo, NY. Tuesday Morning, March 8 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 I Chairperson(s): Xinxin Ding, New York State Department of Health, Albany, NY. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #706 CELLULAR DISTRIBUTION OF SELECTIVE AGE DEPENDENT TESTICULAR CYTOCHROME P450-DEPENDENT ALKOXYRESORUFIN O-DEALKYLATION IN SPRAGUE-DAWLEY RATS. J. E. Seng 1 , J. Gandy 2 , R. Ansari 2 and J. Leakey 3 . 1 Charles River Laboratories, Discovery and Developmental Services, Redfield, AR, 2 Department of Pharmacology & Toxicology, University of Arkansas Medical Sciences, Little Rock, AR and 3 National Center for Toxicological Research, Jefferson, AR. #707 ORAL ADMINISTRATION OF EGCG IS NON- TOXIC AND MODULATES CYP19 AND CYP2E1 IN THE FEMALE BALB/C MOUSE. M. J. Scandlyn, M. G. Goodin and R. J. Rosengren. Pharmacology & Toxicology, University of Otago, Dunedin, New Zealand. #708 MAJOR DETERMINANTS IN SEX DIFFERENCE ON DAILY RHYTHM OF HEPATIC P450 MONOOXYGENASE ACTIVITIES IN RATS. J. Hirao 1 , S. Arakawa 1 , M. Nishimura 2 , N. Niino 1 , K. Ito 1 , N. Kiyosawa 1 , K. Muramatsu 1 and T. Furukawa 1 . 1 Medicinal Safety Research Laboratories, SANKYO CO., LTD., Fukuroi, Shizuoka, Japan and 2 Biomedical Research Laboratories, SANKYO CO., LTD., Shinagawa, Tokyo, Japan. Sponsor: N. Matsunuma. 104 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #709 INTERINDIVIDUAL VARIATION OF EXPRESSION LEVEL OF CYP3A4 AND ITS RELATED PHARMACOGENETIC GENES IN JAPANESE LIVER TISSUE. A. Miyajima-Tabata 1 , S. Ozawa 1 , J. He 1 , H. Tanaka 2 , K. Nakai 2 , M. Sunouchi 1 , Y. Kamikawa 3 , K. Kubota 4 , H. Ogata 2 and Y. Ohno 1 . 1 Division of Pharmacology, National Institute of Health Sciences, Setagaya, Tokyo, Japan, 2 Department of Biopharmaceutics, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan, 3 Department of Pharmacology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan and 4 Second Department of Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. Sponsor: M. Ema. #710 USE OF NOVEL MULTIPLEXED QPCR ASSAYS TO ACCURATELY QUANTIFY HUMAN CYTOCHROME P450 EXPRESSION. R. D. Larsen 1 , C. Chang 1 , M. Tan 1 , C. Patten 2 and S. Parikh 2 . 1 2 BD Biosciences Clontech, Palo Alto, CA and BD Biosciences Discovery Labware, Billerica, MA. Sponsor: D. Stresser. #711 USING P450-GLO LUMINESCENT ASSAYS TO SCREEN FOR XENOBIOTIC EFFECTS ON CYTOCHROMES P450. J. Cali 1 , D. Liu 1 , R. Bulliet 1 and D. Ma 1 . 1 Promega Corp, Madison, WI and 2 R&D, Promega Biosciences, Sac Louis Obispo, CA. #712 DIOXIN AND DIET EFFECTS ON GROWTH AND P450 INDUCTION. M. La Merrill 1 and D. W. Threadgill 2,1 . 1 Curriculum in Toxicology, UNC-CH, Chapel Hill, NC and 2 Genetics, UNC-CH, Chapel Hill, NC. #713 DIOXIN INDUCTION OF CYP1A1 EXPRESSION IS SUPPRESSED IN HEPATITIS C VIRUS REPLICATING CELLS. G. R. Anderson, A. Hasan, I. Qadri and L. C. Quattrochi. Medicine, University of Colorado Health Sciences Ctr, Denver, CO. #714 DIFFERENTIAL REGULATION OF LIVER MITOCHONDRIAL CYTOCHROME P4501A1 (P450MT2) BY 3-METHYLCHOLANTHRENE IN MICE DEFICIENT IN THE CYTOCHROME P4501A2 GENE. B. Moorthy, S. Kondraganti and W. Jiang. Pediatrics, Baylor College of Medicine, Houston, TX. #715 ENDOGENOUS SUBSTRATES OF CYP1B1 WHICH MAY BE ENDOGENOUS LIGANDS OF THE ARYL HYDROCARBON RECEPTOR. B. Stapleton 1 , A. Annalora 1 , C. Chiaro 5 , M. Doshi 3 , A. Bailey 1 , J. Omdahl 2 , B. Bejjani 4 , D. Edward 3 , G. Perdew 5 and C. Marcus 1 . 1 Toxicology, University New Mexico, Albuquerque, NM, 2 Biochemistry, University New Mexico, Albuquerque, NM, 3 Opthalmology & Visual Sciences., University IL, Chicago, IL, 4 Genetics & Pediatrics, WA. St. University, Spokane, WA and 5 Cell & Molecular Biology, Penn. St. University, University Park, PA. #716 THE RESPONSE OF THE RAT HEPATIC P450 SYSTEM TO FIVE ARCHETYPAL HUMAN MICROSOMAL ENZYME INHIBITORS. S. J. Schomaker, S. E. Boldt and D. E. Amacher. Safety Sciences Groton, Pfizer Inc., Groton, CT. #717 EFFECTS OF DIESEL EXHAUST PARTICLES ON CYTOCHROME P450 ACTIVITIES IN PRIMARY CULTURES OF ADULT RAT HEPATOCYTES: A USEFUL INDICATOR FOR THE STUDY OF HEALTH RISK. T. Jeon 1 , S. Hyun 1 , S. Lee 1 , C. Jin 1 , D. Lee 1 , G. Kim 1 , I. Jun 1 , K. Chung 2 , C. Moon 3 and T. Jeong 1 . 1 College of Pharmacy, Yeungnam University, Kyungsan, South Korea, 2 College of Pharmacy, Sungkyunkwan University, Suwon, South Korea and 3 College of Pharmacy, Seoul National University, Seoul, South Korea. #718 IN VITRO EVALUATION OF HISTAMINE AND ITS MAJOR METABOLITES AS INHIBITORS OR INDUCERS OF CYTOCHOME P450 EXPRESSION IN HUMAN LIVER. S. A. Tonetta 1 , F. Nodikum-Moffor 2 , B. L. Paris 2 and B. M. Richard 1 . 1 Nonclinical, Maxim Pharmaceuticals, San Diego, CA and 2 Metabolism, Xenotech LLC, Lenexa, KS. #719 COMPARATIVE STUDIES OF CYTOCHROME P4503A4 INDUCTION RESPONSE IN PRIMARY CULTURES OF CRYOPRESERVED AND FRESH HUMAN HEPATOCYTES. J. Johnson 1 , C. M. Chandler 1 , S. Kim 2 , L. Tarabelsi 1 , D. M. Stresser 1 , M. Sinz 2 and J. G. Zhang 1 . 1 BD Discovery Labware, woburn, MA and 2 Bristol Myers Squibb Co., Wallingford, CT. #720 REGULATIONS OF HUMAN CYP3A4 PROXIMAL AND XREM PROMOTER ACTIVITIES IN HEPA I AND HEPG2 CELLS. Y. Y. Sheen, K. N. Min, J. Y. An, K. E. Joung, Y. W. Kim and D. Kim. Pharmacy, Ewha Womans University, Seoul, seoul, South Korea. Sponsor: J. Chung. #721 ROLE OF NF-κB IN REGULATION OF PXR TRANSCRIPTIONAL ACTIVITY: A MECHANISM FOR THE SUPPRESSION OF CYTOCHROME P450 3A4 BY INFLAMMATORY AGENTS. X. Gu 1 , T. Sheng 2 , S. Ke 1 , P. E. Thomas 3 , M. A. Gallo 3 , W. Xie 4 and Y. Tian 1 . 1 Interdisciplinary Faculty of Toxicology, College Station, TX, 2 The University of Texas Medical Branch, Galveston, TX, 3 EOHSI, Rutgers University, Piscataway, NJ and 4 University of Pittsburgh, Pittsburgh, PA. #722 DOWN-REGULATION OF HEPATIC CYTOCHROME P450S IN ENDOTOXEMIC MICE IS INDEPENDENT OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA (PPARα). T. Richardson and E. T. Morgan. Pharmacology, Emory University, Atlanta, GA. #723 GENERATION AND CHARACTERIZATION OF A TRANSGENIC MOUSE MODEL WITH HEPATIC EXPRESSION OF HUMAN CYP2A6. J. Gu, Q. Zhang, T. Su, H. Cui, X. Zhuo, P. J. Swiatek, L. Zhang, W. Yang and X. Ding. Wadsworth Center, Albany, NY. TUESDAY up-to-date information at www.toxicology.org 105
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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