Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY Wednesday Morning, March 9 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: SAFETY EVALUATION-SPONTANEOUS DISEASE AND CONTROL PARAMETERS Chairperson(s): Carol Auletta, Huntingdon Life Sciences, East Millstone, NJ. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #1636 HISTOPATHOLOGICAL BACKGROUND FINDINGS IN THE COMMON MARMOSET (CALLITHRIX JACCHUS). S. Friderichs-Gromoll, J. Kaspareit and E. Buse. Covance Laboratories GmbH, 48163 Muenster, Germany. Sponsor: G. Weinbauer. #1637 HISTOPATHOLOGY DATABASE FOR CARCINOGENICITY STUDIES WITH SPRAGUE- DAWLEY RATS. A. Babb, V. Price, M. Milligan, K. Davis, R. D. Jones and J. Seng. Toxicology, Charles River Laboratories–DDS–Arkansas Division, Redfield, AR. #1638 A COMPARISON OF PATHOLOGICAL CHANGE AND SURVIVAL IN DIFFERENT RODENT STRAINS OVER A TWO-YEAR STUDY DURATION. J. Noakes, R. W. Lewis and J. A. Wright. Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, United Kingdom. Sponsor: R. Dearman. #1639 IN-LIFE PARAMETERS AND TUMOUR DATA FROM CHARLES RIVER CRL:CD-1 ® (ICR) BR MOUSE DIETARY AND ORAL GAVAGE TUMORIGENICITY STUDIES TERMINATED AFTER TWO YEARS. W. Hooks 1 , C. J. Groom 1 and J. K. Stewart 2 . 1 Toxicology, Huntingdon Life Sciences, Huntingdon, Cambridgeshire, United Kingdom and 2 Pathology, Huntingdon Life Sciences, Huntingdon, Cambridgeshire, United Kingdom. Sponsor: C. Hardy. #1640 SPONTANEOUS LESIONS IN CRJ:CD-1(ICR)- NU/NU MICE BY 106 WEEKS OF AGE DURING THE OBSERVATION PERIOD. T. Nakamura 1 , T. Shibanushi 1 , T. Satoshi 1 , K. Kuzutani 1 and M. Takahashi 2 . 1 Safety Research Department, Kaken Pharmaceutical Co., Ltd., Sizuoka, Japan and 2 Pathology Peer Review Center, Tokyo, Japan. #1641 THROMBOCYTOPENIC PURPURA IN GOTTINGEN MINIPIGS. C. Auletta, H. F. Bolte, S. J. Gosselin and C. Willard-Mack. Huntingdon Life Sciences, East Millstone, NJ. #1642 CLINICAL PATHOLOGY DATABASE FOR NON- CLINICAL GLP STUDIES WITH LANDRACE - CROSS SWINE. T. Gartner, P. Powell, V. Price, J. Seng, R. D. Jones and K. Davis. Toxicology, Charles River Laboratories–DDS–Arkansas Division, Redfield, AR. Abstract 1643 is located on page 175. Wednesday Morning, March 9 11:00 AM to 12:00 NOON Room 215 INFORMATIONAL SESSION: BIOLUMINESCENT METHODS FOR ADME/TOX — PRESENTED BY PROMEGA CORP. Bioluminescence offers significant advantages for configuring sensitive, simple to perform, high through-put assays with ADME/Tox applications. Bioluminescent systems will be described that measure the cytotoxicity of test compounds, their capacity to induce apoptosis, their impact on various CYP450 activities and on the multi-drug transporter (MDR1/Pgp). Wednesday Morning, March 9 11:00 AM to 12:00 NOON Room 223 INFORMATIONAL SESSION: INTRODUCTION TO REAL-TIME PCR — PRESENTED BY APPLIED BIOSYSTEMS An introduction to the fundamentals of real-time PCR technology and applications. This session will include; an overview of absolute and relative quantization methods, chemistry & instrument options, and assay design considerations. Wednesday Afternoon Wednesday Afternoon, March 9 12:00 NOON to 1:00 PM Room RO1 SPECIAL WORKSHOPS: A CONVERSATION WITH THE DIRECTORS The Meet the Directors session is a one-hour special session that will be formatted like a panel discussion with the leaders of several major federal agencies. The objective of this session is to provide meeting attendees a better understanding of the toxicology research activities of the FDA, EPA, NIEHS and NTP. Emphasis will be on change of direction or new initiatives that may impact the practice of toxicology in the future. Speakers will also identify opportunities for non-agency toxicologists to participate in the initiatives of the agency. • New Direction for Intramural and Extramural Research, Dr. Ken Olden, NIEHS. • Changed Emphasis of NTP Based on the Recent Vision and Road Map, Dr. Chris Portier, NTP. • Current and Future Impact on the FDA Regulatory Actions Based on NCTR Research, Dr. Dan Casciano, NCTR. • Current and Future Impact of EPA Regulatory Actions Based on EPA Research, Dr. Bill Farland, U.S. EPA. 174 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Wednesday Afternoon, March 9 12:00 NOON to 1:00 PM Room 208 ISSUES SESSION: REORGANIZATION OF THE NIH GRANT REVIEW PROCESS AND ITS POTENTIAL IMPACT ON TOXICOLOGY RESEARCH AND TRAINING Chairperson(s): David Eaton, University of Washington, Seattle, WA. Panelists: Anne Sassaman, Director of Extramural Programs, NIEHS; Richard Okita, Administrator, Pharmacological and Physiological Sciences Branch, NIGMS; Mary Vore, Chair, XNDA Study Section; Alvaro Puga, Member, XNDA Study Section (Former Chair of AL-TOX1); Elliot Postow, Center for Scientific Review; and Patricia Greenwel, Center for Scientific Review. Wednesday Afternoon, March 9 12:15 PM to 1:15 PM Room 215 INFORMATIONAL SESSION: ADVANCES IN REAL-TIME PCR — PRESENTED BY APPLIED BIO SYSTEMS An overview of recent advances including; Validated TaqMan® Gene Expression and SNP Assays for quantization and genotyping of the Cytochromes P450 and other drug metabolizing enzymes, FAST thermal cycling options, and TaqMan® Assays for microRNA quantization. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Room RO2 With the reorganization of the NIH Study Sections, significant changes have occurred in the way that toxicology-related grants are assigned to study sections and reviewed. This session will explore the advantages and disadvantages of the reorganization to our discipline, and the implications for toxicology research and training of the next generation of environmental health scientists. Wednesday Afternoon, March 9 12:00 NOON to 1:00 PM Room RO8 ROUNDTABLE SESSION: CONDUCTING A COMPREHENSIVE TOXICOLOGICAL AND SAFETY EVALUATION OF NANOMATERIALS: CURRENT CHALLENGES AND DATA NEEDS Chairperson(s): William H. Farland, U.S. EPA, Washington, DC. #1695 12:00 CONDUCTING A COMPREHENSIVE TOXICOLOGICAL AND SAFETY EVALUATION OF NANOMATERIALS: CURRENT CHALLENGES AND DATA NEEDS. M. P. Holsapple 1 and W. H. Farland 2 . 1 HESI, Washington, DC and 2 U.S. EPA, Washington, DC. #1696 12:05 INHALATION AS A CRITICAL EXPOSURE ROUTE FOR EVALUATING NANOMATERIALS. T. D. Landry. Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI. #1697 12:10 DERMAL EXPOSURE ROUTE FOR EVALUATING NANOMATERIALS. N. A. Monteiro- Riviere. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #1698 12:15 THE VALUE OF EXISTING TESTING STRATEGIES FOR EVALUATING NANOMATERIALS. J. M. Carter. Central Product Safety, Procter & Gamble, Cincinnati, OH. #1699 12:20 MODE OF ACTION CONSIDERATIONS IN THE EVALUATION OF SAFETY OF ENGINEERED NANOSCALE MATERIALS. N. J. Walker. NIEHS, Research Triangle Park, NC. Abstract 1700 is located on page 179. SYMPOSIUM SESSION: DEVELOPMENTAL TOXICOLOGY OF THE LUNG Chairperson(s): John M. Rogers, U.S. EPA, Research Triangle Park, NC and Charles G. Plopper, University of California, Davis, Davis, CA. Endorsed by: Reproductive and Development SS Student Advisory Committee Respiratory problems account for a large proportion of hospital admissions to pediatric wards, and the incidence of childhood asthma is increasing for unknown reasons. A number of toxicants have been demonstrated to adversely affect lung development in humans and/or laboratory animals. Lung development begins early in gestation and continues well after birth. The molecular control of normal lung development has been intensely studied and is becoming well elucidated, involving multiple complex signaling networks. In contrast, mechanisms of toxicity to the developing lung are poorly understood. This symposium will present an overview of normal lung development and examples in humans and laboratory animal species of chemicals and conditions that adversely affect lung development. Effects of tobacco smoke and constituents have been well-studied and will be highlighted. Possible modes of action for developmental toxicity to the lung will be presented and research needs will be discussed. #1643 1:30 DEVELOPMENTAL TOXICOLOGY OF THE LUNG. J. M. Rogers. Developmental Biology Branch, U.S. EPA, Research Triangle Park, NC. #1644 1:40 GENETIC PATHWAYS CONTROLLING LUNG MORPHOGENESIS. W. Cardoso. Pulmonary Biology, Cincinnati Children’s Hospital, Cincinnati, OH. Sponsor: J. Rogers. #1645 2:10 EFFECTS OF ENVIRONMENTAL TOBACCO SMOKE (ETS) ON THE DEVELOPING LUNG. K. E. Pinkerton, J. L. Peake and J. P. Joad. Center for Health and the Environment, University of California, Davis, CA. #1646 2:40 EFFECT OF MATERNAL NICOTINE EXPOSURE DURING DIFFERENT PHASES OF LUNG DEVELOPMENT ON LUNG GROWTH IN THE OFFSPRING: PROTECTICE EFFECT OF COPPER. G. S. Maritz. Medical Biosciences, University of the Western Cape, Bellville, Western Province, South Africa. Sponsor: J. Rogers. #1647 3:10 PRENATAL PERFLUOROOCTANE SULFONATE EXPOSURE AFFECTS PERINATAL LUNG DEVELOPMENT AND CAUSES RESPIRATORY DISTRESS IN RATS. R. C. Grasty. Toxicology, UNC Chapel Hill, Research Triangle Park, NC. WEDNESDAY up-to-date information at www.toxicology.org 175
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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