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44 th Annual Meeting and ToxExpo Program Description MONDAY #579 PREDICTION OF TRANSCRIPTION FACTORS COMMONLY AFFECTED BY GLUTAMATE- CYSTEINE LIGASE EXPRESSION IN MICE EXPOSED TO ACETAMINOPHEN, CARBON TETRACHLORIDE OR TUMOR NECROSIS FACTOR. S. Shi, D. Botta, T. Bammler, R. P. Beyer and T. J. Kavanagh. Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: RECEPTOR: PPAR Chairperson(s): Andrew Burdick, Penn State University, University Park, PA. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #580 MOLECULAR MECHANISMS OF PPARA- MEDIATED GENE EXPRESSION OF PXR. S. aouabdi, G. Gibson and N. Plant. school of biological and molecular sciences, university of surrey, guildford, surrey, United Kingdom. #581 DECREASED LONGEVITY AND ENHANCEMENT OF AGE-DEPENDENT LESIONS IN MICE LACKING THE NUCLEAR RECEPTOR PEROXISOME PROLIFERATOR- ACTIVATED RECEPTOR ALPHA. P. Howroyd 1,2 , C. Swanson 1 , C. Dunn 1 , R. C. Cattley 1,3 and J. C. Corton 4,1 . 1 CIIT, Research Triangle Park, NC, 2 EPL, Research Triangle Park, NC, 3 Amgen, Thousand Oaks, CA and 4 ToxicoGenomics, Chapel Hill, NC. #582 CONSTITUTIVE EXPRESSION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA-REGULATED GENES IN DWARF MICE. A. J. Stauber 2 , J. Liu 4 , M. P. Waalkes 4 , H. Brown-Borg 3 , K. A. Voss 5 , J. J. Kopchick 6 and J. C. Corton 1,2 . 1 ToxicoGenomics, Chapel Hill, NC, 2 CIIT Centers for Health Research, Research Triangle Park, NC, 3 University of North Dakota, Grand Forks, ND, 4 NCI at NIEHS, Research Triangle Park, NC, 5 USDA, Athens, GA and 6 Ohio University, Athens, OH. #583 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR β (PPARβ) REGULATES EXPRESSION OF CANCER-RELATED GENES IN LIVER. W. Shan 1,2 and J. M. Peters 1 . 1 Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA and 2 The Intercollege Graduate Degree Program in Genetics, The Pennsylvania State University, University Park, PA. #584 GENE EXPRESSION PATTERNS ASSOCIATED WITH FENOFIBRATE INDUCED MYOPATHY. N. R. Bordelon, B. H. Romach, R. Brown and R. T. Miller. SA, GSK, Research Triangle Park, NC. #585 EVALUATION OF THE ACTIVITY OF THE PESTICIDE CYHALOFOP-BUTYL IN A PEROXISOME-PROLIFERATOR RECEPTOR-α REPORTER ASSAY. G. D. Charles 1 , L. Kan 1 , T. R. Hanley 2 and B. B. Gollapudi 1 . 1 The Dow Chemical Company, Midland, MI and 2 Dow AgroSciences LLC, Indianapolis, IN. #586 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR β (PPARβ) SELECTIVELY REGULATES KERATINOCYTE DIFFERENTIATION AND PROLIFERATION. D. J. Kim 1,2 , A. N. Billin 3 , T. M. Willson 3 and J. M. Peters 1,2 . 1 Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 2 Graduate Program in Molecular Toxicology, The Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA and 3 Discovery Research, GlaxoSmithKline, Research Triangle Park, NC. #587 THE PEROXISOME PROLIFERATOR- ACTIVATED RECEPTOR β (PPARβ) AGONIST GW0742 INHIBITS SKIN CARCINOGENESIS. M. K. Devlin 1,2 , D. J. Kim 1 , A. N. Billin 3 , T. M. Willson 3 and J. M. Peters 1,2 . 1 Department of Veterinary Sciences and The Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA, 2 Graduate Program in Molecular Medicine, Huck Institute for Life Sciences, Pennsylvania State University, University Park, PA and 3 Discovery Research, GlaxoSmithKline, Research Triangle Park, NC. #588 TRANSCRIPTIONAL REGULATION OF TISSUE-SPECIFIC INHIBITOR OF MATRIX METALLOPROTEINASE 1 (TIMP1) BY PEROXISOME PROLIFERATOR-ACTIVATOR RECEPTOR β (PPARβ). M. T. Bility 1,2 , D. J. Kim 1,2 , A. N. Billin 3 , T. M. Willson 3 and J. M. Peters 1,2 . 1 Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 2 Graduate Program in Molecular Toxicology, The Huck Institutes for Life Sciences, The Pennsylvania State University, University Park, PA and 3 Discovery Research, GlaxoSmithKline, Research Triangle Park, NC. #589 TRANSCRIPTION PROFILING REVEALS HEPATIC HYPERTROPHY TO BE INDISTINGUISHABLE FROM THE PHARMACOLOGY OF PPARα AGONISM IN THE RAT. A. T. De Souza 1 , P. D. Cornwell 1 , X. Dai 2 , M. J. Caguyong 3 and R. G. Ulrich 1 . 1 Preclinical Molecular Profiling, Rosetta Inpharmatics, a wholly owned subsiduary of Merck & Co. Inc., Seattle, WA, 2 Informatics, Rosetta Inpharmatics, a wholly owned subsiduary of Merck & Co. Inc., Seattle, WA and 3 Project Management, Rosetta Inpharmatics, a wholly owned subsiduary of Merck & Co. Inc., Seattle, WA. 90 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: NEUROTOXICITY OF METALS: DOSIMETRY AND EFFECTS Chairperson(s): Donald Smith, University of California Santa Cruz, Santa Cruz, CA and Vanessa Fitsanakis, Vanderbilt University Medical Center, Nashville, TN. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #590 DISTRIBUTION OF COPPER (CU) AND ZINC (ZN) TRANSPORTER IN RAT CHOROID PLEXUS, BRAIN REGIONAL CAPILLARIES, AND CHOROIDAL Z310 CELLS BY REAL TIME RT-PCR. M. Chigurupati, G. Li, B. Choi, S. X. Wang and W. Zheng. School of Health Sciences, Purdue University, West Lafayette, IN. #591 COPPER (CU) TRANSPORT AND TRANSPORTERS IN THE BLOOD-BRAIN BARRIER (BBB) AND BLOOD-CSF BARRIER (BCB). B. Choi, J. S. Crossgrove, M. Chigurupati and W. Zheng. School of Health Sciences, Purdue University, West Lafayette, IN. #592 THE EFFECTS OF COPPER DIMETHYLDITHIOCARBAMATE (CDDC) ON RAT HIPPOCAMPAL ASTROCYTES. L. Passaint and L. D. Trombetta. Pharmaceutical Sciences, St. Johns Universtty, Jamaica, NY. #593 MANGANESE EXPOSURE ALTERS IRON REGULATORY MECHANISMS AT BLOOD- CEREBROSPINAL FLUID BARRIER (BCB) AND SELECTED REGIONS OF BLOOD-BRAIN BARRIER (BBB) IN RATS. G. Li 1 , J. Liu 2 , M. P. Waalkes 2 and W. Zheng 1 . 1 School of Health Sciences, Purdue University, West Lafayette, IN and 2 Inorganic Carcinogenesis Section, NCI at NIEHS, Research Triangle Park, NC. #594 OVEREXPRESSION OF DMT1 IN THE CHOROID PLEXUS FOLLOWING MANGANESE (MN) EXPOSURE. X. Wang, J. G. Li and W. Zheng. Health Sciences, Purdue University, West Lafayette, IN. Sponsor: W. Zheng. #595 IRON DEFICIENT AND MANGANESE ENHANCED DIETS ALTER METALS AND TRANSPORTERS IN THE DEVELOPING RAT BRAIN. S. J. Garcia 1 , T. Syversen 2 , K. Gellein 3 and M. Aschner 4 . 1 Physiology/ Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC, 2 Neuroscience, Norwegian University of Science & Technology, Trondheim, Norway, 3 Chemistry, Norwegian University of Science & Technology, Trondheim, Norway and 4 Pediatrics, Vanderbilt University Medical Center, Nashville, NC. #596 INFLUENCE OF SUBACUTE MANGANESE SULFATE ON DOPAMINE AND N-METHYL-D- ASPARTATE RECEPTORS. H. Komiskey. Xavier University of Louisiana, New Orleans, LA. #597 BIOLOGICAL MARKERS OF MN EXPOSURE: RELATIONSHIPS BETWEEN MN DOSE, PARTITIONING IN BLOOD, AND ACCUMULATION IN BRAIN. C. Kern 1 , L. Cadena 1 , R. Gwiazda 1 , R. Lucchini 2 and D. R. Smith 1 . 1 Environmental Toxicology, University of California, Santa Cruz, CA and 2 Institute of Occupational Health, University of Brescia, Brescia, Italy. #598 PROGRESSION OF NEUROCHEMICAL EFFECTS IN DIFFERENT BRAIN REGIONS AS A FUNCTION OF THE MAGNITUDE AND DURATION OF MANGANESE EXPOSURE. R. Gwiazda, C. Kern and D. Smith. Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA. #599 DETERMINATION OF DEPLETED URANIUM (DU) IN RATS FOLLOWING 6-MONTH EXPOSURE TO SURGICALLY IMPLANTED DU PELLETS. V. A. Fitsanakis 1 , K. M. Erikson 2 , S. J. Garcia 3 , T. L. Syversen 4 and M. Aschner 1 . 1 Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 2 3 Nutrition, UNC-G, Greensboro, NC, Physiology & Pharmacology, Wake Forest University Medical School, Winston-Salem, NC and 4 Neuroscience, Norwegian University of Science & Technology, Trondheim, Norway. #600 NEUROLOGICAL EFFECTS OF ACUTE URANIUM EXPOSURE. D. Barber 1 , S. Hancock, 2 , A. McNally 1 , J. Hinckley 2 , E. Binder 2 , M. Ehrich 2 and B. Jortner 2 . 1 Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL and 2 Laboratory for Neurotoxicity Studies, VPI&SU, Blacksburg, VA. #601 DIFFERENTIAL EFFECT OF LEAD (PB) EXPOSURE ON THE N-METHYL-D-ASPARTATE (NMDA) INDUCED INWARD CURRENT IN DOPAMINE (DA)-CONTAINING NEURONS AND HIPPOCAMPAL CA1 NEURONS. D. K. Pitts and M. W. Lewis. Pharmaceutical Sciences, Wayne State University, Detroit, MI. #602 ORAL EXPOSURE TO INORGANIC LEAD (PB) IN RATS: BLOOD CONCENTRATIONS, BRAIN CONCENTRATIONS AND EFFECTS ON ACOUSTIC STARTLE. R. Commissaris, A. Davis and D. K. Pitts. Pharmaceutical Sciences, Wayne State University, Detroit, MI. #603 LIPID PEROXIDATION AND DISTRIBUTION OF INORGANIC ARSENIC AND ITS METABOLITES IN RAT NERVOUS SYSTEM. E. Garcia-Chavez 1 , I. Jimenez 2 , B. Segura 3 , L. C. Sanchez-Pena 1 , J. C. Guadarrama 2 and L. M. Del Razo 1 . 1 Toxicology, Cinvestav-IPN, Mexico D.F., Mexico, 2 Physiol. Biophys. & Neurosci., Cinvestav-IPN, Mexico D.F., Mexico and 3 FES-Iztacala, UNAM, Mexico D.F., Mexico. MONDAY up-to-date information at www.toxicology.org 91
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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Program - Society of Toxicology

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