Program - Society of Toxicology
Program - Society of Toxicology
Program - Society of Toxicology
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1373 10:50 IDENTIFYING CANDIDATES FOR THE CDM<br />
GENE, WHICH CONFERS RESISTANCE TO<br />
CADMIUM-INDUCED TESTICULAR DAMAGE<br />
IN MICE. L. Martin 1 , H. Allayee 2 , D. Shih 3 , G. Lee 1 ,<br />
D. Hovland 4 , R. Hess 5 , K. Carnes 5 , R. M. Cantor 3,6 , A.<br />
J. Lusis 3 and M. Collins 1 . 1 Molecular <strong>Toxicology</strong>,<br />
UCLA, LA, CA, 2 Institute for Genetic Medicine, USC,<br />
LA, CA, 3 Human Genetics, UCLA, LA, CA,<br />
4 5 <strong>Toxicology</strong>, Amgen, Thousand Oaks, CA, Veterinary<br />
Biosciences, University <strong>of</strong> Illinois, Urbana, IL and<br />
6 Pediatrics, UCLA, LA, CA. Sponsor: O. Hankinson.<br />
#1374 11:10 PERIPUBERTAL DEHP EXPOSURE INHIBITS<br />
ANDROGEN-DEPENDENT DEVELOPMENT IN<br />
SPRAGUE-DAWLEY RATS. N. Noriega, J. Furr, C.<br />
Lambright, V. S. Wilson and L. E. Gray. RTD, U.S. EPA<br />
ORD NHEERL, Research Triangle Park, NC.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room RO6<br />
2 GeneGo, Inc., St. Joseph, MI.<br />
#1379<br />
#1380<br />
#1381<br />
#1382<br />
#1383<br />
9:50<br />
10:10<br />
10:30<br />
10:50<br />
11:10<br />
PREDICTION OF HEPATOCARCINOGENICITY<br />
OF CHEMICALS USING THE GENE<br />
EXPRESSION IN THE 28-DAY REPEAT-DOSE<br />
TOXICITY STUDY. H. Matsumoto 1 , F. Saito 1 , Y.<br />
Yoshikuni 1 , Y. Sudo 1 , M. Otsuka 1 , H. Miyaura 1 , I.<br />
Fukuda 5 , K. Saito 2 , K. Sumida 2 , M. Sekijima 3 , K.<br />
Nakayama 3 and T. Shirai 4 . 1 Chemicals Evaluation and<br />
Research Institute, Japan, Tokyo, Japan, 2 Sumitomo<br />
Chemical Co., Ltd.,, Osaka, Japan, 3 Mitsubishi<br />
Chemical Safety Institute Ltd.,, Ibaraki, Japan,<br />
4 Graduate School <strong>of</strong> Medical Sciences, Nagoya City<br />
University, Nagoya, Japan and 5 Mitsui Knowledge<br />
Industry Co., Ltd.,, Tokyo, Japan.<br />
TOXICOGENOMICS FOCUSING ON THE<br />
HEMOPOIETIC STEM CELL TOXICOLOGY. Y.<br />
Hirabayashi 1 , B. Yoon 1 , K. Kitada 2 , T. Matsushita 1,3 , K.<br />
Kobayashi 2 , K. Igarashi 1 , Y. Kodama 1 , J. Kanno 1 and T.<br />
Inoue 4 . 1 Division <strong>of</strong> Cellular & Molecular <strong>Toxicology</strong>,<br />
National Institute <strong>of</strong> Health Sciences, Tokyo, Japan,<br />
2 Kamakura Research Labs, Chugai Pharmaceutical, Co.,<br />
Ltd.,, Kamakura, Japan, 3 Fuji Gotenba Research Labs,<br />
Chugai Pharmaceutical, Co., Ltd.,, Shizuoka, Japan and<br />
4 Center for Biological Safety & Research, National<br />
Institute <strong>of</strong> Health Sciences, Tokyo, Japan.<br />
QC METRICS AND THRESHOLDS FOR<br />
ASSESSING THE OVERALL QUALITY OF A<br />
MICROARRAY STUDY. L. Shi 1 , W. Tong 1 , F.<br />
Goodsaid 2 , F. Frueh 2 , F. C. Fuscoe 1 and D. A.<br />
Casciano 3 . 1 Division <strong>of</strong> Systems <strong>Toxicology</strong>, NCTR,<br />
U.S. FDA, Jefferson, AR, 2 Office <strong>of</strong> Clinical<br />
Pharmacology and Biopharmaceutics, CDER, U.S.<br />
FDA, Rockville, MD and 3 Office <strong>of</strong> the Director,<br />
NCTR, U.S. FDA, Jefferson, AR.<br />
PROTOCOLS FOR THE ASSURANCE OF<br />
MICROARRAY DATA QUALITY AND PROCESS<br />
CONTROL. L. D. Burgoon 1,5,6 , J. E. Eckel-Passow 3 ,<br />
C. Gennings 4 , D. R. Boverh<strong>of</strong> 2,5,6 , J. W. Burt 2,5,6 , C. J.<br />
Fong 2,5,6 and T. R. Zacharewski 2,5,6 . 1 Pharmacology &<br />
<strong>Toxicology</strong>, Michigan State University, East Lansing,<br />
MI, 2 Biochemistry & Molecular Biology, Michigan<br />
State University, East Lansing, MI, 3 Health Sciences<br />
Research, Mayo Clinic Cancer Center, Rochester, MN,<br />
4 Biostatistics, Virginia Commonwealth University,<br />
Richmond, VA, 5 National Food Safety and <strong>Toxicology</strong><br />
Center, Michigan State University, East Lansing, MI<br />
and 6 Center for Integrative <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI.<br />
DBZACH: A COMPREHENSIVE<br />
TOXICOGENOMIC INFORMATION<br />
MANAGEMENT AND KNOWLEDGE<br />
DISCOVERY SYSTEM. R. Aiyar 2,3,4 , L. D.<br />
Burgoon 1,3,4 , P. C. Boutros 2,3,4 , E. Dere 2,3,4 , S.<br />
Doran 2,3,4 , S. S. Pai 2,3,4 , J. Vakharia 2,3,4 , R. Rotman 2,3,4 ,<br />
A. Adams 2,3,4 , B. Lau 2,3,4 , R. Patel 2,3,4 and T. R.<br />
Zacharewski 2,3,4 . 1 Pharmacology & <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI,<br />
2 Biochemistry & Molecular Biology, Michigan State<br />
University, East Lansing, MI, 3 National Food Safety &<br />
<strong>Toxicology</strong> Center, Michigan State University, East<br />
Lansing, MI and 4 Center for Integrative <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI.<br />
PLATFORM SESSION: TOXICOGENOMICS: ROLE IN<br />
PREDICTIVE TOXICOLOGY AND CARCINOGENICITY<br />
Chairperson(s): Alema Galijativic, Merck &Co., Inc., West Point, PA and<br />
Supratim Choudhary, U.S. FDA, College Park, MD.<br />
#1375 8:30 GENE ONTOLOGY MAPPING OF EARLY<br />
TRANSCRIPTIONAL RESPONSES ASSOCIATED<br />
WITH HEPATOCYTE PROLIFERATION IN THE<br />
LIVER OF DIETHYLHEXYLPHTHALATE-<br />
EXPOSED MICE. R. Currie 1 , V. Bombail 1 , D. J.<br />
Moore 1 , F. Lim 1 , J. Oliver 1 , K. Chipman 2 , I. Kimber 1 ,<br />
G. Orphanides 1 and J. Moggs 1 . 1 Syngenta CTL,<br />
Macclesfield, Cheshire, United Kingdom and<br />
2 University <strong>of</strong> Birmingham, Birmingham, United<br />
Kingdom.<br />
#1376 8:50 COMPARATIVE ANALYSIS OF GENE<br />
NETWORKS AT MULTIPLE DOSES AND TIME<br />
POINTS IN LIVERS OF RATS EXPOSED TO<br />
ACETAMINOPHEN. H. Sone 1,2 , H. Toyoshiba 1,2 , T.<br />
Yamanaka 1 , F. Parham 1 , R. Irwin 1 , G. Boorman 1 and C.<br />
J. Portier 1 . 1 ETP, NIEHS, Research Triangle Park, NC<br />
and 2 Environmental Health Sciences Division, NIES,<br />
Tsukuba, Ibaraki, Japan.<br />
#1377 9:10 A SIGNATURE GENE NETWORK APPROACH<br />
TO TOXICITY. S. Ekins 1 , C. Giroux 2 , Y. Nikolsky 1 ,<br />
A. Bugrim 1 and T. Nikoskaya 1 . 1 GeneGo Inc., St<br />
Joseph, MI and 2 Institute <strong>of</strong> Environmental Health<br />
Sciences, Wayne State University, Detroit, MI.<br />
#1378 9:30 A GENETIC NETWORK APPROACH TO<br />
COMPARATIVE TOXICOGENOMICS AND RISK<br />
ASSESSMENT: THE OXIDATIVE STRESS<br />
RESPONSE. C. N. Giroux 1 , S. Ekins 2 , J. Fan 1 , I.<br />
Abdullah 1 , Y. Nikolsky 2 , A. Bugrim 2 and T.<br />
Nikolskaya 2 . 1 Institute <strong>of</strong> Environmental Health<br />
Sciences, Wayne State University, Detroit, MI and<br />
156<br />
SOT’s 44 th Annual Meeting