Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1545 SUBCHRONIC EXPOSURE TO LOW LEVELS OF POLYCHLORINATED BIPHENYLS REDUCES DOPAMINE TRANSPORTER AND VESICULAR MONOAMINE TRANSPORTER 2 LEVELS. M. Caudle, J. R. Richardson and G. W. Miller. Center for Neurodegenerative Disease, Emory University, Atlanta, GA. #1546 ACRYLAMIDE DISRUPTS UPTAKE OF DOPAMINE INTO RAT STRIATAL SYNAPTIC VESICLES. R. M. LoPachin 1 and D. S. Barber 2 . 1 Anesthesiology, Albert Einstein College of Medicine, Bronx, NY and 2 Center for Environmental Health and Toxicology, University of Florida, Gainesville, FL. #1547 INHIBITION OF HUMAN α7 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS BY THE VOLATILE ORGANIC SOLVENT TRICHLOROETHYLENE. C. A. Meacham, A. S. Bale, P. J. Bushnell and T. J. Shafer. Neurotoxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #1548 XYLENE BLOCKS VOLTAGE-GATED CALCIUM CURRENTS IN PHEOCHROMOCYTOMA CELLS. T. J. Shafer. Neurotoxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #1549 NEUROTOXIC (1, 2, 4-) AND NON-NEUROTOXIC (1, 3, 5-) TRIETHYLBENZENES. V. S. Palmer, D. D. Tshala-Katumbay, R. J. Kayton, P. S. Spencer and M. I. Sabri. Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, OR. #1550 RAPID-ONSET GAMMA-DIKETONE AXONOPATHY IN HIPPOCAMPAL NEURONS IN CULTURE. D. D. Tshala-Katumbay, B. Sampo, V. S. Palmer, G. A. Banker, M. I. Sabri and P. S. Spencer. Center for Research on Occupational and Environmental Toxicology, and Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR. #1551 GAMMA-DIKETONE TOXICITY: A ROLE FOR STATHMIN IN NERVE AND TESTES DAMAGE? M. I. Sabri 1 , S. B. Hashemi 1 , S. Chohan 1 , S. Khalil 1 , A. B. Cranson 1 , D. D. Tshala-Katumbay 1 , V. S. Palmer 1 , J. G. Pounds 2 and P. S. Spencer 1 . 1 Center for Research on Occupational and Environmental Toxicology; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR and 2 Molecular Biosciences, Pacific Northwest National Laboratory, Richland, WA. #1552 EFFECTS OF SUBACUTE AND CHRONIC ACRYLAMIDE DOSING ON FAST- TRANSPORTED PROTEINS INTO RAT NEUROMUSCULAR JUNCTIONS. D. W. Sickles and A. Testino. Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA. #1553 REDUCTIONS IN NEUROMUSCULAR JUNCTION CHOLINESTERASE ACTIVITY BY SUBACUTE AND CHRONIC ACRYLAMIDE EXPOSURE. B. Newman, L. Oblak, D. Kumiski and D. Sickles. Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA. Wednesday Morning, March 9 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 II Chairperson(s): Rao Uppu, Southern University and A&M College, Baton Rouge, LA. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #1554 HUMAN FLAVIN-CONTAINING MONOOXYGENASE: QUANTIFICATION IN HUMAN TISSUES. J. R. Cashman and J. Zhang. Human BioMolecular Research Institute, San Diego, CA. Sponsor: D. Schlenk. #1555 OXIDATION OF SELENOMETHIONINE BY FLAVIN-CONTAINING MONOOXYGENASES (FMOS). D. Shi and D. Schlenk. Department of Environmental Sciences, University of California, Riverside, CA. #1556 COMPARISON OF MAJOR PHASE I AND PHASE II METABOLISM REACTIONS IN CRYOPRESERVED CYNO MONKEY AND HUMAN HEPATOCYTES. B. R. Snodgrass 1 , P. V. Gagne 1 , P. L. Picano 1 , K. J. Lohnes 1 , S. P. Cain 2 , G. G. Zhang 1 , C. J. Patten 1 and C. L. Crespi 1 . 1 Research & Development, BD Discovery Labware, Woburn, MA and 2 Operations, BD Discovery Labware, Woburn, MA. #1557 COMPARISON OF CELLULAR MODELS FOR ASSESSING LIVER TOXICITY. R. Maitra, K. Moore, S. Frank and A. Higgins. Icoria, Inc., Research Triangle Park, NC. Sponsor: J. Hamilton. #1558 PANCREATIC AND HEPATIC ETHANOL TOXICITY IN HEPATIC ALCOHOL DEHYDROGENASE DEFICIENT DEER MICE: MORPHOLOGICAL AND BIOCHEMICAL CHARACTERIZATION. K. Bhopale 1 , H. Wu 1 , P. Boor 1 , G. A. Ansari 1 and B. S. Kaphalia 1 . 1 Pathology, University of Texas Medical Branch, Galveston, TX, 2 Pathology, University of Texas Medical Branch, Galveston, TX, 3 Pathology, University of Texas Medical Branch, Galveston, TX, 4 Pathology, University of Texas Medical Branch, Galveston, TX and 5 Pathology, University of Texas Medical Branch, Galveston, TX. #1559 VARIABILITY IN METABOLISM OF CHLORAL HYDRATE IN HUMAN HEPATOCYTES. A. Bronley-DeLancey 2 , D. G. Hoel 2 and D. C. McMillan 1 . 1 Department of Pharmacology, Medical University of South Carolina, Charleston, SC and 2 Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC. #1560 TOXICOKINETIC ASPECTS OF HEPATOTOXIC INTERACTIONS BETWEEN BENZENE AND TCE. A. Freidig 1 , H. Wortelboer 1 , W. Heijne 1 , R. Stierum 1 , M. Schut 1 , D. Jonker 1 , H. El-Masri 2 , D. Moffett 2 and J. Groten 1 . 1 TNO Voeding, Zeist, Netherlands and 2 ATSDR, Atlanta, GA. 168 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1561 IN VITRO AND IN VIVO KINETICS OF MIDAZOLAM IN COMMERCIALLY RAISED GAMEBIRDS. K. Cortright and A. Craigmill. Environmental Toxicology, UC Davis, Davis, CA. #1562 HEPATIC MICROSOMAL METABOLISN OF LITHOCHOLIC ACID. A. K. Deo and S. M. Bandiera. Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. #1563 IN VITRO METABOLISM OF 4-VINYLPHENOL AND STYRENE IN MOUSE, RAT AND HUMAN MICROSOMES. M. Bartels 1 , D. Rick 1 , F. Zhang 1 , E. Leibold 2 , H. Gelbke 2 and G. Cruzan 3 . 1 Toxicology, Dow Chemical, Midland, MI, 2 BASF, Aktiengesellschaft, Ludwigshafen/Rhein, Germany and 3 ToxWorks, Bridgeton, NJ. #1564 COVALENT MODIFICATION OF AMINO ACID NUCLEOPHILES BY STYRENE OXIDE. W. Yuan, J. Chung and J. Zheng. Pharmaceutical Sciences, Northeastern University, Boston, MA. #1565 NITROREDUCTION OF TATTOO PIGMENT YELLOW 74 BY XANTHINE OXIDASE: FORMATION OF A DNA ADDUCT AND MUTAGENICITY OF THE NITROSO REDUCTION PRODUCT. P. C. Howard 1 , Y. Cui 1 , L. H. Couch 1 , M. I. Churchwell 1 , D. R. Doerge 1 , P. P. Fu 1 , J. Wang 2 , T. Chen 2 , N. Mei 2 and M. M. Moore 2 . 1 Division Biochemical Toxicology, NCTR, U.S. FDA, Jefferson, AR and 2 Division Genetic and Reproductive Toxicology, NCTR, U.S. FDA, Jefferson, AR. #1566 REACTIONS OF NITRIC OXIDE-DERIVED OXIDANTS WITH 4-ACETAMIDOPHENOL: FORMATION OF ELECTROPHILIC INTERMEDIATES. R. M. Uppu 1 and R. J. Martin 2 . 1 Environmental Toxicology, Southern University, Baton Rouge, LA and 2 School of Human Ecology, Louisiana State University, Baton Rouge, LA. #1567 THE ROLES OF LIVER AND TARGET-TISSUE P450-MEDIATED DMBA METABOLISM IN DMBA-INDUCED DNA ADDUCT FORMATION IN THE MAMMARY GLAND. H. Cui, J. Gu, L. Zhang, Q. Zhang and X. Ding. Wadsworth Center, Albany, NY. #1568 VINCLOZOLIN IN VITRO METABOLISM BY RAT LIVER MICROSOMES. A. Sierra-Santoyo 1 , R. Harrison 2 , B. Edwards 2 , H. A. Barton 2 and M. F. Hughes 2 . 1 Toxicology Section, CINVESTAV-IPN, Mexico City, D.F., Mexico and 2 NHEERL/ORD/ETD/PKB, U.S. EPA, Research Triangle Park, NC. #1569 HYDROLYTIC METABOLISM OF PYRETHROIDS BY HUMAN CARBOXYLESTERASES AND RODENT AND HUMAN LIVER MICROSOMES. M. K. Ross 1 , P. M. Potter 2 and A. Borazjani 1 . 1 Center for Environmental Health Sciences, Mississippi State University, Mississippi State, MS and 2 Mol. Pharmacology, St. Jude’s Children’s Research Hospital, Memphis, TN. #1570 METABOLISM OF ARSENICALS MAY INFLUENCE THEIR PROLIFERATIVE EFFECTS ON HUMAN CACO-2 CELLS. G. S. Bayse 1 , W. G. Kirlin 2 , A. M. Rollins-Hairston 2 and K. Jackson 1 . 1 Chemistry, Spelman College, Atlanta, GA and 2 Pharmacology/Toxicology, Morehouse School of Medicine, Atlanta, GA. #1571 A NOVEL HALOENOL LACTONE DERIVATIVE POTENTIATES CYTOTOXICITY INDUCED BY CISPLATIN RETARDING THE GLUTATHIONE- MEDIATED DETOXIFICATION OF CISPLATIN IN HUMAN RENAL TUMOR CELL LINES. J. Zheng and W. Wang. Pharmaceutical Sciences, Northeastern University, Boston, MA. #1572 BIOACTIVATION OF 1-CHLORO-2-HYDROXY-3- BUTENE TO 1-CHLORO-3-BUTEN-2-ONE, A NOVEL CROSS-LINKING AGENT. A. A. Elfarra, R. J. Krause, X. Zhang and C. A. Klumb. Department of Comparative Biosciences, University of Wisconsin, Madison, WI. #1573 4’-FLUORO SUBSTITUTION OF DESMETHYLATED ARZOXIFENE COULD DECREASE TOXICITY WHILE MAINTAINING ANTIESTROGENIC ACTIVITY. H. liu, G. R. Thatcher and J. L. Bolton. Medicinal Chemsitry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL. #1574 REDUCTION OF 1-FURAN-2-YL-3-PYRIDIN-2- YL-PROPENONE, AN ANTI-INFLAMMATORY AGENT, BY CARBONYL REDUCTASE IN RAT LIVER MICROSOMES. S. Lee 1 , T. Jeon 1 , C. Jin 1 , S. Hyun 1 , G. Kim 1 , I. Jun 1 , D. Lee 1 , E. Lee 1 , Y. Jahng 1 , D. Kim 2 and T. Jeong 1 . 1 Yeungnam University, Kyungsan, South Korea and 2 Bioanalysis and Biotransformation Research Center, Seoul, South Korea. #1575 PHASE 1 AND PHASE 2 METABOLISMS OF RUTAECARPINE IN MICE AND RATS. G. Kim, D. Lee, S. Lee, T. Jeon, S. Hyun, C. Jin, I. Jun, E. Lee, Y. Jahng and T. Jeong. College of Pharmacy, Yeungnam University, Kyungsan, Kyungbuk, South Korea. #1576 METABOLIC SHIFT FOLLOWING MULTIPLE DOSES OF [14C]-1, 3-DINITROBENZENE TO RATS. J. J. Tobias and T. Miller. Toxicology, University of Kentucky, Lexington, KY. #1577 METABOLISM OF METHACRYLONITRILE TO CYANIDE: INHIBITION BY CAFFEINE AND POTENTIATION BY ALCOHOL. M. Y. Farooqui. Biology, University of Texas Pan American, Edinburg, TX. #1578 METABOLISM OF GERANYL NITRILE AND CITRONELLYL NITRILE BY PRIMARY HEPATOCYTES FROM MICE, RATS AND HUMANS. R. A. Kemper 1 , D. L. Nabb 1 , S. A. Gannon 1 , T. A. Snow 1 and A. Api 2 . 1 DuPont Haskell Laboratory, Newark, DE and 2 Research Institute for Fragrance Materials (RIFM), Woodcliff, NJ. WEDNESDAY up-to-date information at www.toxicology.org 169
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Author Index (Continued) 44 th Annu
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