Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
Wednesday Afternoon, March 9
12:00 NOON to 1:00 PM
Room 208
ISSUES SESSION: REORGANIZATION OF THE NIH GRANT
REVIEW PROCESS AND ITS POTENTIAL IMPACT ON
TOXICOLOGY RESEARCH AND TRAINING
Chairperson(s): David Eaton, University of Washington, Seattle, WA.
Panelists: Anne Sassaman, Director of Extramural Programs, NIEHS;
Richard Okita, Administrator, Pharmacological and Physiological Sciences
Branch, NIGMS; Mary Vore, Chair, XNDA Study Section; Alvaro Puga,
Member, XNDA Study Section (Former Chair of AL-TOX1); Elliot Postow,
Center for Scientific Review; and Patricia Greenwel, Center for Scientific
Review.
Wednesday Afternoon, March 9
12:15 PM to 1:15 PM
Room 215
INFORMATIONAL SESSION: ADVANCES IN REAL-TIME PCR —
PRESENTED BY APPLIED BIO SYSTEMS
An overview of recent advances including; Validated TaqMan® Gene
Expression and SNP Assays for quantization and genotyping of the
Cytochromes P450 and other drug metabolizing enzymes, FAST thermal cycling
options, and TaqMan® Assays for microRNA quantization.
Wednesday Afternoon, March 9
1:30 PM to 4:30 PM
Room RO2
With the reorganization of the NIH Study Sections, significant changes have
occurred in the way that toxicology-related grants are assigned to study sections
and reviewed. This session will explore the advantages and disadvantages of the
reorganization to our discipline, and the implications for toxicology research
and training of the next generation of environmental health scientists.
Wednesday Afternoon, March 9
12:00 NOON to 1:00 PM
Room RO8
ROUNDTABLE SESSION: CONDUCTING A COMPREHENSIVE
TOXICOLOGICAL AND SAFETY EVALUATION OF
NANOMATERIALS: CURRENT CHALLENGES AND DATA NEEDS
Chairperson(s): William H. Farland, U.S. EPA, Washington, DC.
#1695 12:00 CONDUCTING A COMPREHENSIVE
TOXICOLOGICAL AND SAFETY EVALUATION
OF NANOMATERIALS: CURRENT
CHALLENGES AND DATA NEEDS. M. P.
Holsapple 1 and W. H. Farland 2 . 1 HESI, Washington,
DC and 2 U.S. EPA, Washington, DC.
#1696 12:05 INHALATION AS A CRITICAL EXPOSURE
ROUTE FOR EVALUATING NANOMATERIALS.
T. D. Landry. Toxicology and Environmental Research
and Consulting, The Dow Chemical Company, Midland,
MI.
#1697 12:10 DERMAL EXPOSURE ROUTE FOR
EVALUATING NANOMATERIALS. N. A. Monteiro-
Riviere. Center for Chemical Toxicology Research and
Pharmacokinetics, North Carolina State University,
Raleigh, NC.
#1698 12:15 THE VALUE OF EXISTING TESTING
STRATEGIES FOR EVALUATING
NANOMATERIALS. J. M. Carter. Central Product
Safety, Procter & Gamble, Cincinnati, OH.
#1699 12:20 MODE OF ACTION CONSIDERATIONS IN THE
EVALUATION OF SAFETY OF ENGINEERED
NANOSCALE MATERIALS. N. J. Walker. NIEHS,
Research Triangle Park, NC.
Abstract 1700 is located on page 179.
SYMPOSIUM SESSION: DEVELOPMENTAL TOXICOLOGY OF THE
LUNG
Chairperson(s): John M. Rogers, U.S. EPA, Research Triangle Park, NC and
Charles G. Plopper, University of California, Davis, Davis, CA.
Endorsed by:
Reproductive and Development SS
Student Advisory Committee
Respiratory problems account for a large proportion of hospital admissions to
pediatric wards, and the incidence of childhood asthma is increasing for
unknown reasons. A number of toxicants have been demonstrated to adversely
affect lung development in humans and/or laboratory animals. Lung development
begins early in gestation and continues well after birth. The molecular
control of normal lung development has been intensely studied and is becoming
well elucidated, involving multiple complex signaling networks. In contrast,
mechanisms of toxicity to the developing lung are poorly understood. This
symposium will present an overview of normal lung development and examples
in humans and laboratory animal species of chemicals and conditions that
adversely affect lung development. Effects of tobacco smoke and constituents
have been well-studied and will be highlighted. Possible modes of action for
developmental toxicity to the lung will be presented and research needs will be
discussed.
#1643 1:30 DEVELOPMENTAL TOXICOLOGY OF THE
LUNG. J. M. Rogers. Developmental Biology Branch,
U.S. EPA, Research Triangle Park, NC.
#1644 1:40 GENETIC PATHWAYS CONTROLLING LUNG
MORPHOGENESIS. W. Cardoso. Pulmonary Biology,
Cincinnati Children’s Hospital, Cincinnati, OH.
Sponsor: J. Rogers.
#1645 2:10 EFFECTS OF ENVIRONMENTAL TOBACCO
SMOKE (ETS) ON THE DEVELOPING LUNG. K.
E. Pinkerton, J. L. Peake and J. P. Joad. Center for
Health and the Environment, University of California,
Davis, CA.
#1646 2:40 EFFECT OF MATERNAL NICOTINE EXPOSURE
DURING DIFFERENT PHASES OF LUNG
DEVELOPMENT ON LUNG GROWTH IN THE
OFFSPRING: PROTECTICE EFFECT OF
COPPER. G. S. Maritz. Medical Biosciences,
University of the Western Cape, Bellville, Western
Province, South Africa. Sponsor: J. Rogers.
#1647 3:10 PRENATAL PERFLUOROOCTANE SULFONATE
EXPOSURE AFFECTS PERINATAL LUNG
DEVELOPMENT AND CAUSES RESPIRATORY
DISTRESS IN RATS. R. C. Grasty. Toxicology, UNC
Chapel Hill, Research Triangle Park, NC.
WEDNESDAY
up-to-date information at www.toxicology.org 175