Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY #1152 ROLE OF PLASMA GLUTATHIONE IN HEPATIC TOXICITY CAUSED BY VANADIUM COMPOUNDS IN MICE. T. Hasegawa 1 , M. Satoh 2 and Y. Seko 1 . 1 Environmental Biochemistry, Yamanashi Institute of Environmental Sciences, Fujiyoshida, Yamanashi, Japan and 2 Department of Hygienics, Gifu Pharmaceutical University, Gifu, Japan. #1153 SPLEEN REPERCUSSIONS AFTER CHRONIC INHALATION OF VANADIUM PENTOXIDE (V2O5) EVALUATED IN MICE. T. I. FORTOUL 1 , G. Pinon-Zarate 1 , A. Gonzalez-Villalva 1 , V. Rodriguez- Lara 1 , M. Rojas-Lemus 1 , P. Mussali-Galante 1 , M. Avila- Casado 1 , V. Delgado 1 , F. Pasos 1 , B. Chavez 1 and M. AVILA-COSTA 2 . 1 Biologia Celular Y Tisular, Facultad de Medicina, UNAM, Mexico, Mexico and 2 Neuromorfologia, Fes Iztacala, UNAM, Mexico, Mexico. #1154 ROLE OF OXIDATIVE STRESS IN THE MODULATION OF AHR-REGULATED GENE EXPRESSION BY HEAVY METALS. R. H. Elbekai and A. O. El-Kadi. University of Alberta, Edmonton, AB, Canada. #1155 INTEGRATIVE ANALYSIS OF GENOME-WIDE GENE EXPRESSION AND PATHWAY MAPPING IN MOUSE EMBRYONIC FIBROBLAST (MEF) EXPOSED TO CADMIUM, ARSENIC AND METHYLMERCURY: INDUCTION OF OXIDATIVE STRESS, DISRUPTION OF UBIQUITIN-PROTEASOME SYSTEM AND CELL CYCLE REGULATION. X. Yu, J. S. Sidhu, J. F. Robinson, S. Hong and E. M. Faustman. Environmental Health, IRARC, UW, Seattle, WA. #1156 EFFECT OF COMBINED LEAD, CADMIUM AND ARSENIC EXPOSURE ON THE EXPRESSION OF CELLULAR PROTECTIVE FACTORS IN RAT KIDNEYS AT LOEL DOSE LEVELS. G. Wang, X. Chen, M. M. Lipsky, M. H. Whittaker and B. A. Fowler. Toxicology Program, University of Maryland, Baltimore, MD. #1157 COMPARISON OF METALS IN CYTOTOXICITY, FREE RADICAL GENERATION, AND HEAT SHOCK PROTEIN EXPRESSION IN A HUMAN BRONCHIAL EPITHELIAL CELL LINE, BEAS- 2B. S. Han 1,2 and V. Vallyathan 1 . 1 Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV and 2 Genetics and Developmental Biology, West Virginia University, Morgantown, WV. #1158 METAL-INDUCED OXIDATION OF THIOREDOXIN-1 AND THIOREDOXIN-2. J. M. Hansen and D. P. Jones. Medicine, Emory University, Atlanta, GA. #1159 INDUCTION OF OXIDATIVE STRESS IN RESPONSE TO INGESTION OF LEAD, CADMIUM AND ARSENIC MIXTURES. M. H. Whittaker, B. A. Fowler, G. Wang, C. Xue-Qing and M. Lipsky. Toxicology Program, The University of Maryland, Baltimore, Baltimore, MD. #1160 CHANGING METAL ACCUMULATION IN NEW ORLEANS: DIFFERENCES BETWEEN SURVEY I (1992) AND SURVEY II (2000). H. W. Mielke 1 , E. Powell 1 , C. Gonzales 1 and P. Mielke (Emeritus) 2 . 1 College of Pharmacy, Xavier University, New Orleans, LA and 2 Statistics, Colorado State University, Fort Collins, CO. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: GENE REGULATION: METALS Chairperson(s): Jay Gandolfi, University of Arizona, Tucson, AZ. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1161 TOXICOGENOMICAL STUDY ON HUMAN BLADDER EPITHELIUM EXPOSED TO ARSENIC. X. Zheng 1 , T. G. Bredfeldt 1 , G. S. Watts 2 and A. Gandolfi 1 . 1 Pharmacology/Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ and 2 Arizona Cancer Center, University of Arizona, Tucson, AZ. #1162 DIFFERENTIAL EFFECTS OF CHRONIC LOW LEVEL ARSENIC EXPOSURES ON TRANSCRIPTION FACTOR BINDING IN CARDIOVASCULAR TISSUES. L. R. Klei 1,2 , M. A. Ihnat 3 , N. V. Soucy 2 , A. A. Nemec 1 and A. Barchowsky 1,2 . 1 Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 2 Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH and 3 Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. #1163 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E IS A CELLULAR TARGET FOR ARSENIC BUT NOT CHROMIUM TOXICITY. P. Joseph and S. Othumpangat. NIOSH, Morgantown, WV. #1164 EFFECT OF ARSENITE ON PU.1, C/EBPS, AND NFKB ACTIVATION IN U937 PROMONOCYTIC LEUKEMIA CELLS. M. Yamamoto 1 , S. Hirano 1 , C. R. Jefcoate 2 and F. Matsumura 3 . 1 Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan, 2 Pharmacology, University of Wisconsin-Madison, Madison, WI and 3 Environmental Toxicology, University of California- Davis, Davis, CA. #1165 IDENTIFICATION OF MOUSE SLC39A8 AS THE TRANSPORTER RESPONSIBLE FOR CADMIUM-INDUCED TOXICITY IN THE TESTIS. L. He 1 , T. P. Dalton 1 , B. Wang 1 , M. L. Miller 1 , L. Jin 1 , K. F. Stringer 2 , X. Chang 1 , C. S. Baxter 1 and D. W. Nebert 1 . 1 Department of Environmental Health, and the Center for Environmental Genetics (CEG), University of Cincinnati, Cincinnati, OH and 2 Department of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 138 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1166 ROLE OF EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (EIF4E) IN CADMIUM- INDUCED CYTOTOXICITY AND CELL DEATH. S. Othumpangat and P. Joseph. Toxicology and Molecular Biology Branch, NIOSH, Morgantown, WV. #1167 MECHANISMS OF ARSENITE-STIMULATED HEMEOXYGENASE-1 UPREGULATION IN HUMAN KERATINOCYTES. K. L. Cooper and L. G. Hudson. College of Pharmacy, University of NM, Albuquerque, NM. #1168 MERCURY, CADMIUM, ZINC, AND ARSENITE INHIBIT PAX3 DNA BINDING VIA THE PAIRED DOMAIN. F. A. Leal 1 , A. F. Machado 2 , M. D. Collins 1 and J. M. Fukuto 1 . 1 Molecular Toxicology IDP, University of California, Los Angeles, CA and 2 Department of Environmental and Occupational Health, California State University, Northridge, CA. Sponsor: O. Hankinson. #1169 NFκB MEDIATES ZINC-INDUCED COX-2 EXPRESSION IN HUMAN BRONCHIAL EPITHELIAL CELLS. W. wu 1 . 1 Center for Environmental Medicine, University of North Carolina, Chapel Hill, NC and 2 Human Studies Division, U.S. EPA, Research Triangle Park, NC. Sponsor: M. Madden. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: PHARMACEUTICALS-METHODS OF EVALUATION Chairperson(s): Patrick Hayden, MatTek Corporation, Ashland, MA. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1170 COMPARISON OF BCNU AND SARCNU TOXICITY IN LONG-TERM CULTURES OF PRECISION-CUT LUNG SLICES. C. A. Tyson, K. Amin, C. Ip and H. P. Behrsing. Toxicology Laboratory, SRI International, Menlo Park, CA. #1171 A HIGH-THROUGHPUT IN VITRO MODEL OF HUMAN TRACHEAL/BRONCHIAL EPITHELIUM (EPIAIRWAY) FOR PRECLINICAL SAFETY AND EFFICACY TESTING OF PHARMACEUTICALS. P. J. Hayden, G. R. Jackson, J. Kubilus, J. E. Sheasgreen and M. Klausner. MatTek Corp., Ashland, MA. #1172 VASCULAR PERMEABILITY IN THE RAT. S. Rowton and P. Robinson. Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: D. Everett. #1173 REDUCED STRESS IN GROUP HOUSED NON- HUMAN PRIMATES. S. Grainger 1 , J. Hedley 1 and M. Niehof 2 . 1 Covance Laboratories Ltd., Harrogate, United Kingdom and 2 Covance Laboratories GmbH, Munster, Germany. Sponsor: D. Everett. #1174 PREDICTING ANTIEPILEPTIC DRUG TOXICITY USING HEPATIC PROTEIN COVALENT BINDING AND GENE EXPRESSION POTENTIAL. A. M. Leone 1 , L. M. Kao 1 , M. McMillian 1 , A. Y. Nie 1 , J. B. Parker 1 , M. F. Kelley 1 , M. D. Johnson 1 , E. Usuki 2 , A. Parkinson 2 and P. Lord 1 . 1 Mechanistic Toxicology, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ and 2 XenoTech LLC, Lenexa, KS. #1175 IN VIVO AND IN VITRO NON-CLINICAL DRUG SAFETY ASSESSMENT: A KEY PARTNER FOR ANTICANCER DRUG DEVELOPMENT. N. Lhote 1 , Y. Sibiril 3 , D. Bazot 1 , A. Beamonte 1 , J. Delongeas 1 , D. Parent-Massin 3 and N. Claude 2 . 1 Servier Group, Gidy, France, 2 Servier Group, Courbevoie, France and 3 LTA EA3880, UBO Brest, France. #1176 PHARMACOKINETICS AND ENHANCED ORAL BIOAVAILABILITY OF NANOSTRUCTURED DRUG CRYSTALS: COMPARISON OF PARTICLE ENGINEERING TECHNOLOGIES FOR DANAZOL, KETOCONAZOLE AND NAPROXEN IN BEAGLE DOGS. G. G. Kupperblatt 2 , S. A. Saghir 1 , D. A. Markham 1 , T. L. Rogers 2 , C. J. Tucker 3 , J. E. Hitt 2 and E. J. Elder 2 . 1 Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, 2 Dowpharma, The Dow Chemical Company, Midland, MI and 3 Corporate R&D, The Dow Chemical Company, Midland, MI. #1177 REDUCTION AND REFINEMENT IN RADIOLABELLED PRIMATE METABOLISM STUDIES. J. Kelly, J. Hedley and R. Allen. Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: D. Everett. #1178 ADJUVANT ARTHRITIS IN THE MALE LEWIS RAT. S. Rowton and P. Robinson. Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: D. Everett. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: SAFETY EVALUATION-NON PHARMACEUTICAL Chairperson(s): Eugenia Theophilus, R.J. Reynolds Tobacco Company, Winston Salem, NC. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1179 EVALUATION OF GENOTOXICITY AND SENSITIZATION POTENTIAL OF PEPTIDE COUPLING REAGENTS. D. A. Seid 1 , S. S. Kim 2 and S. Kim 1 . 1 Applied Biosystems, Foster City, CA and 2 University of California, Berkeley, CA. #1180 COMPARISON OF PHOTOTOXICITY TESTING METHODS USED TO SCREEN LEAD COMPOUNDS L. LEE, G. STEVENS, AND B. JESSEN. PFIZER GLOBAL R&D. L. Lee. Pfizer Global R&D, San Diego, CA. Sponsor: G. Stevens. TUESDAY up-to-date information at www.toxicology.org 139
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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