Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY Wednesday Morning, March 9 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: MODULATION OF CARCINOGENESIS Chairperson(s): Howard P. Glauert, University of Kentucky, Lexington, KY and Coral Alfred Lamartiniere, University of Alabama at Birmingham, Birmingham, AL. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #1486 THE THERAPEUTIC EFFECTS OF LYOPHILIZED BLACK RASPBERRIES ON NMBA-INDUCED CARCINOGENESIS. R. M. Aziz, R. Nines and G. D. Stoner. Cancer Chemoprevention and Support, The Ohio State University, Columbus, OH. #1487 EFFECTS OF DIETARY SELENIUM ON THE HEPATIC TUMOR PROMOTING ACTIVITIES OF PCBs. D. N. Stemm 1 , L. W. Robertson 3 , J. C. Tharappel 2 , B. T. Spear 4 , H. J. Lehmler 3 and H. P. Glauert 2 . 1 Graduate Center for Toxicology, University of Kentucky, Lexington, KY, 2 Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, 3 School of Public Health, University of Iowa, Iowa and 4 Department of Microbiology and Immunology, University of Kentucky, Lexington, KY. #1488 EFFECTS OF SELECTED DIETARY ANTIOXIDANT PHYTOCHEMICALS ON THE HEPATIC TUMOR PROMOTING ACTIVITY OF PCB-77. J. C. Tharappel 1 , D. N. Stemm 2 , R. P. Bunaciu 1 , L. W. Robertson 3 , H. J. Lehmler 3 , B. T. Spear 4 and H. P. Glauert 1 . 1 Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, 2 Graduate Center for Toxicology, University of Kentucky, Lexington, KY, 3 School Of Public Health, University of Iowa, Iowa and 4 Department of Microbiology and Immunology, University of Kentucky, Lexington, KY. #1489 CHANGES IN DRUG METABOLISM AS A POTENTIAL MECHANISM FOR THE SYNERGISTIC INDUCTION OF APOPTOSIS IN MDA-MB-231 CELLS BY EGCG AND 4-OH TAMOXIFEN. E. C. Stuart, J. P. Wilson, B. J. Bray and R. J. Rosengren. Pharmacology & Toxicology, Univeristy of Otago, Dunedin, New Zealand. #1490 PHYTOESTROGENS AND DIETARY FATTY ACIDS INFLUENCE SPONTANEOUS MAMMARY TUMOR DEVELOPMENT IN IN TG.NK (MMTV/C-NEU) MICE. M. Luijten 1 , A. Verhoef 1 , J. Dormans 1 , D. Beems 1 , H. Van Kranen 2 , N. Nagelkerke 2 , H. Adlercreutz 2 and A. Piersma 1 . 1 National Institute for Public Health and the Environment, Bilthoven, Netherlands and 2 Folkhalsan Research Center, Helsinki, Finland. Sponsor: J. Vos. #1491 INFLUENCE OF METHOXYCHLOR EXPOSURE ON BREAST CANCER INCIDENCE IN FEMALE SPRAGUE-DAWLEY RATS. S. M. Bandiera, J. K. Tai, E. G. Hrycay and T. K. Chang. Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. #1492 BREAST CANCER CHEMOPREVENTION WITH THE POLYPHENOL RESVERATROL. T. G. Whitsett and C. A. Lamartiniere. Toxicology, University of Alabama at Birmingham, Birmingham, AL. #1493 RESVERATROL ACTION ON STERIOD AND GROWTH FACTOR SIGNALING IN TRAMP MICE. C. E. Harper, B. B. Patel, J. Wang and C. A. Lamartiniere. Toxicology, University of Alabama at Birmingham, Birmingham, AL. #1494 SUPRESSION OF MMP EXPRESSION AND INVASION OF HUMAN CERVICAL CANCER CELL LINES HELA AND DOTC2 4510 BY NUTRIENTS. M. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath. Cancer Division, Matthias Rath Research, Santa Clara, CA. #1495 ALTERED TRANSCRIPTIONAL REGULATION OF GENES INVOLVED IN AFLATOXIN GENOTOXICITY BY SULFORAPHANE (SFN) AND DIINDOLYLMETHANE (DIM). K. Gross- Steinmeyer 1 , P. L. Stapelton 1 , F. Liu 1 , J. H. Tracy 1 , T. K. Bammler 1 , S. C. Strom 2 and D. L. Eaton 1 . 1 Env. Occup. Health Sciences., University Washington, Seattle, WA and 2 Pathology, University Pittsburgh, Pittsburgh, PA. #1496 MICROARRAY ANALYSIS OF LPS AND NAC- INDUCED GENE EXPRESSION AND RESULTANT SYNERGISM, POTENTIATION, AND ANTAGONISM IN WEHI-231 B LYMPHOMA CELLS. K. R. Martin. Nutritional Sciences, Penn State University, University Park, PA. #1497 MODULATION OF ADULT RAT BENZO(A)PYRENE (BAP) METABOLISM AND DNA ADDUCT CONCENTRATIONS BY NEONATAL RESVERATROL (RVT) EXPOSURE. A. RAMESH. Pharmacology, Meharry Medical College, Nashville, TN. #1498 EFFECT OF DIETARY FAT ON FLUORANTHENE (FLA) METABOLISM AND DNA ADDUCT FORMATION IN F-344 RATS. S. WALKER, M. MATHIS, A. ADDAI and A. RAMESH. Pharmacology, Meharry Medical College, Nashville, TN. #1499 TRANSPLACENTAL GENOTOXICITY OF DIBENZO[A, L]PYRENE (DBP) AND THE EFFECT OF INDOLE -3-CARBINOL (I3C) IN THE MATERNAL DIET. Z. YU 1,2 , B. Mahadevan 1 , L. K. Siddens 1,2 , D. J. Albershardt 1 , S. K. Krueger 1,2 , M. Louderback 1 , W. M. Baird 1 and D. E. Williams 1,2,3 . 1 Environmental and Molecular Toxicity, Oregon state university, corvallis, OR, 2 Linus Pauling Institute, Oregon State University, corvallis, OR and 3 Marine and Freshwater Biomedical Sciences Center, Oregon State University, corvallis, OR. #1500 STUDY OF THE INHIBITING EFFECT OF DIETARY HYDROQUINONE ON ACETYLAMINO-FLUORENE INDUCTION OF INITIATION OF RAT LIVER CARCINOGENESIS. M. J. Iatropoulos, A. M. Jeffrey, J. Duan and G. M. Williams. New York Medical College, Valhalla, NY. 164 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1501 β-SITOSTEROL IN PSYLLIUM SEED HUSK RESTORES GAP JUNCTIONNAL INTERCELLULAR COMMUNICATION IN HA- RAS TRANSFECTED RAT LIVER EPITHELIAL CELLS. Y. Nakamura 1 , I. Hiroki 1 , N. Yoshikawa 1 , K. Sato 1 , K. Ohtsuki 1 , C. Chang 2 , B. L. Upham 2 and J. E. Trosko 2 . 1 Food Science, Kyoto Pref. University, Kyoto, Japan and 2 NFSTC, Michigan State University, Lansing, MI. #1502 THE EFFECTS OF CO-ADMINISTRATION OF ANTIOXIDANTS AND DIMETHYLARSINIC ACID (DMA) ON THE BLADDER EPITHELIUM OF FEMALE F344 RATS. S. M. Cohen 1 , L. L. Arnold 1 , M. Cano 1 and M. Wei 2 . 1 Path/Micro, University of Nebraska Medical Center, Omaha, NE and 2 Pathology, Osaka City University Medical School, Osaka, Japan. #1503 RAPID INDUCTION OF COLORECTAL TUMORS IN RATS INITIATED WITH 1, 2- DIMETHYLHYDRAZINE FOLLOWED BY DEXTRAN SODIUM SULFATE TREATMENT–POSSIBLE APPLICATION FOR A NEW MEDIUM-TERM RAT COLON BIOASSAY. T. Imai, J. Onose, M. Hasumura, Y. Cho and M. Hirose. Division of Pathology, National Institute of Health Sciences, Tokyo, Japan. Sponsor: M. Ema. Wednesday Morning, March 9 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: CARCINOGENICITY BIOASSAYS Chairperson(s): Marie Amoruso, ExxonMobil Biomedical Sciences Inc., Annandale, NJ and James E. Swauger, RJR Tobacco Company, Winston Salem, NC. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #1504 LACK OF CARCINOGENIC EFFECTS IN F-344 RATS FED BIS(2-ETHYLHEXYL)-1, 4- BENZENEDICARBOXYLATE (DEHT). L. E. Navarro 1 , K. M. Ruble 1 , J. A. Deyo 1 and R. M. David 2 . 1 Eastman Chemical Company, Kingsport, TN and 2 Eastman Kodak Company, Rochester, NY. #1505 DIMETHYLARSINIC ACID (DMA): RESULTS OF CHRONIC TOXICITY/ONCOGENICITY STUDIES IN FISCHER F344 RATS AND B6C3F1 MICE. M. Eldan 1 , L. L. Arnold 2 , M. van Gemert 3 and S. M. Cohen 2 . 1 Luxembourg Industries (Pamol) Ltd.,, Tel-Aviv, Israel, 2 Path/Micro, University of Nebraska Medical Center, Omaha, NE and 3 Exponent, Washington, DC. #1506 GINGIVAL CARCINOGENICITY IN FEMALE HARLAN SPRAGUE-DAWLEY RATS AFTER ORAL TREATMENT FOR TWO YEARS WITH 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN AND DIOXIN-LIKE COMPOUNDS. K. Yoshizawa 1 , N. J. Walker 2 , M. P. Jokinen 5 , A. E. Brix 6 , D. M. Sells 7 , T. Marsh 1 , M. E. Wyde 3 , D. Orzech 3 , J. K. Haseman 4 and A. Nyska 1 . 1 Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, NC, 2 Laboratory of Computational Biology and Risk Analysis, NIEHS, Research Triangle Park, NC, 3 Toxicology Operation Branch, NIEHS, Research Triangle Park, NC, 4 Biostastistics Branch, NIEHS, Research Triangle Park, NC, 5 Pathology Associates–A Charles River Company, Durham, NC, 6 Experimental Pathology Laboratories, Research Triangle Park, NC and 7 Battelle Columbus Laboratories, Columbus, OH. #1507 CHRONIC TOXICITY AND ONCOGENICITY STUDY OF OCTAMETHYLCYCLOTETRASILOXANE (D4) IN FISCHER 344 RATS. K. P. Plotzke 1 , P. A. Jean 1 , J. W. Crissman 1 , K. M. Lee 2 and R. G. Meeks 1 . 1 Dow Corning Corporation, Midland, MI and 2 Battelle, Richland, WA. #1508 CHRONIC TOXICITY AND ONCOGENICITY STUDY OF HEXAMETHYLDISILOXANE (HMDS) IN FISCHER-344 RATS. M. L. Jovanovic 1 , S. D. Crofoot 1 , J. W. Crissman 1 , P. A. Smith 2 , K. P. Plotzke 1 and R. G. Meeks 1 . 1 Dow Corning Corporation, Midland, MI and 2 RCC Ltd., Itingen, Switzerland. #1509 CHRONIC TOXICITY AND ONCOGENICITY STUDY OF DECAMETHYLCYCLOPENTASILOXANE (D5) IN FISCHER-344 RATS. S. D. Crofoot 1 , M. L. Jovanovic 1 , J. W. Crissman 1 , P. A. Smith 2 , K. P. Plotzke 1 and R. G. Meeks 1 . 1 Dow Corning Corporation, Midland, MI and 2 RCC Ltd., Itingen, Switzerland. #1510 CHRONIC TOXICITY AND ONCOGENICITY STUDY OF POLYDIMETHYLSILOXANE (PDMS) 10 CST FLUID IN FISCHER 344 RATS. R. G. Meeks 1 , P. A. Jean 1 , J. W. Mertens 2 , K. S. Regan 3 , J. W. Crissman 1 and K. P. Plotzke 1 . 1 Dow Corning Corporation, Midland, MI, 2 WIL Research Laboratories, Ashland, OH and 3 Regan Path/Toxicology Services, Ashland, OH. #1511 HISTOGENESIS OF SPONTANEOUS LESIONS IN THE V-HA-RAS (TG.AC) MOUSE. A. HARGREAVES, M. Jacobsen, C. Sadler, S. Barrett and J. Wright. CTL Pathology, Syngenta, Macclesfield, United Kingdom. Sponsor: I. Kimber. #1512 A CARCINOGEN BIOASSAY FOR COMPLEX MIXTURES. K. LaDow 1 , D. Warshawsky 1 , R. Albert 1 , W. Xue 1 , S. Spalding 1 , G. P. Boivin 2 , D. Ginsburg 1 and P. Succop 1 . 1 Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH and 2 Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH. WEDNESDAY up-to-date information at www.toxicology.org 165
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Author Index (Continued) 44 th Annu
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SOT Affiliates for 2005 44 th Annua
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Headquarters Staff 44 th Annual Mee
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Program - Society of Toxicology

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