Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description THURSDAY #2119 UP-REGULATION OF HEAT SHOCK PROTEIN 27 AND RETINOL BINDING PROTEIN CONTRIBUTES TO 11-DEOXY-16, 16-DIMETHYL PROSTAGLANDIN E2 MEDIATED CYTOPROTECTION. J. L. Lord 1 , Z. Jia 1 , D. W. Cromey 2 , R. C. Lantz 2 , T. J. Monks 1 and S. S. Lau 1 . 1 Department of Pharmacology& Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ and 2 Cell Biol & Anat, College of Medicine, University of Arizona, Tucson, AZ. #2120 ASSESSMENT OF IN VITRO TOXICITY OF SELECTED CHEMO-THERAPUETIC DRUGS USING HUMAN PRIMARY RENAL CELLS. W. Li, M. Lam, A. Birkeland, L. Warfe, D. Choy, J. Post and M. Sullivan. Pharmacology, Berlex, Richmond, CA. #2121 NEPHROTOXICITY OF N-(3, 5- DICHLOROPHENYL)-3- HYDROXYSUCCINAMIC ACID IN MALE AND FEMALE FISCHER 344 RATS. G. O. Rankin, D. K. Anestis, K. R. Saunders and S. K. Hong. Pharmacology, Marshall University, Huntington, WV. #2122 COMPARISON OF THE IN VITRO NEPHROTOXIC POTENTIAL OF DICLOFENAC AND ACETAMINOPHEN IN ISOLATED RENAL PROXIMAL TUBULES FROM MALE FISCHER 344 RATS. S. L. Miles, J. G. Ball and G. O. Rankin. Pharmacology, Marshall University, Huntington, WV. #2123 IN VITRO GSH ADDUCT FORMATION: EVIDENCE FOR BIOACTIVATION OF THE NEPHROTOXICANT N-(3, 5- DICHLOROPHENYL)SUCCINIMIDE THROUGH ALCOHOL-O-GLUCURONIDATION AND SULFATION. D. Cui 1,2 , G. O. Rankin 3 and P. J. Harvison 1 . 1 Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, Philadelphia, PA, 2 Department of Pharmaceutical Candidates Optimization, Bristol-Myers Squibb, Princeton, NJ and 3 Department of Pharmacology, Marshall University School of Medicine, Huntington, WV. #2124 EFFECT OF ENANTIOMER-BASED INHIBITORS OF CA 2+ -INDEPENDENT PHOSPHOLIPASE A 2 ON RENAL AND CANCER CELL DEATH. L. Zhang, W. Zhang and B. S. Cummings. Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA. #2125 IDENTIFICATION AND CHARACTERIZATION OF IPLA γ IN MITOCHONDRIA. G. R. Kinsey 1 , J. McHowat 2 and R. G. Schnellmann 1 . 1 Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC and 2 Pathology, St. Louis University, St. Louis, MO. #2126 ISCHEMIA-INDUCED CLEAVAGE OF CADHERINS IN NRK CELLS: EVIDENCE FOR A ROLE OF MT1-MMP. M. Pulido 1 , K. Bayless 2 , R. Burghardt 3 , G. Davis 2 and A. Parrish 1 . 1 Pharmacology and Toxicology, Texas A&M University System Health Science Center, College Station, TX, 2 Pathology, Texas A&M University System Health Science Center, College Station, TX and 3 Veterinary Anatomy, Texas A&M University, College Station, TX. #2127 ROLE OF HEAT SHOCK PROTEINS AND SIGNALING PATHWAYS IN DETERMINING RESPONSE OF HUMAN PROXIMAL TUBULAR CELLS TO S-(1, 2-DICHLOROVINYL)-L- CYSTEINE (DCVC). D. A. Putt, L. H. Lash, S. E. Hueni and B. P. Horwitz. Pharmacology, Wayne State University Sch. Med., Detroit, MI. #2128 IDENTIFICATION AND LOCALIZATION OF CALPAIN 10 TO MITOCHONDRIA. D. Arrington and R. G. Schnellmann. Pharmaceutical Sciences, MUSC, Charleston, SC. #2129 EPITHELIAL BARRIER CHARACTERISTICS AND EXPRESSION OF CELL ADHESION MOLECULES IN PROXIMAL TUBULE- DERIVED CELL LINES COMMONLY USED FOR IN VITRO NEPHROTOXICITY TESTING. W. C. Prozialeck, P. C. Lamar and C. S. Smith. Pharmacology, Midwestern University, Downers Grove, IL. #2130 CYTOTOXICITY AND METABOLISM OF S-1, 2- DICHLOROVINYL-GLUTATHIONE (DCV-GSH) AND CHLORAL (CH) BY HUMAN PROXIMAL TUBULE CELLS (HPTC) IN CULTURE. E. A. Lock, L. Tolliver-Ho and R. G. Schnellmann. Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC. #2131 PROTEOMIC CHARACTERIZATION OF THE EFFECTS OF A KINASE INHIBITOR ON PROTEIN EXPRESSION IN RAT KIDNEY. J. Leonard 1 , M. Courcol 1 , E. Boitier 1 , M. Duchesne 2 , F. Parker 2 , Z. Jayyosi 3 , R. A. Roberts 1,4 and J. Gautier 1 . 1 Drug Safety Evaluation, Sanofi Aventis, Vitry-sur- Seine, France, 2 Functional Genomics, Sanofi Aventis, Vitry-sur-Seine, France, 3 Drug Safety Evaluation, Sanofi Aventis, Bridgewater, NJ and 4 Safety Assessment (current address), Astra Zeneca, Alderley Park, United Kingdom. #2132 REGULATION OF GRP78 IN THE GLOMERULAR MESANGIAL CELL STRESS RESPONSE. A. Nanez 1,2 , H. Falahatpisheh 1,2 , Y. Qian 3 , E. Tiffany-Castiglioni 3 and K. S. Ramos 1,2 . 1 Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, 2 Center for Genetics and Molecular Medicine, University of Louisville, Louiville, KY and 3 Department of Veterinary Anatomy & Public Health, Texas A&M University, College Station, TX. #2133 REDUCTION OF CYCLOSPORIN A NEPHROTOXICITY BY GADOLINIUM CHLORIDE. Z. Zhong and J. Sun. Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC. Sponsor: J. Lemasters. #2134 THE EFFECT OF S-ADENOSYL-L-METHIONINE (SAME) AND ASCORBIC ACID ON P- AMINOPHENOL TOXICITY IN RENAL SLICES. M. Valentovic, R. Harmon and D. Hoover. Pharmacology, Marshall University School of Medicine, Huntington, WV. 212 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #2135 HUMAN PRECISION-CUT KIDNEY-CORTEX SLICES AS A TOXICOLOGY MODEL FOR EVALUATING THE HYPERAMMONEMIC EFFECT OF VALPROATE: A CARBON 13 NMR STUDY. G. Baverel, A. Vittorelli, C. Gauthier, C. Michoudet and G. Martin. Metabolic and Renal Pathophysiology, INSERM U499, Lyon Cedex 08, France. Sponsor: J. Descotes. #2136 UTILITY OF A SUBCLINICAL RENAL INJURY MODEL IN RATS FOR DETECTION OF INCREASED SENSITIVITY TO SITE-SPECIFIC NEPHROTOXIC METALS. E. F. Madden, R. P. Brown and P. L. Goering. Center for Devices and Radiological Health, U.S. FDA, Silver Spring, MD. #2137 PREPLACED RENAL CELL DIVISION IS THE CRITICAL MECHANISM OF PROTECTION IN MICE AGAINST S-1, 2-DICHLOROVINYL-L- CYSTEINE-INDUCED ACUTE RENAL FAILURE AND DEATH. M. C. Korrapati 1 , J. Chilakapati 1 , E. A. Lock 2 , J. Latendresse 3 , A. Warbritton 3 and H. M. Mehendale 1 . 1 ULM, Monroe, LA, 2 MUSC, Charleston, SC and 3 NCTR, Jefferson, AR. #2138 INHIBITION OF TISSUE REPAIR LEADS TO PROGRESSION OF INJURY, ACUTE RENAL FAILURE AND DEATH IN MICE. R. N. Reddy and H. M. Mehendale. Toxciology, University of Lousiana Monroe, Monroe, LA. #2139 ROLE OF LOWER PROGRESSION OF DCVC- INITIATED RENAL INJURY IN DIABETES- INDUCED PROTECTION FROM NEPHROTOXICITY. A. V. Dnyanmote 1 , H. M. Mehendale 1 , E. A. Lock 2 and J. R. Latendresse 3 . 1 Toxicology, University of Louisiana at Monroe, Monroe, LA, 2 Pharmaceutical Sciences, MUSC, Charleston, SC and 3 Pathology Associates Intl., NCTR, Jefferson, AR. #2140 TISSUE DISTRIBUTION AND RENAL ONTOGENY OF ORGANIC CATION TRANSPORTERS IN MICE. Y. M. Alnouti, J. S. Petrick, T. R. Knight and C. D. Klaassen. University of Kansas Medical Center, Kansas City, KS. #2141 DIETARY MODULATION OF THE RENAL TOXICITY OF P-NONYLPHENOL (NP) IN SPRAGUE-DAWLEY RATS. S. Cooper 1 , X. Fu 1 , J. R. Latendresse 2 and K. B. Delclos 1 . 1 NCTR, Jefferson, AR and 2 Charles River Laboratories, Jefferson, AR. #2142 ETIOLOGY OF HYDRONEPHROSIS WITHOUT OBSTRUCTION IN THE MOUSE KIDNEY BY LACTATIONAL EXPOSURE TO DIOXIN. N. Nishimura 1 , J. Yonemoto 1 , Y. Takeuchi 1 , C. Yokoi 1 , H. Nishimura 3 and C. Tohyama 2 . 1 Endocrine Disruptors and Dioxin Project, National Institute for Environmental Studiess and Dioxin Project, Tsukuba, Japan, 2 Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan and Thursday Morning, March 10 8:30 AM to 11:30 AM La Louisiane Ballroom B POSTER SESSION: PESTICIDES Chairperson(s): Derek Gammon, CAL-EPA, Sacramento, CA and Kevin Crofton, U.S. EPA, Research Triangle Park, NC. Displayed: 8:30 AM–11:30 AM Attended: 10:00 AM–11:30 AM #2143 EFFECTS OF CONAZOLE FUNGICIDES ON DEVELOPMENT AND PARTURITION IN THE RAT. M. G. Narotsky 1 , J. C. Rockett 1 , C. R. Blystone 2 , A. K. Goetz 2 , H. Ren 1 , D. S. Best 1 , H. P. Nichols 1 , J. E. Schmid 1 and D. J. Dix 1 . 1 Reproductive Toxicology Division, U.S. EPA, ORD, NHEERL, Research Triangle Park, NC and 2 Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC. #2144 TRIADIMEFON INDUCES RAT THYROID TUMORS THROUGH A NON-TSH MEDIATED MODE OF ACTION. D. C. Wolf 1 , J. Allen 1 , G. Sun 1 , J. R. Thibodeaux 2 , M. George 1 , S. D. Hester 1 , S. Thai 1 , D. Delker 1 , G. Nelson 1 , E. Winkfield 1 , B. Roop 1 , S. Leavitt 1 , W. Ward 1 and S. C. Nesnow 1 . 1 Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC and 2 Reproductive Toxicology Division, U.S. EPA, Research Triangle Park, NC. #2145 MYCLOBUTANIL AND TRIADIMEFON METABOLISM BY RAT CYP ISOFORMS AND LIVER MICROSOMES. J. Tang 1 , Y. Sey 2 , R. Murrel 3 , J. Rockett 4 , D. Dix 4 and H. Barton 2 . 1 Curriculum in Toxicology, UNC-Chapel Hill, Chapel Hill, NC, 2 Experimental Toxicology Division, U.S. EPA NHEERL, Research Triangle Park, NC, 3 Department of Environmental and Molecular Toxicology, NC State University, Raleigh, NC and 4 Reproductive Toxicology Division, U.S. EPA NHEERL, Research Triangle Park, NC. #2146 COMPARATIVE LIVER P450 ENZYME ACTIVITY AND HISTOPATHOLOGY IN MICE TREATED WITH THE CONAZOLE FUNGICIDES: MYCLOBUTANIL, PROPICONAZOLE AND TRIADIMEFON. J. Allen, D. C. Wolf, M. George, S. D. Hester, G. Sun, S. Thai, D. Delker, G. Nelson, E. Winkfield, B. Roop, S. Leavitt, W. Ward and S. C. Nesnow. Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC. 3 Aichi Mizuho University, Toyota, Japan. #2147 COMPARISON OF HEPATIC GENE EXPRESSION PROFILES FROM MICE EXPOSED TO THREE TOXICOLOGICALLY DIFFERENT CONAZOLES. W. Ward, S. D. Hester, S. Thai, J. Allen, C. Jones, D. C. Wolf and S. Nesnow. Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC. THURSDAY up-to-date information at www.toxicology.org 213
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Itinerary Planner Computer Stations
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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