Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #459 THE INCREASE IN TOTAL IGE IN SERUM OF FEMALE MICE AFTER INTRANASAL EXPOSURE OF CARBON BLACK PARTICLES WITH POLLEN. K. Kobayashi 1 , K. Itoh 1 , Y. Inoue 1 , Y. Kudo 1 , M. Tsunoda 1 , T. Satoh 1 , C. Yashiro 2 , Y. Sugita-Konishi 2 and Y. Aizawa 1 . 1 Preventive Medicine and Public Health, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan and 2 Division of Microbiology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan. #460 DIESEL AND HARDWOOD SMOKE EMISSIONS DIFFERENTIALLY AFFECT CLEARANCE AND INFLAMMATION OF INTRATRACHEALLY INSTILLED PSEUDOMONAS AERUGINOSA. M. Reed 1 and K. S. Harrod 2 . 1 Toxicology, Lovelace Respiratory Research Institute, Albuquerque, NM and 2 Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM. Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall #465 PHARMACOLOGY AND TOLERABILITY OF INS50589, A REVERSIBLE P2Y 12 RECEPTOR ANTAGONIST WITH ANTI-PLATELET AGGREGATION ACTIVITY, ADMINISTERED BY CONTINUOUS INTRAVENOUS INFUSION IN RATS AND DOGS. M. S. Cowlen, C. S. Crean, R. Krishnamoorthy, P. S. Watson, J. L. Boyer, W. M. Peterson and S. A. Anderson. Inspire, Durham, NC. #466 RANGE-FINDING TOXICITY STUDIES WITH SQ109, AN ANTI-TUBERCULAR AGENT, IN RATS AND DOGS. E. Glaze 1 , Y. Chen 2 , L. Alex 2 , R. Morrissey 3 , L. Jia 1 , P. Noker 4 and J. Tomaszewski 1 . 1 2 NIH, Rockville, MD, University of Illinois, Chicago, IL, 3 Pathology Associates, Chicago, IL and 4 Southern Research Institute, Birmingham, AL. #467 SAFETY ASSESSMENT OF A NOVEL P38 INHIBITOR IN CYNOMOLGUS MONKEYS FOLLOWING DAILY ORAL DOSING. S. L. Wild 1 , T. Pabst Marra 1 , G. Jang 1 , W. Min 1 , R. House 3 , A. Mould 2 and M. Cosenza 1 . 1 Amgen Inc., Thousand Oaks, CA, 2 Covance Laboratories Inc., Madison, WI and 3 DynPort Vaccine Company LLC, Frederick, MD. POSTER SESSION: PHARMACEUTICALS-GENERAL Chairperson(s): Mary Moslem, University of Texas, Galveston, TX. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #461 SAFETY EVALUATION OF AEROSOLIZED CYCLOSPORINE IN RATS AND DOGS. T. Wang 1 , R. Steigerwalt 1 , M. Lynch 2 , R. Kovelesky 1 , C. Rodriguez 1 and K. Sprugel 1 . 1 Drug Assessment and Development, Chiron Corporation, Emeryville, CA and 2 Toxicology, Battelle, Columbus, OH. #462 TOXICITY OF A SELECTIVE INHIBITOR OF LCK IS DUE TO INHIBITION OF LCK AND IS NOT CHEMOTYPE-RELATED. R. F. Stachlewitz 1 , A. J. Schwartz 1 , B. Bettencourt 1 , J. Syed 1 , D. Conlon 1 , J. E. Erickson 1 , E. O’Connor 1 , D. J. Calderwood 2 and G. C. Hirst 2 . 1 Discovery Safety, Metabolism & Pharmacokinetics, Abbott Bioresearch Center, Abbott Laboratories, Worcester, MA and 2 Chemistry, Abbott Bioresearch Center, Abbott Laboratories, Worcester, MA. #463 THE IMMUNOHISTOCHEMICAL EXPRESSION OF UROPLAKIN III IN RAT BLADDER TISSUE. S. Grainger. Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: D. Everett. #464 BORTEZOMIB (VELCADE®) DOES NOT INDUCE THE FORMATION OF PROTEINASE K- RESISTANT PRION PROTEIN IN MURINE AND HUMAN NEURONAL CELL LINES IN VITRO. V. G. Sasseville 1 , A. Raczynski 1 , V. Csizmadia 1 , W. Riordan 1 , J. Ironside 2 , M. Rolfe 1 and P. Bouchard 1 . 1 Millennium Pharmaceuticals, Inc., Cambridge, MA and 2 University of Edinburgh, Edinburgh, United Kingdom. Sponsor: C. Alden. #468 CYTOFLAVINE REDUCES HYPOXIA CAUSED BY SEVERE ALCOHOLIC INTOXICATION AND MILD HEAD TRAUMA. A. D. Tsivinsky 1,3 , B. V. Batotsyrenov 2 , T. N. Savateeva 1 , V. E. Marusanov 3 and A. L. Kovalenko 1 . 1 Institute of Toxicology, St.Petersburg, Russian Federation, 2 Regional Poison Center, St.Petersburg, Russian Federation and 3 Postgraduate Medical Academy, St.Petersburg, Russian Federation. Sponsor: J. Waksman. #469 TEMPO ATTENUATION OF DICLOFENAC ADDUCTION AND ENTEROPATHY. L. Kaphalia 1 , J. F. Aronson 1 , K. A. Nethery 1 and M. Treinen Moslen 1,2 . 1 Pathology, University of Texas Medical Branch, Galveston, TX and 2 Internal Medicine, University of Texas Medical Branch, Galveston, TX. #470 ENDOSCOPY STUDY OF THE GASTROINTESTINAL TOLERANCE OF STRONTIUM RANELATE IN CYNOMOLGUS MONKEYS. C. Fisch 1 , M. Attia 1 , F. Dargent 1 , S. de Jouffrey 1 , I. Dupin-Roger 2 and J. Claude 3 . 1 CIT, Evreux, France, 2 Laboratoires Servier, Courbevoie, France and 3 Paris V University, Paris, France. #471 TC 1734-112: PRECLINICAL SAFETY ASSESSMENT OF A SELECTIVE α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST. V. M. Traina, G. J. Gatto and M. Bencherif. Toxicology, Targacept, Inc., Winston-Salem, NC. #472 OPIOIDS: OCCUPATIONAL CONTACT DERMATITIS AND THE LOCAL LYMPH NODE ASSAY (LLNA). M. J. Olson 1 , F. J. Guerriero 2 , M. Cunningham-Hill 2 and N. Tapscott 2 . 1 GlaxoSmithKline, Research Triangle Park, NC and 2 GlaxoSmithKline, Philadelphia, PA. 82 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #473 USE OF NALTREXONE TO PREVENT ADVERSE EFFECTS OF SUFENTANIL IN BEAGLE DOGS. M. Soloviev 1 , M. J. Taylor 2 , T. R. Edwards 1 , J. Culwell 2 , C. R. Rampersand 2 , J. A. Felice 2 , D. Argonza 2 , M. Calimlin 2 , R. Ordonio 2 , R. Afan 2 , T. J. Siacotos 2 and G. J. Schaefer 1 . 1 WIL Research Laboratories, Ashland, OH and 2 Durect Corporation, Cupertino, CA. #474 FLORIDA RED TIDES: MOLECULAR THERAPEUTICS FROM A SEA OF RED. D. Baden 1 , A. J. Bourdelais 1 and W. Abraham 2 . 1 Center for Marine Science, UNCW, Wilmington, NC and 2 Division of Research, Mt Sinai Medical Center, Miami Beach, FL. #475 EFFICACY OF PIROXICAM IN ALLEVIATING TETRACYCLINE-INDUCED MUSCLE DAMAGE. J. Jahun 1 and H. M. Lantum 2 . 1 Faculty of Vet. Medicine, Amadou Bello University, Zaria, Nigeria and 2 African Society for Toxicological Sciences (ASTS), Rochester, NY. Monday Afternoon, March 7 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: SAFETY EVALUATION-EVALUATION OF METHODS IN VITRO/IN VIVO Chairperson(s): Albert Li, Advanced Pharmaceutical Sciences Inc., Columbia, MD. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #476 THE EFFECTS OF CONTINUOUS INTRAVENOUS INFUSION OF SALINE ON BODY WEIGHT GAIN, FOOD INTAKE AND CLINICAL PATHOLOGY IN THE GÖTTINGEN MINI PIG. M. Mus and C. Copeman. IPN, CTBR Bio- Research Inc., Senneville, QC, Canada. Sponsor: M. Vezina. #477 BACKGROUND INCIDENCE OF EXPERIMENTAL DESIGN-RELATED EVENTS ON INTRAVENOUS INFUSION STUDIES. C. Copeman and M. Vezina. IPN, CTBR Bio-Research Inc., Senneville, QC, Canada. #478 VALIDATION OF A NEWLY INVENTED PORT CATHETER SYSTEM FOR CONTINUOUS INFUSION STUDIES. P. Nowak, S. Korte, F. Vogel and W. Mueller. Covance Laboratories GmbH, 48163 Muenster, Germany. Sponsor: G. Weinbauer. #479 CONTINUOUS SUBCUTANEOUS INFUSION IN RODENTS AND NON RODENTS. M. Stilianesis, S. Groom and C. Copeman. Toxicology, CTBR, Senneville, QC, Canada. Sponsor: M. Vezina. #480 A METHOD FOR LONG-TERM CONTINUOUS SUBCUTANEOUS INFUSION IN RATS AND DOGS. G. Washer, S. Jerat, M. Landry, S. Vachon, N. Galliard, J. Laliberte, P. Ha and J. Hooson. ITR Laboratories Canada Inc., Baie d’Urfe, QC, Canada. #481 SUCCESSFULL PREVALIDATION OF AN IN VITRO RECONSTITUTED HUMAN CORNEA MODEL TO ASSESS THE EYE IRRITATING POTENTIAL OF CHEMICALS. B. De Wever 1 , F. Van Goethem 2 , F. Straube 3 , N. Alepee 4 and E. Adriaens 5 . 1 SkinEthic Laboratories, Nice, France, 2 Johnson & Johnson Pharmaceutical R&D, Beerse, Belgium, 3 Novartis Pharmacology, Basel, Switzerland, 4 5 Pfizer Global R&D, Amboise, France and University of Ghent, Ghent, Belgium. #482 IN VITRO SKIN IRRITATION : STRONG REPRODUCIBILITY FOR 50 CHEMICALS TESTED ON THE SKINETHIC RECONSTITUTED HUMAN EPIDERMAL MODEL. B. De Wever 1 , C. Tornier 1 , H. Maibach 2 , E. Adriaens 3 and M. Rosdy 1 . 1 SkinEthic Laboratories, Nice, France, 2 University Center of San Francisco, San Francisco, CA and 3 University of Ghent, Ghent, Belgium. #483 DETERMINATION OF THE DOSE-RESPONSE RELATIONSHIP FOR SURFACTANTS USING THE BCOP. S. Yan and E. Choudhury. Limited Brands, Paramus, NJ. #484 EVALUATION OF A SOLUBILITY PROTOCOL FOR IN VITRO CYTOTOXICITY TESTING. J. Strickland 1,2 , M. Paris 1,2 , W. Stokes 1 , S. Casati 3 , R. Tice 1,2 , H. Raabe 4 , C. Cao 5 , R. Clothier 6 , J. Harbell 4 , G. Mun 4 , A. Sizemore 4 , G. Moyer 4 , J. Madren-Whalley 4 , C. Krishna 5 , M. Owen 6 , N. Borne 6 , M. Wenk 7 and M. Vallant 8 . 1 NICEATM, NIEHS, Research Triangle Park, NC, 2 ILS, Inc., Research Triangle Park, NC, 3 JRC, ECVAM, Ispra, Italy, 4 IIVS, Gaithersburg, MD, 5 ECBC, USArmy, Aberdeen Proving Ground, MD, 6 University of Nottingham, Nottingham, United Kingdom, 7 8 BioReliance, Rockville, MD and NIEHS, Research Triangle Park, NC. #485 INTEGRATED DISCRETE MULTIPLE ORGAN CULTURE: A NOVEL IN VITRO EXPERIMENTAL SYSTEM FOR TOXICITY STUDIES. A. P. LI 1,3 , Y. Sakai 1 and C. Bode 2 . 1 Advanced Pharmaceutical Sciences, Inc., Columbia, MD, 2 Tissue Transformation Technologies, Inc., Edison, NJ and 3 The ADMET Group LLC, Rockville, MD. #486 EFFECTS OF NANOSPHERES ON THE ADHESION AND CELL VIABILITY OF ASTROCYTES. C. Au 1 , L. Mutkus 2 , A. Dobson 2 , J. Riffle 3 , J. Lallli 3 , R. Claus 3 and M. Aschner 1 . 1 Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 2 Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC and 3 NanoSonic Inc., Blacksburg, VA. #487 IN VITRO MODEL OF PENETRATION AND ACTIVE DECONTAMINATION OF A CORROSIVE. L. MATHIEU 1 , C. Godard 1 , H. Coudouel 1 and A. H. Hall 2 . 1 Scientific Researches, Prevor, Talence, France and 2 Scientific communications, TCMTS Inc., Elk Mountain, WY. #488 TESTING CASCADE TO PREDICT THE POTENTIAL OF DRUG DISCOVERY COMPOUNDS TO INDUCE MITOCHONDRIAL DYSFUNCTION. L. D. Marroquin, G. J. Stevens and Y. Will. Safety Sciences, Pfizer, San Diego, CA. MONDAY up-to-date information at www.toxicology.org 83
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Program - Society of Toxicology

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