Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1347 9:10 IMMUNOGENICITY AND SAFETY TESTING OF VACCINES: A REGULATORY PERSPECTIVE ON GENERAL REQUIREMENTS AND SPECIAL ISSUES OF THE RESPIRATORY TRACT. K. L. Hastings. Office of New Drugs, CDER, U.S. FDA, Rockville, MD. #1348 9:35 UNIQUE ISSUES ASSOCIATED WITH TOXICOLOGY ASSESSMENT OF VACCINES FOR BIOWARFARE AGENTS. R. House. Dynport Vaccine Company, Frederick, MD. #1349 10:00 WHO SPONSORED PRECLINICAL TOXICITY TESTS FOR INHALED MEASLES VACCINE. M. Papania. Centers for Disease Control and Prevention, Atlanta, GA. Sponsor: M. Reed. #1350 10:25 NONCLINICAL SAFETY EVALUATION OF TLR4 AGONISTS ADMINISTERED BY NASAL SPRAY. C. M. Lynch. Nonclinical Development, Corixa Corporation, Seattle, WA. Sponsor: M. Reed. Wednesday Morning, March 9 8:30 AM to 11:30 AM Room RO3 WORKSHOP SESSION: TOXICOLOGICAL RESEARCH AND TESTING: BEST PRACTICES AND OPPORTUNITIES FOR LABORATORY ANIMAL REFINEMENT, REDUCTION, AND REPLACEMENT Chairperson(s): Stephen Lasley, University of Illinois College of Medicine, Peoria, IL and William Stokes, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Endorsed by: Animals in Research* Risk Assessment SS In the performance of toxicology studies, whether for purposes of product safety testing or identifying mechanisms of toxicant action, it is becoming increasingly important to adopt practices and approaches that refine, reduce, and replace the numbers of laboratory animals utilized. Incorporation of best practices into studies will help ensure that animals are used in the most humane and judicious manner consistent with successful attainment of the research or testing objectives. Adoption of these practices is of timely importance because of continually increasing regulatory oversight of animal care and use, and thus consideration of these issues from different viewpoints is of broad interest to toxicologists. Best practices for regulatory testing involves careful consideration and appropriate incorporation of in vitro methods, humane endpoints, and tiered testing strategies (Stokes). Current best practices for housing and providing environmental enrichment for study animals should be consistently utilized, and factors considered that might potentially influence study outcomes (Brown). GLP requirements for pre-clinical safety studies are important factors to address, and optimal animal welfare practices consistent with compliance must be ensured (McCormack). Application of toxicogenomics to pre-clinical safety studies involving animals is an emerging concern, and potential opportunities for these methodologies to refine, reduce, and replace animal use are being developed (Schechtman). Finally, updating of European Union animal welfare laws continue to evolve, and their potential impact on harmonization of animal care programs and toxicological research is a relevant concern to multinational companies (Donovan). #1351 8:30 TOXICOLOGICAL RESEARCH AND TESTING: BEST PRACTICES AND OPPORTUNITIES FOR LABORATORY ANIMAL REFINEMENT, REDUCTION, AND REPLACEMENT. S. M. Lasley 1 and W. S. Stokes 2 . 1 Department of Pharmacology, University of Illinois College of Medicine, Peoria, IL and 2 NICEATM, NIEHS/NIH/DHHS, Research Triangle Park, NC. #1352 8:35 BEST PRACTICES FOR USING HUMANE ENDPOINTS AND TIERED TESTING STRATEGIES TO REFINE, REDUCE, AND REPLACE ANIMAL USE IN TOXICOLOGICAL RESEARCH AND TESTING. W. S. Stokes. NICEATM, NIEHS/NIH/DHHS, Research Triangle Park, NC. #1353 9:05 BEST PRACTICES FOR ENVIRONMENTAL ENRICHMENT AND HOUSING FOR LABORATORY ANIMALS USED IN TOXICOLOGICAL RESEARCH AND TESTING. M. J. Brown. Charles River Laboratories, East Thetford, VT. Sponsor: S. Lasley. #1354 9:35 BALANCING ANIMAL WELFARE AND GLP COMPLIANCE IN NONCLINICAL LABORATORY SAFETY STUDIES. J. F. McCormack. Office of Regulatory Affairs, US Food and Drug Administration, Rockville, MD. Sponsor: W. stokes. #1355 10:05 APPLICATION OF TOXICOGENOMICS TO PRE- CLINICAL SAFETY TESTING: VALIDATION CONSIDERATIONS FOR POTENTIAL LABORATORY ANIMAL REFINEMENT, REDUCTION, AND REPLACEMENT. L. M. Schechtman. FDA/NCTR, Rockville, MD. #1356 10:35 REVISIONS TO EUROPEAN ANIMAL WELFARE LEGISLATION: IMPACT ON ANIMAL CARE AND TOXICOLOGY STUDIES. J. C. Donovan. BioResources, Wyeth Research, Collegeville, PA. Sponsor: S. Lasley. Wednesday Morning, March 9 8:30 AM to 11:30 AM Room 220 PLATFORM SESSION: AH RECEPTOR Chairperson(s): Mark Hahn, Woods Hole Oceanographic Institute, Woods Hole, MA and Richard Pollenz, University of South Florida, Tampa, FL. #1357 8:30 THE ROLE OF THE COOH-TERMINAL TRANSACTIVATION DOMAIN OF THE MOUSE AH RECEPTOR IN LIGAND-DEPENDENT AND INDEPENDENT DEGRADATION. R. S. Pollenz and J. Popat. Biology, University of South Florida, Tampa, FL. #1358 8:50 KINETIC STUDIES OF ARYL HYDROCARBON RECEPTOR ACTIVATION BY INDOLO[3, 2- B]CARBAZOLES, INDIGOS AND 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN IN HUMAN HEPG2 CELLS. A. Rannug 1 , S. Pettersson 1 , L. Poellinger 2 and M. Backlund 1,2 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and 2 Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. 154 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1359 9:10 DRE BINDING IS NOT REQUIRED FOR REPRESSION OF AHR SIGNALING BY AHRR. B. R. Evans 1,2 , L. L. Allan 3,4 , D. H. Sherr 3 and M. E. Hahn 1 . 1 Biology, Woods Hole Oceanographic Institution, Woods Hole, MA, 2 Biology, Boston University, Boston, MA, 3 Environmental Health, Boston University School of Public Health, Boston, MA and 4 Microbiology, Boston University School of Medicine, Boston, MA. #1360 9:30 ERK KINASE ACTIVITY CONTRIBUTES TO AH RECEPTOR TARGETED PROTEIN DEGRADATION AND TRANSCRIPTIONAL POTENTIAL. S. CHEN and R. H. Tukey. Laboratory of Environmental Toxicology, Departments of Chemistry & Biochemistry and Pharmacology, University of California, San Diego, La Jolla, CA. #1361 9:50 INVOLVEMENT OF KINASE SIGNALING PATHWAYS IN AH-RECEPTOR MEDIATED GENE EXPRESSION IN RAT LIVER CELLS. B. V. Madhukar 1 , G. Chen 1 , C. Sorrentino 2 and M. S. Denison 2 . 1 Pediatrics/Human Development, Michigan State University, East Lansing, MI and 2 Environmental Toxicology, University of California at Davis, Davis, CA. #1362 10:10 ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR ALTERS IN VIVO HEPATOCYTE PROLIFERATION. K. A. Mitchell 1 , S. A. Hattenbach 2 and C. J. Elferink 1 . 1 Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX and 2 UTMB Summer Undergraduate Research Program, University of Houston-Downtown, Houston, TX. #1363 10:30 TEMPORAL AND DOSE-DEPENDENT HEPATIC GENE EXPRESSION PATTERNS IN MICE PROVIDE NEW INSIGHTS INTO TCDD- MEDIATED HEPATOTOXICITY. D. R. Boverhof, L. D. Burgoon, C. Tashiro, B. Chittim, J. R. Harkema and T. R. Zacharewski. Biochemistry & Molecular Biology, National Food Safety & Toxicology Center, and Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #1364 10:50 EXPRESSION OF DOMINANT NEGATIVE N- CADHERIN RESULTS IN AHR-DEPENDENT GENE INDUCTION IN HEPA 1C1C7 WILD-TYPE CELLS. L. M. Van Pay 1 and B. Allen-Hoffmann 1,2 . 1 Molecular and Environmental Toxicology, University of Wisconsin, Madison, WI and 2 Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI. #1365 11:10 ERα IS A LIGAND-DEPENDENT MODULATOR OF AHR TRANSCRIPTION: INTERPLAY BETWEEN THE TWO RECEPTOR SYSTEMS. J. Matthews, B. Whilen and J. Gustafsson. Department of Biosciences, Karolinska Institute, Huddinge, Sweden. Wednesday Morning, March 9 8:30 AM to 11:30 AM Room RO1 PLATFORM SESSION: FEMALE AND MALE REPRODUCTIVE SYSTEMS Chairperson(s): Kimberly Miller, University of Maryland, Baltimore, MD and Wendy Jefferson, NIEHS, Research Triangle Park, NC. #1366 8:30 THERAPEUTIC CONCENTRATIONS OF HALOPERIDOL DO NOT DIRECTLY AFFECT OVARIAN FUNCTION AND OOCYTE QUALITY AS TESTED IN MOUSE OVARIAN FOLLICLE CULTURE MODEL. R. Cortvrindt 1,2 , E. Gobbers 1 , V. Van Merris 1 and J. Smitz 1 . 1 EggCentris NV, Zellik, Belgium and 2 Follicle Biology Laboratory, Vrije Universiteit Brussel, Brussels, Belgium. Sponsor: G. Daston. #1367 8:50 BCL-2 FAMILY MEMBERS PROTECT AGAINST METHOXYCHLOR-INDUCED TOXICITY OF MOUSE OVARIAN ANTRAL FOLLICLES IN VITRO. K. P. Miller 1 , C. Greenfeld 2 and J. A. Flaws 1 . 1 Program in Toxicology, University of Maryland-School of Medicine, Baltimore, MD and 2 Department of Physiology, University of Maryland-School of Medicine, Baltimore, MD. #1368 9:10 REVERSAL OF BENZO-A-PYRENE EFFECTS ON OXYTOCIN-INDUCED CA 2+ OSCILLATIONS IN HUMAN MYOMETRIAL PHM1-41 CELLS. R. Barhoumi, I. Awooda, S. Safe and R. C. Burghardt. Faculty of Toxicology, Texas A&M University, College Station, TX. #1369 9:30 EFFECTS OF ATRAZINE AND AN ATRAZINE METABOLITE MIXTURE ON DIFFERENTIATED MAMMARY EPITHELIAL CELL MILK PROTEIN PRODUCTION IN CULTURE. E. P. Hines, R. Barbee, M. Blanton, M. S. Pooler and S. E. Fenton. Reproductive Toxicology Division, U.S. EPA, ORD, NHEERL, Research Triangle Park, NC. #1370 9:50 NEONATAL EXPOSURE TO THE PHYTOESTROGEN GENISTEIN ALTERS REPRODUCTION IN FEMALE CD-1 MICE. W. Jefferson 1,2 , E. Padilla-Bank 1 and R. Newbold 1 . 1 Laboratory of Molecular Toxicology, NIEHS, NIH/DHHS, Research Triangle Park, NC and 2 Molecular and Environmental Toxicology Department, North Carolina State University, Raleigh, NC. #1371 10:10 ESTROGEN-INDUCED PATTERN OF GENE EXPRESSION AT HIGH AND LOW DOSES IN FETAL MALE RAT TESTIS. J. M. Naciff, K. M. Hess, J. E. Maritnez, G. J. Overmann, L. M. Foertsch, S. M. Torontali, G. J. Carr, J. P. Tiesman and G. P. Daston. Procter & Gamble Company, Cincinnati, OH. #1372 10:30 LOW DOSE CELLULAR RESPONSES IN THE FETAL RAT TESTIS IN UTERO EXPOSED TO DI (N-BUTYL) PHTHALATE. E. Kleymenova, C. Swanson and K. W. Gaido. CIIT CHR, Research Triangle Park, NC. WEDNESDAY up-to-date information at www.toxicology.org 155
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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