Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY 1:15 PM–2:45 PM Workshop Session II (break out rooms) 2:45 PM–3:15 PM Paracelsus in Practice (Room 213) Moderator: David Cragin, Merck and Company, Inc., Whitehouse Station, NJ. 3:15 PM–3:30 PM Program Conclusion and Evaluation Kenneth McMartin, LSU Health Science Center, Shreveport, LA. 3:30 PM–4:30 PM Visit ToxExpo Tuesday Morning, March 8 8:30 AM to 9:30 AM Room 223 INFORMATIONAL SESSION: THE ROSETTA RESOLVER® SYSTEM: AN ENTERPRISE SOLUTION FOR GENE EXPRESSION ANALYSIS AND PREDICTIVE TOXICOLOGY The Rosetta Resolver® System, an enterprise gene expression analysis solution, is a cornerstone in drug discovery for routinely processing and managing data from thousands of high-density microarrays. This presentation will focus on the current challenges of toxicogenomics data analysis in drug development, and how the use of the Resolver system addresses those challenges. Tuesday Morning, March 8 8:30 AM to 11:30 AM Room RO2 SYMPOSIUM SESSION: ALTERED IRON HOMEOSTASIS (AIH) AS A BASIS FOR PULMONARY IMMUNOTOXICOLOGIC EFFECTS OF PARTICULATE MATTER Chairperson(s): Mitch Cohen, New York University School of Medicine, Tuxedo, NY and Andrew Ghio, National Health & Environmental Effect Research Laboratory, Chapel Hill, NC. Endorsed by: Immunotoxicology SS* Inhalation Specialty Section Student Advisory Committee The scientific literature is replete with reports on the pulmonary toxicologic and immuno-toxicologic effects of particulate matter (PM). Although it has become increasingly accepted that the composition of PM is a major factor influencing biological effects, mechanisms to describe how composition might induce observed toxicities are mostly lacking. The altered iron homeostasis (AIH) theory postulates that specific components in PM induce alterations in the levels of free catalytically-active iron within the lungs as well as in iron availability to both lung epithelial and immune cells. These changes, in turn, impact upon local responses to infectious agents and allergens, as well as upon the release of cell products that might contribute to cardiopulmonary changes. The AIH theory not only provides a basis to explain how select PM constituents might induce these effects, but also how day-to-day or regional differences in the amounts of these components (relative to that of iron) may underlie the variability in reported health effects induced with equivalent doses of differing PM samples. Following introductory talks about the role of iron homeostasis in maintenance of immune cell functions and how components of PM may be selectively mobilized, this symposium will highlight specifically how AIH could be the basis for the observed alterations in allergic, immunologic, and cardiopulmonary responses after host exposures to PM. #636 8:30 ALTERED IRON HOMEOSTASIS (AIH) AS A BASIS FOR PULMONARY IMMUNOTOXICOLOGIC EFFECTS OF PARTICULATE MATTER. M. Cohen. Environmental Medicine, New York University, Tuxedo, NY. #637 8:35 THE ROLE OF IRON (FE) HOMEOSTASIS IN IMMUNE CELL FUNCTIONALITY. C. L. Bowlus. Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA. Sponsor: M. Cohen. #638 9:10 MOBILIZATION OF METALS FROM PARTICLES: IMMUNOTOXICOLOGIC IMPLICATIONS. A. E. Aust. Department of Chemistry and Biochemistry, Utah State University, Logan, UT. #639 9:45 METALS, PARTICLES AND IMPACT UPON PULMONARY ALLERGIC RESPONSES. M. Gilmour. National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, Durham, NC. #640 10:20 EFFECTS OF PARTICLES ON FE TRANSPORT AND THE IMMUNOTOXICOLOGIC OUTCOMES. A. J. Ghio. National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC. #641 10:55 DO ALTERED FE STATUS-INDUCED EFFECTS ON TRANSCRIPTION FACTORS HAVE A ROLE IN PM-INDUCED PULMONARY/CARDIOVASCULAR DISEASES? K. Salnikow. Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD. Tuesday Morning, March 8 8:30 AM to 11:30 AM Room 208 SYMPOSIUM SESSION: BEYOND LIVER TOXICOGENOMICS: GENE EXPRESSION BASED BIOMARKERS IN NON-HEPATIC TISSUES Chairperson(s): Kyle Kolaja, Iconix, Mountain View, CA and David J. Dix, National Health & Environmental Effects Research Laboratory, Research Triangle Park, NC. Endorsed by: Carcinogenesis SS Toxicologic and Exploratory Pathology SS Toxicogenomics, the genome scale analysis of chemically induced changes in complex populations of mRNA to understand toxicity, has already dramatically impacted predictive and mechanistic toxicology. Gene expression based biomarkers can provide a precise and rapid assessment of toxicity or exposure, but most toxicogenomics efforts to date have been conducted in liver due to toxicological interest, technical ease of data creation, relative homogeneity of tissue sample, and historical inertia. Recently analysis of gene expression data in nonhepatic organs and tissues has started to gain momentum, and this session will include presentations of significant and promising examples ranging from toxicogenomic analyses of vascular, cardiac, kidney, neural and reproductive tissues treated with various drugs, chemicals, and toxicants. From these burgeoning studies, researchers are identifying biomarkers predictive of toxicity and indicative of various mechanisms and pharmacology in non-hepatic tissues. #642 8:30 BEYOND LIVER TOXICOGENOMICS: GENE EXPRESSION BASED BIOMARKERS IN NON- HEPATIC TISSUES. K. L. Kolaja. Toxicology, Iconix Pharmaceuticals, Mountain View, CA. 98 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #643 8:35 MEASURING GENE EXPRESSION IN BLOOD VESSELS: THE CHALLENGES OF APPLYING TOXICOGENOMICS TO VASCULITIS. M. P. Lawton. Molecular and Investigative Toxicology, Pfizer, Inc., Groton, CT. #644 9:10 GENE EXPRESSION PROFILING TO IDENTIFY BIOMARKERS OF REPRODUCTIVE TOXICITY. D. J. Dix. Office of Research and Development, U.S. EPA, Research Triangle Park, NC. #645 9:45 EXPOSURE-INDUCED NEURODEGENERATION: A TOXICOGENOMICS CASE STUDY OF NEURONAL FUNCTION AND NEURODEGENERATIVE DISEASE. A. Brooks 1,2 , D. Cory-Slechta 3 , E. Richfeild 3 and M. Thiruchelvam 3 . 1 Environmental Medicine, Univeristy of Rochester Medical Center, Rochester, NY, 2 Functional Genomics Center, Univeristy of Rochester Medical Center, Rochester, NY and 3 Environmental and Occupational Medicine, UMDNJ, Piscataway, NJ. #646 10:20 GENE EXPRESSION-BASED BIOMARKERS OF CARDIAC AND RENAL PHARMACO- AND TOXICOGENOMICS. K. L. Kolaja. Chemogenomics and Toxicology, Iconix Pharmaceuticals, Mountain View, CA. #647 10:55 APPLICATION OF TOXICOGENOMICS BEYOND LIVER. Y. Yang, R. Ciurlionis, S. J. Abel, E. A. Blomme and J. F. Waring. R463, Abbott Laboratories, Abbott Park, IL. Tuesday Morning, March 8 8:30 AM to 11:30 AM La Louisiane Ballroom B SYMPOSIUM SESSION: EMERGING ISSUES IN RISK ASSESSMENT AND RISK PERCEPTION OF NANOMATERIALS Chairperson(s): Joyce S. Tsuji, Exponent Environmental Group Inc., Bellevue, WA and Annette B. Santamaria, Exponent, Houston, TX. Endorsed by: Inhalation SS Risk Assessment SS* Nanotechnology has been hailed as the new industrial revolution akin to silicon chip development in the last century. Nanomaterials are generally
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Author Index (Continued) 44 th Annu
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SOT Affiliates for 2005 44 th Annua
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Program - Society of Toxicology

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