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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1843 SMOOTH MUSCLE CELL MARKERS OF FENOLDOPAM INDUCED VASCULAR INJURY. D. Brott 1,2 , L. Foster-Brown 1 , E. Dubois 1 , H. Jones 3 , R. J. Richardson 2 and C. Louden 1,2 . 1 Global Safety Assessment, AstraZeneca Pharmaceuticals, Wilmington, DE, 2 Toxicology Program, EHS, The University of Michigan, Ann Arbor, MI and 3 Global Safety Assessment, AstraZeneca Pharmaceuticals, Alderley, United Kingdom. #1844 ACROLEIN-INDUCED DYSLIPIDEMIA IN MICE: A RISK FACTOR OF CARDIOVASCULAR DISEASE. D. J. Conklin 1 , R. Prough 2 , D. Clark 1 , B. Hill 1 , S. Srivastava 1 , S. Liu 1 and A. Bhatnagar 1,2 . 1 Cardiology, University of Louisville, Louisville, KY and 2 Biochemistry and Molecular Biology, University of Louisville, Louisville, KY. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: OXIDATIVE STRESS II Chairperson(s): Susan MacKenzie, DuPont Labs, Newark, DE and Timothy Phillips, University of Texas, College Station, TX. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1845 ATTENUATION OF HYPEROXIA-INDUCED RETINOPATHIES IN NEONATAL RATS BY RETINOIC ACID. X. I. Couroucli, L. Kong, Y. Wei, W. Jiang and B. Moorthy. Pediatrics, Baylor College of Medicine, Houston, TX. #1846 THE SUSCEPTIBILITY OF INBRED MOUSE STRAINS TO HYPEROXIA-INDUCED LUNG INJURY. G. S. Whitehead, K. G. Berman, L. H. Burch, W. Foster and D. A. Schwartz. Medicine, Duke University, Durham, NC. #1847 OXIDATION OF PURINE NUCLEOSIDES AND NUCLEOTIDES WITH DIMETHYLDIOXIRANE: STRUCTURAL CHARACTERIZATION OF REACTION PRODUCTS. L. M. Ball, D. E. Degen, W. Ye, Y. Li, R. Sangaiah and A. Gold. Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC. #1848 PI3-KINASE MEDIATED INDUCTION OF NRF-2 PROTEIN BY OXIDANTS IN CARDIOMYOCYTES. S. E. Purdom 1 and Q. M. Chen 2,1 . 1 Interdisciplinary Graduate Program in Genetics and Genomics, University of Arizona, Tucson, AZ and 2 Department of Pharmacology, University of Arizona, Tucson, AZ. #1849 HYPERGLYCEMIA-INDUCED OXIDATIVE STRESS ACTIVATES THE HEXOSAMINE PATHWAY AND INHIBITS MITOCHONDRIAL BIOGENESIS. C. M. Palmeira 1 , J. Berthiaume 2 , J. A. Bjork 2 , A. P. Rolo 1 and K. B. Wallace 2 . 1 Department of Zoology, University of Coimbra, Center for Neurosciences and Cell Biology, Coimbra, Portugal and 2 Department of Biochemistry & Molecular Biology, University of Minnesota, Medical School, Duluth, MN. #1850 HYDROQINONE, ρ-BENZOQUINONE, BUT NOT BENZENE OR PHENOL CAUSE AN INCREASE IN REACTIVE OXYGEN SPECIES IN HD3 CELLS. J. Wan 1 and L. M. Winn 1,2 . 1 Pharmacology and Toxicology, Queen’s University, Kingston, ON, Canada and 2 School of Environmental Studies, Queen’s University, Kingston, ON, Canada. #1851 MEASUREMENT OF OXIDATIVE STRESS USING KINETIC HIGH CONTENT CELL-BASED ASSAYS. V. Abraham and J. R. Haskins. Cellomics, Pittsburgh, PA. Sponsor: E. McGuire. #1852 ANALYSIS OF THE ROLE OF THE ANTIOXIDANT RESPONSE ELEMENT IN THE PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS. C. B. Rideaux, J. C. Kern, D. A. Johnson and J. A. Johnson. Univeristy of Wisconsin-Madison, Madison, WI. #1853 ORAL GLUTATHIONE RAPIDLY ELEVATES GLUTATHIONE LEVELS IN LUNG EPITHELIAL LINING FLUID AND LAVAGED CELLS. C. T. kariya 1 , H. Leitner 1 , E. Min 3 and B. J. Day 3,1,2 . 1 Molecular Toxicology and Environmental Health Sciences, UCHSC, Denver, CO, 2 Medicine, UCHSC, Denver, CO and 3 Medicine, National Jewish Medical and Research Center, Denver, CO. #1854 SELECTIVE ENHANCEMENT OF HYPEROXIC LUNG INJURY BY AUROTHIOGLUCOSE IN GLUTATHIONE-DEFICIENT MICE SUGGESTS CROSS-TALK BETWEEN THIOREDOXIN AND GLUTATHIONE SYSTEMS. S. E. Welty, L. K. Rogers, T. E. Tipple, T. N. Hansen and C. V. Smith. Center for Developmental Pharmacolcogy and Toxicology, Columbus Children’s Research Institute, Columbus, OH. #1855 PHENOTYPIC ANCHORING OF ACETAMINOPHEN-INDUCED OXIDATIVE STRESS AND GENE EXPRESSION PROFILES IN RAT LIVER. C. L. Powell 1,2 , P. Ross 2 , A. Heinloth 3 , G. Boorman 4 , M. Cunningham 4 , R. Paules 3 and I. Rusyn 1,2 . 1 Curriculum in Toxicology, UNC, Chapel Hill, NC, 2 Department Envr Science & Engr, UNC, Chapel Hill, NC, 3 NIEHS, National Center for Toxicogenomics, Research Triangle Park, NC and 4 NIEHS, Envr Toxicology Program, Research Triangle Park, NC. Sponsor: I. Rusyn. #1856 NEAR-INFRARED LIGHT TREATMENT IN A CELLULAR MODEL OF MITOCHONDRIAL DYSFUNCTION. K. DeSmet 1 , M. M. Henry 2 , E. Buchmann 3 , M. Connelly 3 , H. T. Whelan 3,1 and J. T. Eells 1,3,2 . 1 Health Sciences, University of Wisconsin- Milwaukee, Milwaukee, WI, 2 Ophthalmology, Medical College of Wisconsin, Milwaukee, WI and 3 Neurology, Medical College of Wisconsin, Milwaukee, WI. #1857 TOLL-LIKE RECEPTOR 4 (TLR4) CONTRIBUTES TO OZONE-INDUCED INCREASES IN COSTIMULATORY MOLECULE (CD86) EXPRESSION IN MICE. G. Backus 1,2 , A. K. Bauer 2 , H. Cho 2 and S. R. Kleeberger 2 . 1 Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC and 2 NIH/NIEHS, Research Triangle Park, NC. 190 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo #1858 ARSENIC TRIOXIDE INDUCED OXIDATIVE STRESS IN SPRAGUE-DAWLEY RATS. A. K. patlolla and P. B. Tchounwou. Biology, Jackson State University, Jackson, MS. #1859 EFFECT OF ACETAMINOPHEN ON CYTOSOLIC AND MITOCHONDRIAL GLUTATHIONE IN THE LIVERS OF WILD-TYPE, GCLM-HETEROZYGOUS, AND GCLM-NULL MICE. I. Mohar, L. A. McConnachie, C. Fernandez and T. J. Kavanagh. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. #1860 ANTIOXIDANT GENE EXPRESSION LEVELS IN BRAIN AREAS THAT ARE TARGETS OF 1, 3-DNB MEDIATED NEUROTOXICITY. T. R. Miller 1 and P. Venkatakrishnan 1 . 1 Graduate Center for Toxicology, University of Kentucky, Lexington, KY and 2 Graduate Center for Toxicology, University of Kentucky, Lexington, KY. #1861 ENHANCED RENAL TOXICITY OF FERRIC NITRILOTRIACETATE IN NRF2 DEFICIENT MICE. K. KANKI 1 , T. Umemura 1 , Y. Kitamura 1 , Y. Ishii 1 , Y. Kodama 2 , K. Itoh 3 , M. Yamamoto 3 , A. Nishikawa 1 and M. Hirose 1 . 1 Division of Pathology, National Institute of Health Sciences, Tokyo, Japan, 2 Division of Toxicology, National Institute of Health Sciences, Tokyo, Japan and 3 Graduate school of Comprehensive Human Sciences, Tsukuba University, Tsukuba, Japan. #1862 THE BIO-NANO INTERFACE: EXAMINING THE INTERACTIONS BETWEEN WATER SOLUBLE FULLERENES AND BIOLOGICAL MEMBRANES. C. M. Sayes 1 , J. Mendez 1 , K. D. Ausman 4 , J. L. West 2,4 , J. H. Hafner 3,4 and V. L. Colvin 1,4 . 1 Chemistry, Rice University, Houston, TX, 2 Bioengineering, Rice University, Houston, TX, 3 Physics and Astronomy, Rice University, Houston, TX and 4 Center for Biological and Environmental Nanotechnology, Rice University, Houston, TX. #1863 INVOLVEMENT OF REACTIVE OXYGEN FORMATION IN THE 3-HYDROXY-3- METHYLGLUTARYL-COA REDUCTASE INHIBITOR- INDUCED SKELETAL MUSCLE CELL DEATH. A. Wolf 1 , L. Ndountse-Tchapda 1 , U. Schramm 1 and W. E. Trommer 2 . 1 Biomarker Development, Novartis Pharmacology AG, Basel, Switzerland and 2 Department of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany. #1864 SURFACE ACTIVITY OF ERIONITE SAMPLES FROM DIFFERENT LOCALITIES. M. Gulumian 1,2 , M. Semano 1 and G. Hearne 3 . 1 Toxicology, NIOH, Johannesburg, Gauteng, South Africa, 2 Department of Haematology and Molecular Medicine, University of the Witwatersrand, Johannesburg, Gauteng, South Africa and 3 Department of Physics, University of the Witwatersrand, Johannesburg, Gauteng, South Africa. Sponsor: M. Karol. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: IMMUNOTOXICOLOGY IN VITRO/MECHANISMS Chairperson(s): Norbert Kaminski, Michigan State University, Pharmacology and Toxicology, East Lansing, MI and Brian Freed, University of Colorado, Clinical Immunology Laboratory, Denver, CO. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1865 IDENTIFICATION OF NF-κB MODIFICATIONS GENERATED BY CIGARETTE SMOKE ALDEHYDES. C. Lambert, J. Li, M. Portas, S. Lazis, M. Quintana, J. McCue and B. M. Freed. Allergy and Clinical Immunology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO. #1866 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) INDUCES THE EXPRESSION OF FAS AND FAS LIGAND THROUGH DISTINCT PATHWAYS INVOLVING DRE AND NF-KAPPAB MOTIFS ON THE PROMOTERS. N. P. Singh 1 . 1 Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA and 2 Microbiology & Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA. Sponsor: P. Nagarkatti. #1867 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) DISRUPTS THE NORMAL DAILY RHYTHMS OF HEMATOPOIETIC PRECURSORS. R. Garrett and T. A. Gasiewicz. Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY. #1868 INTERFERON-GAMMA REVERSES TCDD- MEDIATED SUPPRESSION OF THE IGM ANTIBODY RESPONSE AND ATTENUATES CYP1A1 INDUCTION. N. Kaminski 2,3 , B. Kim 1 , R. Crawford 2 and M. Holsapple 2 . 1 Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan, South Korea, 2 Pharmacology and Toxicology, Michigan State University, East Lansing, MI and 3 Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #1869 MAP KINASES, BUT NOT CALCIUM OR REACTIVE OXYGEN SPECIES, ARE INVOLVED IN PPARγ AGONIST-INDUCED PRO/PRE-B CELL APOPTOSIS. D. Liu, J. Emberley, D. Sherr and J. Schlezinger. Environmental Health, Boston University School of Public Health, Boston, MA. #1870 CASPASE-8 IS NOT THE MOST PROXIMAL CASPASE INVOLVED IN DMBA-INDUCED BONE MARROW B CELL APOPTOSIS. D. H. Sherr, H. Ryu, J. K. Emberley, L. L. Allan and J. J. Schlezinger. Environmental Health, Boston University, Boston, MA. #1871 THE ROLE OF PAH METABOLISM IN AHR- DEPENDENT INHIBITION OF HUMAN B CELL PROLIFERATION. L. L. Allan 1,2 , J. J. Schlezinger 2 , M. Shansab 2 and D. H. Sherr 2 . 1 Microbiology, Boston University School of Medicine, Boston, MA and 2 Environmental Health, Boston University School of Medicine, Boston, MA. #1872 DISTINCT EFFECTS OF TGF-B1 ON THE SURVIVAL AND DIVISION OF CD4+ AND CD8+ T CELLS: A ROLE FOR T CELL INTRINSIC SMAD3. S. C. McKarns and R. H. Schwartz. Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. WEDNESDAY up-to-date information at www.toxicology.org 191
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Annual Meeting Events Calendar (Con
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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