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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1814 EFFECT OF A COMPLEX MIXTURE FROM COAL TAR–SRM 1597 ON THE METABOLIC ACTIVATION OF CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS IN CHINESE HAMSTER V79 CELLS. B. Mahadevan 1 , C. P. Marston 1 , W. Dashwood 1 , E. Brooks 1 , Y. Li 2 , C. Pereira 2 , J. Doehmer 3 and W. M. Baird 1 . 1 Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 2 Department of Statistics, Oregon State University, Corvallis, OR and 3 GenPharm Toxicology BioTechAG, Martinsried, Germany. #1815 COMPETING ROLES OF ALDO-KETO REDUCTASE 1A1 AND CYP1A1/CYP1B1 IN THE METABOLIC ACTIVATION OF (+/-)- BENZO(A)PYRENE-7, 8-DIOL IN HUMAN BRONCHOALVEOLAR CELLS: INFLUENCE OF CYP INDUCTION. H. Jiang, D. Vudathala, I. A. Blair and T. M. Penning. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA. Sponsor: S. Burchiel. #1816 COMPARISON OF GENE EXPRESSION IN KIDNEY AND URINARY BLADDER FROM RATS TREATED WITH DIMETHYLARSINIC ACID. K. Bailey 1 , S. D. Hester 1 , A. Wang 2 , J. L. Robertson 2 , D. C. Wolf 1 and B. Sen 1 . 1 Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC and 2 Department of Biomed Sciences and Path, VA-MD Regional College of Vet. Med., Blacksburg, VA. #1817 SPECIATION OF ARSENIC IN THE MATERNAL AND FETAL MOUSE TISSUES FOLLOWING GESTATIONAL EXPOSURE TO ARSENITE. V. Devesa 1 , B. Adair 2 , J. Liu 3 , M. Styblo 1,4 , M. P. Waalkes 3 and D. J. Thomas 2 . 1 CEMALB, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2 U.S. EPA, Research Triangle Park, NC, 3 NCI at NIEHS, Research Triangle Park, NC and 4 Pediatrics, UNC, Chapel Hill, NC. #1818 UPTAKE OF INORGANIC AND ORGANIC DERIVATIVES OF ARSENIC AND ASSOCIATION WITH GENOTOXIC EFFECTS IN MAMMALIAN CELLS IN VITRO. E. Dopp 1 , L. M. Hartmann 2 , A. M. Florea 1 , U. V. von Recklinghausen 1 , U. Rauen 3 , A. W. Rettenmeier 1 and A. V. Hirner 2 . 1 Institute of Hygiene and Occupational Medicine, University of Duisburg- Essen, Essen, NRW, Germany, 2 Institute of Environmental Chemistry, University of Duisburg- Essen, Essen, Germany and 3 Institute of Physiological Chemistry, University of Duisburg-Essen, Essen, Germany. Sponsor: E. Nelson. #1819 GENE EXPRESSION ANALYSIS TO IDENTIFY INTERSPECIES CONCORDANCE OF THE MECHANISMS OF ARSENIC-INDUCED BLADDER CANCER. B. Sen 1 , R. Grindstaff 1 , Y. Turpaz 2 , J. Retief 2 and D. C. Wolf 1 . 1 Environmental Carcinogenesis Division, U.S. EPA, Research Triangle Park, NC and 2 Affymetrix, Santa Clara, CA. #1820 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR β (PPARβ) SUPPRESSES ANGIOGENESIS. A. D. Burdick 1 , A. N. Billin 2 , T. M. Willson 2 and J. M. Peters 1 . 1 Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA and 2 Discovery Research, GlaxoSmithKline, Research Triangle Park, NC. #1821 IMMUNOHISTOCHEMICAL ANALYSIS OF EXOCRINE PANCREATIC TOXICITY INDUCED BY 2, 3, 7, 8-TETRACHLORODIBENZO-P- DIOXIN IN FEMALE HARLAN SPRAGUE- DAWLEY RATS. T. Marsh, J. F. Foley, A. Nyska, B. Cai, S. Peddada, N. J. Walker and K. Yoshizawa. NIEHS, Research Triangle Park, NC. #1822 INCREASED MITOCHONDRIAL GLUTATHIONE CONTENT ENHANCES APOPTOSIS IN NRK-52E CELLS INDUCED BY THE DNA ALKYLATING AGENT CISPLATIN. L. H. Lash 1 , F. Xu 1 and L. H. Matherly 2,1 . 1 Pharmacology, Wayne State University Sch. Med., Detroit, MI and 2 Karmanos Cancer Institute, Wayne State University Sch. Med., Detroit, MI. #1823 CISPLATIN REDUCES VIABILITY, BUT NOT HEAT SHOCK PROTEIN LEVELS IN RAT KIDNEY CELLS. J. A. Flaws 1 , J. K. Babus 1 , M. Lipsky 2 and B. Fowler 3 . 1 Department of Epidemiology, University of Maryland, Baltimore, MD, 2 Department of Pathology, University of Maryland, Baltimore, MD and 3 Division of Toxicology, ATSDR, Atlanta, GA. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: CARDIOVASCULAR DISEASE I–GENE EXPRESSION Chairperson(s): Christopher States, University of Louisville, Louisville, KY and Ellen Silbergeld, Johns Hopkins, Baltimore, MD. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1824 TCDD-INDUCED GENE EXPRESSION CHANGES IN DEVELOPING ZEBRAFISH HEARTS. S. A. Carney 1 , C. Burns 2,3 , R. E. Peterson 1 and W. Heideman 1 . 1 University of Wisconsin, Madison, WI, 2 Massachusetts General Hospital, Charlestown, MA and 3 Harvard Medical School, Boston, MA. #1825 CHARACTERIZATION OF TCDD CARDIOTOXICITY IN EMBRYONIC ZEBRAFISH. D. S. Antkiewicz, R. E. Peterson and W. Heideman. University of Wisconsin, Madison, WI. #1826 STUDIES TO IDENTIFY GENE CHANGES IN THE HEART DURING RECOVERY FROM HEART TOXICITY INDUCED BY BIS(2- CHLOROETHOXY)METHANE. J. Dunnick 1 , J. Parker 2 , P. Blackshear 3 and A. Nyska 1 . 1 Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, NC, 2 Constella Group, Inc., Research Triangle Park, NC and 3 Integrated Laboratory System, Inc., Research Triangle Park, NC. 188 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1827 INCREASED GENE EXPRESSION AND LEVELS OF ANTIOXIDANTS AND PHASE 2 ENZYMES IN CARDIAC CELLS TREATED WITH 3H-1, 2- DITHIOLE-3-THIONE: PROTECTION AGAINST OXIDANT AND ELECTROPHILE-INDUCED CELL INJURY. Z. Cao 1,2 , H. Zhu 1 , D. Hardej 1 , L. D. Trombetta 1 and Y. Li 1 . 1 Pharmaceutical Sciences, St. John’s University, Jamaica, NY and 2 Harvard Medical School, Boston, MA. #1828 DIFFERENTIAL GENE EXPRESSION IN MICRODISSECTED MESENTERIC VASCULAR ELEMENTS OF RATS 1-HOUR FOLLOWING FENOLDOPAM (SKF-82526) ADMINISTRATION. D. A. Dalmas 1 , M. S. Scicchitano 1 , Y. Chen 2 , H. Olsen 2 , L. A. Tierney 1 , P. K. Narayanan 1 , H. C. Thomas 1 , R. W. Boyce 1 , S. Clark 2 and L. W. Schwartz 1 . 1 Safety Assessment, GlaxoSmithKline (GSK), King of Prussia, PA and 2 Transcriptome Analysis, GSK, Collegeville, PA. #1829 GENOMIC ANALYSIS OF THE MECHANISM OF CYCLOPHOSPHAMIDE-INDUCED CARDIOTOXICITY IN RATS: COMPARISON WITH HUMAN CASES OF MYOCARDITIS. K. K. Daniels, M. S. Orr and W. B. Mattes. Toxicogenomics, Gene Logic Inc., Gaithersburg, MD. #1830 A RAT HEART GENE-EXPRESSION SIGNATURE PREDICTIVE OF HERG POTASSIUM CHANNEL BINDING. X. Xu, R. J. Brennan, G. Napolitano and K. Kolaja. Chemogenomics and Toxicology, Iconix Pharmaceuticals Inc., Mountain View, CA. #1831 AHR AND ARNT SPECIFICALLY BIND PUTATIVE DIOXIN RESPONSE ELEMENTS (DRES) UPSTREAM OF BETA-ADRENERGIC RECEPTOR GENES. J. M. Ciak and R. J. Sommer. Biology Department, Bates College, Lewiston, ME. #1832 GLUTATHIONE-S-TRANSFERASE A4-4 MODULATES INOS EXPRESSION THROUGH NF- κB TRANSLOCATION. Y. Yang 1 , Y. Yang 2 , Y. C. Awasthi 2 and P. J. Boor 1 . 1 Pathology, UTMB, Galveston, TX and 2 Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX. #1833 CHEMICAL INDUCTION OF ANTIOXIDATIVE AND PHASE 2 DEFENSES IN CARDIOVASCULAR TISSUES IN VIVO: INVOLVEMENT OF NRF2 SIGNALING AND IMPLICATIONS FOR CARDIOVASCULAR PROTECTION. Y. Li 1 , Z. Cao 1 , H. Zhu 1 , E. Hussey 1 , H. Scaramell 1 , K. Itoh 2 , M. Yamamoto 2 , J. M. Cerreta 1 and L. D. Trombetta 1 . 1 St. John’s University, Jamaica, NY and 2 University of Tsukuba, Tsukuba, Japan. #1834 UPREGULATION OF ENDOGENOUS ANTIOXIDANTS AND PHASE 2 PROTEINS BY RESVERATROL IN CULTURED AORTIC SMOOTH MUSCLE CELLS LEADS TO CYTOPROTECTION AGAINST OXIDATIVE AND ELECTROPHILIC STRESS. H. Zhu, Z. Cao and Y. Li. Pharmaceutical Sciences, St. John’s University, Jamaica, NY. #1835 DEXRAZOXAN INHIBITS ALTERATIONS IN GLYCOLYTIC AND OXIDATIVE CARDIAC METABOLISM INDUCED BY DOXORUBICIN. R. A. Carvalho 1 , R. B. Sousa 1 , C. M. Palmeira 1 and K. B. Wallace 2 . 1 Biochemistry, University of Coimbra, Coimbra, Portugal and 2 Biochemistry & Molecular Biology, University of Minnesota School of Medicine, Duluth, MN. #1836 METALLOTHIONEIN PROTECTION FROM PROTEIN NITRATION CAUSED BY LPS/TNF- ALPHA-DERIVED INTRACELLULAR PEROXYNITRITE. J. Wang, Y. Kang and L. Cai. Medicine, University of Louisville, Louisville, KY. #1837 THE ROLE OF ENDOTHELIN-1 AND REACTIVE OXYGEN SPECIES IN CARDIAC HYPERTROPHY OBSERVED IN ARYL HYDROCARBON (AHR) NULL MICE. A. K. Lund 1 and M. K. Walker 1,2 . 1 College of Pharmacy, University of New Mexico, Albuquerque, NM and 2 Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM. #1838 PCB-INDUCED INFLAMMATORY RESPONSE IN CAVEOLIN-1 DEFICIENT MICE. Z. Majkova, E. Smart, A. Daugherty, M. Toborek and B. Hennig. University of Kentucky, Lexington, KY. #1839 PREVENTION OF DIABETES-ENHANCED LPS CARDIOTOXICITY IN CARDIAC-SPECIFIC METALLOTHIONEIN-OVEREXPRESSING TRANSGENIC MICE. L. Cai and Y. Kang. Medicine, Pharmacology and Toxicology, University of Louisville, Louisville, KY. #1840 GENETIC BACKGROUND-DEPENDANT VARIATION IN EGFR-RELATED CARDIAC DYSFUNCTION. D. J. Barrick 1 , M. La Merrill 1 , M. Rojas 3 , S. Smyth 3 and D. W. Threadgill 2,1 . 1 Curriculum in Toxicology, UNC-CH, Chapel Hill, NC, 2 Genetics, UNC-CH, Chapel Hill, NC and 3 Carolina Cardiovascular Biology Center, UNC-CH, Chapel Hill, NC. #1841 EFFECTS OF ARSENIC ON ENDOTHELIAL CELL ACTIVATION AND ACETYLATED-LDL UPTAKE BY MACROPHAGES. F. E. Pereira, M. Bunderson, J. C. Schneider, M. C. Schneider, D. D. Coffin and H. D. Beall. Center for Environmental Health Sciences, University of Montana, Missoula, MT. #1842 EXAMINATION OF THE VASCULAR INJURY IN SPRAGUE-DAWLEY (SD) RATS INDUCED BY THE PHOSPHODIESTERASE (PDE) IV INHIBITOR SCH 534385: A COMPARISION WITH SCH 351591. J. Zhang 1 , E. H. Herman 1 , A. Knapton 1 , T. J. Miller 1 , P. Espandiari 1 , R. Snyder 2 , J. P. Hanig 1 and J. L. Weaver 1 . 1 DAPR, U.S. FDA, Silver Spring, MD and 2 Schering-Plough Research Institute, Lafayette, NJ. WEDNESDAY up-to-date information at www.toxicology.org 189
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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