Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY #812 SPONTANEOUS HEMORRHAGE OF THE PANCREATIC ISLET IN SPRAGUE-DAWLEY RATS. M. Imaoka, T. Suzuki, K. Nozaki, H. Satoh, T. Sugawara and K. Furuhama. Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. Tuesday Morning, March 8 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: SIGNAL TRANSDUCTION: OXIDANT STRESS Chairperson(s): Dean P. Jones, Emory University SOM, Atlanta, GA. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #813 NRF2 ACTIVATION INVOLVES AN OXIDATIVE- STRESS INDEPENDENT PATHWAY IN TETRAFLUOROETHYLCYSTEINE-INDUCED CYTOTOXICITY. H. Ho 1 , C. White 2 , C. Fernandez 2 , N. Fausto 3 , T. Kavanagh 2 , S. Nelson 1 and S. Bruschi 1 . 1 Medicinal Chemistry, University of Washington, Seattle, WA, 2 Environmental and Occupational Health, University of Washington, Seattle, WA and 3 Pathology, University of Washington, Seattle, WA. #814 NRF2-DEPENDENT ARE ACTIVATION IS A GAIN OF FUNCTION ALTERATION SPECIFIC TO DIFFERENTIATED AND FUNCTIONALLY ACTIVATED ASTROCYTES. J. A. Johnson, J. Li, D. A. Johnson and M. J. Calkins. School of Pharmacy, University of Wisconsin, Madison, WI. #815 INDUCTION OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 IN MOUSE LIVER DURING EXTRAHEPATIC CHOLESTASIS IS DEPENDENT UPON NRF2 ACTIVATION. A. L. Slitt 1 , L. M. Aleksunes 2 , J. M. Maher 1 , M. Z. Dieter 1 , N. J. Cherrington 3 , J. E. Manautou 2 , J. Y. Chan 4 and C. D. Klaassen 1 . 1 Pharmacology, Toxicology, & Therapeutics, University of Kansas Medical Center, Kansas City, KS, 2 Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 3 Pharmacology and Toxicology, University of Arizona, Tucson, AZ and 4 Pathology, University of California Irvine, Irvine, CA. #816 ALTERATIONS IN GENE EXPRESSION BY 2378- TETRACHLORO-P-DIBENZODIOXIN (TCDD) IN LIVERS OF NRF2 KNOCKOUT MICE. M. Matsumoto 1 , H. Sato 2 , K. Itoh 3 , M. Yamamoto 3 and Y. Aoki 1 . 1 National Institute for Environmental Studies, Tsukuba, Japan, 2 Institute of Medicinal Molecular Design Inc., Tokyo, Japan and 3 University of Tsukuba TARA Center, Tsukuba, Japan. #817 PHOSPHORYLATION OF NRF2 BY CASEIN KINASE 2 (CK2) REGULATES ACTIVATION AND DEGRADATION. J. Pi 1,2 , Y. Bai 2 , J. Reece 3 , J. William 4 , D. Liu 5 , M. Freeman 6 , W. Fahl 7 , D. Shugar 8 and M. Waalkes 1 . 1 Lab. of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, 2 Division of Biology Sciences, CIIT Centers for Health Research, Research Triangle Park, NC, 3 LST, NIEHS, Research Triangle Park, NC, 4 LSB, NIEHS, Research Triangle Park, NC, 5 LRDT, NIEHS, Research Triangle Park, NC, 6 Vanderbilt University School of Medicine, Nashvile, TN, 7 University of Wisconsin, Madison, WI and 8 Polish Academy of Sciences, Warsaw, Poland. #818 NRF3 NEGATIVELY REGULATES ARE- MEDIATED EXPRESSION AND ANTIOXIDANT INDUCTION OF DETOXIFYING ENZYME GENES. S. KANNAN and A. K. JAISWAL. Pharmacology, Baylor College of Medicine, Houston, TX. Sponsor: B. Moorthy. #819 ANTIOXIDANT INDUCED NUCLEAR IMPORT AND EXPORT OF OXIDATIVE STRESS- RESONSE FACTOR NRF2. A. K. Jain and A. K. Jaiswal. Pharmacology, Baylor College of Medicine, Houston, TX. Sponsor: B. Moorthy. #820 COMPARTMENTAL OXIDATION OF THIOL/DISULFIDE REDOX COUPLES DURING EGF SIGNALING. P. J. Halvey 1 , J. M. Hansen 1 , W. H. Watson 2 , Y. Go 1 and D. P. Jones 1 . 1 Medicine, Emory University, Atlanta, GA and 2 Environmental Health Sciences, Johns Hopkins University, Baltimore, MD. #821 UPREGULATION OF MRP3 AND MRP4 BY SULFHYDRYL-MODIFYING COMPOUNDS IS MEDIATED BY THE TRANSCRIPTION FACTOR NRF2. J. M. Maher 1 , M. Z. Dieter 1 , A. L. Slitt 1 , J. Y. Chan 2 and C. D. Klaassen 1 . 1 University of Kansas Medical Center, Kansas City, KS and 2 University of California Irvine, Irvine, CA. #822 EPIGENETIC EFFECTS OF OXIDATIVE STRESS. B. Upham 1,2 and J. E. Trosko 1,2 . 1 Pediatrics/Human Development, Michigan State University, East Lansing, MI and 2 National Food Safety & Toxicology Ctr., Michigan State University, East Lansing, MI. #823 HISTONE H3.3 MODIFICATIONS DURING REACTIVE OXYGEN SPECIES INDUCED DNA DAMAGE. R. Xie, T. T. Monks and S. S. Lau. Pharmacology and Toxicolocy, University of Arizona, Tucson, AZ. 112 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Tuesday Morning, March 8 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: CARDIOVASCULAR DISEASE II Chairperson(s): Paul Boor, University of Texas Medical Branch, Galveston, TX and Bernard Hennig, University of Kentucky, Lexington, KY. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #824 EVALUATION OF PLASMA VON WILLEBRAND FACTOR (VWF) AND VWF PROPEPTIDE IN DRUG-INDUCED VASCULAR INJURY. D. Brott 1,2 , A. Katein 1 , K. Ershaw 1 , G. Evans 3 , H. Jones 3 , S. Gould 3 , G. Betton 3 , J. Valentin 3 , R. J. Richardson 2 and C. Louden 1,2 . 1 Global Safety Assessment, AstraZeneca Pharmaceuticals, Wilmington, DE, 2 Toxicology Program, Environmental Health Science Department, The University of Michigan, Ann Arbor, MI and 3 Global Safety Assessment, AstraZeneca Pharmaceuticals, Alderley, United Kingdom. #825 MORPHOLOGIC IMAGING OF EXTRACELLULAR MATRIX IN CHEMICAL- INDUCED DEVELOPMENTAL DISSECTING AORTIC ANEURYSM USING MULTIPHOTON FLORESCENCE AND SECOND HARMONIC GENERATION MICROSCOPY BIN GONG, JU SUN, GRACIE VARGAS, PAUL BOOR. B. gong 1 , J. Sun 2 , G. Vargas 2 and P. boor 1 . 1 pathology, UTMB at Galveston, Galveston, TX and 2 biomedical engineering center, UTMB at Galveston, Galveston, TX. #826 EFFECTS OF GONADAL STEROIDS ON CALCIUM CURRENTS AND ACTION POTENTIALS IN GUINEA PIG CARDIAC MUSCLES. S. Nagayama, K. Yunomae, S. Ichisaki, J. Matsuo, M. Haruyama, K. Fukuzaki, R. Nagata and G. Kito. Shin Nippon Biomedical Laboratories, Ltd (SNBL), Kagoshima, Japan. #827 NUCLEOSIDE ANALOG REVERSE TRANSCRIPTASE INHIBITOR (NRTI)-INDUCED ρ – RAT CARDIAC MYOCYTES IN CELL CULTURE. A. Rolo, J. A. Bjork and K. B. Wallace. Biochemistry & Molecular Biology, University of Minnesota Medical School, Duluth, MN. #828 EPHENDRINE AND CAFFEINE CAUSE SIGNIFICANT MORTALITY IN 14 WEEK OLD BUT NOT IN 7 WEEK OLD FISCHER RATS. P. Hanlon 1 , R. Howden 2 , J. Petranka 1 , S. Kleeberger 2 , J. Dunnick 3 , A. Nyska 4 and E. Murphy 1 . 1 Laboratory of Signal Transduction, NIEHS, Research Triangle Park, NC, 2 Laboratory of Respiratory Biology, NIEHS, Research Triangle Park, NC, 3 Toxicology Branch, NIEHS, Research Triangle Park, NC, 4 Laboratory of Environmental Pathology, NIEHS, Research Triangle Park, NC and 5 NIEHS, Research Triangle Park, NC. #829 ACUTE HEMORRHAGIC MYOCARDIAL NECROSIS AND SUDDEN DEATH OF RATS EXPOSED TO A COMBINATION OF EPHEDRINE AND CAFFEINE. A. Nyska 1 , E. Murphy 2 , J. F. Foley 1 , B. J. Collins 4 , J. Petranka 2 , R. Howden 3 , P. Hanlon 2 and J. K. Dunnick 4 . 1 Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, NC, 2 Laboratory of Signal Transduction, NIEHS, Research Triangle Park, NC, 3 Laboratory of Respiratory Biology, NIEHS, Research Triangle Park, NC and 4 Environmental Toxicology Program, NIEHS, Research Triangle Park, NC. #830 EFFECTS OF HYPOKALIEMIA ON THE QT INTERVAL IN DOGS. A. Yvon, J. Provost, Y. Rabemampianina and G. Hanton. Pfizer PGRD, Amboise, France. Sponsor: H. Sterz. #831 DOES AUTONOMIC NERVOUS TONE DIRECTLY AFFECT THE QT INTERVAL? T. Harada, J. Abe, M. Shiotani, Y. Hamada and I. Horii. PGRD Nagoya Lab., Pfizer Inc., Taketoyo, Aichi, Japan. Sponsor: M. Kurata. #832 SENSITIVITY OF CANINE AND RABBIT CARDIAC REPOLARIZATION ASSAYS FOR DETECTION OF POTENTIAL QT LIABILITY. J. Kramer. ChanTest, Inc., Cleveland, OH. Sponsor: T. Narahashi. #833 ACCURATE EVALUATION OF QT INTERVAL IN CONSCIOUS CYNOMOLGUS MONKEYS BY USE OF TELEMETRY ECG. K. Kuwano, T. Jikuzono, S. Otsuka, M. Hijioka, T. Miyake, T. Uchino, M. Shoki, T. Koga, K. Fukuzaki, R. Nagata and G. Kito. Shin Nippon Biomedical Laboratories, Ltd., (SNBL), Kagoshima, Japan. #834 NEW SAFETY ASSESSMENT ON LEFT VENTRICULAR VOLUME AND ITS FUNCTION IN MONKEYS USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY. T. Yamada 1 , H. Tsusaki 1 , H. Yonamine 1 , A. Tamai 1 , M. Shimomoto 2 , G. Kito 1 and R. Nagata 1 . 1 Shin Nippon Biomedical Laboratories, Ltd.,, Kagoshima, Japan and 2 Philips Medical Systems, Fukuoka, Japan. #835 HERG LIABILITY: THINKING OUTSIDE THE BLOCK. B. Wible. ChanTest, Inc., Cleveland, OH. Sponsor: T. Narahashi. #836 VARIABILITY IN THE MEASUREMENT OF HERG POTASSIUM CHANNEL INHIBITION: EFFECTS OF TEMPERATURE AND STIMULUS PATTERN. G. Kirsch. ChanTest, Inc., Cleveland, OH. Sponsor: T. Narahashi. #837 VALIDATION OF QT EVALUATION IN CONSCIOUS GUINEA PIGS WITH A TELEMETRY SYSTEM. M. Shiotani 1 , T. Harada 1 , J. Abe 1 , Y. Hamada 1 , K. Hashimoto 2 and I. Horii 1 . 1 PGRD Nagoya Lab., Pfizer Inc., Taketoyo, Aichi, Japan and 2 Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Nakakoma, Yamanashi, Japan. Sponsor: M. Kurata. TUESDAY up-to-date information at www.toxicology.org 113
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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