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44 th Annual Meeting and ToxExpo Program Description TUESDAY #724 AFFINITY LABELING OF SER-57 IN RAT CYTOCHROME P450C24A1 (CYP24A1) OF THE VITAMIN D PATHWAY: MUTATION AND CHARACTERIZATION. A. J. Annalora 1,2 , A. Pastusyzn 2 , R. Ray 3 , C. B. Marcus 1 and J. L. Omdahl 2 . 1 College of Pharmacy, University of New Mexico, Albuquerque, NM, 2 Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM and 3 Vitamin D Laboratory, Boston University-SOM, Boston, MA. #725 THE USE OF THE MECHANISM BASED INHIBITOR 2-ETHYNYLNAPHTHALENE (2EN) TO PROBE THE ACTIVE SITE OF CYP2B4. D. Cheng, J. R. Reed, R. W. Kelley and W. L. Backes. Pharmacology, LSUHSC, New Orleans, LA. #726 INHIBITION OF THE HUMAN LIVER MICROSOMAL AND HUMAN CYTOCHROME P450 1A2 AND 3A4 METABOLISM OF ESTRADIOL BY DEPLOYMENT-RELATED CHEMICALS. K. A. Usmani, R. L. Rose and E. Hodgson. Environmental & Molecular Toxicology, North Carolina State University, Raleigh, NC. #727 CORRELATIONS BETWEEN ACTIVITIES OF CYPS 2E1/1A2 AND HISTOLOGIC FIBROSIS IN HCV PATIENTS. S. I. Shedlofsky 1,3 , R. T. Tosheva 1 , C. Hallberg 2 and K. E. Anderson 2 . 1 Medicine, University of Kentucky, Lexington, KY, 2 University of Texas Medical Branch, Galveston, TX and 3 General Clinical Research Center, Lexington, KY. #728 ROLE OF CYTOCHROME P450 2E1 (CYP2E1) IN TRICHLOROETHYLENE (TCE) METABOLISM AND DISPOSITION: COMPARATIVE STUDIES USING CYP2E1-/- AND WILD-TYPE MICE. D. Kim and B. I. Ghanayem. Laboratory of Pharmacology and Chemistry, NIEHS/NIH, Research Triangle Park, NC. #729 CYTOCHROME P450 2E1 (CYP2E1) INDUCTION BY PYRIDAZINE PRODUCES QUALITATIVE AND QUANTITATIVE CHANGES IN THE METABOLISM OF TRICHLOROETHYLENE TO POTENTIALLY CARCINOGENIC METABOLITES. S. Lee, S. Muralidhara, C. A. White and J. V. Bruckner*. Department of PBS, University of Georgia, Athens, GA. #730 PROTECTIVE EFFECT OF DIALLYL SULFONE AGAINST LUNG MUTAGENESIS INDUCED BY VINYL CARBAMATE. L. G. Hernandez and P. Forkert. Department of Anatomy and Cell Biology, Queen’s University, Kingston, ON, Canada. #731 ROLE OF TOXICOKINETICS IN THE BIOACTIVATION-MEDIATED LIVER INJURY OF THIOACETAMIDE IN AD LIBITUM FED AND DIET RESTRICTED RATS. J. Chilakapati, M. C. Korrapati and H. M. Mehendale. Toxicology, University of Louisiana at Monroe, Monroe, LA. #732 CYP2E1 OXIDATION MEDIATES THE SPERM TOXICITY OF 1-BROMOPROPANE IN MICE. C. Garner 1 , J. Davis 1 , C. Sloan 1 , J. Burgess 1 , A. Jeffcoat 1 , A. Hughes 1 , A. Parham 1 , J. Mathews 1 , L. Burka 2 and B. Ghanayem 2 . 1 DMPK, RTI International, Research Triangle Park, NC and 2 NIEHS, Research Triangle Park, NC. #733 HEPATIC METABOLISM OF AROMATIC AMINE HAIR DYE COMPONENTS AS COMPARED WITH THAT OF 2-AMINOFLUORENE. L. Stanley 1 , J. Skare 2 , E. Doyle 1 , R. Powrie 1 , D. D’ Angelo 2 and C. Elcombe 1 . 1 CXR Biosciences Ltd., Dundee, United Kingdom and 2 Central Product Safety, Sharon Woods Technical Center, Procter & Gamble Company, Cincinnati, OH. #734 DECHLORINATION OF PCB IUPAC #101 BY HUMAN CYP 2B6 TRANSFECTED INSECT CELL MICROSOMES. D. P. Waller and J. E. McGraw. Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL. #735 REGIO-SPECIFIC (ω TO ω-6) FATTY ACID (LAURIC, MYRISTIC AND PALMITIC) HYDROXYLATION IN HUMAN POOLED LIVER AND RECOMBINANT MICROSOMES. M. L. Haasch and J. C. Allgood. National Center for Natural Products Research, Environmental Toxicology Research Program, Pharmacology, The University of Mississippi, University, MS. #736 ROLE OF CYTOCHROME P450 3A IN HEPATOTOXICITY OF THE CHLOROACETANILIDE HERBICIDE ALACHLOR. S. R. Miranda and S. A. Meyer. Toxicology, University of Louisiana at Monroe, Monroe, LA. #737 INTERINDIVIDUAL VARIABILITY IN P450- MEDIATED METABOLISM OF 4- (METHYLNITROSAMINO)-1-(3-PYRIDYL)-1- BUTANONE(NNK) IN HUMAN WHOLE PERIPHERAL LUNG MICROSOMES. P. J. Brown 1 , K. R. Reid 2 , D. Petsikas 2 and T. E. Massey 1 . 1 Pharmacology and Toxicology, Queen, Kingston, ON, Canada and 2 Surgery, Queen’s University, Kingston, ON, Canada. #738 COMPARATIVE METABOLISM OF AFLATOXIN B1 (AFB1) BY ZEBRAFISH, RAINBOW TROUT AND HUMAN CYTOCHROMES P450. C. L. Miranda, W. Chung, J. Wang and D. R. Buhler. Environment & Molec. Toxicology, Oregon State University, Corvallis, OR. #739 EXPRESSION AND CHARECTERIZATION OF CHANNEL CATFISH CYP 2X1. S. MOSADEGHI, B. Furnes, C. Wong and D. Schlenk. Environmental Toxicology, University of California, Riverside, CA. #740 CHARACTERIZATION AND COMPARISON OF METHODS FOR VESICULAR RECONSTITUTION OF CYTOCHROME P450 2B4 AND NADPH P450 REDUCTASE. J. R. Reed, R. W. Kelley and W. L. Backes. Pharmacology, Louisiana State University Health Science Center, New Orleans, LA. 106 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Tuesday Morning, March 8 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: HEPATOCARCINOGENESIS Chairperson(s): Alan M. Jeffrey, New York Medical College, Valhalla, NY and Lisa M. Kamendulis, Indiana University School of Medicine, Indianapolis, IN. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #741 QUANTITATIVE DOSE-RESPONSE EFFECTS OF ACETYLAMINOFLUORENE HEPATOCARCINOGENESIS IN RATS. A. M. Jeffrey, M. J. Iatropoulos, J. Duan and G. M. Williams. New York Medical College, Valhalla, NY. #742 INFLUENCE OF STRAIN AND DIET ON HEPATOCARCINOGENICITY OF N-BUTYL-N-(4- HYDROXYBUTYL)NITROSAMINE (BBN) IN RATS. A. Hagiwara 1 , T. Murai 2 , E. Miyata 1 , Y. Toda 1 , M. Sano 1 , S. Mori 2 and S. Fukushima 2 . 1 Daiyu-kai Institute of Medical Science, Ichinomiya, Japan and 2 Department of Pathology, Osaka City University Medical School, Osaka, Japan. #743 THIAMETHOXAM INDUCED MOUSE LIVER TUMORS AND THEIR RELEVANCE TO HUMANS 1. MODE OF ACTION STUDIES IN THE MOUSE. S. Lloyd 2 , T. Green 2 , A. Toghill 2 , R. Lee 2 , F. Waechter 2 , J. Noakes 2 and T. P. Pastoor 1 . 1 Syngenta Crop Protection, Greensboro, NC and 2 Syngenta Central Toxicology Laboratory, Alderley Park, United Kingdom. #744 THIAMETHOXAM INDUCED MOUSE LIVER TUMORS AND THEIR RELEVANCE TO HUMANS 2. SPECIES DIFFERENCES IN RESPONSE. C. Waterfield 2 , T. Green 2 , R. Lee 2 , A. Toghill 2 , F. Waechter 2 , R. Peffer 1 , J. Noakes 2 , M. Robinson 2 and T. P. Pastoor 1 . 1 Syngenta Crop Protection, Greensboro, NC and 2 Syngenta CTL, Alderley Park, Cheshire, United Kingdom. #745 THIAMETHOXAM INDUCED MOUSE LIVER TUMORS AND THEIR RELEVANCE TO HUMANS 3. WEIGHT OF EVIDENCE EVALUATION. T. P. Pastoor 1 , P. Rose 2 , S. Lloyd 2 , R. Peffer 1 and T. Green 2 . 1 Syngenta Crop Protection, Greensboro, NC and 2 Syngenta CTL, Alderley Park, Cheshire, United Kingdom. #746 ESTIMATION OF A NO OBSERVED EFFECT LEVEL FOR 4, 4′-OXYDIANILINE, A GENOTOXIC LIVER CARCINOGEN, IN A 16- WEEK FEEDING STUDY USING MALE F344 RATS. Y. Doi 1 , N. Imai 1 , A. Hagiwara 1 , H. Yoshino 1 , S. Tamano 1 , H. Wanibuchi 2 , K. Morimura 2 and S. Fukushima 2 . 1 Daiyu-Kai Institute of Medical Science, Inc., Ichinomiya, Japan and 2 Department of Pathology, Osaka City University Medical School, Osaka, Japan. #747 MUTAGENICITY OF PYRROLIZIDINE ALKALOIDS IN RAT LIVER. T. Chen, N. Mei and R. H. Heflich. Division of Genetic and Reproductive Toxicology, NCTR/FDA, Jefferson, AR. #748 EXPERIMENTAL STUDY ON CARCINOGENESIS INDUCED BY CYANOBACTERIAL MICROCYSTINS AND ORGANIC EXTRACTS OF TAP WATER. J. ZHAO 1,2 , S. Jiang 1 , W. Qu 1 and H. Zhu 1 . 1 EOH, Fudan University, Shanghai, China and 2 EOH, University of Pitt, Pittsburgh, PA. Sponsor: J. Jiang. #749 INHIBITION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION BY CHLOROHYDROXYFURANONES IN WB-F344 CELLS. E. Rintala, P. Hakulinen, J. Maki-Paakkanen and H. Komulainen. Department of Environmental Health, National Public Health Institute, Kuopio, Finland. Sponsor: J. Tuomisto. #750 α2-MACROGLOBULIN: A NOVEL CYTOCHEMICAL MARKER CHARACTERIZING PRENEOPLASTIC AND NEOPLASTIC RAT LIVER LESIONS NEGATIVE FOR HITHERTO ESTABLISHED CYTOCHEMICAL MARKERS. T. Sukata 1,2 , S. Uwagawa 1,2 , K. Ozaki 1,2 , K. Sumida 1 , M. Kushida 1,2 , K. Saito 1 , K. Morimura 2 , K. Oeda 1 , N. Mikami 1 and S. Fukushima 2 . 1 Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.,, Osaka, Japan and 2 Pathology, Osaka City University Medical School, Osaka, Japan. #751 MECHANISMS OF 2-BUTOXYETHANOL CARCINOGENESIS. S. M. Corthals, L. M. Kamendulis and J. E. Klaunig. Division of Toxicology, Indiana University School of Medicine, Indianapolis, IN. #752 EVIDENCE FOR THE INVOLVEMENT OF THE KUPFFER CELL IN HEPATIC CARCINOGENESIS. L. M. Kamendulis, S. M. Corthals and J. E. Klaunig. Division of Toxicology, Indiana University School of Medicine, Indianapolis, IN. #753 MECHANISTIC ANALYSIS OF CARCINOGENIC AND NONCARCINOGENIC LIVER TOXICANTS USING TOXICOGENOMIC DATA DERIVED FROM RAT LIVER OR PRIMARY RAT HEPATOCYTES. M. S. Orr, K. K. Daniels and W. B. Mattes. Toxicogenomics, Gene Logic Inc., Gaithersburg, MD. #754 DEVELOPMENT OF A GENE SIGNATURE THAT DISCRIMINATES BETWEEN GENOTOXIC AND NON-GENOTOXIC COMPOUNDS. G. Vansant, P. Pezzoli, C. Duffy and J. Monforte. Althea Technologies, San Diego, CA. Sponsor: F. Ferre. #755 A GENE EXPRESSION SIGNATURE FOR NON- GENOTOXIC CARCINOGENS. A. Y. Nie, M. K. McMillian, A. M. Leone, J. B. Parker, L. Piechta, S. Bryant, J. Herlich, M. Kemmerer, N. Raghavan, D. Amaratunga, L. Yieh, A. Bittner, J. Wan, M. D. Johnson and P. G. Lord. Mechanistic Toxicology, Johnson & Johnson PRD, LLC, Raritan, NJ. #756 EFFECTS OF 3-METHYLCHOLANTHRENE ON HEPATIC GENE EXPRESSION PATTERNS IN RATS USING CDNA MICROARRAY ANALYSES. S. Kondraganti, W. Jiang, K. Muthiah and B. Moorthy. Pediatrics, Baylor College of Medicine, Houston, TX. TUESDAY up-to-date information at www.toxicology.org 107
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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