Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: METALS TOXICOLOGY Chairperson(s): Elaine M. Faustman, Institute for Risk Analysis & Risk Communication, Seattle, WA and Donald Sens, University of North Dakota, Grand Forks, ND. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1124 THE CHEMICAL FORM OF ALUMINUM AFFECTS ITS PARACELLULAR FLUX ACROSS AND UPTAKE INTO CACO-2 CELLS. Y. Zhou 1 and R. A. Yokel 2,1 . 1 Graduate Center for Toxicology, University of Kentucky, Lexington, KY and 2 College of Pharmacy, University of Kentucky, Lexington, KY. #1125 ORAL ALUMINUM (AL) BIOAVAILABILITY FROM A FOOD CONTAINING AN AL FOOD ADDITIVE: RELEVANCE TO THE MAJOR SOURCES OF AL EXPOSURE FOR HUMANS. R. A. Yokel 1,2 and R. L. Florence 1 . 1 College of Pharmacy, University of Kentucky Medical Center, Lexington, KY and 2 Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington, KY. #1126 DOES ALUMINUM WELDING FUME CAUSE CLINICALLY SIGNIFICANT PNEUMOCONIOSIS AND LUNG CANCER?–AN ANALYSIS OF SPECIFIC CAUSATION. N. Zheng and B. Thomas. Risk Assessment and Management Group, Inc., Houston, TX. Sponsor: A. Jabbour. #1127 PHYSICAL AND CHEMICAL CHARACTERIZATION OF BERYLLIUM PARTICLES FROM SEVERAL WORKPLACES IN QUEBEC–PART A: DETERMINING METHODS FOR THE ANALYSIS OF LOW LEVELS OF BERYLLIUM. J. Zayed 1 , M. Rouleau 1 , C. Dion 2 , P. Plamondon 3 , G. Kennedy 4 and G. L’Esperance 3 . 1 Environmental and occupational Health, University of Montreal, Montreal, QC, Canada, 2 Institut de recherche Robert-Sauve en sante et en securite du travail, Montreal, QC, Canada, 3 Centre for Characterization and Microscopy of Materials, Polytechnique School, Montreal, QC, Canada and 4 Physic Engineer, Polytechnique School, Montreal, QC, Canada. #1128 PHYSICAL AND CHEMICAL CHARACTERIZATION OF BERYLLIUM PARTICLES FROM SEVERAL WORKPLACES IN QUEBEC, CANADA. PART B: TIME-OF-FLIGHT SECONDARY ION MASS SPECTROSCOPY. J. Zayed 1 , M. Rouleau 1 , C. Dion 2 , P. Plamondon 3 and G. L’Esperance 3 . 1 Environmental and occupational Health, University of Montreal, Montreal, QC, Canada, 2 Institut de recherche Robert-Sauve en sante et en securite du travail, Montreal, QC, Canada and 3 Centre for Characterization and Microscopy of Materials, Polytechnique School, Montreal, QC, Canada. #1129 HUMAN SUSCEPTIBILITY GENE CONFERS BERYLLIUM HYPERSENSITIVITY ON FVB MICE. L. M. Tarantino 1 , C. Sorrentino 1 , Y. Zhu 2 , E. M. Rubin 2 , S. S. Tinkle 3 and T. Gordon 1 . 1 Department of Environmental Medicine, NYU School of Medicine, Tuxedo, NY, 2 Department of Genome Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA and 3 NIEHS, Research Triangle Park, NC. #1130 THE ROLE OF HYPOXIA INDUCIBLE FACTOR 1α IN COBALT CHLORIDE INDUCED CELL DEATH IN MOUSE EMBRYONIC FIBROBLASTS. A. Vengellur 2,1 and J. LaPres 1,3,4 . 1 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 2 Graduate Program in Genetics, Michigan State University, East Lansing, MI, 3 National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI and 4 Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #1131 STUDIES OF MECHANISMS OF POTASSIUM DICHROMATE-INDUCED NEPHROTOXICITY IN ISOLATED RAT RENAL CORTICAL SLICES. J. chen and S. K. Chakrabarti. Department of Environmental and Occupational Health, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada. #1132 PROTECTIVE EFFECT OF ALPHA- TOCOPHEROL ON RENAL INJURY CAUSED BY CHROMATE EXPOSURE. L. Arreola-Mendoza 1 , J. L. Reyes 2 , M. C. Namorado 2 , D. Martin 2 and L. M. Del Razo 1 . 1 Toxicology, Cinvesta-IPN, Mexico D.F, Mexico and 2 Physiol. Biophs.& Neurosci, Cinvesta-IPN, Mexico D.F, Mexico. #1133 CHROMIUM(VI) ACTIVATES STAT3 IN BRONCHIAL EPITHELIAL CELLS. K. A. O’Hara, R. J. Vaghjiani, L. R. Klei and A. Barchowsky. Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. #1134 CARCINOGENIC LEAD CHROMATE INDUCES DNA DOUBLE-STRAND BREAKS AND ACTIVATES ATM KINASE IN HUMAN LUNG CELLS. H. Xie 1,2 , S. S. Wise 1,2 , A. L. Holmes 1,2 and J. P. Wise 1,2 . 1 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME and 2 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME. #1135 REPAIR OF CHROMATE-INDUCED CHROMOSOME DAMAGE IS MEDIATED BY XRCC1. E. G. Duzevik 1,2 , S. S. Wise 1,2 , R. C. Munroe 1,2 and J. P. Wise 1,2 . 1 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME and 2 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME. 136 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1136 IMPAIRMENT OF CHROMIUM-DNA ADDUCT FORMATION BY HYPOXIA. T. J. O’Brien 1,2 , H. G. Mandel 1,2 , K. D. Sugden 4 , A. Komarov 3 and S. R. Patierno 1,2 . 1 Pharmacology and Physiology, The George Washington University Med. Ctr., Washington, DC, 2 The GW Cancer Institute, The George Washington University Med. Ctr., Washington, DC, 3 Biochemistry and Molecular Biology, The George Washington University Med. Ctr., Washington, DC and 4 Chemistry, University of Montana, Missoula, MT. #1137 ACUTE INHALATION TOXICITY OF TRIMETHYL GALLIUM IN RATS. G. R. Kiplinger 1 , G. P. Rosini 2 , S. V. Kala 3 , E. C. Bisinger, Jr. 4 and J. L. Orr 4 . 1 WIL Research Laboratories, Inc., Ashland, OH, 2 Akzo Nobel Polymer Chemicals LLC, Chicago, IL, 3 Baylor School of Medicine, Houston, TX and 4 Akzo Nobel Chemicals Inc., Chicago, IL. #1138 OAT1 TRANSPORTS N-ACETYLCYSTEINE (NAC)-S CONJUGATES OF BOTH METHYLMERCURY AND INORGANIC MERCURY IN MDCK CELLS. S. Ahmad and R. K. Zalups. Basic Sciences, School of Medicine, Mercer University, Macon, GA. #1139 MERCURIC CHLORIDE ALTERS BAX-BCL2 RATIO IN LEYDIG CELLS TOWARD APOPTOTIC PATHWAY. M. Mansour, J. Persaud, R. Ricks, K. Ali, H. El-kholy and A. Atkinson. College of Veterinary Medicine, Nursing & Allied Health, Tuskegee University, Tuskegee, AL. Sponsor: R. Dalvi. #1140 EFFECTS OF SUBCHRONIC EXPOSURE TO MERCURIC CHLORIDE ON RAT FERTILITY AND REPRODUCTIVE PERFORMANCE: A CROSSOVER MATING TRIAL STUDY. K. A. Ali, A. Atkinson, H. EL-Kholy, M. Mansour, C. Harris, D. Chaney and M. Campbell. College of Veterinary Medicine, Nursing & Allied Health, Tuskegee University, Tuskegee, AL. Sponsor: R. Dalvi. #1141 MN INDUCED PULMONARY VEGF- EXPRESSION IN VIVO: A POTENTIAL MECHANISM OF PULMONARY TOXICITY. K. K. Divine, M. M. Falgout, T. H. March and S. Bredow. Lovelace Respiratory Research Institute, Albuquerque, NM. #1142 A POTENTIAL MECHANISM FOR PULMONARY MANGANESE-TOXICITY: MANGANESE INDUCES PULMONARY VEGF EXPRESSION IN VITRO. S. Bredow, M. M. Falgout and K. K. Divine. Lovelace Respiratory Research Institute, Albuquerque, NM. #1143 THE DISTURBANCE OF CELLULAR IRON REGULATION BY SOLUBLE NICKEL EXPOSURE AND ITS POSSIBLE MECHANISMS. H. Chen, T. Davidson and M. Costa. Environmental Medicine, New York University, Tuxedo, NY. #1144 SOLUBLE NICKEL ALTERS IRON HOMEOSTASIS. T. L. Davidson 1 , H. Chen 1 , M. D. Garrick 2 , S. Singleton 2 and M. Costa 1 . 1 Department of Env. Med., New York University, Tuxedo, NY and 2 Department of Biochemistry, SUNY Buffalo, Buffalo, NY. #1145 CHRONIC EXPOSURE TO LEAD IONS FROM LEAD CHROMATE INTERFERES WITH NORMAL MITOTIC PROGRESSION. A. L. Holmes 1,2 , S. J. Sandwick 1,2 , S. S. Wise 1,2 , N. Gordon 3,2 and J. P. Wise 1,2 . 1 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME, 2 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME and 3 Department of Chemistry, University of Southern Maine, Portland, ME. #1146 MICRONUCLEUS FREQUENCY IN BLOOD LYMPHOCYTES FROM CHILDREN ENVIRONMENTALLY EXPOSED TO LEAD. M. Moreno 1,2 , F. Rios 1 , M. Sordo 3 , E. Vera 2 , L. C. Acosta- Saavedra 2 , M. E. Cebrian 2 , E. S. Calderon-Aranda 2 and P. Ostrosky 3 . 1 Facultad de Ciencias Quimico Biologicas, UAG, Chilpancingo, Gro., Mexico, 2 Toxicologia, Cinvestav, Mexico, DF, Mexico and 3 Instituto de Investigaciones Biomedicas, UNAM, Mexico, DF, Mexico. #1147 SPERM NUCLEUS UPTAKES LEAD FROM TESTIS AND EPIDIDYMIS, ALTERING SPERM CHROMATIN CONDENSATION. I. Hernandez- Ochoa 1 , M. Solis-Heredia 1 , V. Rosales-Garcia 2 and B. Quintanilla-Vega 1 . 1 Toxicology Section, CINVESTAV- IPN, Mexico City, D.F., Mexico and 2 Central Laboratory, CINVESTAV-IPN, Mexico City, D.F., Mexico. #1148 ASSOCIATIONS AMONG URIC ACID, LEAD BIOMARKERS, RENAL FUNCTION AND GENETIC POLYMORPHISMS IN KOREAN LEAD WORKERS. V. M. Weaver 1 , B. S. Schwartz 1 , B. G. Jaar 1 , A. C. Todd 2 , K. Ahn 3 , K. T. Kelsey 4 , E. K. Silbergeld 1 , J. Wen 1 and B. Lee 3 . 1 Johns Hopkins University BSPH, Baltimore, MD, 2 Mount Sinai School of Medicine, New York, 3 SoonChunHyang University, Asan, South Korea and 4 Harvard School of Public Health, Boston, MA. #1149 PBPK MODELING OF THE EFFECT OF MICROGRAVITY ON THE RELEASE OF LEAD FROM BONE INTO BLOOD. H. D. Garcia 1 and S. Hays 2 . 1 Life Sciences Systems and Services, Wyle Laboratories, Houston, TX and 2 Intertox, Lyons, CO. Sponsor: C. Lam. #1150 PHARMACOKINETICS OF LEAD (PB) IN SALIVA OF RATS FOLLOWING AN ACUTE ORAL EXPOSURE. K. K. Weitz, D. A. Moore, R. A. Gies, H. Wu and C. Timchalk. Pacific Northwest National Laboratory, Richland, WA. #1151 LEAD DISTRIBUTION FOLLOWING RESPIRATORY EXPOSURE TO LEAD- CONTAINING MATERIALS IN SPRAGUE- DAWLEY RATS. G. M. Fent 1 , T. J. Evans 1 , D. Bannon 2 , M. Dunsmore 1 and S. W. Casteel 1 . 1 Veterinary Pathobiology, University of Missouri, Columbia, MO and 2 US Army center for Health Promotion and Preventitive Medicine, Aberdeen Proving Ground, MD. TUESDAY up-to-date information at www.toxicology.org 137
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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