Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description #1674 4:30 VINYL CHLORIDE: LEGACY AND LESSONS LEARNED. R. O. McClellan. Toxicology and Human Health Risk Analysis, Albuquerque, NM. #1675 4:40 METABOLISM OF VINYL HALIDES AND REACTIONS OF ELECTROPHILIC PRODUCTS. F. P. Guengerich. Biochemistry and Center in Molecular Toxicology, Vanderbilt University, Nashville, TN. Thursday Morning, March 10 8:30 AM to 11:30 AM Room RO4 Thursday Morning WEDNESDAY #1676 5:00 VINYL CHLORIDE: ESTABLISHING THE ROLE OF DOSIMETRY IN RISK ASSESSMENT. M. E. Andersen. CIIT Centers for Health Research, Research Triangle Park, NC. #1677 5:20 VINYL CHLORIDE: TOXICOLOGICAL AND CARCINOGENIC RESPONSES IN HUMANS AND LABORATORY ANIMALS. R. O. McClellan. Toxicology and Human Health Risk Analysis, Albuquerque, NM. Abstract 1678 is located on page 178 Wednesday Afternoon, March 9 4:45 PM to 5:30 PM Room 213 SOT COUNCIL MEETING WITH STUDENTS/POST-DOCTORAL FELLOWS All students and post-doctoral fellows are encouraged to attend this meeting, which provides as a two-way dialog between SOT Council and students. Wednesday Evening Wednesday Evening, March 9 6:00 PM to 7:30 PM See Events Calendar on Pages 2–6 for Room Listings SPECIALTY SECTION MEETINGS: COMPARATIVE AND VETERINARY, DERMAL, DRUG DISCOVERY, FOOD SAFETY, MOLECULAR BIOLOGY, REPRODUCTIVE AND DEVELOPMENTAL, WOMEN IN TOXICOLOGY. Wednesday Evening, March 9 6:00 PM to 11:00 PM See Events Calendar on Pages 2–6 for Room Listings REGIONAL CHAPTER MEETINGS/RECEPTIONS Many of the Regional Chapters meet during the SOT Annual Meeting. Details for these Regional Chapter receptions and meetings are listed in Program’s Events Calendar. SYMPOSIUM SESSION: CROSS-SPECIES TOXICOLOGY IN THE AGE OF GENOMICS Chairperson(s): William B. Mattes, Gene Logic Inc., Gaithersburg, MD and Timothy P. Ryan, Eli Lilly and Company, Greenfield, IN. Endorsed by: National Capital Area Chapter Risk Assessment SS While animal models have been the cornerstone of experimental toxicology and safety assessment for the last two centuries, the question often arises whether the results seen in one species are relevant to what may be expected in another, particularly when the extrapolation is being made to man. Genomic information could change this problem dramatically. At one level, comparisons of coding regions and upstream regulatory regions across genomes can provide clues as to similarities and differences between species vis-à-vis the molecular components of a cell and their regulation. One example where this approach has provided valuable insights is the nuclear receptor gene family. These genomic comparisons can also be used to inform the use of non-mammalian models of toxicity such as Caenorhabditis elegans. Complementary to such genomic comparisons, mRNA profiling with microarrays allows a global view of toxicant-induced transcriptome alterations in various cell types, tissues and species, and allows an experimental view of similarities and differences in signaling and response pathways. Thus transcriptome alterations can be compared in vivo between rat and canine models, and in vitro between rat, canine, and human hepatocytes. The promise is that such tools will allow for any given toxic response a truly molecular assessment of the relevance of various animal models to one another and to man. #1968 8:30 CROSS-SPECIES TOXICOLOGY IN THE AGE OF GENOMICS. W. B. Mattes 1 and T. P. Ryan 2 . 1 Toxicogenomics, Gene Logic Inc., Gaithersburg, MD and 2 Investigative Toxicology, Eli Lily and Company, Greenfield, IN. #1969 8:40 INSIGHTS INTO EVOLUTION OF XENOBIOTIC METABOLISM IN MAMMALS FROM COMPARATIVE GENOMICS OF THE NUCLEAR RECEPTOR GENE FAMILY. D. A. Wheeler 1,2 , A. J. Cooney 3 and Z. Zhang 1 . 1 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 2 Molecular and Human Genetics, Baylor College of Medicine, Houston, TX and 3 Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX. Sponsor: W. Mattes. #1970 9:05 COMPUTATIONAL AND EMPIRICAL INVESTIGATION OF ESTROGEN AND DIOXIN ELICITED EFFECTS: A COMPARATIVE ANALYSIS. T. Zacharewski. Biochemistry & Molecular Biology, Center for Integrative Toxicology, National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI. #1971 9:30 GENOMIC CHARACTERIZATION OF THE ACUTE PHASE RESPONSE IN MICE, DOGS, AND RATS. T. P. Ryan. Investigative Toxicology, Eli Lily and Company, Greenfield, IN. 200 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1972 9:55 CROSS-SPECIES COMPARISONS OF TRANSCRIPTIONAL RESPONSES IN PRIMARY HEPATOCYTES. W. B. Mattes, K. Daniels, D. L. Mendrick and M. S. Orr. Toxicogenomics, Gene Logic Inc., Gaithersburg, MD. #1973 10:20 TOXICO- AND PHARMACOGENETIC ANALYSIS IN A NOVEL MODEL OF PARKINSON’S DISEASE: DOPAMINE NEURON DEGENERATION IN C. ELEGANS. R. Nass, C. Nichols, M. Fullard, M. Garrett and M. Marvanova. Anesthesiology and Pharmacology, and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN. Sponsor: B. Mattes. Thursday Morning, March 10 8:30 AM to 11:30 AM Room 208 SYMPOSIUM SESSION: DEVELOPMENTAL EXPRESSION OF HUMAN PHASE I AND PHASE II TOXICANT METABOLIZING ENZYMES: IMPACT ON EARLY LIFE STAGE SUSCEPTIBILITY Chairperson(s): Ronald Hines, Medical College of Wisconsin, Milwaukee, WI and Melissa A. Runge-Morris, Wayne State University, Detroit, MI. Endorsed by: Mechanisms SS Risk Assessment SS Student Advisory Committee Over the past several years, there has been considerable interest in the dynamic changes that occur in toxicokinetic factors during early life stages and how these changes may impact differential toxicant susceptibility. Advances in molecular and analytical techniques have allowed a better characterization of these changes, as well as some of the underlying control mechanisms. The objectives of this symposium are to: 1) present examples of the information gained about major members of the oxidative Phase I enzymes and how this information has led to the identification of common developmental themes; 2) present information on the developmental expression of two conjugative phase II enzyme classes, N-acetyl transferases and sulfotransferases, and how, combined with the information regarding phase I enzymes, can inform regarding possible differential susceptibility during ontogeny; and 3) demonstrate how such information regarding developmental expression can be integrated into physiological-based toxicokinetic models for predicting temporal-specific changes in toxicant disposition useful for early life stage risk assessment. These advances offer the promise and challenge of predicting changing dose-response relationships during early life and the possible prevention of developmental toxicity. #1974 8:30 ONTOGENY OF HUMAN HEPATIC PHASE I AND PHASE II ENZYMES: IMPLICATIONS FOR DIFFERENTIAL TOXICANT SUSCEPTIBILITY. R. N. Hines 1 and M. A. Runge-Morris 2 . 1 Pediatrics, Medical College of Wisconsin, Milwaukee, WI and 2 Inst. Env. Hlth. Sciences., Wayne State University, Detroit, MI. #1975 8:35 HUMAN HEPATIC PHASE I ENZYME DEVELOPMENTAL EXPRESSION. R. N. Hines. Pediatrics, Med. Col. Wisconsin, Milwaukee, WI. #1976 9:15 SULFOTRANSFERASE EXPRESSION: IMPLICATIONS FOR PRENATAL TOXICITY. M. Runge-Morris. Inst. Envir. Health Sciences., Wayne State University, Detroit, MI. #1977 9:55 DEVELOPMENTAL EXPRESSION OF HUMAN AND MURINE ARYLAMINE N- ACETYLTRANSFERASES(NAT): IMPLICATIONS FOR AROMATIC AMINE GENOTOXICITY. C. A. McQueen. University of Arizona, Tucson, AZ. #1978 10:35 DEVELOPMENT OF PHYSIOLOGICALLY- BASED TOXICOKINETIC MODELS FOR EARLY LIFE STAGES: IMPLICATIONS FOR DIFFERENTIAL TOXICANT SUSCEPTIBILITY. D. Hattis 1 , G. Ginsberg 2 , B. Sonawane 3 and K. Walker 4 . 1 2 Clark University, Worcester, MA, CT Department of Public Health, Hartford, CT, 3 U.S. EPA, Washington, DC and 4 Clark University, Worcester, MA. Thursday Morning, March 10 8:30 AM to 11:30 AM Room 220 SYMPOSIUM SESSION: SYSTEMS BIOLOGY: APPROACHES AND APPLICATIONS TO TOXICOLOGY Chairperson(s): William Slikker, Jr., National Center for Toxicological Research, Jefferson, AR and Thomas Knudsen, University of Louisville, School of Dentistry, Louisville, KY. Endorsed by: Neurotoxicology SS Reproductive and Development SS Risk Assessment SS* Genomics and proteomics provide information on the cellular reaction to drug and chemical exposures but this is only part of what is needed to understand complex developing systems, where susceptibilities to exposure may advance through transitional states of varying susceptibilities. The NIH Director’s Road Map has focused on the need to provide new tools to investigators, to speed the process of discovery, to encourage interdisciplinary research, and to promote translational research. Systems biology will contribute to this missive. Systems biology is the application of systems theory to solving biological problems and is a means to analyze complex behavior in a composite system that may be decomposed into subsystems to facilitate understanding and modeling. In toxicology, it provides a means for identifying pathways that are critical to disease and to discovering on- and off- target effects of compounds. Devising computational models and integrating these models with empirical data provide important insight into complex systems-level behaviors, ultimately striving to deliver the mechanism connecting small molecules (drug or chemical) with a clinical endpoint (phenotype or disease) with regards to metabolic and regulatory networks. The integrative topic of systems biology and application examples focused on several organ systems and stages of development will interests toxicologists with backgrounds in mechanisms, reproduction, development, neuroscience, modeling, and safety and risk assessment. #1979 8:30 SYSTEMS BIOLOGY: APPROACHES AND APPLICATIONS TO TOXICOLOGY. W. Slikker 1 and T. B. Knudsen 2 . 1 Division of Neurotoxicology, NCTR/FDA, Jefferson, AR and 2 Department of Molecular, Cellular and Craniofacial Biology Birth Defects Center, University of Lousiville, School of Dentistry, Louisville, KY. #1980 9:00 EXTRACTING MEANING FROM EXPRESSION DATA. J. Quackenbush. Institute for Genomic Research, Rockville, MD. Sponsor: T. Knudsen. THURSDAY up-to-date information at www.toxicology.org 201
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Program - Society of Toxicology

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