Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
TUESDAY
#724 AFFINITY LABELING OF SER-57 IN RAT
CYTOCHROME P450C24A1 (CYP24A1) OF THE
VITAMIN D PATHWAY: MUTATION AND
CHARACTERIZATION. A. J. Annalora 1,2 , A.
Pastusyzn 2 , R. Ray 3 , C. B. Marcus 1 and J. L. Omdahl 2 .
1 College of Pharmacy, University of New Mexico,
Albuquerque, NM, 2 Department of Biochemistry and
Molecular Biology, University of New Mexico,
Albuquerque, NM and 3 Vitamin D Laboratory, Boston
University-SOM, Boston, MA.
#725 THE USE OF THE MECHANISM BASED
INHIBITOR 2-ETHYNYLNAPHTHALENE (2EN)
TO PROBE THE ACTIVE SITE OF CYP2B4. D.
Cheng, J. R. Reed, R. W. Kelley and W. L. Backes.
Pharmacology, LSUHSC, New Orleans, LA.
#726 INHIBITION OF THE HUMAN LIVER
MICROSOMAL AND HUMAN CYTOCHROME
P450 1A2 AND 3A4 METABOLISM OF
ESTRADIOL BY DEPLOYMENT-RELATED
CHEMICALS. K. A. Usmani, R. L. Rose and E.
Hodgson. Environmental & Molecular Toxicology,
North Carolina State University, Raleigh, NC.
#727 CORRELATIONS BETWEEN ACTIVITIES OF
CYPS 2E1/1A2 AND HISTOLOGIC FIBROSIS IN
HCV PATIENTS. S. I. Shedlofsky 1,3 , R. T. Tosheva 1 ,
C. Hallberg 2 and K. E. Anderson 2 . 1 Medicine,
University of Kentucky, Lexington, KY, 2 University of
Texas Medical Branch, Galveston, TX and 3 General
Clinical Research Center, Lexington, KY.
#728 ROLE OF CYTOCHROME P450 2E1 (CYP2E1) IN
TRICHLOROETHYLENE (TCE) METABOLISM
AND DISPOSITION: COMPARATIVE STUDIES
USING CYP2E1-/- AND WILD-TYPE MICE. D.
Kim and B. I. Ghanayem. Laboratory of Pharmacology
and Chemistry, NIEHS/NIH, Research Triangle Park,
NC.
#729 CYTOCHROME P450 2E1 (CYP2E1) INDUCTION
BY PYRIDAZINE PRODUCES QUALITATIVE
AND QUANTITATIVE CHANGES IN THE
METABOLISM OF TRICHLOROETHYLENE TO
POTENTIALLY CARCINOGENIC
METABOLITES. S. Lee, S. Muralidhara, C. A. White
and J. V. Bruckner*. Department of PBS, University of
Georgia, Athens, GA.
#730 PROTECTIVE EFFECT OF DIALLYL SULFONE
AGAINST LUNG MUTAGENESIS INDUCED BY
VINYL CARBAMATE. L. G. Hernandez and P.
Forkert. Department of Anatomy and Cell Biology,
Queen’s University, Kingston, ON, Canada.
#731 ROLE OF TOXICOKINETICS IN THE
BIOACTIVATION-MEDIATED LIVER INJURY
OF THIOACETAMIDE IN AD LIBITUM FED AND
DIET RESTRICTED RATS. J. Chilakapati, M. C.
Korrapati and H. M. Mehendale. Toxicology, University
of Louisiana at Monroe, Monroe, LA.
#732 CYP2E1 OXIDATION MEDIATES THE SPERM
TOXICITY OF 1-BROMOPROPANE IN MICE. C.
Garner 1 , J. Davis 1 , C. Sloan 1 , J. Burgess 1 , A. Jeffcoat 1 ,
A. Hughes 1 , A. Parham 1 , J. Mathews 1 , L. Burka 2 and B.
Ghanayem 2 . 1 DMPK, RTI International, Research
Triangle Park, NC and 2 NIEHS, Research Triangle
Park, NC.
#733 HEPATIC METABOLISM OF AROMATIC AMINE
HAIR DYE COMPONENTS AS COMPARED
WITH THAT OF 2-AMINOFLUORENE. L.
Stanley 1 , J. Skare 2 , E. Doyle 1 , R. Powrie 1 , D. D’
Angelo 2 and C. Elcombe 1 . 1 CXR Biosciences Ltd.,
Dundee, United Kingdom and 2 Central Product Safety,
Sharon Woods Technical Center, Procter & Gamble
Company, Cincinnati, OH.
#734 DECHLORINATION OF PCB IUPAC #101 BY
HUMAN CYP 2B6 TRANSFECTED INSECT CELL
MICROSOMES. D. P. Waller and J. E. McGraw.
Biopharmaceutical Sciences, University of Illinois at
Chicago College of Pharmacy, Chicago, IL.
#735 REGIO-SPECIFIC (ω TO ω-6) FATTY ACID
(LAURIC, MYRISTIC AND PALMITIC)
HYDROXYLATION IN HUMAN POOLED LIVER
AND RECOMBINANT MICROSOMES. M. L.
Haasch and J. C. Allgood. National Center for Natural
Products Research, Environmental Toxicology Research
Program, Pharmacology, The University of Mississippi,
University, MS.
#736 ROLE OF CYTOCHROME P450 3A IN
HEPATOTOXICITY OF THE
CHLOROACETANILIDE HERBICIDE
ALACHLOR. S. R. Miranda and S. A. Meyer.
Toxicology, University of Louisiana at Monroe,
Monroe, LA.
#737 INTERINDIVIDUAL VARIABILITY IN P450-
MEDIATED METABOLISM OF 4-
(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-
BUTANONE(NNK) IN HUMAN WHOLE
PERIPHERAL LUNG MICROSOMES. P. J. Brown 1 ,
K. R. Reid 2 , D. Petsikas 2 and T. E. Massey 1 .
1 Pharmacology and Toxicology, Queen, Kingston, ON,
Canada and 2 Surgery, Queen’s University, Kingston,
ON, Canada.
#738 COMPARATIVE METABOLISM OF AFLATOXIN
B1 (AFB1) BY ZEBRAFISH, RAINBOW TROUT
AND HUMAN CYTOCHROMES P450. C. L.
Miranda, W. Chung, J. Wang and D. R. Buhler.
Environment & Molec. Toxicology, Oregon State
University, Corvallis, OR.
#739 EXPRESSION AND CHARECTERIZATION OF
CHANNEL CATFISH CYP 2X1. S. MOSADEGHI,
B. Furnes, C. Wong and D. Schlenk. Environmental
Toxicology, University of California, Riverside, CA.
#740 CHARACTERIZATION AND COMPARISON OF
METHODS FOR VESICULAR
RECONSTITUTION OF CYTOCHROME P450
2B4 AND NADPH P450 REDUCTASE. J. R. Reed, R.
W. Kelley and W. L. Backes. Pharmacology, Louisiana
State University Health Science Center, New Orleans,
LA.
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SOT’s 44 th Annual Meeting