Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY #1181 SUBCHRONIC TOXICITY STUDY OF HEXACHLOROBENZENE (HCB) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS. J. D. Johnson 1 , D. Vasconcelos 1 , M. Ryan 1 , A. Fuciarelli 2 , S. Graves 1 , M. Hejtmancik 1 , A. Braen 3 , M. Vallant 4 , H. Toyoshiba 4 , R. Chhabra 4 , N. Walker 4 and M. Hooth 4 . 1 Health and Life Sciences, Battelle, Columbus, OH, 2 Colorado State University, Fort Collins, CO, 3 4 Hoffmann-La Roche, Nutley, NJ and NIEHS, NIH, Research Triangle Park, NC. #1182 SUBCHRONIC TOXICITY OF ALPHA-METHYL- 1, 3-BENZODIOXOLE-5-PROPIONALDEHYDE IN RATS. A. Lapczynski, D. Isola and A. Api. Research Institute for Fragrance Material, Inc., Woodcliff Lake, NJ. #1183 SUBCHRONIC TOXICITY OF ACETYL CEDRENE IN RATS. C. Letizia, D. A. Isola and A. Api. Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ. #1184 CNS AND CARDIORESPIRATORY EFFECTS OF TWO NOVEL BISPYRIDINIUM OXIMES (ICD-39 AND ICD-585). F. T. Chang, D. Spriggs and S. DeBus. Applied Pharmacology, USAMRICD, APG-EA, MD. Sponsor: A. Sciuto. #1185 TOXICOLOGICAL EVALUATION OF CIGARETTES WITH TWO BANDED CIGARETTE PAPER TECHNOLOGIES. E. H. Theophilus, D. R. Meckley, K. W. Shreve, P. H. Ayres, B. R. Bombick, M. F. Borgerding, C. D. Garner, D. H. Pence and J. E. Swauger. Research & Development, R. J. Reynolds Tobacco Company, Winston-Salem, NC. #1186 TOXICOLOGICAL EVALUATION OF A CIGARETTE PAPER WITH REDUCED IGNITION PROPENSITY: IN VITRO AND IN VIVO TESTS. M. Misra 1 , R. D. Leverette 1 , J. T. Hamm 1 , M. B. Bennett 1 , J. D. Heck 1 , R. Morrissey 2 and N. Rajendran 3 . 1 Lorillard Tobacco Company, Greensboro, NC, 2 PAI, Chicago, IL and 3 IIT Research Institute, Chicago, IL. #1187 TOXICOLOGICAL EVALUATION OF DIAMMONIUM PHOSPHATE (DAP) AND UREA AS INGREDIENTS ADDED TO CIGARETTE TOBACCO. M. S. Stavanja, P. H. Ayres, G. M. Curtin, B. R. Bombick, M. F. Borgerding, C. D. Garner, D. H. Pence and J. E. Swauger. R.J. Reynolds Tobacco Company, Winston-Salem, NC. #1188 IN VITRO TOXICITY EVALUATION OF TOOTHPASTES USING RECONSTRUCTED HUMAN ORAL AND GINGIVAL MUCOSA MODELS. B. De Wever 1 , B. Vande Vannet 2 , P. Bottenberg 2 and M. Cappadoro 1 . 1 SkinEthic Laboratories, Nice, France and 2 Free University of Brussels, Brussels, Belgium. #1189 IN VITRO SAFETY EVALUTION STUDIES OF LUTEIN AND ZEAXANTHIN. X. Chen 1 , B. A. Fowler 2 and F. Khachik 3 . 1 Program in Toxicology, Department of Epidemiology & Preventive Medicine, University of Maryland, Baltimore, Baltimore, MD, 2 Division of Toxicology, Agency for toxic Substances and Disease Registry, Atlanta, GA and 3 Chemistry and Biochemistry, University of Maryland, College Park, MD. #1190 AEROSOL CHARACTERIZATION FOR CONSUMER LAUNDRY ENZYME-CONTAINING STAIN REMOVERS. F. Ayala-Fierro 1 , D. P. Davis 1 , J. Billman 2 , C. Jeng 3 , R. E. Rogers 3 and A. Lefebvre 3 . 1 Clinical Studies and Toxicology, The Dial Corporation, Scottsdale, AZ, 2 Research and Development, The Dial Corporation, Scottsdale, AZ and 3 Toxcon HSRC, Edmonton, AB, Canada. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: HYPERSENSITIVITY II Chairperson(s): Frank Gerberick, Procter & Gamble, Miami Valley Laboratories, Cincinnati, OH. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1191 ENHANCING EFFECT OF CHLORINATED ORGANIC SOLVENTS ON INFLAMMATORY MEDIATOR PRODUCTION. M. Seo, M. Satoh and H. Nagase. DEPARTMENT OF HYGIENICS, GIFU PHARMACEUTICAL UNIVERSITY, GIFU, Japan. #1192 RELATIONSHIP BETWEEN CD86/CD54 EXPRESSION AND CELL VIABILITY IN IN VITRO SKIN SENSITIZATION TEST OF WATER- SOLUBLE CHEMICALS USING THP-1 CELLS. T. Ashikaga 1 , H. Sakaguchi 2 , K. Yoneyama 1 , S. Sono 1 , M. Miyazawa 2 , Y. Yoshida 2 , Y. Ito 2 , H. Suzuki 2 , H. Itagaki 1 and H. Toyoda 1 . 1 Shiseido Co., Ltd.,, Kanagawa, Japan and 2 Kao Corporation, Tochiga, Japan. #1193 THE RELASHIONSHIP BETWEEN CD86/CD54 EXPRESSION AND THP-1 CELL VIABILITY IN AN IN VITRO SKIN SENSITIZATION TEST FOR WATER-INSOLUBLE CHEMICALS. H. SAKAGUCHI 1 , T. ASHIKAGA 2 , M. MIYAZAWA 1 , Y. YOSHIDA 1 , Y. ITO 1 , K. YONEYAMA 2 , S. SONO 2 , H. ITAGAKI 2 , H. TOYODA 2 and H. SUZUKI 1 . 1 Kao Corporation, Tochigi, Japan and 2 Shiseido Co., Ltd.,, Kanagawa, Japan. #1194 PHENOTYPIC ALTERATIONS AND CYTOKINE PRODUCTION IN THP-1 CELLS IN RESPONSE TO ALLERGENS. M. MIYAZAWA, Y. ITO, Y. YOSHIDA, H. SAKAGUCHI and H. SUZUKI. Kao Corporation, TOCHIGI, Japan. Sponsor: J. AVALOS. #1195 EVALUATION OF CYTOKINES RELEASE FROM THP-1 CELLS AS PREDICTIVE MARKERS OF CONTACT SENSITIZATION. R. Slim, R. Petty, M. S. LaGattuta and J. R. Piccotti. Worldwide Safety Sciences, Pfizer Global Research & Development, Ann Arbor, MI. 140 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1196 USE OF HISTORICAL LOCAL LYMPH NODE DATA IN THE DEVELOPMENT OF ALTERNATIVE TEST METHODS FOR SKIN SENSITIZATION. C. Ryan 1 , P. Kern 2 , D. Basketter 3 , G. Patlewicz 3 , R. Dearman 4 , I. Kimber 4 and F. Gerberick 1 . 1 Procter & Gamble Company, Cincinnati, OH, 2 Procter & Gamble Company, Brussels, Belgium, 3 SEAC, Unilever, Sharnbrook, United Kingdom and 4 Central Toxicology Laboratory, Syngenta, Macclesfield, United Kingdom. #1197 DEVELOPMENT OF A PEPTIDE REACTIVITY MODEL FOR SCREENING THE SKIN SENSITIZATION POTENTIAL OF CONTACT ALLERGENS. J. D. Vassallo 1 , J. G. Chaney 1 , R. E. Bailey 1 , S. W. Morrall 1 , B. B. Price 1 , J. Lepoittevin 2 and F. G. Gerberick 1 . 1 Central Product Safety, Procter & Gamble, Cincinnati, OH and 2 Laboratorie de Dermatochimie, Universite Louis Pasteur, Strasburg, France. #1198 IDENTIFICATION OF POTENTIAL MARKERS FOR THE PREDICTION OF SKIN SENSITIZATION: REAL-TIME PCR ANALYSIS OF ALLERGEN-TREATED DENDRITIC CELLS. L. Gildea 1 , C. A. Ryan 1 , B. C. Hulette 1 , L. Foertsch 1 , R. J. Dearman 2 , I. Kimber 2 and F. Gerberick 1 . 1 Procter & Gamble Company, Cincinnati, OH and 2 Syngenta Central Toxicology Laboratory, Macclesfield, United Kingdom. #1199 EFFECTS OF LIPOPHILICITY AND VISCOSITY OF SOLVENTS ON DPM/LN BACKGROUND LEVEL IN MURINE LOCAL LYMPH NODE ASSAY (LLNA). W. Wang-Fan, L. G. Ullmann and G. Arcelin. Toxicology, RCC Ltd., Fuellinsdorf, Switzerland. Sponsor: K. Sachsse. #1200 INFLUENCE OF AGEING ON LOCAL LYMPH NODE ASSAY RESPONSES TO HEXYL CINNAMIC ALDEHYDE. C. Betts, A. Banyard, L. Beresford, R. J. Dearman and I. Kimber. Syngenta CTL, Macclesfield, Cheshire, United Kingdom. #1201 CORRELATION OF LLNA AND HUMAN SKIN SENSITISATION THRESHOLDS. D. A. Basketter 1 , C. Clapp 1 , B. Safford 1 , D. Jefferies 1 , I. Kimber 2 , R. Dearman 2 , C. A. Ryan 3 and F. Gerberick 3 . 1 SEAC, Unilever, Sharnbrook, United Kingdom, 2 Syngenta CTL, Macclesfield, United Kingdom and 3 Procter & Gamble, Cincinnati, OH. #1202 POTENCEY ESTIMATIONS FOR SEVERAL FRAGRANCE MATERIALS IN THE LOCAL LYMPH NODE ASSAY AND THEIR CORRELATION TO HUMAN STUDIES. J. Lalko and A. Api. Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ. #1203 ASSESSMENT OF THE LOCAL LYMPH NODE ASSAY USING A MODIFIED LOATS AUTOMATED MICRONUCLEUS ASSAY SYSTEM. J. Kerzee, Y. Xu and J. W. Parton. MicaGenix, Inc., Greenfield, IN. #1204 CYTOKINE EXPRESSION PROFILES OF CD4 AND CD8 CELLS FROM PEANUT ALLERGEN- PRIMED MICE. P. Wachholz, R. J. Dearman and I. Kimber. Immunology, Syngenta Central Toxicology Laboratory, Macclesfield, United Kingdom. #1205 ORAL AND SUBCUTANEOUS EXPOSURE TO PURIFIED PEANUT ALLERGENS AND PEANUT EXTRACT: THE FOOD MATRIX EFFECT. F. van Wijk 1,2 , R. Pieters 1 , S. Nierkens 1 , S. Koppelman 2 and L. Knippels 2 . 1 Immunotoxicology, IRAS, Utrecht, Netherlands and 2 TNO, Zeist, Netherlands. #1206 INFLUENCE OF BACTERIAL ENDOTOXIN ON IGE ANTIBODY RESPONSES PROVOKED IN MICE BY PROTEIN ALLERGENS. R. J. Dearman 1 , D. Fox 2 , S. Attenborough 2 and I. Kimber 1 . 1 Syngenta CTL, Macclesfield, United Kingdom and 2 Syngenta Jealotts Hill, Bracknell, United Kingdom. #1207 CYTOKINE FINGERPRINTING OF CHEMICAL ALLERGENS : COMPARISONS OF MESSAGE VERSUS PROTEIN. B. Flanagan 1 , C. J. Betts 2 , H. T. Caddick 2 , R. J. Dearman 2 and I. Kimber 2 . 1 Liverpool University, Liverpool, United Kingdom and 2 Syngenta CTL, Macclesfield, United Kingdom. #1208 IMPACT OF ROUTE AND INTENSITY OF EXPOSURE DURING SENSITIZATION IN BN RATS. J. H. Arts 1 , N. Bloksma 2,3 , A. H. Penninks 1 and F. Kuper 1 . 1 TAP, TNO Nutrition and Food Research, Zeist, Netherlands, 2 Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands and 3 Faculty of Biology, Utrecht University, Utrecht, Netherlands. Sponsor: V. Feron. #1209 TOPICAL EXPOSURE OF MICE TO PHTHALATE IS WITHOUT ADJUVANT EFFECT. D. Shaw, R. J. Dearman and I. Kimber. Syngenta CTL, Macclesfield, United Kingdom. #1210 AUGMENTATION OF OVALBUMIN-INDUCED IGE AND AIRWAY HYPERREACTIVITY RESPONSE BY PERFLUOROOCTANOIC ACID (PFOA). K. J. Fairley 1 , S. Kearns 1 , L. P. Myers 1 , R. Purdy 2 and B. J. Meade 1 . 1 Agriculture and Immunotoxicology Group, NIOSH, Morgantown, WV and 2 Independent Toxiologist, River Falls, WI. #1211 EVALUATION OF DERMAL SENSITIZATION TO WESTERN RED CEDAR EXTRACT AND ABIETIC ACID USING THE LOCAL LYMPH NODE ASSAY. R. A. Brundage, S. Azadi, B. J. Meade, P. D. Siegel and D. N. Weissman. HELD/ASB, NIOSH, Morgantown, WV. #1212 INDUCTION OF CONTACT SENSITIZATION BY ANNATTO EXTRACT BIXIN BUT NOT BY NORBIXIN IN FEMALE BALB/C MICE. W. Auttachoat 1 , D. R. Germolec 2 , K. L. White Jr 1 and T. L. Guo 1 . 1 Virginia Commonwealth University, Richmond, VA and 2 NIEHS, Research Triangle Park, NC. #1213 DIFFERENTIAL ALLERGIC AND NEUROTROPHIN RESPONSES TO FUNGAL COMPONENT EXTRACTS IN MICE. M. Ward 1 , N. Haykal-Coates 1 , Y. Chung 2 , L. Copeland 1 and M. Selgrade 1 . 1 NHEERL, U.S. EPA, Research Triangle Park, NC and 2 SPH, UNC, Chapel Hill, NC. TUESDAY up-to-date information at www.toxicology.org 141
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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SOT Affiliates for 2005 44 th Annua
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Program - Society of Toxicology

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