Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#1050 2:50 GENDER DIFFERENCE OF ACETAMINOPHEN-
INDUCED HEPATOTOXICITY IN MOUSE. G. Dai,
N. Chou, L. He, M. Gyamfi, A. J. Mendy and Y. Y. Wan.
Pharmacology, Toxicology and Therapeutics, University
of Kansas Medical Center, Kansas City, KS.
#1051 3:10 ALTERED HEPATOBILIARY DISPOSITION OF
ACETAMINOPHEN GLUCURONIDE IN MRP3
KNOCKOUT MICE AND THEIR
SUSCEPTIBILITY TO HEPATOTOXICITY. J. E.
Manautou 1 , R. de Waart 2 , N. Zelcer 3 , C. Kunne 2 , M.
Goedken 1 , P. Borst 3 and R. Oude Elferink 2 .
1 Department of Pharmaceutical Sciences, University of
Connecticut, Storrs, CT, 2 Liver Center, Academic
Medical Center, Amsterdam, Netherlands and 3 The
Netherlands Cancer Institute, Amsterdam, Netherlands.
#1052 3:30 RAPID ACTIVATION OF WNT/β-CATENIN
PATHWAY FOLLOWING ACETAMINOPHEN-
INDUCED LIVER INJURY AND REGENRATION.
U. M. Apte, A. Micsenyi and S. Monga. Department of
Pathology, University of Pittsburgh School of Medicine,
Pittsburgh, PA.
#1053 3:50 ROLE OF MITOCHONDRIAL BAX
TRANSLOCATION IN ACETAMINOPHEN-
INDUCED HEPATIC NECROSIS IN MICE. M.
Bajt 1 , J. J. Lemasters 2 and H. Jaeschke 1 . 1 Liver
Research Institute, University of Arizona, Tucson, AZ
and 2 Cell and Developmental Biology, University of
North Carolina at Chapel Hill, Chapel Hill, NC.
#1054 4:10 ACETAMINOPHEN-INDUCED UPREGULATION
OF PI-3K AND NF-κB IN MOUSE LIVER:
REGULATION BY TNFα AND CAVEOLIN-1. C.
Gardner 1,3 , H. Chiu 1 , J. D. Laskin 2,3 and D. L. Laskin 1,3 .
1 2 Rutgers University, Piscataway, NJ, UMDNJ-RWJ
Med. School, Piscataway, NJ and 3 EOHSI, Piscataway,
NJ.
Tuesday Afternoon, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: DEVELOPMENTAL NEUROTOXICITY II
Chairperson(s): Merle Paule, U.S. FDA, Jefferson, AR and John Barnett, West
Virginia University, Morgantown, WV.
Displayed: 1:30 PM–4:30 PM
Attended: 1:30 PM–3:00 PM
#1055 EXPOSURE TO METHYLMERCURY AND
PCB153 DURING PREGNANCY AND
LACTATION. EFFECTS ON BRAIN AND
LYMPHOCYTE CHOLINERGIC MUSCARINIC
RECEPTORS IN RAT DAMS AND PUPS. T.
Coccini 1 , A. F. Castoldi 1 , G. Randine 1 , P. Grandjean 2
and L. Manzo 1,3 . 1 Toxicology Division, Maugeri
Foundation, Pavia, Italy, 2 University of Odense,
Odense, Denmark and 3 University of Pavia, Pavia, Italy.
#1056 DEVELOPMENTAL NEUROPATHOLOGY OF
METHYL MERCURY CHLORIDE. D. M. de
Groot 1 , B. Bisselink 1 , S. A. Hartgring 1 , L. van der
Horst 1 , M. Pelgrim 1 , M. Waanders 1 , M. Kuijpers 1 , J.
O’Callaghan 2 , W. Kaufmann 3 , J. Lammers 1 , B.
Pakkenberg 4 , I. Waalkens 1 and H. Gundersen 5 . 1 TNO
Nutrition and Food Research, Zeist, Netherlands,
2 3 NIOSH, Morgantown, VA, BASF, Ludwigshafen,
Germany, 4 Research Laboratory for Stereology and
Neuroscience, Copenhagen, Denmark and 5 University
of Aarhus, Aarhus, Denmark. Sponsor: V. Feron.
#1057 PRENATAL EXPOSURE TO METHYL
MERCURY OR METHYLAZOXY METHANOL:
EFFECTS ON EARLY POSTNATAL MOTOR
ACTIVITY. D. M. de Groot 1 , M. Kuijpers 1 , J.
O’Callaghan 2 , M. van Dael 1 , H. Gundersen 3 , S.
Hartgring 1 , L. van der Horst 1 , W. Kaufmann 4 , M. Otto 1 ,
B. Pakkenberg 5 , M. Pelgrim 1 , I. Waalkens 1 and J.
Lammers 1 . 1 TNO Nutrition and Food Research, Zeist,
Netherlands, 2 NIOSH, Morgantown, VA, 3 University of
Aarhus, Aarhus, Denmark, 4 BASF, Ludwigshafen,
Germany and 5 Research Laboratory for Stereology and
Neuroscience, Copenhagen, Denmark. Sponsor: V.
Feron.
#1058 METHYLMERCURY (MEHG) ELICITS ACUTE
AND LONG-TERM EFFECTS ON NEWBORN
RAT HIPPOCAMPAL NEUROGENESIS
THROUGH CELL CYCLE MACHINERY. K.
Burke 1 , Y. Cheng 1 , K. Reuhl 2 , A. Petrov 1 and E.
DiCicco-Bloom 1 . 1 Neurosci & Cell Biol, Robert Wood
Johnson Med. Sch, Piscataway, NJ and 2 Pharmacol &
Toxicology, Rutgers University, Piscataway, NJ.
#1059 MEHG DIFFERENTIALLY AFFECTS KINETICS
OF SIPSCS OF RAT CEREBELLAR PURKINJE
AND GRANULE CELLS. Y. Yuan and W. D. Atchison.
Pharmacology/Toxicology, Michigan State University,
East Lansing, MI.
#1060 GESTATIONAL LEAD EXPOSURE PRODUCES
ROD-MEDIATED ELECTRORETINOGRAPHIC
(ERG) SUPERNORMALITY AND DECREASES IN
RETINAL DOPAMINE METABOLISM OF ADULT
RATS. D. A. Fox 1 and S. Kala 2 . 1 University of
Houston, Houston, TX and 2 Baylor College of
Medicine, Houston, TX.
#1061 GESTATIONAL LEAD EXPOSURE PRODUCES A
SELECTIVE DECREASE IN MOUSE RETINAL
DOPAMINERGIC AMACRINE CELL DENSITY
AND DISTRIBUTION. J. E. Johnson, A.
Giddabasappa, Q. Chen and D. A. Fox. University of
Houston, Houston, TX.
#1062 DEVELOPMENTAL EXPOSURE TO LEAD
ELEVATES APP AND AβLEVELS IN THE AGING
BRAIN BUT DOES NOT ALTER THE
PROTEOLYTIC PROCESSING OF APP. M. Basha,
M. Murali, W. Wei, H. K. Siddiqi and N. H. Zawia.
Biomediacl and Pharmaceutical Sciences, University of
Rhode Island, Kingston, RI.
TUESDAY
up-to-date information at www.toxicology.org 131