Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
MONDAY
#34 11:10 PHYSIOLOGICALLY BASED
PHARMACOKINETIC (PBPK) MODELING AS
AN ALTERNATIVE TO RELATIVE POTENCY
FACTORS (RPFS) IN CUMULATIVE RISK
ASSESSMENT: AN EXAMPLE WITH
ACETYLCHOLINESTERASE- (ACHE)
INHIBITING PESTICIDES. R. Conolly, J. Wang and
Y. Tan. Center for Computational Systems Biology &
Human Health Assessment, CIIT Centers for Health
Research, Research Triangle Park, NC.
Monday Morning, March 7
9:30 AM to 12:00 NOON
Room RO2
WORKSHOP SESSION: ROLE OF NUTRIGENOMICS IN SAFETY
ASSESSMENT OF FUNCTIONAL FOODS
Chairperson(s): Madhu Soni, Burdock Group, Vero Beach, FL and Timothy
Zacharewski, Michigan State University, East Lansing, MI.
Endorsed by:
Food Safety SS*
Mechanisms SS
Risk Assessment SS
The recent completion of human genome (blueprint) has triggered an explosion
in research into how drugs might be individualized to capitalize on each patient
s unique genetic code. The line between food and drug is blurring in the era of
the genome. It appears that the food industry is on the verge of a new era where
companies will design foods and market them to consumers according to the
consumer′s genetic makeup. Increased use of bioactive ingredients (so called
functional foods) is challenging toxicologists when making safety determinations.
This evaluation is different from that of drugs or toxins as efficacy or
benefit analysis of the ingredients has not been factored in the safety determination.
The evaluation of absorption, body distribution and metabolism will
result in a realistic assessment of ranges in target tissue concentrations.
Biological effects (both desirable and undesirable) can then be determined based
upon genomic and proteomic changes, the result of which will be a bottom up
approach rather than a top down methodology that imposes unrealistic safety
factors. Thus, data from gene nutrient interaction will open the ways for new
concepts of risk-benefit evaluation. The proposed workshop will cover recent
discoveries in nutrition, genomics and proteomics and how these developments
will change currently used methodology for risk assessment of bioactive/functional
foods. This workshop will focus on applied genomic technologies and
their impact on nutrition, health sciences and particularly on safety determination
of functional foods. The objectives achieved will be: (1) Provide examples
of the impact of genotype (cardiovascular diseases, cancer susceptibility,
allergy, etc) on the response to foods and food components; (2) Identify relevant
biomarkers that are applicable for assessing the benefits and risks of selected
foods; (3) FDA s thinking on use of microarray data in regulatory approvals; and
(4) Regulatory and other challenges in determining safety of “nutriomic” foods.
#35 9:30 ROLE OF NUTRIGENOMICS IN SAFETY
ASSESSMENT OF FUNCTIONAL FOODS. M. G.
Soni 1 and T. R. Zacharewski 2 . 1 Burdock Group, Vero
Beach, FL and 2 Biochemistry and Molecular Biology,
Michigan State University, East Lansing, MI.
#36 9:40 RISK ASSESSMENT OF FOOD AND FOOD
COMPONENTS AT (NEAR) PHYSIOLOGICAL
CONCENTRATIONS. B. van Ommen. Physiological
Sciences, TNO Nutrition and Food Research, Zeist,
Netherlands. Sponsor: M. Soni.
#37 10:05 GENE AND PROTEIN EXPRESSION CHANGES
DURING IMMUNE RESPONSES TO FOOD
ALLERGENS. R. J. Dearman and I. Kimber. Syngenta
CTL, Macclesfield, United Kingdom.
#38 10:30 NUTRIGENOMICS AND INFLAMMATION. K.
Kornman. Interleukin Genetics, Waltham, MA. Sponsor:
M. Soni.
#39 10:55 USE OF MICROARRAY DATA IN REGULATORY
APPROVAL. D. G. Hattan and T. S. Thurmond. Office
of Food Additive Safety, U.S. FDA Center for Food
Safety & Applied Nutrition, College Park, MD.
#40 11:20 IMPACT OF MOLECULAR NUTRITION ON THE
SAFETY ASSESSMENT OF FUNCTIONAL
FOODS: A SWOT ANALYSIS. P. Gillies 1,2 , P. Kris-
Etherton 2 and J. Vanden Heuvel 3 . 1 Nutrition & Health,
DuPont, Newark, DE, 2 Department of Nutritional
Sciences, The Pennsylvania State University, State
College, PA and 3 Department of Veterinary Medicine,
The Pennsylvania State University, State College, PA.
Monday Morning, March 7
9:30 AM to 12:00 NOON
Room 208
PLATFORM SESSION: NANO PARTICLES
Chairperson(s): Mary Jane Cunningham, Houston Advanced Research
Center, The Woodlands, TX and Adrian Nordone, Cabot Corporation, Billerica,
MA.
#41 9:30 A NEW GENERATION OF MULTIFUNCTIONAL
NANOPARTICLES POSSESSING MAGNETIC
MOTOR EFFECT FOR DRUG OR GENE
DELIVERY. K. Yu 1 , J. Kim 1 , M. Cho 1 , B. Kim 2 , J.
Lee 2 and T. Yoon 2 . 1 Laboratory of Toxiclogy, College of
Veterinary Medicine, Seoul National University, Seoul,
South Korea and 2 Materials Chemistry Laboratory,
School of Chemistry, Seoul National University, Seoul,
South Korea.
#42 10:00 THE AGGREGATION OF SINGLE-WALLED
CARBON NANOTUBES IN FRESH WATER AND
SEA WATER. H. Cheng and J. Cheng. Biology and
Chemsitry, City University of Hong Kong, Hong Kong,
N/A, Hong Kong.
#43 10:30 PROTOCOLS FOR ASSESSING IN VITRO
TOXICITY OF NANOPARTICULATES. M.
Palazuelos 1 , A. Moraga 2 , K. Powers 1 and B. Moudgil 3 .
1 Particle Engineering Research Center, University of
Florida, Gainesville, FL, 2 Interdisciplinary Center for
Biotechnology Research, University of Florida,
Gainesville, FL and 3 Center for Human and
Environmental Toxicology, University of Florida,
Gainesville, FL. Sponsor: S. Roberts.
#44 11:00 ASSESSING THE POTENTIAL HAZARD OF
ENGINEERED NANOPARTICLES IN THE
WORK ENVIRONMENT. A. J. Nordone 1 , J. Jose 2
and C. A. Gray 2 . 1 Cabot Corporation, Leuven, Belgium
and 2 Cabot Corporation, Billerica, MA.
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SOT’s 44 th Annual Meeting