Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#24 9:30 THE DEVELOPMENT AND APPLICATION OF
BIOMARKERS OF TOXICITY. J. Dean 2 and A. L.
Lavin 1 . 1 ILSI Health and Environmental Sciences
Institute, Washington, DC and 2 Sanofi-Synthelabo, Inc.,
Malvern, PA.
#25 9:40 NEW BRIDGING BIOMARKERS FOR SAFETY
ASSESSMENT. J. T. MacGregor. Toxicology
Consulting Services, Arnold, MD.
#26 10:05 SERUM CARDIAC TROPONINS AS
BIOMARKERS OF DRUG-INDUCED
CARDIOTOXICITY. M. J. York. Pathology,
GlaxoSmithKline, Ware, Hertfordshire, United
Kingdom. Sponsor: A. Lavin.
#27 10:30 INHIBIN B AS A POTENTIAL BIOMARKER OF
TESTICULAR TOXICITY. J. Stewart. Safety
Assessment, AstraZeneca Pharmaceuticals,
Macclesfield, Cheshire, United Kingdom. Sponsor: A.
Lavin.
#28 10:55 BIOMARKERS OF NEPHROTOXICITY. S.
Beushausen 1 and A. Lavin 2 . 1 WWSS, Pfizer, Inc., St.
Louis, MO and 2 Health and Environmental Sciences
Institute, Washington, DC.
#29 11:20 REGULATORY ASPECTS OF NEW
BIOMARKERS OF TOXICITY. F. Frueh.
FDA/CDER, Rockville, MD. Sponsor: A. Lavin.
Monday Morning, March 7
9:30 AM to 12:00 NOON
Room 220
WORKSHOP SESSION: DOSE-ADDITIVITY OF MIXTURES:
WHERE ARE WE GOING WITH THE SCIENCE?
Chairperson(s): Rory Conolly, CIIT Centers for Health Research, Research
Triangle Park, NC and William H. Farland, U.S. EPA, Washington, DC.
Endorsed by:
Carcinogenesis SS
Mixtures Task Force*
Risk Assessment SS
Student Advisory Committee
A growing challenge in human risk assessment is development of methods to
evaluate risks posed by low-level exposures to environmentally relevant
mixtures. Development of Relative Potency factors (RPFs), which assume
fundamental dose additivity, are currently used as the primary method for evaluating
the risks of mixtures of compounds acting though similar modes of
action. Examples of these are the RPF schemes for dioxins (Toxic Equivalency
Factors) and organophosphate and carbamate pesticides. The aim of the workshop
is provide a broad overview and discussion of the state of the science for
the use and justification of relative potency factors in environmental and human
health risk assessment. The workshop will include presentations describing
specific examples of how RPFs are currently applied to cancer assessments of
dioxin-like compounds and to non-cancer neurotoxicity endpoints such as
exemplified by organophosphate and carbamate pesticides. The recently
completed National Toxicology Program chronic rodent studies testing critical
RPF hypotheses will be discussed as a specific example of the potential impact
of experimental findings on RPF assumptions. In addition, the workshop will
discuss the central importance of dosimetry and exposure assessments to evaluation
of the RPF approach, particularly addressing implications for
understanding potential health risks associated with low-level exposures to
chemical mixtures. The Workshop presentations will be designed to engender
both Panel and Audience discussion focused on defining the scientific justification
and limitations of the use of RPF approaches, and identifying future
research needs that will improve risk assessment tools used to assess health
impacts associated with low-level exposures to a broad spectrum of environmental
chemicals.
#30 9:30 DOSE-ADDITIVITY OF MIXTURES: WHERE
ARE WE GOING WITH THE SCIENCE? R.
Conolly. CIIT Centers for Health Research, Research
Triangle Park, NC.
#31 9:40 CAN MODE OF ACTION PREDICT MIXTURE
TOXICITY FOR RISK ASSESSMENT? C. J.
Borgert 1,2 . 1 Applied Pharmacology and Toxicology,
Inc., Gainesville, FL and 2 Physiological Sciences,
University of FL College of Veterinary Medicine,
Gainesville, FL.
#32 10:10 THE USE OF TEFS IN ASSESSING MIXTURES
OF DIOXINS, FURANS AND DIOXIN-LIKE PCBs.
W. H. Farland, M. DeVito and L. Birnbaum. Office of
Research and Development, U.S. EPA, Washington,
DC.
#33 10:40 TESTING THE TOXIC EQUIVALENCY FACTOR
(TEF) HYPOTHESIS: THE NTP DIOXIN/PCB
CANCER BIOASSAYS. N. J. Walker 1 , M. E. Wyde 1 , P.
W. Crockett 2 , A. Nyska 1 , J. R. Bucher 1 and C. J.
Portier 1 . 1 NIEHS, Research Triangle Park, NC and
2 Constella Group, Research Triangle Park, NC.
MONDAY
up-to-date information at www.toxicology.org 51