Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY #869 A HUMAN DIETARY IODIDE PBPK MODEL TO EVALUATE THE EFFECTS OF PERCHLORATE ON THYROIDAL IODIDE CONTENT. J. W. Fisher 1 , J. L. Campbell 1 and D. Guth 2 . 1 Environmental Health Science, University of Georgia, Athens GA, GA and 2 The Boeing Company, Seattle, WA. #870 USE OF A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL TO ESTIMATE ABSORBED CARBARYL DOSE IN CHILDREN AFTER TURF APPLICATION. M. Okino 1 , F. W. Power 1 , J. B. Knaak 4 , R. Tornero-Velez 2 , C. Lunchick 5 , A. Lowit 3 , J. N. Blancato 2 and C. C. Dary 1 . 1 2 NERL\EDRB, U.S. EPA, Las Vegas, NV, NERL, U.S. EPA, Research Triangle Park, NC, 3 Office of Pesticide Programs, U.S. EPA, Washington, DC, 4 Pharmacology and Toxicology, SUNY, Buffalo, Buffalo, NY and 5 Bayer CropScience, Research Triangle Park, NC. #871 ASSESSING THE RISKS ASSOCIATED WITH CHILDREN INGESTING LEAD IN SCHOOL DRINKING WATER: PBPK MODELING AND RISK COMMUNICATION. M. K. Peterson, R. C. Pleus and S. M. Hays. Intertox, Inc., Seattle, WA. Tuesday Morning, March 8 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: IMMUNOMODULATION Chairperson(s): Deborah Keil, NIOSH, Morgantown, WV and Ghulam Ansari, UTMB, Pathology, Galveston, TX. Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #872 ENFUVIRTIDE DOES NOT IMPAIR HOST RESISTANCE TO INFECTIONS IN RATS. T. D. Steele 1 , W. Geng 1 , F. Burleson 2 and G. Burleson 2 . 1 Nonclinical Drug Safety, Hoffmann-LaRoche, Inc., Nutley, NJ and 2 Burleson Research Technologies, Raleigh, NC. #873 EFFECTS OF METHYLPREDNISOLONE ON CELL PHENOTYPES IN A MURINE CANDIDA HOST DEFENSE MODEL. C. Maier, C. Genell, A. Hillegas and D. J. Herzyk. Safety Assessment, GlaxoSmithKline, King of Prussia, PA. #874 AH RECEPTOR ACTIVATION ELEVATES INTERFERON GAMMA (IFNγ) AND INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) LEVELS IN THE LUNGS OF MICE INFECTED WITH INFLUENZA A VIRUS. H. Neff-LaFord 1 and B. Lawrence 2 . 1 Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, WA and 2 Pharmaceutical Sciences, Washington State University, Pullman, WA. #875 INCREASED NUMBERS OF NEUTROPHILS IN TCDD-TREATED MICE INFECTED WITH INFLUENZA A VIRUS ARE CAUSED BY AN AH RECEPTOR-MEDIATED MECHANISM THAT IS LIKELY SPECIFIC TO THE LUNG. S. Teske 1 , A. A. Bohn 2 and B. Lawrence 1,2 . 1 Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, WA and 2 Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA. #876 ∆9-TETRAHYDROCANNABINOL ALTERS HOST RESISTANCE TO INFLUENZA A/PR/8 INFECTION IN C57BL/6 MICE. J. P. Buchweitz 1,3 , N. E. Kaminski 1,3 and J. R. Harkema 2 . 1 Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 2 Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI and 3 Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #877 EXPOSURE TO THC, A MARIJUANA CANNABINOID, INDUCES ALTERATIONS IN TH1/TH2 CYTOKINE PROFILE RESULTING IN SUPPRESSION OF IMMUNITY AND INCREASED SUSCEPTIBILITY TO BREAST CANCER. R. McKallip 1 , P. S. Nagarkatti 2 and M. Nagarkatti 1 . 1 Department Micro/Immunol, VCU/MCV, Richmond, VA and 2 Pharmacology and Toxicology, VCU/MCV, Richmond, VA. #878 IMMUNE FUNCTIONAL AND HISTOPATHOLOGICAL ALTERATIONS FOLLOWING EXPOSURE IN FEMALE B6C3F1 MICE TO THE WIDELY USED VEHICLE ELMIRON® K. L. White Jr. 1 , A. Nyska 2 , R. D. Brown 1 , D. L. Musgrove 1 , T. L. Guo 1 and D. R. Germolec 2 . 1 Virginia Commonwealth University, Richmond, VA and 2 NIEHS, Research Triangle Park, NC. #879 INTERACTIONS OF MERCURY WITH LIVER- STAGE RESPONSES TO MALARIA INFECTION. J. F. Nyland 1 , A. Lima 1 , G. Mouton 2 , K. West 3 , F. Zavala 1 and E. Silbergeld 1 . 1 EHS & MMI, Johns Hopkins, Baltimore, MD, 2 Grambling State, Grambling, LA and 3 University Hosp of West Indies, Kingston, Jamaica. #880 THE EFFECTS OF CIGARETTE SMOKE EXPOSURE AND PREGNANCY ON INNATE AND ADAPTIVE IMMUNE RESPONSES IN B6C3F1 MICE. E. M. Vancza, S. P. Ng and J. T. Zelikoff. New York University School of Medicine, Tuxedo, NY. #881 SMOKING DURING PREGNANCY REDUCES IMMUNE TUMOR SURVEILLANCE MECHANISMS IN THE OFFSPRING: A TOXICOLOGICAL MODEL. S. P. Ng 1 , A. E. Silverstone 2 , Z. Lai 2 and J. T. Zelikoff 1 . 1 Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY and 2 Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse, NY. 116 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #882 GESTATIONAL EXPOSURE TO PFOS SUPPRESSES IMMUNOLOGICAL FUNCTION IN F1 MICE. D. E. Keil 1 , T. Mehlman 1 , L. Butterworth 1 and M. M. Peden-Adams 2 . 1 Analytical Sciences Branch, NIOSH, Morgantown, WV and 2 Department of Pediatrics, Medical University of South Carolina, Charleston, SC. #883 CHANGES IN THE OVINE HYPOTHALAMIC- PITUITARY-ADRENAL AXIS DURING PREGNANCY AND LACTATION FOLLOWING CHALLENGE WITH ESCHERICHIA COLI LIPOPOLYSACCHARIDE. L. C. Kabaroff 1 , N. Karrow 1 and H. Boermans 2 . 1 Animal and Poultry Science, University of Guelph, Guelph, ON, Canada and 2 Toxicology, University of Guelph, Guelph, ON, Canada. #884 TETRACHLORODIBENZO-P-DIOXIN (TCDD) INHIBITS DIFFERENTIATION AND INCREASES APOPTOTIC CELL DEATH OF PRECURSOR T CELLS IN THE FETAL MOUSE THYMUS. E. Besteman, K. Zimmerman, B. Smith and S. Holladay. Virginia Tech, Blacksburg, VA. #885 POST-NATAL EXPOSURE OF THE RAT TO CYCLOSPORINE DOES NOT RESULT IN PROLONGED IMPAIRMENT OF THE IMMUNE SYSTEM. J. Descotes 1 , G. Ravel 2 , F. Horand 2 and P. C. Barrow 2 . 1 Poison Center, Lyon, France and 2 MDS Pharmacology Services, Saint Germain s/ L’Arbresle, France. #886 EFFECT OF TRIBUTYLTIN CHLORIDE ON NATURAL IMMUNODEFENCES IN THE F1 GENERATION IN MICE. Y. Sugita-Konishi 1 , K. Kimura 2 , K. Kobayashi 1 , M. Tsunoda 3 and Y. Suzuki 2 . 1 Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan, 2 Department of Veterinary Sciences, Azabu University, Sagamihara, Japan and 3 Department of Preventive Medicine and Public Health, Kitazato University, School of Medicine, Sagamihara, Japan. #887 ALTERED SPLENOCYTE FUNCTIONS IN FOURTEEN-MONTH OLD MICE PRENATALLY EXPOSED TO DIETHYLSTILBESTROL. R. M. Gogal 1,2 , J. Fenaux 1 , D. Lindsay 1 , C. Hardy 1 , D. Ward 1 , G. Saunders 1 and S. Ahmed 1 . 1 Biomedical Sciences and Pathobiology, Va Tech, Blacksburg, VA and 2 Biomecical Sciences, Via Virginia Colleg of Osteopathic medicine, Blacksburg, VA. #888 T-CELL MEDIATED IMMUNITY IN ADULT SPRAGUE-DAWLEY RATS IMPLANTED WITH DEPLETED URANIUM. L. B. Healey 1 , J. M. Rutkiewicz 1 , S. R. Lohrke 2 , D. P. Arfsten 2 and K. A. Grasman 1 . 1 Wright State University, Dayton, OH and 2 Naval Health Research Center Environmental Health Effects Laboratory, Wright-Patterson AFB, OH. #889 IMMUNE FUNCTION IN ADULT RATS EXPOSED TO DBT IN DRINKING WATER. J. DeWitt 1 , C. Copeland 2 and R. Luebke 2 . 1 Curriculum in Toxicology, UNC, Chapel Hill, NC and 2 NHEERL/ETD/ITB, U.S. EPA, Research Triangle Park, NC. #890 IN VIVO AND IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF 1, 2:5, 6-DIBENZANTHRACENE IN FEMALE BALB/C MICE. C. Jin 1 , T. Jeon 1 , S. Lee 1 , S. Hyun 1 , D. Lee 1 , G. Kim 1 , I. Jun 1 , E. Lee 1 , H. Jeong 2 and T. Jeong 1 . 1 College of Pharmacy, Yeungnam University, Kyungsan, South Korea and 2 College of Pharmacy, Chosun University, Gwangju, South Korea. #891 EVALUATION OF THE IMMUNOMODULATORY EFFECTS OF DIBENZ(A, H)ANTHRACENE IN ADULT FEMALE B6C3F1MICE. D. M. Hernandez, W. Auttachoat, T. L. Guo and K. L. White Jr.. Virginia Commonwealth University, Richmond, VA. #892 CYTOCHROME P450 1B1 (CYP1B1) IS REQUIRED FOR 7, 12-DIMETHYLBENZ(A)- ANTHRACENE (DMBA) INDUCED SPLEEN CELL IMMUNOTOXICITY IN C57BL/6N MICE. J. Gao, S. W. Burchiel, F. T. Lauer and S. Dunaway. College of Pharmacy Toxicology Program, The University of New Mexico, Albuquerque, NM. #893 NONCOPLANAR PCB-INDUCED IMMUNOTOXICITY IN A FISH MODEL IS NOT AHR-MEDIATED. J. T. Zelikoff and J. Duffy. Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY. #894 METALLOTHIONEIN INFLUENCES ON IMMUNE CAPACITY IN METAL-STRESSED SYSTEMS. K. Zaffuto, D. Unfricht, E. Canpolat, G. Jin, N. Hadjout, X. Yin and M. A. Lynes. Molecular and Cell Biology, University of Connecticut, Storrs, CT, CT. #895 THE PARADOXICAL EFFECTS OF LEAD IN IFNγKNOCKOUT (KO) BALB/C MICE. D. Gao, J. Kasten-Jolly and D. A. Lawrence. Wadsworth Center, Albany, NY. #896 ROLE OF COPPER CHELATION, ALTERATION OF RED-OX BALANCE, AND STRESS MEDIATORS IN MODULATION OF CYTOKINE RESPONSES BY SODIUM METHYLDITHIOCARBAMATE. S. B. Pruett, C. L. Schwab, Q. Zheng and R. Fan. Cell. Biol. & Anatomy, LSU Health Sciences Center, Shreveport, LA. #897 SODIUM METHYLDITHIOCARBAMATE SUPPRESSES INNATE IMMUNITY: ROLE OF TLR SIGNALING AND CYTOKINE PRODUCTION. C. L. Schwab, Q. Zheng, R. Fan and S. B. Pruett. Cell. Biol. & Anatomy, LSU Health Sciences Center, Shreveport, LA. #898 IDENTIFICATION OF BIOMARKERS FOR DRUG-INDUCED STRESS: COMPARISON OF MOUSE AND RAT MODELS. P. Hebert 1 , S. B. Pruett 1 , J. M. LaPointe 2 and T. T. Kawabata 2 . 1 Cell. Biol. & Anatomy, LSU Health Sciences Center, Shreveport, LA and 2 Safety Sciences, Pfizer, Inc., Groton, CT. #899 ROLE OF CORTICOSTERONE IN STRESS- MEDIATED SUPPRESSION OF TUMOR RESISTANCE. J. Adams, S. B. Pruett and P. Hebert. Cell. Biol. & Anatomy, LSU Health Sciences Center, Shreveport, LA. TUESDAY up-to-date information at www.toxicology.org 117
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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