Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
WEDNESDAY
#1959 SIGNALING PATHWAYS OF PARAQUAT-
INDUCED APOPTOSIS: A MODEL FOR
PARKINSON’S DISEASE. H. M. Klintworth 1 and Z.
Xia 1,2 . 1 Env. & Occ. Health Sciences, University of
Washington, Seattle, WA and 2 Phamacology, University
of Washington, Seattle, WA.
#1960 THE ORGANOCHLORINE PESTICIDE
METHOXYCHLOR ALTERS BRAIN
MITOCHONDRIAL RESPIRATION, H 2 O 2
PRODUCTION AND CALCIUM/CAMP
RESPONSE ELEMENT BINDING PROTEIN
LEVELS. R. A. Schuh 3,1 , T. Kristian 1 , J. Flaws 3 and G.
Fiskum 1 . 1 Anesthesiology, University of Maryland
Baltimore, Baltimore, MD, 2 Anesthesiology, University
of Maryland Baltimore, Baltimore, MD, 3 Epidemiology
and Experimental Therapeutics, University of Maryland
Baltimore, Baltimore, MD and 4 Anesthesiology,
University of Maryland Baltimore, Baltimore, MD.
#1961 DIELDRIN EXPOSURE CAUSES OXIDATIVE
DAMAGE IN DOPAMINE NEURONS. J. M.
Hatcher 1 , T. S. Guillot 1 , J. R. Richardson 1,2 and G. W.
Miller 1,2 . 1 Center for Neurodegerative Disease, Emory
University, Atlanta, GA and 2 Environmental and
Occupational Health, Rollins School of Public Health,
Emory University, Atlanta, GA.
#1962 MECHANISM OF SELECTIVE TOXICITY OF
IVERMECTIN IN INSECTS AND MAMMALS. T.
Narahashi 1 , X. Zhao 1 , V. L. Salgado 2 and J. Z. Yeh 1 .
1 Molecular Pharmacology and Biological Chemistry,
Northwestern University Medical School, Chicago, IL
and 2 Bayer CropScience, Global Biology Insecticides,
Monheim, Germany.
#1963 SULFONE METABOLITE OF FIPRONIL
BLOCKS GABA- AND GLUTAMATE-
ACTIVATED CHLORIDE CHANNELS IN
MAMMALIAN AND INSECT NEURONS. X. Zhao 1 ,
J. Z. Yeh 1 , V. L. Salgado 2 and T. Narahashi 1 .
1 Molecular Pharmacology and Biological Chemistry,
Northwestern University Medical School, Chicago, IL
and 2 Bayer CropScience, Global Biology Insecticides,
Monheim, Germany.
#1964 IMMORTALIZED MICROGLIAL CELLS AS A
MODEL SYSTEM FOR OXIDATIVE STRESS:
PESTICIDE-INDUCED GENOMIC CHANGES. J.
E. Royland 1 , P. R. Kodavanti 1 , M. Pooler 2 , O.
Makwana 2 and B. Veronesi 1 . 1 Neurotoxicology
Division, U.S. EPA, Durham, NC and 2 Toxicology
Program, NC State University, Raleigh, NC.
#1965 NEUROTOXIC EFFECTS OF MANCOZEB AND
MANEB IN VIVO AND IN VITRO. L. M. Domico 1,
2 , G. Zeevalk 2 , M. Thiruchelvam 2 and K. R. Cooper 1 .
1 Joint Graduate Program in Toxicology, Rutgers, The
State University of New Jersey, Piscataway, NJ and
2 University of Medicine and Dentistry of New Jersey,
Piscataway, NJ.
#1966 EFFECT OF PYRETHROIDS ON GABA
RELEASE IN THE HIPPOCAMPUS OF FREELY
MOVING RATS. M. M. Hossain 1,3 , T. Suzuki 1,3 , I.
Sato 1,3 , T. Takewaki 3 , K. Suzuki 2 and H. Kobayashi 1,3 .
1 Veterinary Medicine, Iwate University, Morioka, Iwate,
Japan, 2 Agro-bioscience, Iwate University, Morioka,
Iwate, Japan and 3 United Graduate School of Veterinary
Sciences, Gifu University, Gifu, Japan. Sponsor: G.
Corcoran.
#1967 EFFECTS OF PHENYL SALYGENIN
PHOSPHATE (PSP) AND PHENYLMETHANE
SULFONYL FLUORIDE (PMSF) ON RAT
DORSAL ROOT GANGLIA (DRG) CULTURES. E.
Brigo 1 , A. Moretto 1 , P. Glynn 2 , D. E. Read 2 and M.
Lotti 1 . 1 Medicina del Lavoro, Universita’ di Padova,
Padova, Italy and 2 Toxicology Unit, MRC, Leicester,
United Kingdom.
Abstract 1968 is located on page 200.
Wednesday Afternoon, March 9
4:30 PM to 6:00 PM
Room 207
SUNSET SESSION: ADVANCES IN MATERIAL SAFETY DATA
SHEET COMMUNICATION
Chairperson(s): Melissa McDiarmid, University of Maryland, Baltimore, MD
and James Bus, Dow Chemical Company, Midland, MI.
Endorsed by:
Occupational and Public Health SS*
Regulatory and Safety Evaluation SS
Risk Assessment SS
OSHA is currently reviewing its Material Safety Data Sheets (MSDS) requirements,
as is the American National Standards Institute (ANSI). Employers using
hazardous chemicals are required by OSHA’s Hazard Communications Standard
to have MSDSs available to workers. Developing and providing effective
communication is a major challenge within the public health and occupational
health communities. Some MSDSs are difficult for workers to read; some
MSDSs are outdated; and some MSDSs omit needed health information. On the
other hand, some manufacturers produce what might be considered examples of
“best practice” MSDS writing: excellent, readable, and timely information.
Another source of information, the New Jersey Hazardous Substances Fact
Sheets, covers only about 1, 600 workplace chemicals. However, the program
receives 80, 000 hits per month on its website for its fact sheets, which are
considered by many environmental and labor advocates to be good sources of
essential health and safety information. The message that reproductive health
includes both men and women, and that it can be affected by their workplace
exposures, needs to reach the workers and their employers through MSDS
communication. Paul and Kurtz surveyed Massachusetts MSDSs in 1994 for
products containing two known reproductive toxicants, lead and glycol ethers,
and found that over 60% did not mention possible reproductive health effects.
They also found that where reproductive hazards were mentioned in MSDSs,
they were 18 times more likely to address developmental effects than male
reproductive risks. How can MSDS writing be improved to a best practice standard
while avoiding national or international standards conflicts? The NIOSH
Reproductive Health Research Team is interested in finding ways to improve the
quality of MSDSs in general, and particularly the quality of reproductive health
information. Representatives from NIOSH, industry, academia, and the New
Jersey Right to Know Program will present and discuss multiple facets of this
issue.
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SOT’s 44 th Annual Meeting