Program - Society of Toxicology
Program - Society of Toxicology
Program - Society of Toxicology
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#173 PERIPHERAL LYMPH NODES: ISSUES WITH<br />
THE COLLECTION AND ANALYSIS FOR<br />
IMMUNOTOXICITY STUDIES. P. J. Haley 1 , L.<br />
Chouinard 2 , P. Ciaccio 1 , D. Ennulat 3 , L. Gore 3 , S.<br />
Emeigh Hart 1 and J. Lapointe 4 . 1 Global Safety<br />
Assessment, AstraZeneca, Wilmington, DE, 2 CTBR,<br />
Montreal, QC, Canada, 3 GlaxoSmithKline, King <strong>of</strong><br />
Prussia, PA and 4 Pfizer, Groton, CT.<br />
#174 VALIDATION OF A METHOD FOR THE<br />
DETECTION OF ANTI-PROTEIN-X IGG<br />
ANTIBODIES IN RAT AND DOG SERUM BY<br />
ENZYME LINKED IMMUNOSORBENT ASSAY<br />
(ELISA). M. Ionescu, N. Rouleau, G. Desilets, A.<br />
Michaux, M. Duchesneau and L. LeSauteur.<br />
Immunology, CTBR Bio-Research Inc., Senneville, QC,<br />
Canada.<br />
#175 THE REAL TIME MONITOR OF ANTIBODY-<br />
CELL BINDING BY BIOSENSOR ASSAY. K.<br />
Harada, N. Ohtake, S. Hayashi, E. Furukawa, Y.<br />
Kikuchi and J. Kawahara. Pharmaceutical Development<br />
Laboratories, Pharmaceutical Division, Kirin Brewery<br />
Co., Ltd.,, Maebashi-shi, Gunma, Japan. Sponsor: E.<br />
Weaver.<br />
#176 ADVANTAGE OF USING WHOLE SHEEP RED<br />
BLOOD CELLS VERSUS CELL MEMBRANE IN<br />
ELISA ASSAYS TO ASSESS<br />
IMMUNOSUPPRESSION IN VIVO. T. Tsuchiya, A.<br />
Minakawa, H. Watanabe, E. Ohta, M. Sasaki, T. Ikeda,<br />
K. Samura and M. Nishikibe. Tsukuba Safety<br />
Assessment Laboratories, Banyu Pharmaceutical Co.,<br />
Ltd.,, Tsukuba, Ibaraki, Japan. Sponsor: N. Imura.<br />
#177 AN ALTERNATIVE KLH-BASED PROTOCOL<br />
FOR THE SRBC PLAQUE-FORMING CELL<br />
ASSAY: DOSE RANGE FINDER STUDY. M. van<br />
Zijverden, E. Klein Koerkamp, P. van den Berg and A.<br />
Penninks. <strong>Toxicology</strong> and Applied Pharmacology, TNO<br />
Nutrition and Food Research, Zeist, Netherlands.<br />
Sponsor: V. Feron.<br />
#178 SENSITIVITY OF THE KEYHOLE LIMPET<br />
HEMOCYANIN (KLH) ELISA MODEL IS<br />
DIRECTLY RELATED TO DOSE USED FOR<br />
SENSITIZATION. V. L. Peachee 1,2 , C. M. Sheth 1 , A.<br />
M. Halpen 2 and K. L. White 1,2 . 1 Pharmacology and<br />
<strong>Toxicology</strong>, Virginia Commonwealth University,<br />
Richmond, VA and 2 ImmunoTox, Inc., Richmond, VA.<br />
#179 EVALUATION OF T CELL RESPONSES TO<br />
KEYHOLE LIMPET HEMOCYANIN IN THE RAT<br />
MODEL. A. E. Hillegas, C. A. Genell, C. C. Maier and<br />
D. J. Herzyk. Safety Assessment, GlasxoSmithKline,<br />
King <strong>of</strong> Prussia, PA.<br />
#180 COMPARISON OF ANTIBODY TITER AND<br />
CONCENTRATION IN A RAT<br />
IMMUNOTOXICITY MODEL. J. R. Piccotti, J. D.<br />
Alvey, C. Y. Malinczak and R. M. Slim. Worldwide<br />
Safety Sciences, Pfizer Global Research &<br />
Development, Ann Arbor, MI. Sponsor: M. Bleavins.<br />
#181 THE UTILITY OF HOST RESISTANCE ASSAYS<br />
IN LEAD CANDIDATE SELECTION AND<br />
PHARMACEUTICAL SAFETY ASSESSMENT. S.<br />
Groom, C. Thompson and K. Rioux. <strong>Toxicology</strong>, CTBR,<br />
Senneville, QC, Canada.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SIGNAL TRANSDUCTION: KINASES<br />
Chairperson(s): Dennis Petersen, University <strong>of</strong> Colorado, Denver, CO.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#182 ALTERED SIGNAL TRANSDUCTION IN HUMAN<br />
KERATINOCYTES FOLLOWING EXPOSURE TO<br />
BI-FUNCTIONAL ALKYLATING AGENTS. G. D.<br />
Minsavage and J. F. Dillman. Applied Pharmacology<br />
Branch Army Medical Research Institute <strong>of</strong> Chemical<br />
Defense, Aberdeen Proving Ground, MD.<br />
#183 2, 4, 6-TRINITROTOLUENE CAUSES<br />
REDUCTION OF ENOS ACTIVITY BUT<br />
PHOSPHORYLATES ENOS THROUGH<br />
ACTIVATION OF PI3K/AKT SIGNALING IN<br />
ENDOTHELIAL CELLS. Y. sun and Y. Kumagai.<br />
Social and Environmental Medicine, University <strong>of</strong><br />
Tsukuba, Tsukuba, Ibaraki, Japan. Sponsor: A.<br />
Naganuma.<br />
#184 PROTEIN KINASE Cζ MEDIATES LPS<br />
ACTIVATION OF NUCLEAR FACTOR KAPPA B<br />
(NF-κB) IN KIDNEY EPITHELIAL CELLS. W. W.<br />
Polk, J. V. Kushleika, M. E. Ellis, P. L. Simmonds and J.<br />
S. Woods. Environmental and Occupational Health<br />
Sciences, University <strong>of</strong> Washington, Seattle, WA.<br />
#185 4-HYDROXYNONENAL-MEDIATED<br />
INHIBITION OF ERK-ELK-AP-1 SIGNALING. B.<br />
P. Sampey, J. A. Doorn and D. R. Petersen.<br />
Pharmaceutical Sciences, University <strong>of</strong> Colorado HSC,<br />
Denver, CO.<br />
#186 INORGANIC PHOSPHATE CONTROLS CELL<br />
GROWTH THROUGH AKT/MEK-MEDIATED<br />
ERK-DEPENDENT MNK1 TRANSLOCATION IN<br />
NORMAL HUMAN BRONCHIAL EPITHELIAL<br />
CELLS. S. Chang 1 , G. R. Beck 2 , K. Lee 3 , D. Cho 4 and<br />
M. Cho 1 . 1 Laboratory <strong>of</strong> <strong>Toxicology</strong>, College <strong>of</strong><br />
Veterinary Medicine, Seoul National University, Seoul,<br />
South Korea, 2 Laboratory <strong>of</strong> Cancer Prevention,<br />
National Cancer Institute, Frederick, MD, 3 Laboratory<br />
<strong>of</strong> MOlecular Oncology, Korea Institute <strong>of</strong> Radiological<br />
& Medical Sciences, Seoul, South Korea and<br />
4 Reproductive <strong>Toxicology</strong>, National Institute <strong>of</strong><br />
Toxicological Research, KFDA, Seoul, South Korea.<br />
#187 ACTIVATION OF THE TRANSCRIPTION<br />
FACTOR AP-1 BY 2, 2’4, 4’-<br />
TETRACHLOROBIPHENYL (TCB) INVOLVES<br />
EXTRACELLULAR SIGNAL-REGULATED<br />
KINASES (ERKS) ENHANCED EXPRESSION OF<br />
C-FOS PROTOONCOGENE AND IN RAT LIVER<br />
CELLS. G. Chen, B. V. Madhukar and B. Wood.<br />
Pediatrics/Human Development, Michigan State<br />
University, East Lansing, MI.<br />
62<br />
SOT’s 44 th Annual Meeting
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