Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1705 3:10 ASSESSMENT OF SPECTRAL INTEGRATION AND NORMALIZATION IN NMR-BASED METABONOMIC ANALYSES. B. Webb-Robertson 1 , D. F. Lowry 1 , K. H. Jarman 1 , S. J. Harbo 2 , Q. R. Meng 2 , J. G. Pounds 1 and K. M. Lee 2 . 1 Pacific Northwest National Laboratory, Richland, WA and 2 Toxicology Northwest, Battelle Memorial Institute, Richland, WA. #1706 3:30 THE COMPARATIVE TOXICOGENOMICS DATABASE (CTD). C. Mattingly 1 , M. Rosenstein 1 , G. Colby 1 , J. N. Forrest 2,1 and J. L. Boyer 2,1 . 1 MDI Biological Laboratory, Salisbury Cove, ME and 2 Yale University School of Medicine, New Haven, CT. Sponsor: W. Toscano. #1707 3:50 WITHIN- AND BETWEEN-ANIMAL VARIATION, AND REFERENCE RANGES OF HEMATOLOGICAL AND SERUM BIOCHEMICAL PARAMETERS IN CYNOMOLGUS MONKEYS. T. Koga 1,2 , K. Kanefuji 2 and R. Nagata 3 . 1 SNBL, Kagoshima, Japan, 2 The Institute of Statistical Mathematics, Tokyo, Japan and 3 SNBL, Tokyo, Japan. #1708 4:10 THEORETICAL TARGET SEQUENCE FOR THE INTERACTION BETWEEN AFLATOXIN B1 AND PROTEINS. J. Olivero-Verbel, I. Lans, I. Ospino, R. Vivas, E. Martínez and A. Padilla. Environmental and Computational Chemistry Group, University of Cartagena, Cartagena, Bolivar, Colombia. #1709 4:30 A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES WITH GENOMIC, PROTEOMIC AND METABONOMIC COMPONENTS. W. Bao 1 , J. Fostel 2 , M. D. Waters 2 , B. Merrick 2 , D. Ekman 1 , M. Kostich 1 , J. Schmid 1 and D. J. Dix 1 . 1 Office of Research and Development, U.S. EPA, Research Triangle Park, NC and 2 National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Room 208 PLATFORM SESSION: HYPERSENSITIVITY I Chairperson(s): Jean Regal, University of Minnesota, Pharmacology, Duluth, MN and Marsha Ward, U.S. EPA, Environmental Toxicology, Research Triangle Park, NC. #1710 1:30 INFLUENCE OF PROTEIN ALLERGENS ON DENDRITIC CELL ACTIVATION. S. M. George 1 , M. Cumberbatch 2 , C. Portsmouth 2 , A. Destrument 2 , R. J. Dearman 2 , D. Archer 1 , M. Alcocer 1 and I. Kimber 2 . 1 School of Biological Sciences, Nottingham University, Nottingham, United Kingdom and 2 Immunology, Syngenta CTL, Macclesfield, United Kingdom. #1711 1:52 CUTANEOUS CYTOKINE SECRETION PROFILES INDUCED IN MICE FOLLOWING EXPOSURE TO IRRITANTS OR CHEMICAL ALLERGENS. M. Cumberbatch, R. J. Dearman and I. Kimber. Immunology, Syngenta CTL, Macclesfield, United Kingdom. #1712 2:14 VALIDATION OF A MURINE MODEL OF CHEMICAL-INDUCED ASTHMA IN MICE, USING TRIMELLITIC ANHYDRIDE AND 1- CHLORO-2, 4-DINITROBENZENE. J. Vanoirbeek 1 , M. Tarkowski 2 , N. Ben 1 and P. Hoet 1 . 1 Lab. of Pneumology–Lungtoxicology, K.U.Leuven, Leuven, Belgium and 2 Department of Immunotoxicology, Institute of Occupational Medicine, Lodz, Poland. #1713 2:36 CCL2 KO MICE DEMONSTRATE ENHANCED TH2 RESPONSES FOLLOWING DERMAL SENSITIZATION. L. P. Myers 1 , P. Simeonova 2 and B. J. Meade 1 . 1 Agriculture and Immunotoxicology Group, NIOSH, Morgantown, WV and 2 Health Effects Laboratory Division, NIOSH, Morgantown, WV. #1714 2:58 DOSE-DEPENDENT INCREASE IN THE PRODUCTION OF NERVE GROWTH FACTOR, NEUROTROPHIN-3, AND NEUROTROPHIN-4 IN A PENICILLIUM CHRYSOGENUM-INDUCED ALLERGIC ASTHMA MODEL. Y. Chung 1 , A. Farraj 2 , N. H. Coates 3 , S. H. Gavett 3 and M. D. Ward 3 . 1 Environmental Sciences and Engineering, UNC/U.S. EPA, Chapel Hill, NC, 2 CVM, NCSU, Raleigh, NC and 3 ORD, NHEERL, U.S. EPA, Research Triangle Park, NC. #1715 3:20 CYTOKINE, ANTIBODY AND PULMONARY RESPONSES IN BALB/C MICE FOLLOWING DERMAL EXPOSURE TO SELECTED DIISOCYANATES. E. H. Boykin 1 , N. H. Coates 1 , L. M. Plitnik 2 , D. L. Doerfler 1 , S. H. Gavett 1 and M. K. Selgrade 1 . 1 ETD, U.S. EPA, Research Triangle Park, NC and 2 Merck and Co., Inc., West Point, PA. #1716 3:42 IN UTERO EXPOSURE TO GENISTEIN (GEN) BY GAVAGE INCREASES IGE AND IGG1 PRODUCTION BY ADULT B6C3F1 MICE FOLLOWING TREATMENT WITH RESPIRATORY ALLERGEN TRIMELLITIC ANHYDRIDE (TMA). T. L. Guo, R. P. Chi, W. Auttachoat, D. M. Hernandez and K. L. White, Jr.. Virginia Commonwealth University, Richmond, VA. #1717 4:04 DIFFERENTIAL EXPRESSION OF ARGINASE IN OVALBUMIN (OA) AND TRIMELLITIC ANHYDRIDE (TMA) INDUCED ASTHMA. J. F. Regal 1 , A. L. Greene 1 , R. R. Regal 2 , M. Rutherford 4 , C. Giulivi 3 , G. Flickinger 4 , J. Hendrickson 4 and M. Mohrman 1 . 1 Biochemistry & Molecular Biology, University of Minnesota, Duluth, MN, 2 Mathematics & Statistics, University of Minnesota, Duluth, MN, 3 Molecular Biosciences, University of California-Davis, Davis, CA and 4 Veterinary & Biomedical Sciences, University of Minnesota, St. Paul, MN. 180 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Room RO8 PLATFORM SESSION: MOLECULAR MECHANISMS OF OXIDATIVE STRESS Chairperson(s): Dennis Petersen, University of Colorado, Denver, CO and Ramesh Gupta, Murray State University, Hopkinsville, KY. #1718 1:30 4-HYDROXYNONENAL MODIFICATION OF MOLECULAR CHAPERONES IN A RAT MODEL OF CHRONIC ALCOHOLIC LIVER INJURY. D. L. Carbone 1 , J. A. Doorn 2 , Z. Kiebler 1 and D. R. Petersen 1 . 1 University of Colorado Health Sciences Center, Denver, CO and 2 University of Iowa, Iowa City, IA. #1719 1:50 TOXICITY ASSESSMENT OF SILVER NANOPARTICLES (AG 15, 100 NM) IN ALVEOLAR MACROPHAGES. S. Hussain 1 , K. Hess 2 , J. M. Gearhart 1 , K. T. Geiss 3 and J. M. Schlager 3 . 1 Mantech Environment Technology, Inc., Wright-Patterson AFB, Dayton, OH, 2 Geo-Centers, Inc., Wright-Patterson AFB, Dayton, OH and 3 Human Effectiveness Directorate, Wright-Patterson AFB, OH. #1720 2:10 LIPIDOMIC ANALYSIS OF THE EFFECT OF INHIBITION OF CA 2+ -INDEPENDENT PHOSPHOLIPASE A 2 ON OXIDANT-INDUCED NEURONAL CELL DEATH. B. Peterson, K. Guthrie and B. S. Cummings. Pharmacology and Biomed. Sciences., University of Georgia, Athens, GA. #1721 2:30 IDENTIFICATION AND CHARACTERIZATION OF SMALL MOLECULE ACTIVATORS OF THE ANTIOXIDANT RESPONSE ELEMENT. J. T. Kern 1 , H. Luesch 2 , P. G. Schultz 2,3 and J. A. Johnson 1 . 1 2 University of Wisconsin-Madison, Madison, WI, The Scripps Research Institute, La Jolla, CA and 3 Genomics Institute of the Novartis Research Foundation, San Diego, CA. #1722 2:50 PI3 KINASE/AKT, A SURVIVAL PATHWAY AGAINST CYP2E1 DEPENDENT TOXICITY. A. A. Caro and A. I. Cederbaum. Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York. Sponsor: D. Petersen. #1723 3:10 INHIBITION OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE BY 4- HYDROXYNON-2-ENAL AND 4-OXONON-2- ENAL. J. A. Doorn 1 , T. D. Hurley 2 and D. R. Petersen 3 . 1 Medicinal and Natural Products Chemistry, University of Iowa, Iowa City, IA, 2 Biochemistry, Indiana University, Indianapolis, IN and 3 Pharmaceutical Sciences, University of Colorado, Denver, CO. #1724 3:30 INDUCTION OF OXIDATIVE STRESS IN HUMAN LUNG CELLS BY THE ESTROGEN METABOLITE, 4-METHOXYESTRADIOL. Y. J. Cheng 1 , P. Lin 2 and L. W. Chang 1 . 1 Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Kaoshiung, Taiwan and 2 Institute of Toxicology, Chung Shan Medical University, Taichung, Taiwan. #1725 3:50 PROTEOMIC IDENTIFICATION OF NONLETHAL OXIDATIVE INJURY BIOMARKERS. L. Xie and Q. M. Chen. Pharmacology, University of Arizona, Tucson, AZ. #1726 4:10 GR-DEFICIENT MICE (GR1(A1NEU)) ARE SUSCEPTIBLE TO DIQUAT-INDUCED HEPATIC INJURY. L. K. Rogers, X. Meng, M. S. Augustine, S. E. Welty and C. V. Smith. Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Columbus, OH. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: ENDOCRINE DISRUPTORS Chairperson(s): Stephen Safe, Texas A&M University, College Station, TX and Tammy Stoker, U.S. EPA, Research Triangle Park, NC. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1727 CAN THE HERSHBERGER ASSAY SPECIFICALLY DETECT AN ANDROGENIC OR ANTI-ANDROGENIC ACTIVITY OF CHEMICAL? -RELATIONSHIP BETWEEN IN VITRO AND IN VIVO ASSAYS-. M. Nakai 1 , S. Noda 1 , M. Iida 2 , M. Takeyoshi 1 , Y. Minobe 1 , K. Yamasaki 1 , Y. Yakabe 1 and M. Takahashi 3 . 1 Chemicals Evaluation and Research Institute, Kitakatsushika-gun, Japan, 2 Otsuka Pharmceutical Co., Ltd.,, Tokushima, Japan and 3 Pathology Peer Review Center, Tokyo, Japan. #1728 ABILITY OF THE MALE RAT PUBERTAL ASSAY TO DETECT ENVIRONMENTAL CHEMICALS THAT ALTER THYROID HORMONE HOMEOSTASIS. T. E. Stoker, S. C. Laws, J. M. Ferrell and R. L. Cooper. EB, RTD, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #1729 GENE EXPRESSION PROFILING REVEALS COMMON TARGETS FOR VARIOUS ANDROGEN RECEPTOR ANTAGONISTS IN DEVELOPING FETAL RAT TESTIS. X. Mu, K. Liu and K. W. Gaido. CIIT Centers for Health Research, Research Triangle Park, NC. #1730 APPLICATION OF GENE EXPRESSION ANALYSIS OF MANNOSE 6- PHOSPHATE/INSULIN-LIKE GROWTH FACTOR-II RECEPTOR (M6P/IGF2R) IN VENTRAL PROSTATE FOR SCREENING OF CHEMICALS WITH ANDROGEN-MEDIATED ACTIVITIES IN THE RAT HERSHBERGER ASSAY. T. Yamada, K. Bando, S. Kawamura, Y. Okuno and T. Seki. Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd.,, Osaka, Japan. #1731 EFFECTS OF AN ANTIANDROGEN ON PROTEIN AND GENE PROFILES IN ADULT RAT TESTES. C. Friry-Santini 1,3 , P. Kennel 1 , D. Rouquie 1 , M. Samson 2 , M. Benhamed 3 and R. Bars 1 . 1 Research Center, Bayer CropScience, Sophia Antipolis, France, 2 Unit 638, INSERM, Nice, France and 3 Unit 407, INSERM, Oullins, France. Sponsor: N. Carmichael. WEDNESDAY up-to-date information at www.toxicology.org 181
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Contents Program Overview .........
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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