Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
MONDAY
#58 11:10 THE TRANSCRIPTIONAL RESPONSE TO A
PEROXISOME PROLIFERATOR-ACTIVATED
RECEPTOR ALPHA AGONIST INCLUDES
INCREASED EXPRESSION OF PROTEOME
MAINTENANCE GENES. S. P. Anderson 1 , P.
Howroyd 2,3 , J. Liu 4 , X. Qian 4 , R. Bahnemann 5 , C.
Swanson 3 , M. Kwak 6 , T. W. Kensler 6 and J. C.
Corton 7,3 . 1 GSK, Research Triangle Park, NC, 2 EPL,
Research Triangle Park, NC, 3 CIIT, Research Triangle
Park, NC, 4 NCI at NIEHS, Research Triangle Park, NC,
5 6 BASF, Ludwigshafen, Germany, Johns Hopkins
University, Baltimore, MD and 7 ToxicoGenomics,
Chapel Hill, NC.
#59 11:30 ROLE OF PPARALPHA IN CALORIC
RESTRICTION EFFECTS IN THE MOUSE
LIVER. J. C. Corton 1,4 , U. Apte 2 , S. P. Anderson 3 , P.
Limaye 2 , L. Yoon 3 , J. Latendresse 5 , J. Everitt 4 , K. A.
Voss 6 , C. Kimbrough 3 , J. S. Wong 7 , S. S. Gill 7 , R. A.
Chandraratna 8 , M. Kwak 9 , T. W. Kensler 9 , T. M.
Stulnig 10 , K. R. Steffensen 10 , J. Gustafsson 10 and H. M.
Mehendale 2 . 1 ToxicoGenomics, Chapel Hill, NC,
2 3 University of Louisiana, Monroe, LA, GSK, Research
Triangle Park, NC, 4 CIIT, Research Triangle Park, NC,
5 6 7 PAI, Jefferson, AR, USDA, Athens, GA, University
of California, Riverside, CA, 8 Allergan, Irvine, CA,
9 Johns Hopkins University, Baltimore, MD and
10 Karolinska Institute, Huddinge, Sweden.
Monday Morning, March 7
9:30 AM to 12:30 PM
Exhibit Hall
POSTER SESSION: LIVER I
Chairperson(s): Hartmut Jaeschke, University of Arizona, Tucson, AZ.
Displayed: 9:30 AM–12:30 PM
Attended: 9:30 AM–11:00 AM
#60 TOXICOGENETIC ANALYSIS OF
SUSCEPTIBILITY TO ACETAMINOPHEN-
INDUCED LIVER INJURY. A. Hege 1 , C. Lodestro 3 ,
D. Lee 3 , L. D. Balletta 3 , B. U. Bradford 2 , A. Maki 2 , R.
Tennant 4 , M. A. Bogue 5 , K. Paigen 5 , D. W. Threadgill 1,3
and I. Rusyn 1,2 . 1 Curriculum in Toxicology, UNC,
Chapel Hill, NC, 2 Department of Environmental
Sciences and Engineering, UNC, Chapel Hill, NC,
3 Department of Genetics, UNC, Chapel Hill, NC,
4 5 NIEHS, Research Triangle Park, NC and The Jackson
Laboratory, Bar Harbor, ME.
#61 PARACETAMOL TOXICITY IN RATS
PRETREATED WITH CYTOCHROME P450 OR
GLUTATHIONE INHIBITORS USING AN
INTEGRATED GENOMICS APPROACH. M. F.
DeCristofaro 1 , D. Bodian 1 , E. Perentes 2 , I. M.
Nicholls 2 , P. End 2 , J. Harleman 2 , S. Chibout 3 , F.
Staedtler 3 and H. Firat 3 . 1 Biomarker Development,
Novartis Pharmaceuticals Corporation, East Hanover,
NY, 2 Preclinical Safety, Novartis Pharmacology AG,
Basel, Switzerland and 3 Biomarker Development,
Novartis Pharmacology AG, Basel, Switzerland.
#62 DECREASED ACETAMINOPHEN AND
BROMOBENZENE-INDUCED
HEPATOTOXICITY AND LETHALITY IN TYPE 2
DIABETIC MICE. M. S. Mitra 1 , S. P. Sawant 1 , A. V.
Dnyanmote 1 , J. R. Latendresse 2 , A. Warbritton 2 and H.
M. Mehendale 1 . 1 University of Louisiana at Monroe,
Monroe, LA and 2 NCTR, Jefferson, AR.
#63 ROLE OF POLY(ADP-RIBOSE) POLYMERASE
(PARP) ACTIVATION IN ACETAMINOPHEN-
INDUCED LIVER CELL NECROSIS IN MICE. C.
Cover 1 , P. Fickert 2 , T. Knight 1 , A. Fuchsbichler 2 , M.
Trauner 2 and H. Jaeschke 1 . 1 Liver Research Institute,
University of Arizona, Tucson, AZ and 2 Department of
Medicine, Medical University of Graz, Graz, Austria.
#64 PROTEOMIC ANALYSIS OF WHOLE LIVER
AND SUBCELLULAR FRACTIONS FOLLOWING
ACETAMINOPHEN-INDUCED
HEPATOTOXICITY IN MALE RATS. M. E. Bruno 1 ,
B. A. Wetmore 1 , J. H. Madenspacher 1 , R. Pieper 1 , A. M.
McGrath 2 , C. L. Gatlin 2 , A. J. Makusky 2 , M. Zhao 2 , J.
Zhou 2 , J. Taylor 2 , S. Steiner 2 , J. M. Fostel 1 , M. D.
Waters 1 , R. W. Tennant 1 , K. B. Tomer 1 and B. A.
Merrick 1 . 1 National Ctr Toxicogenomics, NIEHS,
Research Triangle Pk, NC and 2 Proteomics Division,
Large Scale Biology Corporation, Germantown, MD.
#65 ROLE OF THE XENOBIOTIC RECEPTOR PXR
IN ACETAMINOPHEN HEPATOTOXICITY. K. K.
Wolf 2 , S. G. Wood 1 , B. W. Walton-Strong 3 , K. Yasuda 7 ,
L. Lan 7 , P. R. Sinclair 1,3,2 , S. A. Wrighton 4 , E. H.
Jeffery 5 , R. M. Evans 6 , E. G. Schuetz 7 and J. F.
Sinclair 1,3,2 . 1 Veterans Administration Medical Center,
White River Junction, VT, 2 Pharmacology and
Toxicology, Dartmouth Medical School, Hanover, NH,
3 Biochemistry, Dartmouth Medical School, Hanover,
NH, 4 Department of Drug Disposition, Lilly Research
Laboratories, Indianapolis, IN, 5 Department of Food
Science and Human Nutrition, University of Illinois,
Urbana, IL, 6 Howard Hughes Medical Institute, Gene
Expression Laboratory, The Salk Institute for Biological
Studies, La Jolla, CA and 7 Department of
Pharmaceutical Sciences, St. Jude Children’s Research
Hospital, Memphis, TN.
#66 THE EFFECT OF S-ADENOSYL-L-METHIONINE
(SAME)ON MITOCHONDRIAL GLUTATHIONE
AND PROTEIN CARBONYLS FOLLOWING
ACETAMINOPHEN (APAP) TREATMENT IN
MICE. M. Terneus, K. Kiningham and M. Valentovic.
Pharmacology, Marshall University School of Medicine,
Huntington, WV.
#67 EVIDENCE SUGGESTING A ROLE FOR
NAD(P)H:QUINONE OXIDOREDUCTASE 1 IN
THE PROTECTION AGAINST
ACETAMINOPHEN HEPATOTOXICITY BY
CLOFIBRATE TREATMENT. J. S. Moffit 1 , L. M.
Aleksunes 1 , A. M. Slitt 2 , M. Kardas 1 , C. D. Klaassen 2
and J. E. Manautou 1 . 1 Department of Pharmaceutical
Sciences, University of Connecticut, Storrs, CT and
2 Department of Pharmacology, Toxicology and
Therapeutics, University of Kansas Medical Center,
Kansas City, KS.
54
SOT’s 44 th Annual Meeting