Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: MECHANISMS OF CARCINOGENESIS Chairperson(s): Michael A. Pereira, Ohio State University, Columbus, OH and Mark S. Miller, Wake Forest University School of Medicine, Winston Salem, NC. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1786 CHANGES IN THE METHYLATION STATUS OF GC-RICH REGIONS OF DNA DURING THE PROMOTION STAGE OF SKIN TUMORIGENESIS. A. N. Carnell-Bachman 1 , G. M. Curtin 2 , D. J. Doolittle 2 and J. I. Goodman 1 . 1 Pharmacology and Toxicology, Michigan State University, East Lansing, MI and 2 Research and Development, R. J. Reynolds Tobacco Company, Winston-Salem, NC. #1787 DIETHANOLAMINE (DEA) AND PHENOBARBITAL (PB) PRODUCE AN ALTERED PATTERN OF METHYLATION IN GC-RICH REGIONS OF DNA IN B6C3F1 MOUSE HEPATOCYTES SIMILAR TO THAT RESULTING FROM CHOLINE DEFICIENCY. J. I. Goodman 1 , L. M. Kamendulis 2 and A. N. Carnell-Bachman 1 . 1 Pharmacology and Toxicology, Michigan State University, East Lansing, MI and 2 Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN. #1788 DNA HYPOMETHYLATION INDUCED BY DRINKING WATER DISINFECTION BY- PRODUCTS IN MOUSE AND RAT KIDNEY. L. Tao 1 , W. Wang 1 , P. M. Kramer 2 , L. Li 2 and M. A. Pereira 1,2 . 1 Internal Medicine, Ohio State University, Columbus, OH and 2 Molecular Biology and Biochemistry, Medical College of Ohio, Toledo, OH. #1789 LOSS OF HISTONE ACETYLATION BY NICKEL: AN EPIGENETIC MECHANISM OF NICKEL CARCINOGENESIS. Q. ke, T. Kluz and M. Costa. Department of Environmental Health, New York University School of Medicine, Nelson Institute, Tuxedo, NY. #1790 SEXUAL DIMORPHISM IN DNA METHYLATION IN THE LIVER OF HEXACHLOROBENZENE- TREATED RAT : A POSSIBLE MECHANISM FOR TUMOR PROMOTION. N. J. Raynal, M. Charbonneau, B. Alt, L. Lee and D. G. Cyr. INRS- Institut Armand-Frappier, Universite du Quebec, Pointe- Claire, QC, Canada. #1791 LOSS OF BRG1 AND LUNG CANCER PATHOGENESIS. C. Bartlett 1 , G. Rosson 2 and B. Weissman 2,1 . 1 Curriculum in Toxicology, UNC-CH, Chapel Hill, NC and 2 Pathology and Laboratory Medicine, UNC-CH, Chapel Hill, NC. Sponsor: C. Harper. #1792 SECONDARY GENETIC ALTERATIONS IN LUNG TUMORS POSSESSING A PRIMARY KI- RAS MUTATION. H. S. Floyd 1 , J. Jennings-Gee 1 , N. D. Kock 2 and M. S. Miller 1 . 1 Cancer Biology, Wake Forest University, Winston-Salem, NC and 2 Comparative Medicine, Wake Forest University, Winston-Salem, NC. #1793 COMPARISON OF EXPRESSION PROFILES OF ENU-INDUCED FORESTOMACH TUMORS AND URETHANE-INDUCED LUNG TUMORS IN RASH2 MICE. M. Okamura 1 , A. Unami 2 , Y. Oishi 2 , K. Sumida 3 , Y. Kashida 1 , N. Machida 1 and K. Mitsumori 1 . 1 Tokyo university of agriculture and technology, Tokyo, Japan, 2 Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,, Osaka, Japan and 3 Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.,, Osaka, Japan. Sponsor: M. Takahashi. #1794 CYTOCHROME P4502E1 (CYP2E1) MEDIATED METABOLISM IS A PRE-REQUISITE FOR THE PATHOGENESIS OF URETHANE-INDUCED GENOTOXICITY AND CARCINOGENICITY. U. Hoffler 1,2 , D. Dixon 2 , S. Peddada 2 and B. I. Ghanayem 2,1 . 1 Department of Pharmacology, Meharry Medical College, Nashville, TN and 2 NIEHS/NIH, Research Triangle Park, NC. #1795 EFFECTS OF AFB 1 ON EXPRESSION OF P53 AND MDM2 AND ON APOPTOSIS IN HUMAN LUNG CELLS. T. L. Watterson 1 , T. R. Van Vleet 2 and R. A. Coulombe 1 . 1 Toxicology Graduate Program, Utah State University, Logan, UT and 2 Drug Safety Evaluation, Bristol-Myers Squibb Company, Mt. Vernon, IN. #1796 NOVEL LAVENDAMYCINS AND AB RING SYSTEM ANALOGUES: IN VITRO CYTOTOXICITY, APOPTOSIS INDUCTION AND METABOLISM BY NAD(P)H:QUINONE OXIDOREDUCTASE 1 (NQO1). M. Hassani 1 , W. Cai 2 , K. C. Bray 1 , M. Behforouz 2 and H. D. Beall 1 . 1 Center for Environmental Health Sciences, The University of Montana, Missoula, MT and 2 Department of Chemistry, Ball State University, Muncie, IN. #1797 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR N- GLUCURONIDATION 4-AMINOBIPHENYL IN MICE LIVER MICROSOMES AND EXPRESSED HUMAN SUPERSOMES. M. H. Al-Zoughool. Environmental Health, University of Cincinanti, Cincinnati, OH. #1798 URINARY BLADDER ENDPOINTS IN WORKERS AND RATS EXPOSED TO PERFLUOROOCTANESULFONYL FLUORIDE (POSF) AND RELATED COMPOUNDS. G. Olsen 1 , B. Alexander 2 , S. Cohen 3 and J. Butenhoff 1 . 1 3M Company, St. Paul, MN, 2 University of Minnesota, Minneapolis, MN and 3 University of Nebraska Med. Ctr., Omaha, NE. 186 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1799 DNA DAMAGE AND CYTOGENETIC EFFECTS OF OCHRATOXIN A IN RATS IN VIVO. A. Mally 1 , G. Pepe 2 , S. Ravoori 3 , M. Fiore 2 , R. C. Gupta 3 , P. Mosesso 2 and W. Dekant 1 . 1 Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany, 2 Dipartimento die Agrobiologia e Agrochimica, Universita degli Studi della Tuscia, Viterbo, Italy and 3 Pharmacology&Toxicology, Brown Cancer Center, University of Louisville, Louisville, KY. #1800 α 2U -GLOBULIN AND RENAL TUMORS IN NATIONAL TOXICOLOGY PROGRAM (NTP) STUDIES. A. M. Doi, G. D. Hill, J. R. Hailey and J. R. Bucher. NTP, NIEHS, Research Triangle Park, NC. #1801 THE TSC-2 TUMOR SUPPRESSOR GENE MODULATES MULTIPLE CELL PROLIFERATION PATHWAYS. M. T. Labenski 1 , X. Wei 1 , A. Hunt 1 , G. Tsaprailis 1 , M. S. Chacko 2 , M. D. Person 2 , J. Shen 2 , S. C. Hensley 3 , T. J. Monks 1 and S. S. Lau 1 . 1 Pharmacology and Toxicology, University of Arizona, Tucson, AZ, 2 Pharmacology and Toxicology, University of Texas at Austin, Austin, TX and 3 UTMDACC, Science Park, Smithville, TX. #1802 GLOBAL EXPRESSION PROFILING OF MALE RAT KIDNEY: CO-ADMINISTRATION OF A SPECIFIC ESTROGEN RECEPTOR (ER) ANTAGONIST INHIBITS A DYNAMIC 17B- ESTRADIOL (E2) RESPONSE. P. H. Koza-Taylor 1 , G. D. Cappon 4 , J. D. Obourn 3 , J. C. Cook 2 and M. P. Lawton 1 . 1 MIT, Pfizer, Groton, CT, 2 FD & LS, Pfizer, Groton, CT, 3 ED, Pfizer, Groton, CT and 4 Toxicology Sciences, Pfizer, Groton, CT. #1803 APOPTOSIS, SENESCENCE AND CYTODIFFERENTIATION IN CARCINOGENIC MODELING. N. H. Chiu 4 , G. Merlino 2 , K. H. Kim 3 , C. J. Kermp 3 and J. Beaubier 5 . 1 NCEADC, U.S. EPA, Washington, DC, 2 Lab. Molecular Biology, National Cancer Institute, Bethesda, MD, 3 Division Human Biol, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 4 Office Science Technology Office of Water, U.S. EPA, Washington, DC and 5 Office Pesticide Pollution Prevention Toxics, U.S. EPA, Washington, DC. Sponsor: D. Singh. #1804 NUMBER OF CRITICAL CELL-CYCLE-EVENTS IN CANCER DEVELOPMENT OF P53-P27 KO MICE. N. Chiu 3 , K. H. Kim 2 , C. Kemp 2 and J. Beaubier 4 . 1 NCEADC, U.S. EPA, Washington DC, DC, 2 Division Human Biology Public Health Sciences, Fred Hutchindon Cancer Research Center, Seattle, WA, 3 Office Science & Technology, Office of Water, U.S. EPA, Washington, DC and 4 Office Pollution Prevention and Toxics, U.S. EPA, Washington, DC. Sponsor: D. Singh. #1805 ARNT, A PUTATIVE COACTIVATOR OF C- MYC/MAX SIGNALING PATHWAY, INTERACTS WITH C-MYC. R. wu, M. Hoagland and H. Swanson. University of Kentucky, Lexington, KY. #1806 A POTENTIAL ROLE FOR C-MYB, BAX AND THE ARYL HYDROCARBON RECEPTOR IN BENZENE-INITIATED TOXICITY. H. J. Badham 1 and L. M. Winn 1,2 . 1 Pharmacology and Toxicology, Queen’s University, Kingston, ON, Canada and 2 School of Environmental Studies, Queen’s University, Kingston, ON, Canada. #1807 THE ESTROGENIC ACTIVITIES OF ARYL HYDROCARBON RECEPTOR AGONISTS ARE DUE TO DIRECT ACTIVATION OF ESTROGEN RECEPTOR α M. Abdelrahim 1 , K. Kim 2 , S. Pearce 3 , E. Ariazi 3 , H. Liu 3 , V. Jordan 3 and S. Safe 1,2 . 1 Institute of Biosciences & Technology, Texas A&M University System Health Science Center, Houston, TX, 2 Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX and 3 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL. #1808 INHIBITION OF ESTROGEN RECEPTOR- NEGATIVE BREAST CANCER CELL GROWTH BY ARYL HYDROCARBON RECEPTOR AGONISTS. L. Kotha and S. Safe. Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX. #1809 CONSEQUENCES OF INTERACTION OF THE EQUINE ESTROGEN METABOLITE, 4- HYDROXYEQUILENIN, WITH ESTROGEN RECEPTOR α M. Chang and J. L. Bolton. University of Illinois at Chicago, Chicago, IL. #1810 G2/M BLOCK OF PRIMARY MAMMARY EPITHELIAL CELLS FROM PRE-MENOPAUSAL WOMEN IN RESPONSE TO GENOTOXIC CARCINOGEN EXPOSURE. J. Brooks 1 , J. Wang 1 , A. Humphrey 1 , J. Hearnes 2 , J. Pietenpol 2 , J. Price 2 and S. E. Eltom 1 . 1 Pharmacology, Meharry Medical College, Nashville, TN and 2 Vanderbilt University, Nashville, TN. #1811 CHANGES IN ESTROGEN METABOLISM IN CATECHOL-O-METHYLTRANSFERASE (COMT) DEFICIENT MICE ARE ASSOCIATED WITH INCREASED DEVELOPMENT AND ALTERED GENE EXPRESSION IN THE MOUSE MAMMARY GLAND. C. Borgeest 1 , C. A. Zahnow 2 , S. O. DaCosta 1 , B. L. McAtee 1 , J. A. Flaws 3 , J. K. Babus 3 , S. Biswal 1 and J. D. Yager 1 . 1 Environmental Health Science, Johns Hopkins University, Baltimore, MD, 2 Cancer Biology, Johns Hopkins University, Baltimore, MD and 3 Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD. #1812 INVESTIGATION OF OCTAMETHYLCYCLOTETRASILOXANE (D4) AND DECAMETHYLCYCLOPENTASILOXANE (D5) AS DOPAMINE D2-RECEPTOR AGONISTS. P. A. Jean, K. A. McCracken, J. A. Arthurton and K. P. Plotzke. Dow Corning Corporation, Midland, MI. #1813 TRANSPLACENTAL AND POSTNATAL EXPOSURE OF AIDS DRUGS ZIDOVUDINE (AZT) AND LAMIVUDINE (3TC) IN C3B6F 1 TRP53(+/-) TRANSGENIC MICE. F. W. Lee, S. M. Lewis, C. Crawford, W. T. Allaben and J. E. Leakey. U.S. FDA, NCTR, Jefferson, AR. WEDNESDAY up-to-date information at www.toxicology.org 187
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Annual Meeting Events Calendar (Con
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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