Program - Society of Toxicology
Program - Society of Toxicology
Program - Society of Toxicology
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1981 9:30 MODELING GENE NETWORKS IN THE<br />
NEURONAL ADAPTATION TO ALCOHOL. J. S.<br />
Schwaber. Department <strong>of</strong> Pathology, Anatomy and Cell<br />
Biology, Thomas Jefferson University, Philadelphia, PA.<br />
Sponsor: W. Slikker.<br />
#1982 10:00 SYSTEMS BIOLOGY AND DOSE RESPONSE<br />
ASSESSMENT. M. Andersen. Division <strong>of</strong><br />
Biomathematics and Physical Sciences, CIIT, Research<br />
Triangle Park, NC.<br />
#1983 10:30 AN ±OMICS± APPROACH TO ELUCIDATE<br />
MECHANIMS OF DISRUPTED<br />
NEPHROGENESIS AND FUNCTIONAL<br />
INTERACTIONS BETWEEN AHR AND<br />
WILMS±TUMOR SUPPRESSOR GENE. K. S.<br />
Ramos. Department <strong>of</strong> Biochemistry and Molecular<br />
Biology, University <strong>of</strong> Louisville, Louisville, KY.<br />
#1984 11:00 COMPUTATIONAL SYSTEMS ANALYSIS OF<br />
DEVELOPMENTAL TOXICITY. T. B. Knudsen and<br />
A. V. Singh. Department <strong>of</strong> Molecular, Cellular and<br />
Crani<strong>of</strong>acial Biology, University <strong>of</strong> Louisville,<br />
Louisville, KY.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
Room RO8<br />
WORKSHOP SESSION: CELLULAR/MOLECULAR MECHANISMS<br />
INVOLVED IN ENVIRONMENTAL CHEMICALS- INDUCED<br />
DOPAMINERGIC NEUROTOXICITY AND THE CONSEQUENCES ON<br />
NEURODEGENERATIVE DISEASES<br />
Chairperson(s): Anumantha Kanthasamy, Iowa State University, Ames, IA<br />
and Syed F. Ali, NCTR FDA, Little Rock, AR.<br />
Endorsed by:<br />
Neurotoxicology SS*<br />
Student Advisory Committee<br />
#1985 8:30 CELLULAR/MOLECULAR MECHANISMS<br />
INVOLVED IN ENVIRONMENTAL CHEMICALS-<br />
INDUCED DOPAMINERGIC NEUROTOXICITY<br />
AND THE CONSEQUENCES ON<br />
NEURODEGENERATIVE DISEASES. A. G.<br />
Kanthasamy. Iowa State University, Ames, IA.<br />
#1986 8:35 OXIDATIVE STRESS-SENSITIVE KINASE IN<br />
NEUROTOXINS-INDUCED SELECTIVE<br />
DOPAMINERGIC CELL DEATH: RELEVANCE<br />
TO PARKINSON’S DISEASE. A. G. Kanthasamy.<br />
Biomedical Sciences, Iowa State University, Ames, IA.<br />
#1987 9:15 ROLE OF PROINFLAMATORY CYTOKINES IN<br />
CHEMICALLY-INDUCED DOPAMINERGIC<br />
NEURODEGERATION. J. O’Callaghan.<br />
Neurotoxicology Laboratory, CDC/NIOSH,<br />
Morgantown, WV.<br />
#1988 9:55 BIOLOGICAL BASES FOR PCB INDUCED<br />
ALTERATION IN DOPAMINE-MEDIATED<br />
NEUROLOGICAL FUNCTION. R. F. Seegal 2 , K. L.<br />
Marek 3 , S. A. Factor 4 , R. J. McCaffrey 5 , R. F. Hasse 5<br />
and A. G. Kanthasamy 1 . 1 Biomedical Sciences, Iowa<br />
State University, Ames, IA, 2 New York State<br />
Department <strong>of</strong> Health, Wadsworth Center, Albany, NY,<br />
3 Institute <strong>of</strong> Neurodegenerative Disorders, New Haven,<br />
CT, 4 Albany Medical Center, Albany, NY and<br />
5 University <strong>of</strong> Albany, Albany, NY.<br />
#1989 10:35 ROLE OF NITRIC OXIDE IN<br />
METHAMPHETAMINE-INDUCED<br />
DOPAMINERGIC NEUROTOXICITY IN MICE. S.<br />
F. Ali 1 and Y. Itzhak 2 . 1 Division <strong>of</strong> Neurotoxicology,<br />
NCTR/FDA, Jefferson, AR and 2 Department <strong>of</strong><br />
Psychiatry and Behavioral Sciences, University <strong>of</strong><br />
Miami School <strong>of</strong> Medicine, Miami, FL.<br />
THURSDAY<br />
Environmental neurotoxic chemical exposures are increasingly recognized as<br />
dominant risk factors in the etiology <strong>of</strong> many neurodegenerative disorders<br />
including Parkinson’s disease, Alzheimer’s disease Amyotrophic Lateral<br />
Sclerosis and Huntington’s disease. Exposure to environmental neurotoxic<br />
agents (metals, pesticides, PCBs and others) is <strong>of</strong>ten superimposed with the<br />
pathological hallmarks <strong>of</strong> neurodegenerative disorders. In recent years, cell<br />
death mechanisms have been investigated extensively. Despite this growing<br />
amount <strong>of</strong> information regarding the cell death process, little effort has been<br />
made to integrate this body <strong>of</strong> knowledge with the area <strong>of</strong> neurotoxicology and<br />
establish its relevance to neurodegenerative diseases. This workshop is designed<br />
to fill this gap by entertaining discussion <strong>of</strong> key cell death signaling molecules<br />
and other cellular targets during neurotoxic chemical exposures that may impact<br />
the disease process <strong>of</strong> neurodegenerative disorders. Specifically, novel findings<br />
obtained from both in vitro and in vivo models <strong>of</strong> neurotoxicity using state-<strong>of</strong>the-art<br />
approaches including toxicogenomics, transgenics, knock-outs, and<br />
RNA interference (RNAi) will be presented at this workshop. The workshop<br />
presentations are expected to uncover unifying concepts and set the groundwork<br />
for translation <strong>of</strong> key analogies between neurotoxicology research and neurodegenerative<br />
disorders. Also, questions provided by the speakers will serve as<br />
catalysts for discussion with the audience. Overall, this workshop is likely to<br />
accelerate understanding <strong>of</strong> the role <strong>of</strong> environmental neurotoxic agents in the<br />
etiopathogenesis <strong>of</strong> neurodegenerative disorders as well as to foster the development<br />
<strong>of</strong> novel therapeutic strategies.<br />
202<br />
SOT’s 44 th Annual Meeting