Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
TUESDAY
#838 ASTEMIZOLE : SPECIES DIFFERENCES IN QT
PROLONGATION AND ARRHYTHMOGENESIS.
J. Le Bigot, P. Lainee, A. Betat, G. Froget, L. Camus
and R. Forster. CIT, Evreux, France.
#839 VALIDATION OF THE ISOLATED RABBIT
HEART FOR CARDIOVASCULAR SAFETY
ASSESSMENT. E. Tanhehco, P. Senese and M.
Gralinski. CorDynamics, Inc., Chicago, IL.
#840 NON-SURGICAL TELEMETRY TECHNIQUES
FOR ELECTROCARDIOGRAM (ECG)
DETERMINATION IN DOGS AND MONKEYS
DURING TOXICOLOGY STUDIES. P. Shaver-
Walker, M. Vezina, N. Leblond and C. Copeman. IPN,
CTBR Bio-Research Inc., Senneville, QC, Canada.
#841 GENERATION OF BACKGROUND
ELECTROCARDIOGRAM (ECG) TELEMETRY
DATA IN DOGS USING A POSITIVE CONTROL
SUBSTANCE (DL-SOTALOL) FOR QT
PROLONGATION. M. Vezina, N. Leblond, K.
Tenneson and C. Copeman. IPN, CTBR Bio-Research
Inc., Senneville, QC, Canada.
#842 THE ROLE OF CALPAIN-CALPASTATIN
SYSTEM IN 2-BUTOXYETHANOL-INDUCED
HEMOLYSIS. P. S. Palkar, V. S. Bhave, B. K. Philip,
P. B. Limaye and H. M. Mehendale. Department of
Toxicology, University of Louisiana at Monroe,
Monroe, LA.
#843 ADHESION-MOLECULE CHANGES IN 2-
BUTOXYETHANOL (BE) FISCHER F344 RAT
MODEL FOR THROMBOTIC SEQUELAE OF
HEMOLYTIC ANEMIAS. T. L. Ortel 2 , A. Potti 2 , D.
Lewis 2 , J. Wu 2 and A. Nyska 1 . 1 Laboratory of
Experimental Pathology, NIEHS, Research Triangle
Park, NC and 2 Division of Hematology, Duke
University Medical Center, Durham, NC.
#844 2-BUTOXYETHANOL FEMALE RAT MODEL OF
HEMOLYSIS AND DISSEMINATED
THROMBOSIS: X-RAY CHARACTERIZATION
OF OSTEONECROSIS AND GROWTH PLATE
SUPPRESSION. D. N. Lewis 1 , K. Johnson 1 , D.
Malarkey 1 , S. Ward 1 , M. Streicker 3 , S. Shabat 4 , S.
Peddada 2 , M. Nyska 4 and A. Nyska 1 . 1 Laboratory of
Experimental Pathology, NIEHS, Research Triangle
Park, NC, 2 Biostatistics Branch, NIEHS, Research
Triangle Park, NC, 3 Integrated Laboratory Systems
(ILS), Research Triangle Park, NC and 4 Department of
Orthopaedic Surgery, Sapir Medical Center, Kfar-Saba,
44281, Israel.
#845 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN
ALTERS FETAL MURINE CARDIAC GROWTH
AND GENE EXPRESSION, AND LEADS TO
CARDIAC HYPERTROPHY AND ALTERED
CARDIAC FUNCTION AFTER BIRTH. E. A.
Thackaberry, B. A. Nunez, I. D. Ivnitski-Steele and M.
K. Walker. College of Pharmacy, U of New Mexico,
Albuquerque, NM.
#846 SUB-CHRONIC, LOW LEVEL 2, 3, 7, 8-
TETRACHLORODIBENZO-P-DIOXIN (TCDD)
EXPOSURE INCREASES BLOOD PRESSURE IN
ADULT MICE AS MEASURED BY TELEMETRY.
P. G. Kopf, A. K. Lund and M. K. Walker. College of
Pharmacy, University of New Mexico, Albuquerque,
NM.
Tuesday Morning, March 8
9:30 AM to 12:30 PM
Exhibit Hall
POSTER SESSION: PBPK MODELS
Chairperson(s): Jeffery Fisher, Univeristy of Georgia, Athens, GA and Elaina
Kenyon, U.S. EPA, Research Triangle Park, NC.
Displayed: 9:30 AM–12:30 PM
Attended: 9:30 AM–11:00 AM
#847 A HARMONIZED PBPK MODEL FOR
TRICHLOROETHYLENE RISK ASSESSMENT. T.
R. Covington 1 , H. J. Clewell 1 , J. W. Fisher 2 , D. A.
Keys 2 , C. Hack 3 and J. Q. Zhao 3 . 1 ENVIRON Health
Sciences Institute, Ruston, LA, 2 University of Georgia,
Athens, GA and 3 Toxicology Excellence for Risk
Assessment, Cincinnati, OH.
#848 PHYSIOLOGICAL MODELING OF THE
DERMAL ABSORPTION OF
OCTAMETHYLCYCLOTETRASILOXANE (D4)
AND DECAMETHYLCYCLOPENTASILOXANE
(D5). M. B. Reddy 1 , K. P. Plotzke 2 , J. R. Looney 3 , M. J.
Utell 3 , M. L. Jovanovic 2 , J. M. McMahon 2 , D. A.
McNett 2 and M. E. Andersen 4 . 1 Colorado State
University, Fort Collins, CO, 2 Dow Corning
Corporation, Midland, MI, 3 University of Rochester,
Rochester, NY and 4 CIIT, Research Triangle Park, NC.
#849 ALTERATION OF HEXACHLOROBENZENE
DISPOSITION BY PCB126 COEXPOSURE AND
APPLICATION OF PBPK MODELING IN A
MEDIUM-TERM LIVER FOCI BIOASSAY. Y. LU,
M. Lohitnavy, O. Lohitnavy, E. Perrigo and R. Yang.
Environmental and Radiological Health Sciences,
Colorado State University, Fort Collins, CO.
#850 PREDICTIVE PHYSIOLOGICALLY BASED
PHARMACOKINETIC (PBPK) MODELING OF
PYRETHROID PESTICIDES. S. J. Godin 1 , R.
Tornero-Velez 2 , E. J. Scollon 3 , M. F. Hughes 3 and M. J.
Devito 3 . 1 Curriculum in Toxicology, University of North
Carolina, Chapel Hill, NC, 2 NERL, U.S. EPA, ORD,
Research Triangle Park, NC and 3 NHEERL, U.S. EPA,
ORD, Research Triangle Park, NC.
#851 ROUTE-TO-ROUTE EXTRAPOLATION OF
METABOLIC INTERACTIONS IN MIXTURES
OF ALKYLBENZENES USING A PBPK MODEL.
R. Tardif, A. Nong and K. Krishnan. Occupational and
Environmental Health, Universite de Montreal,
Montreal, QC, Canada.
#852 A PBPK MODEL FOR A MIXTURE OF DIOXIN-
LIKE CHEMICALS. M. Easterling 1 , N. J. Walker 2 , F.
M. Parham 2 and C. J. Portier 2 . 1 Constella Group,
Durham, NC and 2 NIEHS, Durham, NC.
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SOT’s 44 th Annual Meeting