Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1934 EVALUATION OF SYSTEMIC TOXICITY IN MIXTURES OF TRICHLOROETHYLENE (TCE), HEPTACHLOR (HEPT), AND DI(2- ETHYLHEXYL)PHTHALATE (DEHP) ASSESSED IN A 5X5X5 DESIGN. J. Simmons 1 , S. Yeatts 2 , J. Zhao 2 , C. Gennings 2 , A. McDonald 1 and R. MacPhail 1 . 1 NHEERL/ORD, U.S. EPA, Resesarch Triangle Park, NC and 2 Department Biostatistics, VCU, Richmond, VA. #1935 FIRST-PASS EFFECTS ON THE BIOAVAILABILITY OF HISTAMINE DIHYDROCHLORIDE. A MULTIPLE- CANNULAE DOG MODEL FOR INVESTIGATION OF HEPATIC ELIMINATION. B. M. Richard 1 , T. M. Tuell 1 , R. R. Lane 1 , J. M. Trang 2 , S. Authier 3 , C. A. Zerouala 3 , S. J. Watson 3 , L. Berryman 3 and S. A. Tonetta 1 . 1 Nonclinical, Maxim Pharmaceuticals, San Diego, CA, 2 PK/PD, PK/PD International, Tucson, AZ and 3 Toxicology, LAB Pre- Clinical Research International, Laval, QC, Canada. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: NEUROTOXICITY, PESTICIDES Chairperson(s): Nikolay Filipov, Mississippi State University, Mississippi State, MS and Timothy Shafer, U.S. EPA, Research Triangle Park, NC. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1936 REACTIVITY AND MODELING STUDIES PREDICT THAT FLUORINATED AMINOPHOSPHONATES (FAP) INHIBIT CHOLINESTERASES (CHE) VIA P—C BOND CLEAVAGE. G. F. Makhaeva 1 , A. Y. Aksinenko 1 , V. B. Sokolov 1 , A. N. Razdolsky 1 , N. N. Strakhova 1 , V. V. Malygin 1 , J. W. Kampf 2 , F. A. Nasser 3 and R. J. Richardson 3 . 1 Institute of Physiologically Active Compounds RAS, Chernogolovka, Russian Federation, 2 Chemistry Department, University of Michigan, Ann Arbor, MI and 3 EHS Department, Toxicology Program, University of Michigan, Ann Arbor, MI. #1937 X-RAY CRYSTAL STRUCTURES OF FLUORINATED AMINOPHOSPHONATE (FAP) COMPOUNDS SHOW AN ELONGATED P—C BOND AND DIMERIZATION. F. A. Nasser 1 , J. W. Kampf 2 , G. F. Makhaeva 3 , A. Y. Aksinenko 3 , V. B. Sokolov 3 , N. N. Strakhova 3 , V. V. Malygin 3 and R. J. Richardson 1 . 1 EHS Department, Toxicology Program, University of Michigan, Ann Arbor, MI, 2 Chemistry Department, University of Michigan, Ann Arbor, MI and 3 Institute of Physiologically Active Compounds RAS, Chernogolovka, Russian Federation. #1938 MASS SPECTOMETRY REVEALS THAT SERINE ESTERASES ARE PHOSPHORYLATED AND AGED BY FLUORINATED AMINOPHOSPHONATE (FAP) COMPOUNDS. N. D. Miller 1 , J. S. Pierce 1 , P. Glynn 2 , R. M. Worden 3 , J. Sun 3 , G. F. Makhaeva 4 , A. Y. Aksinenko 4 , V. B. Sokolov 4 , V. V. Malygin 4 and R. J. Richardson 1 . 1 2 University of Michigan, Ann Arbor, MI, University of Leicester, Leicester, United Kingdom, 3 Michigan State University, East Lansing, MI and 4 Institute of Physiologically Active Compounds RAS, Chernogolovka, Russian Federation. #1939 COMPARISON BETWEEN ELLMAN AND RADIOMETRIC METHODS FOR ASSESSING CHOLINESTERASE (CHE) INHIBITION IN RATS TREATED WITH N-METHYL CARBAMATE INSECTICIDES. D. L. Hunter 1 , D. Chen 4 , R. S. Marshall 1 , S. Padilla 1 , W. Setzer 2 , V. C. Moser 1 and A. Lowit 3 . 1 NTD, U.S. EPA, Research Triangle Park, NC, 2 3 ETD, U.S. EPA, Research Triangle Park, NC, OPP, U.S. EPA, Arlington, VA and 4 Enloe High School, Raleigh, NC. #1940 TIME COURSE AND DOSE RESPONSE ASSESSMENT OF CHOLINESTERASE (CHE) INHIBITION IN ADULT RATS TREATED ACUTELY WITH CARBARYL, METHOMYL, METHIOCARB, OXAMYL OR PROPOXUR. S. Padilla 1 , R. S. Marshall 1 , D. L. Hunter 1 , P. Phillips 1 , K. McDaniel 1 , V. C. Moser 1 and A. Lowit 2 . 1 NTD, U.S. EPA, Research Triangle Park, NC and 2 OPP, U.S. EPA, Arlington, VA. #1941 COMPARISON OF ACUTE NEUROBEHAVIORAL EFFECTS OF N-METHYL CARBAMATE INSECTICIDES. V. C. Moser 1 , P. M. Phillips 1 , K. L. McDaniel 1 , R. S. Marshall 1 , S. Padilla 1 and A. Lowit 2 . 1 NTD/NHEERL, U.S. EPA, Research Triangle Park, NC and 2 HED/OPP, U.S. EPA, Arlington, VA. #1942 THE ORGANOPHOSPHOROUS INSECTICIDE FENTHION DOES NOT AFFECT PHAGOCYTOSIS OF ROD OUTER SEGMENTS BY RETINAL PIGMENT EPITHELIUM CELLS IN CULTURE. A. M. Geller and L. L. Degn. Neurotoxicology, U.S. EPA, Research Triangle Park, NC. #1943 CONCURRENT EXPOSURE TO REPEATED STRESS AND CHLORPYRIFOS ALTERED NMDA AND TOTAL MUSCARINIC RECEPTOR RESPONSES IN HIPPOCAMPUS, CEREBRAL CORTEX AND HYPOTHALAMUS. T. Pung, K. Fuhrman, B. Klein, D. Blodgett, B. S. Jortner and M. Ehrich. Virginia Tech, Blacksburg, VA. #1944 NEUROTROPHIN CONCENTRATION AFTER IN VIVO EXPOSURE TO NEUROPATHIC AND NON- NEUROPATHIC ORGANOPHOSPHATES. M. J. Pomeroy-Black, M. F. Ehrich and B. S. Jortner. Laboratory for Neurotoxicity Studies, Department of Biomedical Science and Pathobiology, Virginia- Maryland Regional College of Veterinary Medicine, Blacksburg, VA. 196 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1945 CHLORPYRIFOS INDUCES APOPTOSIS IN OLIGODENDROCYTE PROGENITOR (CG-4) CELLS. S. O. Heyliger 1 , M. D. Saulsbury 1 , D. J. Johnson 1 , D. P. Round 1 , J. K. Morse 1 and S. Green 2 . 1 Pharmaceutical Sciences, Hampton University, Hampton, VA and 2 Pharmacology, Howard University School of Medicine, Washington, DC. #1946 ROLE OF A-ESTERASES IN THE AGE-RELATED DIFFERENCES IN ORGANOPHOSPHATE DETOXICATION. E. C. Meek 1 , H. Chambers 2 and J. E. Chambers 1 . 1 Center for Environmental Health Sciences, Mississippi State University, Mississippi State, MS and 2 Department of Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS. #1947 EFFECT OF ORGANOPHOSPHATE INSECTICIDE EXPOSURE ON DOPAMINE METABOLISM IN STRIATAL SLICES. J. A. Whitehead 1 , E. C. Meek 1 , J. E. Chambers 1 , S. C. Sistrunk 1 , H. W. Chambers 2 and N. M. Filipov 1 . 1 Center for Environmental Health Sciences, Coll. Vet. Med., Mississippi State University, Mississippi State, MS and 2 Entomology, Mississippi State University, Mississippi State, MS. #1948 THIOFLAVIN-T, AN ACETYLCHOLINESTERASE PERIPHERAL SITE LIGAND, DECREASES NG108-15 CELL PROLIFERATION. H. M. Campanha and E. J. Flynn. Pharmacology and Physiology, UMD-New Jersey Medical School, Newark, NJ. #1949 TOXICITY OF CHLORPYRIFOS AND CHLORPYRIFOS OXON IN A TRANSGENIC MOUSE MODEL OF THE HUMAN PARAOXONASE (PON1) Q192R POLYMORPHISM. T. B. Cole 1,2,3 , B. J. Walter 1 , D. M. Shih 4 , A. Tward 4 , A. J. Lusis 4 , L. G. Costa 1 and C. E. Furlong 2,3 . 1 Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 2 Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, 3 Genome Sciences, University of Washington, Seattle, WA and 4 Microbiology and Molecular Genetics, UCLA, Los Angeles, CA. #1950 EFFECTS OF DIAZINON AND CYPERMETHRIN ON DIFFERENTIATING NEURONAL AND GLIAL CELL LINES. M. Sachana 1 , W. Harris 3 , J. Tack 3 , J. Flaskos 2 and A. J. Hargreaves 3 . 1 Veterinary Pathology, University of Liverpool, Neston, United Kingdom, 2 Laboratory of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotelian University, Thessalonika, Greece and 3 School of Science, Faculty of Science and Land Based Studies, Nottingham Trent University, Nottingham, United Kingdom. Sponsor: R. Gupta. #1951 GLUCOSE CONSUMPTION ENHANCES PARATHION TOXICITY: FUNCTIONAL AND NEUROCHEMICAL CORRELATES. J. Liu, A. Abbey and S. Karanth. Physiological Sciences, Oklahoma State University, Stillwater, OK. #1952 IMMEDIATE EARLY ALTERATION AND DIFFERENTIAL PERSISTENCE OF PKA (PROTEIN KINASE A) / P-CREB (PHOSPHORYATED CREB) PATHWAY IN THE CENTRAL NERVOUS SYSTEM OF HENS DEVELOPING DELAYED NEUROTOXICITY (OPDIN) BY A SINGLE DOSE OF DIISOPROPYLPHOSPHOROFLUORIDATE (DFP) TREATMENT. T. V. Damodaran, R. Gupta and M. Abou-Donia. Pharmacology/ Pediatrics, Duke University Medical Center, Durham, NC. #1953 ACTIONS OF PYRETHROID INSECTICIDES ON THE SPONTANEOUS RELEASE OF GLUTAMATE FROM CULTURED HIPPOCAMPAL NEURONS. D. A. Meyer 2 and T. J. Shafer 1 . 1 Neurotoxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC and 2 Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC. #1954 EFFECT OF PYRETHROIDS ON GLUTAMATE RELEASE IN THE HIPPOCAMPUS OF FREELY MOVING RATS. H. Kobayashi 1,3 , M. M. Hossain 1,3 , T. Suzuki 1,3 , I. Sato 1,3 , T. Takewaki 3 and K. Suzuki 2 . 1 Veterinary Medicine, Iwate University, Morioka, Iwate, Japan, 2 Agro-bioscience, Iwate University, Morioka, Iwate, Japan and 3 United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan. Sponsor: G. Corcoran. #1955 EFFECTS OF EXPOSURE TO THE PESTICIDE ATRAZINE ON STRIATAL NEUROCHEMISTRY IN MALE C57BL/6 MICE ARE AGE- DEPENDENT. N. M. Filipov, A. Coban, S. C. Sistrunk and A. B. Norwood. Center for Environmental Health Sciences, Basic Sciences, Coll. Vet. Med., Mississippi State University, Mississippi State, MS. #1956 EFFECTS OF 14-DAY EXPOSURE TO THE HERBICIDE ATRAZINE ON DOPAMINE NEURONS IN THE SUBSTANTIA NIGRA AND VENTRAL TEGMENTAL AREA OF JUVENILE MALE C57BL/6 MICE. A. Coban, A. B. Norwood and N. M. Filipov. Center for Environmental Health Sciences, Basic Sciences, Coll. Vet. Med., Mississippi State University, Mississippi State, MS. #1957 DECREASE OF THE STRIATAL DOPAMINE RELEASE CAUSED BY ACUTE ATRAZINE EXPOSURE IS BLOCKED BY HALOPERIDOL ADMINISTRATION. V. M. Rodriguez, M. Thiruchelvam and D. A. Cory-Slechta. Environmental and Community Medicine, Environmental and Occupational Health Sciences Institute, The University of Medicine and Dentistry of New Jersey and Rutgers, Piscataway, NJ. #1958 GENDER DIFFERENCES IN A PESTICIDE MODEL OF PARKINSON’S DISEASE. M. Thiruchelvam, H. Mehta, B. Winnik, B. Buckley, E. K. Richfield and D. A. Cory-Slechta. EOHSI, UMDNJ–Robert Wood Johnson Medical School, Piscataway, NJ. WEDNESDAY up-to-date information at www.toxicology.org 197
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Annual Meeting Events Calendar (Con
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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