Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description THURSDAY Thursday Morning, March 10 8:30 AM to 11:30 AM La Louisiane Ballroom B POSTER SESSION: PERSISTENT ORGANIC POLLUTANTS Chairperson(s): Jay Silkworth, General Electric Company, Schenectady, NY. Displayed: 8:30 AM–11:30 AM Attended: 8:30 AM–10:00 AM #2033 EFFECTS OF TCDD ON THE LEVELS OF BIOGENIC AMINES IN DIFFERENT BRAIN REGIONS OF RATS AFTER SUBCHRONIC EXPOSURE. K. Masters, J. Byers and E. A. Hassoun. Pharmacology, The University of Toledo, Toledo, OH. #2034 IGF-1 MEDIATES THE EFFECTS OF TCDD AND HXCDD ON BODY WEIGHT AND THE INHIBITION OF PEPCK. C. R. Croutch 1 , M. Lebofsky 1 , P. F. Terranova 2 and K. K. Rozman 1,3 . 1 Pharmacology Toxicology and Ther, University of KS Med. Center, Kansas City, KS, 2 Center for Reprod. Sciences. and Mol. and Integrative Phys., University of KS Med. Center, Kansas City, KS and 3 Environment Toxicology, GSF-Institut fur Toxikologie, Neuherberg, Germany. #2035 COMPARATIVE 14-WEEK TOXICITY STUDIES OF 2, 3, 7, 8-TETRACHLORODIBENZO-P- DIOXIN (TCDD) IN FEMALE HARLAN SPRAGUE-DAWLEY (HSD) AND FISCHER 344 (F344) RATS. M. Hejtmancik 1 , L. Fomby 1 , D. Vasconcelos 1 , M. Ryan 1 , M. Vallant 2 , D. Orzech 2 , R. Chhabra 2 , A. Nyska 2 , H. Toyoshiba 2 , N. Walker 2 and M. Hooth 2 . 1 Battelle Columbus, Columbus, OH and 2 ETP, NIEHS, Research Triangle Park, NC. #2036 EFFECTS OF 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN (TCDD) ON PROLACTIN (PRL) GENE EXPRESSION IN VIVO AND IN VITRO. J. Cao and S. L. Petersen. Molecular and Cellular Biology Program, Amherst, MA. #2037 INVOLVEMENT OF PROSTAGLANDIN PATHWAY IN CIRCULATION FAILURE INDUCED BY 2, 3, 7, 8- TETRACHLORODIBENZO-P-DIOXIN IN DEVELOPING ZEBRAFISH. H. Teraoka 1 , W. Dong 1,2 , A. Shindo 1 , Y. Harada 3 and T. Hiraga 1 . 1 School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan, 2 College of Animal science and Technology, Inner Mongolia University for Nationalities, TongLiao, China and 3 Graduate School of Medical Science, Kitasato University, Sagamihara, Japan. #2038 DOSE- AND TIME-DEPENDENT HEPATIC GENE EXPRESSION PROFILING IN FEMALE RATS EXPOSED TO PCB126. R. J. Foxenberg 1 , B. J. Ovando 1 , K. M. Kransler 1 , C. M. Vezina 2 and J. R. Olson 1 . 1 Pharmacology and Toxicology, SUNY at Buffalo, Buffalo, NY and 2 Pharmacy, University of Wisconsin, Madison, WI. #2039 EFFECTS OF AMMONIUM PERCHLORATE ON LIVER ENZYMES AND THE THYROID AXIS OF RATS PRETREATED WITH PCB126. E. D. McLanahan 1 , J. Campbell 1 , S. Muralidhara 1 , J. Hedge 2 , L. Narayanan 3 , J. Bruckner 1 , K. Crofton 2 , D. Mattie 3 , D. Keys 1 , M. Mumtaz 4 , D. Ferguson 1 and J. Fisher 1 . 1 Interdisciplinary Toxicology Program, University of Georgia, Athens, GA, 2 Neurotoxicology Division, U.S. EPA/ORD/NHEERL, Research Triangle Park, NC, 3 AFRL/HEPB, Wright-Patterson AFB, OH and 4 Division of Toxicology, ATSDR, Atlanta, GA. #2040 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN MODULATES A TRANSLOCATION OF PKC-βII VIA RECEPTOR FOR ACTIVATED C KINASE (RACK-1) IN DEVELOPING NEURONAL CELLS IN CULTURE. J. Yang. Pharmacology/Toxicology, Catholic University of Daegu, Daegu, South Korea. Sponsor: P. Kodavanti. #2041 TCDD ELICITS TYPICAL DEFENSIVE CELL STRESS RESPONSES FROM MCF10A CELLS: A STUDY ON THE MECHANISM OF ITS CELL RESCUING ACTION FROM UV-INDUCED APOPTOSIS. F. Matsumura and S. Park. Center for Health and the Environment, University of California, Davis, Davis, CA. #2042 SELECTIVE MODIFICATION OF BHLH/PAS GENE EXPRESSION BY TCDD IN RAT HYPOTHALAMUS. J. Linden 1 , M. Korkalainen 2 , J. Tuomisto 2 and R. Pohjanvirta 1,3,2 . 1 Department of Food and Environmental Hygiene, University of Helsinki, Helsinki, Finland, 2 Department of Environmental Health, National Public Health Institute, Kuopio, Finland and 3 Kuopio Department, National Veterinary and Food Research Institute, Kuopio, Finland. #2043 COMPARISON OF THE TCDD-INDUCED CYP1A1 GENE EXPRESSION PROFILE IN LYMPHOCYTES FROM MICE, RATS AND HUMANS. K. Nohara, Y. Miyamoto, K. Ao, T. Ito and C. Tohyama. National Institute for Environmental Studies, Tsukuba, Japan. #2044 ANALYSIS OF TEQ-EQUIVALENT AROCLOR AND TCDD TREATED RATS REVEALS DIFFERENT GENE DOSE-RESPONSE PROFILES AMONG DIOXIN RESPONSIVE GENES. K. Illouz 1 , S. Goodwin 3 , A. Possolo 1 , S. B. Hamilton 2 , T. R. Sutter 3 and J. B. Silkworth 1 . 1 GE Global Research, Schenectady, NY, 2 GE Corporate, Fairfield, CT and 3 Feinstone Center for Genomic Research, U Memphis, Memphis, TN. #2045 DIOXIN-RESPONSIVE DOWN-REGULATION OF SERPINA7, CYP3A9/3A13, AND CES3 REQUIRES A FUNCTIONAL ARYL HYDROCARBON RECEPTOR. B. J. Ovando 1 , C. M. Vezina 2 and J. R. Olson 1 . 1 Pharmacology & Toxicology, University at Buffalo, Buffalo, NY and 2 Pharmacy, Unviversity of Wisconsin, Madison, WI. 206 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #2046 COPLANAR POLYCHLORINATED BIPHENYLS ACTIVATE ARYL HYDROCARBON RECEPTOR IN DEVELOPING TISSUES OF TWO TCDD- RESPONSIVE LACZ MOUSE LINES. J. C. Bemis 1 , D. A. Nazarenko 2 and T. A. Gasiewicz 1 . 1 Environmental Medicine, University of Rochester, Rochester, NY and 2 Toxicology and Applied Biology, Alkemes Inc., Cambridge, MA. #2047 CCN4 AND CCN5 ARE DOWN REGULATED IN RESPONSE TO THE ADIPOGENIC STIMULATION WHILE 2, 3, 7, 8–TETRACHLORODIBENZO-P-DIOXIN (TCDD) ELEVATES CCN5 MESSAGE IN C3H10T1/2 MOUSE EMBRYO FIBROBLASTS. M. Cimafranca and C. Jefcoate. Pharmacology, University of Wisconsin, Madison, WI. #2048 DEVELOPMENT OF A NEW DIOXIN- ANALOGUE: 2, 3, 7, 8- TETRACHLOROPHENOTHIAZINE. K. W. Fried 1,2 , G. I. Georg 3 , P. F. Terranova 4,5,6 and K. K. Rozman 1,7 . 1 Pharmacology, Toxicology & Therapeutics, The University of Kansas Medical Center (KUMC), Kansas City, KS, 2 Institute of Ecological Chemistry, GSF-National Research Center for Environment & Health, Neuherberg, Germany, 3 Medicinal Chemistry, The University of Kansas, Lawrence, KS, 4 Center for Reproductive Sciences, KUMC, Kansas City, KS, 5 Molecular & Integrative Physiology, KUMC, Kansas City, KS, 6 Obstetrics & Gynecology, KUMC, Kansas City, KS and 7 Institute of Toxicology, GSF, Neuherberg, Germany. #2049 COMPARISON OF GC/MS AND CALUX ® BY XDS FOR DETECTION OF DIOXIN LIKE COMPOUNDS IN ENVIRONMENTAL SAMPLES. G. C. Clark 1 , A. C. Chu 1 , J. D. Gordon 1 , M. D. Chu 2 and M. S. Denison 3 . 1 Xenobiotic Detection Systems, Inc., Durham, NC, 2 Alta Analytical Perspectives, Wilmington, NC and 3 Department of Environmental Toxicology, University of California, Davis, Davis, CA. #2050 INDUCTION OF EROD-ACTIVITY IN VITRO BY 2, 3, 7, 8-TETRACHLOROPHENOTHIAZINE. K. W. Fried 1,2 , N. Chahbane 2 , C. Corsten 2 , K. Schramm 2 , A. Kettrup 2 and K. K. Rozman 3 . 1 Department of Pharmacology, Toxicology & Therapeutics, The University of Kansas Medical Center, Kansas City, KS, 2 Institute of Ecological Chemistry, GSF-National Research Center for Environment & Health, Neuherberg, Germany and 3 Institute of Toxicology, GSF, Neuherberg, Germany. #2051 LYMPHOCYTES CHOLINERGIC MUSCARINIC RECEPTORS: IN VIVO AND IN VITRO EFFECTS OF THE COMBINED EXPOSURE TO POLYCHLORINATED BIPHENYLS AND METHYLMERCURY. L. Manzo 1,2 , A. F. Castoldi 2 , G. Randine 2 and T. Coccini 2 . 1 Toxicology Division, University of Pavia, Pavia, Italy and 2 IRCCS Maugeri Foundation, Pavia, Italy. #2052 THE ROLE OF SUPEROXIDE ANION IN 2, 2′, 4, 4′-TETRACHLOROBIPHENYL-INDUCED UPREGULATION OF COX-2 IN HL-60 CELLS. S. Bezdecny 1,2,3 , R. A. Roth 1,2,3 and P. E. Ganey 1,2,3 . 1 Department of Pharmacology and Toxicology, Michigan State University, Lansing, MI, 2 Center for Integrative Toxicology, Michigan State University, East Lansing, MI and 3 National Food safety and Toxicology Center, Michigan State University, East Lansing, MI. #2053 RYR1 MALIGNANT HYPERTHERMIA POINT MUTATION R615C ENHANCES SUSCEPTIBILITY TO NON-COPLANAR 2, 2’, 3, 5’-PENTACHLOROBIPHENYL (PCB 95). T. N. Ta 1 , B. R. Fruen 2 and I. N. Pessah 1 . 1 VM: Molecular Biosciences, UC Davis, Davis, CA and 2 Department of Biochemistry, Molecular Biology, and Biophysics, Minnesota. #2054 ANALYSIS OF THE TUMOR PROMOTING POTENCY OF PCB 28 AND PCB 101 IN RAT LIVER. S. Kunz 1 , H. Schmitz 1 , M. Schwarz 2 , B. Schilling 3 , O. Paepke 3 , H. Lehmler 4 , L. Robertson 4 and D. Schrenk 1 . 1 Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany, 2 Department of Toxicology, University of Tuebingen, Tuebingen, Germany, 3 ERGO Research, Hamburg, Germany and 4 Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA. #2055 TRANSCRIPTIONAL PROFILING OF RAT HEPATIC RESPONSES TO DIETARY EXPOSURE TO AROCLOR 1254. T. M. Basford 1,2 and J. C. Means 1,2 . 1 Chemistry, Western Michigan University, Kalamazoo, MI and 2 Great Lakes Environmental and Molecular Science Center, Kalamazoo, MI. #2056 COMPARISON OF AROCLOR AND TCDD RESPONSIVE GENES BETWEEN IN VIVO AND IN VITRO EXPOSURES USING DNA MICROARRAYS. M. Zhao 1 , S. Arunajadai 2 , K. Illouz 1 , A. Possolo 1 , A. Koganti 3 , S. B. Hamilton 4 , S. Goodwin 5 , T. R. Sutter 5 and J. B. Silkworth 1 . 1 Global Research, GE, Schenectady, NY, 2 U.C Berkeley, Berkeley, CA, 3 In Vitro Technologies, Baltimore, MD, 4 5 GE Corporate, Fairfield, CT and U Memphis, Memphis, TN. #2057 ACCUMULATION OF PBDE-47 IN PRIMARY CULTURES OF RAT NEOCORTICAL CELLS. W. Mundy 1 , T. M. Freudenrich 1 , K. M. Crofton 1 and M. J. DeVito 2 . 1 Neurotoxicolgy Division, U.S. EPA, Research Triangle Park, NC and 2 Experimental Toxicology Division, U.S. EPA, Research Triangle Park, NC. #2058 MIXTURE EFFECTS OF PCBs AND PBDES WITH OTHER CONTAMINANTS/DRUGS. H. L. Esch, L. W. Robertson and G. Ludewig. Department of Occupational & Environmental Health, University of Iowa, Iowa City, IA. THURSDAY up-to-date information at www.toxicology.org 207
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Annual Meeting Events Calendar (Con
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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